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Results identified an interaction between PLCD3 and FLOT2. Inhibition of PLCD3 expression impaired the malignant potential of nasopharyngeal carcinoma (NPC) cells, by restraining its growth, proliferation, mobility and migration. This study demonstrated that PLCD3 may be an oncogenic protein in NPC and that it plays an important role in the progression of NPC partially by interacting with Flot2.
PLCdelta3 regulates microvilli formation in enterocytes and the radial migration of neurons in the cerebral cortex of the developing brain. [review]
In mouse, Plcd1 and Plcd3 may act together in murine hair follicles.
Data are consistent with the idea that phospholipase C d1 and d3 isoforms support the growth and migration of normal and neoplastic mammary epithelial cells in vitro.
Results indicate that PLCdelta1 and PLCdelta3 are required for cardiomyocyte survival and normal cardiac function.
Plcd1 and Plcd3 have synergistic effects on the murine hair follicle in specific regions of the body surface.
These results indicate that PLCdelta3 could participate in stability of microvilli structure via regulating and anchoring of Myo6 to plasma membrane.
PLCdelta3 negatively regulates RhoA expression, inhibits RhoA/Rho kinase signaling, and thereby promotes neurite extension.
PLCdelta1 and PLCdelta3 are essential in trophoblasts for placental development.
double disruption of PLCd1 and PLCd3 results in embryonic lethality because of insufficient vasculariztion of the placenta.
This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.
phospholipase C delta 3
, phospholipase C, delta 3
, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3
, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3
, PLC delta3
, phosphoinositide phospholipase C-delta-3
, phospholipase C-delta-3