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anti-Human LLGL1 Antibodies:
anti-Mouse (Murine) LLGL1 Antibodies:
anti-Rat (Rattus) LLGL1 Antibodies:
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Human Monoclonal LLGL1 Primary Antibody for ELISA, WB - ABIN561683
Russ, Louderbough, Zarnescu, Schroeder: Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation. in PLoS ONE 2012
loss of Llgl1 results in EGFR (show EGFR Antibodies) mislocalization, promoting pre-neoplastic changes
these results revealed that miR (show MLXIP Antibodies)-652-3p execute a tumor-promoter function in non-small cell lung cancer through direct binding and regulating the expression of Lgl1 (show CRISPLD2 Antibodies)
Older age is a strong predictor of CNS involvement in patients seropositive for CASPR2 (show CNTNAP2 Antibodies)-IgG or LGI1 (show LGI1 Antibodies)-IgG. Pain, peripheral manifestations, and stereotypic paroxysmal dizziness spells are common with LGI1 (show LGI1 Antibodies)-IgG.
Reduced expression of Hugl 1 predicts poor survival in lung SqCC patients. The expression of Hugl 1 was inversely correlated with both overall survival rate and tumor stage.
Our results support the growing appreciation that the tumour regulatory functions of Scribble (show SCRIB Antibodies), and other polarity protein family members, are context dependent.
this study provides the evidence that Hugl-1 inhibits glioma cell growth in intracranial model of nude mice, suggesting that Hugl-1 might be a potential tumor target for glioma therapy.
Lgl1 (show CRISPLD2 Antibodies) has a role in inhibiting glioblastoma
PTEN loss leads to the phosphorylation and inactivation of Lgl by atypical protein kinase C (show PRKCZ Antibodies) in glioblastoma cells.
Suggest that Hugl-1 induces growth suppression and apoptosis in a human esophageal squamous cell carcinoma cell line both in vitro and in vivo.
inactivation of Llgl1 enhances hematopoietic stem cells self-renewal and fitness and is associated with unfavorable outcome in human acute myeloid leukemia (show BCL11A Antibodies)
Ablation of Llgl1 gene Results in Severe Brain Malformation.
Lgl1 (show Klra7 Antibodies) is required for the development of the olfactory bulb.
results suggest that neural stem cell-mediated neuron and glia production is tightly regulated through the concerted interplay of sequential Lgl1 (show Klra7 Antibodies)-dependent global and cell intrinsic mechanisms.
These results reveal a novel role for Lgl-1 (show Klra7 Antibodies) in the regulation of virus-specific T-cell responses and antitumor immunity.
Data indicate hyperproliferation, impaired differentiation and increased apoptosis of neural progenitors in the cerebellum of lethal giant larvae homolog 1 (Lgl1 (show Klra7 Antibodies))-Pax2 (show PAX2 Antibodies) protein knockout embryos.
Lgl1 (show Klra7 Antibodies) forms two distinct complexes in vivo, Lgl1 (show Klra7 Antibodies)-NMIIA and Lgl1 (show Klra7 Antibodies)-Par6alpha (show PARD6A Antibodies)-aPKCzeta (show PRKCZ Antibodies), and that the formation of these complexes is affected by the phosphorylation state of Lgl1 (show Klra7 Antibodies).
Collectively these findings indicate that Lgl1 (show Klra7 Antibodies) regulates the polarity of migrating cells by controlling the assembly state of NMII-A, its cellular localization, and focal adhesion assembly.
This is the first study to demonstrate the involvement of Dlg1 (show DLG1 Antibodies), Scrib (show SCRIB Antibodies), and Lgl1 (show Klra7 Antibodies) in a mouse with ocular adenocarcinoma and the simultaneous involvement of these proteins in the same cancer.
Findings reveal that RanBPM plays a novel role in regulating Mgl-1 stability and contributes to its biological function as a tumor suppressor.
mgl-1 mRNA is developmentally expressed in CNS, craniofacial region, eyes, limbs, and the gut (show GUSB Antibodies)
This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene is located within the Smith-Magenis syndrome region on chromosome 17.
disks large homolog 4
, lethal(2) giant larvae protein homolog 1
, human homolog to the D-lgl gene protein