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anti-Mouse (Murine) PYGO1 Antibodies:
anti-Rat (Rattus) PYGO1 Antibodies:
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Transcriptional cofactors Bcl9, Bcl9l and Pygo1/2 act independently of beta-catenin to ensure proper enamel formation.
even in the absence of the potentially redundant Pygo1, Pygo2 does not require the H3K4me2/3 binding activity to sustain its function during mouse development
In mammals, the Pygo1/Pygo2 genes are not absolutely required for canonical Wnt signaling in most developing systems, but rather function as quantitative transducers, or modulators, of Wnt signal intensity
These results suggest that the Pygopus1 plant homeodomain (PHD) dimerization is functionally important for Lgs/Bcl9 recognition as well as for the regulation of the Wnt/beta-catenin signaling pathway.
Data show that human and Drosophila Pygo PHD fingers associate with their cognate HD1 domains from BCL9/Legless to bind specifically to the histone H3 tail methylated at lysine 4 (H3K4me).
Involved in signal transduction through the Wnt pathway (By similarity).
pygopus homolog 1
, pygopus 1
, pygopus-like protein 1