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Human WIF1 Protein expressed in Wheat germ - ABIN1325330
Kansara, Tsang, Kodjabachian, Sims, Trivett, Ehrich, Dobrovic, Slavin, Choong, Simmons, Dawid, Thomas: Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. in The Journal of clinical investigation 2009
the expression of WIF-1 was low in GBC cells due to aberrant hypermethylation of its promoter region. Additionally, an alternative pathogenesis of GBC was indicated in which c-Jun (show JUN Proteins) causes hypermethylation of the WIF-1 promoter region, and represses the expression of WIF-1 through transcriptional regulation and interaction with DNMT1 (show DNMT1 Proteins) as an early event in the tumorigenesis of GBC.
miR (show MLXIP Proteins)-590-3p regulates colon cancer progression via WIF1 and DKK1 (show DKK1 Proteins), which suggests that miR (show MLXIP Proteins)-590-3p may be a promising candidate for therapeutic applications in colon cancer treatment
We identify a loss-of-function mutation in WIF1 (NM_007191 p.W15*), which is involved in mesoderm segmentation, as the suspected cause of the Nail (show CD244 Proteins)-Patella-like disorder observed in this family.
the results of our study show that down-regulated INTS6 (show INTS6 Proteins) expression is associated with a poorer prognosis in hepatocellular carcinoma (HCC (show FAM126A Proteins)) patients. This newly identified INTS6 (show INTS6 Proteins)/WIF-1 axis indicates the molecular mechanism of HCC (show FAM126A Proteins) and may represent a therapeutic target in HCC (show FAM126A Proteins) patients.
the promoters of WIF1, NLK (show NLK Proteins), and APC (show APC Proteins) are highly methylated in the nasopharyngeal cancers (NPC (show NPC1 Proteins)) and gastric carcinoma (GC) cell lines, and the 3 genes are also regulated by miR (show MLXIP Proteins)-BART19-3p expressed by Epstein-Barr virus (EBV); expression of the WIF1, APC (show APC Proteins), and NLK (show NLK Proteins) genes is strongly affected by hypermethylation, and in EBV-associated tumors, the 3 genes are also affected by miR (show MLXIP Proteins)-BART19-3p
Data show the frequency of WIF-1 hypermethylation significantly increased in non-small cell lung cancer (NSCLC) specimens compared with normal lung tissue. WIF-1 hypermethylation is predominant in squamous cell carcinoma (SCC (show CYP11A1 Proteins)), suggesting that WIF-1 methylation contributes to the development of NSCLC, especially SCC (show CYP11A1 Proteins). [review]
Study supported the hypothesis that Wnt inhibitory factor 1 (WIF1) is crucial as a negative regulator of the functions of endothelial cells in angiogenesis and that hypoxia plays an important role in controlling WIF1 expression and angiogenesis.
Our data suggests that total cellular b-catenin levels decrease in the presence of secreted frizzled-related protein 1 (show SFRP1 Proteins) and Wnt inhibitory factor 1, and a significant increase in cell death after tyrosine kinase (show TXK Proteins) inhibitor treatment is observed. On the contrary, when secreted frizzled-related protein 1 (show SFRP1 Proteins) is suppressed, total b-catenin levels increase in the cell and the cells become resistant to tyrosine kinase (show TXK Proteins) inhibitors.
Gallbladder cancer patients with hypermethylated WIF-1 exhibited worse overall survival than those with hypomethylated WIF-1.
In astrocytoma specimens, tumor areas with numerous single cells were identified which strongly express Wif-1.
Wif1 localizes to the enamel knot in which Wif1 regulates apoptosis by mediating and regulating Wnt (show WNT2 Proteins)-beta-catenin (show CTNNB1 Proteins) signaling. Thus, Wif1 plays an essential role in tooth development.
WIF1 has a role in breast neoplasms: its inhibition significantly relieves the cancer stem cell-limiting effects of dietary compound isoliquiritigenin
results demonstrate that Wif1 is not targeted for silencing by DNA methylation (show HELLS Proteins) in OS. Instead, the reduced expression of Wif1 in OS cells is in context with their stage in differentiation
EZH2 (show EZH2 Proteins)-induced downregulation of WIF1 expression may partially regulate Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins)-dependent crypt hyperplasia in response to citrobacter rodentium infection
Dysregulation of this endodermal Shh-Wif1-b-catenin signaling axis contributes to ARM pathogenesis.
It is anticipated that our findings will contribute to expansion of our understanding of WIF1 biological function on heart development and possible modes of treatment of heart diseases
WIF1 secretion by the Mullerian duct mesenchyme plays a role in Mullerian duct regression in fetal males
These data suggest that WIF-1 may take part in the fine-tuning of cartilage and bone turnover, promoting the balance of cartilage versus bone anabolism.
Wnt inhibitory factor 1 (Wif1) is regulated by androgens and enhances androgen-dependent prostate development
Osteoblastic Wif1 overexpression disrupts stem cell quiescence, leading to a loss of self-renewal potential.
In an examination of signaling pathways in developing Xenopus lung, wif1 was expressed in the mesenchyme layer of the entire lungs through stages 39-41.
Data describe the importance of proper level of Wnt (show WNT2 Proteins) signaling for normal development of swimbladder in Wif1 morphant zebrafish.
The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers.
, wnt inhibitory factor 1
, WNT inhibitory factor 1
, wnt inhibitory factor 1-like
, Wnt inhibitory factor-1
, wnt inhibitory factor-1