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anti-Mouse (Murine) TCF7L2 Antibodies:
anti-Human TCF7L2 Antibodies:
anti-Rat (Rattus) TCF7L2 Antibodies:
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Human Monoclonal TCF7L2 Primary Antibody for IHC (p), ELISA - ABIN520776
da Silva Xavier, Loder, McDonald, Tarasov, Carzaniga, Kronenberger, Barg, Rutter: TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. in Diabetes 2009
Show all 2 Pubmed References
Human Polyclonal TCF7L2 Primary Antibody for ICC, IF - ABIN446586
Kwon, Leibovitch, Bansal, Pereira, Chung, Ariztia, Zelent, Farias, Waxman: Targeted interference of SIN3A-TGIF1 function by SID decoy treatment inhibits Wnt signaling and invasion in triple negative breast cancer cells. in Oncotarget 1970
Findings demonstrate an alpha cell-autonomous role for Tcf7l2 in the control of pancreatic glucagon (show GCG Antibodies) secretion and the maintenance of alpha cell mass and function.
Suggest transcription factor 7-like 2 is a possible regulator of glucagon-like peptide 1 receptor (show GLP1R Antibodies) expression in endothelial/smooth muscle cells in diabetic mice.
along with the elevation of miR-17-5p expression in mouse epididymal fat tissue in response to high fat diet consumption, allowed us to suggest that miR-17-5p is among central switches of adipogenic differentiation
TCF7L2 mediates canonic Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling and c-Myc (show MYC Antibodies) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) to c-Myc (show MYC Antibodies) axis can be explored for preventing and treating heart failure.
These findings suggest a unique role for Tcf7l2 in generating distinct neuronal phenotypes from homogeneous progenitor population.
Tcf7l2 may be involved in maintenance of stem/progenitor cells properties.
results indicate that miR (show MLXIP Antibodies)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (show TGFB1 Antibodies)/Smad (show SMAD1 Antibodies) and Wnt (show WNT2 Antibodies) signaling pathway by directly targeting Smad7 (show SMAD7 Antibodies) and Tcf7l2
Tcf7l2 protein levels decline upon initiation of endocrine differentiation in vivo, disclosing the downregulation of this factor in the developing endocrine compartment.
Kaiso (show ZBTB33 Antibodies) and Sox10 (show SOX10 Antibodies) sequentially interact with Tcf7l2 to coordinate the maturation of oligodendrocyte.
Tcf7l2 plays a cell autonomous role in the control of beta cell function and mass, serving as an important regulator of gene expression and islet cell coordination
Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries.
Dorsal and ventral habenulae develop in different regions of prosomere 2. In the process of ventral habenula formation, functional tcf7l2 gene activity is required and in its absence, ventral habenular neurons do not develop.
In embryos, the tcf4 gene is highly regulated at the level of RNA splicing such that the variant proteins that are produced contain or lack domains proposed to be essential in repression or activation of transcription.
Study underscores the involvement of Tcf4 in maintaining proliferative self-renewal in the intestine throughout life.
This study reveals that Tcf4 (tcf7l2) is the major effector of Wnt (show WNT2 Antibodies) signaling in the intestine during zebrafish organogenesis.
XTcf4 has no repressive role but is required to activate expression of Xnr3 and chordin (show CHRD Antibodies) in organizer cells at the gastrula stage
regulation of XTcf-4 by canonical wnt (show WNT2 Antibodies)-signaling is directly controlled by binding to and activating a consensus Lef/Tcf (show HNF4A Antibodies) binding site within its own promoter
TCF7L2 rs7903146 polymorphism is associated with ischemic heart disease.
The IVS3C>T locus in the TCF7L2 gene is not independently statistically significantly associated with the development of type 2 Diabetes Mellitus in the Kyrgyz population.
six of eight SNPs were found to have significant associations between TCF7L2 variants and gestational diabetes mellitus (GDM) risk in the overall population, with the most powerful SNPs being rs7903146, rs12255372 and rs7901695, but the contribution of these SNPs to GDM risk were variable among different racial/ethnic groups - meta-analysis
These results suggest rs12573128 is significantly associated with an increased risk of SCZ in the Chinese Han population.
The study found that TCF7L2 SNPs (rs1225404 and rs7003146) might be associated with breast cancer risk in Northwest Chinese Han populations.
These findings further support the hypothesis that TCF7L2 gene variation contributes to diabetogenesis in a subset of young people with Type 1 diabetes.
The rs7903146 variant in the TCF7L2 gene increases the risk of impaired glucose tolerance or type 2 diabetes in obese adolescents by impairing beta-cell function, and hepatic insulin (show INS Antibodies) sensitivity predicts the development of impaired glucose tolerance or type 2 diabetes over time.
In conclusion, TCF7L2 regulates estradiol- or progesterone-modulated islet and hepatic glucose metabolism.
TCF7L2 rs7903146 and 112/112 haplotype of CAPN10 (show CAPN10 Antibodies) might be associated with gestational diabetes risks.[meta-analysis]
Authors found that KIF23 (show KIF23 Antibodies) was regulated by TCF-4 (show TCF4 Antibodies) at transcriptionally level. Therefore, this evidence indicates KIF23 (show KIF23 Antibodies) over-expression is associated with glioma malignancy and conferred a worse survival time in glioma.
findings report an independent confirmation of the association of the TCF7L2 (show TCF4 Antibodies) gene with milk yield and composition traits.
Genes implied in human type 2 diabetes development, TCF7L2, WFS1 (show WFS1 Antibodies), FTO (show FTO Antibodies), SLC30A8 (show SLC30A8 Antibodies), and GCKR (show GCKR Antibodies), were mapped on Sus scrofa chromosomes 14, 8, 6, 4, and 3, respectively. Only TCF7L2 was significantly associated with five fat traits in pigs.
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
transcription factor 7-like 2 (T-cell specific, HMG-box)
, HMG box transcription factor 4
, T-cell factor 4
, T-cell-specific transcription factor 4
, transcription factor 7-like 2
, transcription factor 7-like 2, T-cell specific, HMG-box
, transcription factor tcf4
, T-cell factor XTCF-4A
, transcription factor Tcf4
, T-cell factor-4 variant A
, T-cell factor-4 variant B
, T-cell factor-4 variant C
, T-cell factor-4 variant D
, T-cell factor-4 variant E
, T-cell factor-4 variant F
, T-cell factor-4 variant G
, T-cell factor-4 variant H
, T-cell factor-4 variant I
, T-cell factor-4 variant J
, T-cell factor-4 variant K
, T-cell factor-4 variant L
, T-cell factor-4 variant M
, T-cell factor-4 variant X2