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anti-Human PKC alpha Antibodies:
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Cow (Bovine) Monoclonal PKC alpha Primary Antibody for ICC, FACS - ABIN153146
Cesare, Dekker, Sardini, Parker, McNaughton: Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. in Neuron 1999
Show all 14 Pubmed References
Chicken Monoclonal PKC alpha Primary Antibody for IF, IP - ABIN967750
Fujino, Wu, Lin, Phillips, Nedivi: cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. in The Journal of comparative neurology 2008
Show all 6 Pubmed References
Chicken Monoclonal PKC alpha Primary Antibody for IF, IP - ABIN967751
Nishizuka: The molecular heterogeneity of protein kinase C and its implications for cellular regulation. in Nature 1988
Show all 5 Pubmed References
Chicken Monoclonal PKC alpha Primary Antibody for ICS - ABIN1176927
Zhang, Bontrager, Hemler: Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. in The Journal of biological chemistry 2001
Show all 4 Pubmed References
Human Polyclonal PKC alpha Primary Antibody for WB - ABIN3043549
Sun, Li, Ma, Liu, Xu, Ye, Hou, Wang, Li, Jiang: The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer. in Japanese journal of clinical oncology 2015
Show all 2 Pubmed References
Human Polyclonal PKC alpha Primary Antibody for IHC (p), WB - ABIN3043025
Cheng, Gu, Zhang, Yuan, Zhao, Jiang, Jia: Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-?-ERK1/2-NF-?B pathway. in International immunopharmacology 2015
Show all 2 Pubmed References
Human Polyclonal PKC alpha Primary Antibody for IHC, ELISA - ABIN1531462
Huang, Cheng, Su, Lin: Syndecan-4 Promotes Epithelial Tumor Cells Spreading and Regulates the Turnover of PKC? Activity under Mechanical Stimulation on the Elastomeric Substrates. in Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015
Human Monoclonal PKC alpha Primary Antibody for ICS - ABIN1177145
Newton: Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. in The Biochemical journal 2003
apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (show CDK2 Antibodies), leading to shortening of G1 and S phases
Neural induction by Syn4 (show SNTG1 Antibodies) through the PKC (show PKC Antibodies) pathway requires inhibition of PKCdelta (show PKCd Antibodies) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC (show PKC Antibodies) of the KCNE1 (show KCNE1 Antibodies) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C (show PKC Antibodies) in Kv4.3 (show KCND3 Antibodies)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2.
high expression of both PLCE1 (show PLCE1 Antibodies) and PRKCA is significantly associated with poor outcomes of the patients with esophageal cancers.
In nasopharyngeal carcinoma, PKCalpha is linked to the invasion of adjacent tissues, especially in the skull base. Down-regulation of PKCalpha is a risk factor for regional lymph node metastasis.
LAV-BPIFB4 (show BPIFB4 Antibodies) isoform modulates eNOS (show NOS3 Antibodies) signalling through Ca2 (show CA2 Antibodies)+/PKC-alpha-dependent mechanism.
Studied interactions between protein kinase C alpha (PKCalpha), FOXC2 (show FOXC2 Antibodies), and p120-catenin (CTNND1 (show CTNND1 Antibodies)) in breast cancer, cell migration/ invasion; found PKCalpha acts as an upstream regulator of FOXC2 (show FOXC2 Antibodies), which in turn represses the expression of p120-catenin (show CTNND1 Antibodies), in both in endocrine resistant ER+breast cancer and basal A triple negative breast cancer
Phosphorylated PKCalpha is elevated in epidermis genetically deleted of DLX3 (show DLX3 Antibodies) and the hyperproliferative response to TPA (show PLAT Antibodies) is increased, suggesting that the homeobox protein indirectly regulates the activity in the pathway, possibly through an effect on reduced phosphatase expression
Results show that PKCalpha expression is under the regulation of miR (show MLXIP Antibodies)-142-3p contributing to reduced osteoclasts survival.
Molecular Determinants for the Binding Mode of Alkylphosphocholines in the C2 Domain of PKCalpha.
Studies suggest that rare deleterious variants of PARD3 (show PARD3 Antibodies) in the aPKC-binding region contribute to human cranial neural tube defect (NTD).
study identified PKCalpha as hepatitis E virus HEV in host defense
ADP inhibits mesothelioma cell proliferation via PKC-alpha/ERK (show EPHB2 Antibodies)/p53 (show TP53 Antibodies) signaling.
Results show that de novo polarisation of the embryo at the 8-cell stage is directed by phospholipase C (PLC (show PLC Antibodies)) and protein kinase C (PKC (show PKC Antibodies)).
However, the mechanism that induces release of IL-6 (show IL6 Antibodies) from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 (show IL6 Antibodies) in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC (show PKC Antibodies), and cAMP response element-binding protein signal transduction pathway.
protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies) (PKCalpha) gain of function mutations may promote synaptic defects in Alzheimer's disease
Erk5 (show MAPK7 Antibodies) MAP kinase (show MAPK1 Antibodies) is activated in response to PDGF (show PDGFA Antibodies)-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2 (show MAP3K2 Antibodies), Mek1 (show MAP2K1 Antibodies)/2, Mek5 (show MAP2K5 Antibodies), PI3-kinase (show PIK3CA Antibodies) and protein kinase C (PKC (show PKC Antibodies)).
PKC-alpha plays a crucial role in the pathophysiology of peritoneal membrane dysfunction induced by peritoneal dialysis fluids, and its therapeutic inhibition might be a valuable treatment option for peritoneal dialysis patients.
these results identify PKCalpha and HMGB1 as important co-regulators involved in hydrogen peroxide-induced poly-ADP-ribose formation.
the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity
We conclude that synaptotagmin-1 (show SYT1 Antibodies) phosphorylation is an essential step in PKC (show PKC Antibodies)-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC (show PKC Antibodies) substrates, Munc13-1 (show UNC13A Antibodies) and Munc18-1 (show STXBP1 Antibodies).
These data indicate that LPA increases CCN2 (show CTGF Antibodies) expression through the activation of PKC (show PKC Antibodies) and PKA. Thus, the regulatory functions of the PKC (show PKC Antibodies) and PKA pathways are implicated in the LPA-induced increase in CCN2 (show CTGF Antibodies) expression
PKC (show PKC Antibodies) activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (show GRM5 Antibodies) and AMPA (show GRIA3 Antibodies)/kainate receptors.
Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (show CA2 Antibodies)+-sensitivity, structure and kinetics are brought about through PKC (show PKC Antibodies) phosphorylation of cardiac troponin T (show TNNT2 Antibodies).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Antibodies) expression by NF-kappaB (show NFKB1 Antibodies)-MT1-MMP (show MMP14 Antibodies)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (show ASS1 Antibodies) Ser (show SIGLEC1 Antibodies)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (show TUBB Antibodies).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (show Akap6 Antibodies)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies)
By regulating VEGFR2 (show KDR Antibodies) expression and activation, PKC-epsilon (show PRKCE Antibodies) expression is critical for activation of Akt (show AKT1 Antibodies) and eNOS (show NOS3 Antibodies) by VEGF (show VEGFA Antibodies) and contributes to VEGF (show VEGFA Antibodies)-stimulated Erk (show MAPK1 Antibodies) activation, whereas PKC-alpha has opposite effects.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (show CA2 Antibodies)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (show PPP1R14A Antibodies) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (show ESR1 Antibodies).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha