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anti-Human PKC alpha Antibodies:
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Cow (Bovine) Monoclonal PKC alpha Primary Antibody for ICC, FACS - ABIN153146
Cesare, Dekker, Sardini, Parker, McNaughton: Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. in Neuron 1999
Show all 14 Pubmed References
Human Polyclonal PKC alpha Primary Antibody for IHC (p), WB - ABIN3043025
Sun, Li, Ma, Liu, Xu, Ye, Hou, Wang, Li, Jiang: The predictive value and potential mechanisms of miRNA-328 and miRNA-378 for brain metastases in operable and advanced non-small-cell lung cancer. in Japanese journal of clinical oncology 2015
Show all 5 Pubmed References
Human Polyclonal PKC alpha Primary Antibody for WB - ABIN3043549
Cheng, Gu, Zhang, Yuan, Zhao, Jiang, Jia: Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-?-ERK1/2-NF-?B pathway. in International immunopharmacology 2015
Show all 5 Pubmed References
Chicken Monoclonal PKC alpha Primary Antibody for ICS - ABIN1176927
Zhang, Bontrager, Hemler: Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins. in The Journal of biological chemistry 2001
Show all 4 Pubmed References
Mammalian Monoclonal PKC alpha Primary Antibody for IHC (fro), WB - ABIN2476256
Donovan, Lansu, Williams, Denning, Gentile: Long QT2 mutation on the Kv11.1 ion channel inhibits current activity by ablating a protein kinase C? consensus site. in Molecular pharmacology 2012
Human Monoclonal PKC alpha Primary Antibody for ICS - ABIN1177144
Newton: Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. in The Biochemical journal 2003
Human Polyclonal PKC alpha Primary Antibody for FACS, IF - ABIN391001
Jaafar, Zeiller, Pirola, Di Grazia, Naro, Vidal, Lefai, Némoz: Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes. in The Journal of biological chemistry 2011
apically localized serine/threonine kinase aPKC directly phosphorylates an N-terminal site of the cell-cycle inhibitor p27Xic1 and reduces its ability to inhibit the cyclin-dependent kinase 2 (show CDK2 Antibodies), leading to shortening of G1 and S phases
Neural induction by Syn4 (show SNTG1 Antibodies) through the PKC pathway requires inhibition of PKCdelta (show PKCd Antibodies) and activation of PKCalpha.
The depletion of membrane PIP(2) underlies receptor-mediated inhibition of IKs and that phosphorylation by PKC of the KCNE1 (show KCNE1 Antibodies) subunit underlies the GqPCR-mediated channel activation.
Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C in Kv4.3 (show KCND3 Antibodies)
Data show that PKC staining colocalizes with monkey retina expresses a retina-specific slice variant of PCP2 (show PCP2 Antibodies).
Modeling of the different conformations of PRKACA (show PRKACA Antibodies)-DNAJB1 (show DNAJB1 Antibodies) Chimeric Kinase revealed no obvious steric interactions of the J-domain with the rest of the RIIbeta (show PRKAR2B Antibodies) holoenzyme.
PKC activation triggers down-regulation of Kv1.3 by inducing a clathrin-mediated endocytic event that targets the channel to lysosomal-degradative compartments.
Protein kinase C acts as a tumor suppressor.Cancer-associated mutations in protein kinase C are generally loss-of-function mutations.[review]
results could not only better explain the role of PI-PLCbeta1/PKC-alpha signaling in erythropoiesis but also lead to a better comprehension of the lenalidomide effect on del(5q) MDS (show PAFAH1B1 Antibodies) and pave the way to innovative, targeted therapies.
A characteristic di-leucine motif (SVRPLL) in the C-terminal cytoplasmic region of ATP11C becomes functional upon PKCalpha activation. Moreover, endocytosis of ATP11C is induced by Ca(2 (show CA2 Antibodies)+)-signaling via Gq-coupled receptors.
The haplotype carrying rs9909004 influences PRKCA expression in the heart and is associated with traits linked to heart failure, potentially affecting therapy of heart failure
our results demonstrate that Pc-induced expression of HO-1 (show HMOX1 Antibodies) is mediated by the PKCA-Nrf-2 (show GABPA Antibodies)/HO-1 (show HMOX1 Antibodies) pathway, and inhibits UVB-induced apoptotic cell death in primary skin cells.
Regulation of vascular smooth muscle cell calcification by syndecan-4 (show SDC4 Antibodies)/FGF-2 (show FGF2 Antibodies)/PKCalpha signalling and cross-talk with TGF-beta1 (show TGFB1 Antibodies).
this study reveals a protective role for miR (show MLXIP Antibodies)-706 by blocking the oxidative stress-induced (show SQSTM1 Antibodies) activation of PKCalpha/TAOK1 (show TAOK1 Antibodies). Our results further identify a major implication for miR (show MLXIP Antibodies)-706 in preventing hepatic fibrogenesis and suggest that miR (show MLXIP Antibodies)-706 may be a suitable molecular target for anti-fibrosis therapy.
