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this work adds substantial information about the role of PLC (show HSPG2 Proteins)-beta2 in invasive breast tumors, demonstrating that its up-regulation in cells with a basal-B triple-negative phenotype is sufficient to down-modulate the expression of surface antigens crucial for malignancy and to reduce the number of cells with a stem-like phenotype.
Hypoxia modulates the expression of PLC-beta-2 in breast tumor cells in a phenotype-related manner, since a decrease of the protein was observed in the BT-474 and MCF7 cell lines while an increase was revealed in MDA-MB-231 cells as a consequence of low oxygen availability.
Gnb isoforms control a signaling pathway comprising Rac1, Plcbeta2, and Plcbeta3 leading to LFA-1 (show ITGAL Proteins) activation and neutrophil arrest in vivo
Neuropeptide Y (show NPY Proteins) decreased PLCB2 expression in HUVECs.
high expression of CD133 in triple-negative breast cancer (TNBC)-derived cells correlates with high invasive potential; aggressive properties of CD133high cells are mitigated by PLC-beta2 which down-modulates expression of CD133 and may play a role in preventing metastatic progression of CD133 positive TNBC
WDR26 (show WDR26 Proteins) functions as a scaffolding protein to promote PLCbeta2 membrane translocation and interaction with Gbetagamma, thereby enhancing PLCbeta2 activation in leukocytes.
In this study, we show that staphylococcal enterotoxin B activates a Galphaq (show GNAQ Proteins) and PLCbeta2-dependent pathway in human T cells
gamma-synuclein (show SNCG Proteins) has a role in promoting a more robust G protein Galphaq (show GNAQ Proteins) activation of PLCbeta2
GPCR (show NMUR1 Proteins) activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4 (show RASGRP4 Proteins).
WDR36 (show WDR36 Proteins) acts as a scaffold protein (show HOMER1 Proteins) tethering a G-protein-coupled receptor (show ADRA1A Proteins), Galphaq (show GNAQ Proteins) and phospholipase C beta 2 in a signalling complex
Data suggest the a decrease in migration of hematopoietic stem progenitor cells (HSPCs) can be explained by impaired calcium release in phospholipase C (show PLC Proteins)-beta2 (PLC (show HSPG2 Proteins)-beta2) knockout (KO) mice and a high baseline level of heme oxygenase 1 (HO-1 (show HMOX1 Proteins)), an enzyme that negatively regulates cell migration.
tristetraprolin (show ZFP36 Proteins) is not involved in LPS (show TLR4 Proteins)-mediated destabilization of PLCbeta-2 mRNA in macrophages
Galphaq (show GNAQ Proteins)-coupled Lpar1 (show LPAR1 Proteins) regulates cell proliferation and migration by activating two distinct PLC (show HSPG2 Proteins)-beta isozymes, PLC (show HSPG2 Proteins)-beta1 and PLC (show HSPG2 Proteins)-beta2, respectively.
GPCR (show GPBAR1 Proteins) activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4 (show RASGRP4 Proteins).
A PLCbeta/PI3Kgamma (show PIK3CG Proteins)-GSK3 signaling pathway regulates cofilin (show CFL1 Proteins) phosphatase slingshot2 and neutrophil polarization and chemotaxis.
The beta2 isoform mediates close to one-half the chemokine-induced calcium signal in resting and anti-IgM-activated B cells.
Taurine supplementation increases insulin (show INS Proteins) secretion, favouring both influx and internal mobilisation of Ca2 (show CA2 Proteins)+; these effects seem to involve multiple pathways.
Expression of Plcb2 was studied in a cell line during myoblast differentiation.
both PLCbeta2/beta3 and PI3Kgamma (show PIK3CG Proteins) play vital roles in platelet cytoskeletal dynamics
may play a role in inositol mediated signal transduction of bitter taste perception
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2
, PKC beta II
, phosphoinositide phospholipase C-beta-2
, phospholipase C-beta-2