We also discuss the contribution of PKC (show PRRT2 Antibodies) enzymes to pancreatic diseases, including insulin (show INS Antibodies) resistance and diabetes mellitus, as well as pancreatitis and the development and progression of pancreatic cancer
Deleting the Prkca gene, which encodes PKCalpha, reverses diabetes-induced autophagy impairment, cellular organelle stress and apoptosis, leading to an NTD reduction. PKCalpha increases the expression of miR-129-2, which is a negative regulator of autophagy. miR-129-2 represses autophagy by directly targeting PGC-1alpha, a positive regulator for mitochondrial function, which is disturbed by maternal diabetes.
This indicates a role for PKC in dynamically controlling the trafficking of SNAT3 (show SLC38A3 Antibodies) transporters in astrocytes in situ.
Results show that de novo polarisation of the embryo at the 8-cell stage is directed by phospholipase C (PLC) and protein kinase C (PKC).
LAV-BPIFB4 (show BPIFB4 Antibodies) isoform modulates eNOS (show NOS3 Antibodies) signalling through Ca2 (show CA2 Antibodies)+/PKC-alpha-dependent mechanism.
However, the mechanism that induces release of IL-6 (show IL6 Antibodies) from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 (show IL6 Antibodies) in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC, and cAMP response element-binding protein signal transduction pathway.
protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies) (PKCalpha) gain of function mutations may promote synaptic defects in Alzheimer's disease
Erk5 MAP kinase is activated in response to PDGF-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2, Mek1/2, Mek5, PI3-kinase and protein kinase C (PKC).
PKC-alpha plays a crucial role in the pathophysiology of peritoneal membrane dysfunction induced by peritoneal dialysis fluids, and its therapeutic inhibition might be a valuable treatment option for peritoneal dialysis patients.
these results identify PKCalpha and HMGB1 as important co-regulators involved in hydrogen peroxide-induced poly-ADP-ribose formation.
the present study demonstrates that nNOS-derived NO signaling modulated by spinal Sig-1R activation increases Nox2 activity and concomitant ROS production, which leads to a ROS-induced increase in PKC-dependent pGluN1 expression in the spinal cord dorsal horn and the development of pain hypersensitivity
PKC activation can enhance hippocampal neurotransmitter release, depending on changes specific to mGluR5 (show GRM5 Antibodies) and AMPA (show GRIA3 Antibodies)/kainate receptors.
Isoenzymes beta and delta of PKC have been found significantly phosphorylated, although their location was not changed as a consequence of Trichinella spiralis infection.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
Significant changes in thin filament Ca2 (show CA2 Antibodies)+-sensitivity, structure and kinetics are brought about through PKC phosphorylation of cardiac troponin T (show TNNT2 Antibodies).
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Antibodies) expression by NF-kappaB (show NFKB1 Antibodies)-MT1-MMP (show MMP14 Antibodies)-dependent and -independent pathway.
calcium-dependent phosphorylation of argininosuccinate synthase (show ASS1 Antibodies) Ser (show SIGLEC1 Antibodies)-328 is mediated by PKCalpha
VDAC phosphorylation is an important determinant of its interaction with dimeric tubulin (show TUBB Antibodies).
Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCalpha, delta, epsilon or zeta, results showed a differential regulation of p53-mediated apoptosis by these PKC isoforms.
degradation of protein kinase C(alpha)in sperm capacitation is mediated by PRKA (show Akap6 Antibodies)
Data suggest that ceramide interacts with the calcium-dependent lipid binding C2 domain of protein kinase C alpha and thereby induces translocation of the enzyme to the Golgi compartment.
analysis of amino acid critical for the catalytic competence and function of protein kinase (show CDK7 Antibodies) Calpha (show PRKACA Antibodies)
By regulating VEGFR2 (show KDR Antibodies) expression and activation, PKC-epsilon (show PRKCE Antibodies) expression is critical for activation of Akt (show AKT1 Antibodies) and eNOS (show NOS3 Antibodies) by VEGF (show VEGFA Antibodies) and contributes to VEGF (show VEGFA Antibodies)-stimulated Erk (show MAPK1 Antibodies) activation, whereas PKC-alpha has opposite effects.
High PKC alpha expression is associated with retinal neovascularization.
We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2 (show CA2 Antibodies)+) transients and contractility.
These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
This study examined the protein expression and spatial-temporal distribution of PKCalpha and CPI-17 (show PPP1R14A Antibodies) in intact smooth muscle tissues.
Results suggest that the action of genistein on protein kinase A is mediated via adenylate cyclase, but does not appear to involve Gs protein or ICI 182780-sensitive estrogen receptor (show ESR1 Antibodies).
The PKCalpha, PKCbeta1, and PKCbeta2 mRNA levels tended to be lower in ischemia-reperfused than in sham-operated eyes in both the retinal arteries and the neuroretina.
protein level of retinal PKC-alpha is increased with maturation
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
, protein kinase C alpha type
, protein kinase C, alpha
, protein kinase C alpha type-like
, aging-associated gene 6
, protein kinase c-alpha
, protein kinase, C alpha
, protein kinase C alpha