Browse our WNT4 Proteins (WNT4)

Fruit Fly (Drosophila melanogaster) Wingless-Type MMTV Integration Site Family, Member 4 (WNT4) interaction partners

1. At different points of development, dWnt4 switches from using the non-canonical pathway components to using a beta (show SUCLA2 Proteins)-catenin-dependent canonical pathway in the escort cells to facilitate the proper differentiation of Germline stem cells.

2. disruption of Wnt4 and components of the canonical Wnt pathway results in a complex germ cell phenotype marked by an expansion of germline stem cell-like cells, pre-cystoblasts and cystoblasts in young females.

3. Wnt4 and the canonical Wnt signaling pathway are essential for ostia formation in Drosophila

4. dSETDB1 is required for the expression of a Wnt ligand, Drosophila Wingless type mouse mammary virus integration site number 4 (dWnt4) in the somatic niche.

5. this study identifies a transcriptional switch involving the kinase Btk29A/Btk and its phosphorylation target, beta-catenin, which functions downstream of Wnt4 in escort cells to terminate Drosophila germ cell proliferation through up-regulation of piwi expression.

6. Wg and Wnt4 act redundantly in planar cell polarity determination in Drosophila.

7. We re-evaluated the expression pattern of DWnt4 during embryogenesis and show that transcripts are not restricted to the dorsal ectoderm but are also present in the cardiogenic mesoderm.

8. In Drosophila, Otk interacts with Wnt4 and opposes canonical Wnt signalling in embryonic patterning.

9. DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis.

10. DWnt4 antagonizes the polarizing effect of four-jointed

Mouse (Murine) Wingless-Type MMTV Integration Site Family, Member 4 (WNT4) interaction partners

1. urinary Wnt4 could be a potential noninvasive biomarker for the early detection of tubular injury.

2. SHH (show SHH Proteins)-dependent activation of WNT (show WNT2 Proteins) signaling supports regeneration of the cortex following long-term glucocorticoid treatment.

3. Wnt4 and Wnt11 (show WNT11 Proteins) cooperatively contribute to mammalian neuromuscular junction formation.

4. GLP-1 (show GCG Proteins) promoted adipogenesis through the modulation of the Wnt4/beta-catenin (show CTNNB1 Proteins) signaling pathway

5. Results suggest that the Wnt4 gene encodes signals that are important for various aspects of female reproductive tract development.

6. Our functional study revealed that WNT4 molecules were involved in regulating zygotic cleavage and early embryogenesis

7. Data indicate that a balance between supporting cell (show PTPRJ Proteins) self-renewal and differentiation is maintained in the developing ovary by relative Wnt4 protein/beta-catenin (show CTNNB1 Proteins) and p27Kip1 (show CDKN1B Proteins) protein (p27 (show CDKN1B Proteins))/Forkhead box L2 (FOXL2 (show FOXL2 Proteins)) activities.

8. decreased expression of Wnt4 in the aging thymus may be one of the molecular triggers underlying the process of age-related thymic senescence.

9. Mir (show MLXIP Proteins)-29c regulates WNT4 signaling.

10. Wnt4 is essential to normal mammalian lung development.

Human Wingless-Type MMTV Integration Site Family, Member 4 (WNT4) interaction partners

1. We found a genetic association between rs11031006 (FSHB) SNP and endometriosis. WNT4 and VEZT genes constitute the most consistently associated genes with endometriosis. In the present study, an association of rs7521902 (WNT4) and rs10859871 (VEZT) was confirmed in women with endometriosis at the genotypic but not the allelic level.

2. urinary Wnt4 could be a potential noninvasive biomarker for the early detection of tubular injury.

3. were not able to replicate or further verify the genetic association of polymorphisms in WNT4 and WNT5B (show WNT5B Proteins) with bone mineral density

4. These findings demonstrate that autocrine human growth hormone (show GH1 Proteins) regulates WNT4 expression and that WNT4 is a potential therapeutic target in human breast cancer.

5. WNT4 encodes wingless-type MMTV integration site family member 4. WNT4 mutations have been found in women with mullerian duct abnormalities, primary amenorrhea, and hyperandrogenism and common variants in WNT4, which are in high linkage disequilibrium with our index SNPs, are associated with endometriosis, ovarian cancer,and bone mineral density of WNT4, and the T allele generates a strong ESR1 (show ESR1 Proteins)-binding site.

6. Our MRKH families included 43 quads, 26 trios, and 30 duos. Of our MRKH probands, 87/147 (59%) had MRKH type 1 and 60/147 (41%) had type 2 with additional anomalies. CONCLUSION(S): Although the prevalence of WNT4, HNF1B (show HNF1B Proteins), and LHX1 (show LHX1 Proteins) point mutations is low in people with MRKH, the prevalence of CNVs was approximately 19%.

7. WNT4 drives a novel signaling pathway in ILC (show CCL27 Proteins) cells, with a critical role in estrogen-induced growth that may also mediate endocrine resistance. WNT4 signaling may represent a novel target to modulate endocrine response specifically for patients with ILC (show CCL27 Proteins).

8. The etiology of MRKH syndrome is still largely unknown, probably because of its intrinsic heterogeneity. Several candidate causative genes have been investigated, but to date only WNT4 has been associated with MRKH with hyperandrogenism. This review summarizes and discusses the clinical features and details progress to date in understanding the genetics of MRKH syndrome.

9. We highlight the cooperation of WNT4, RSPO1 (show RSPO1 Proteins) and FOXL2 (show FOXL2 Proteins) within a regulatory network and the need for further research to better understand their role in defining and maintaining ovarian identity.

10. The WNT4 expression level in eutopic endometrium was significantly reduced compared with that in normal endometrium of the control group.

Xenopus laevis Wingless-Type MMTV Integration Site Family, Member 4 (WNT4) interaction partners

1. identified Wnt4 as the ligand that is expressed in the mesoderm of the ventral blood island and is essential for the expression of hematopoietic and erythroid marker genes

2. XWntless and the Retromer complex are required for the efficient secretion of XWnt4, facilitating its role in Xenopus eye development

3. Study shows that Wnt-4 acts through the Notch (show NOTCH1 Proteins) effector gene hrt1 (show HEY1 Proteins) by upregulating expression of wnt4; Wnt-4 then patterns the proximal pronephric anlagen to establish the specific compartments that span the medio-lateral axis.

Cow (Bovine) Wingless-Type MMTV Integration Site Family, Member 4 (WNT4) interaction partners

1. single inhibition of melatonin receptor 1 or Wnt-4 expression decreased expression of neurogenesis-related genes, and bovine amniotic epithelial cell-derived neural cells were successfully colonized into injured spinal cord, which suggested participation in tissue repair.

Zebrafish Wingless-Type MMTV Integration Site Family, Member 4 (WNT4) interaction partners

1. Fox1 (show A2BP1 Proteins) activation of Wnt4a in the ectoderm signals the epithelial stabilization of pouch-forming cells during late-stage of pouch morphogenesis.

2. Data show that in vivo, wnt11r (show WNT11 Proteins) and wnt4a initiate MuSK (show MUSK Proteins) translocation from muscle membranes to recycling endosomes and that this transition is crucial for AChR accumulation at future synaptic sites.

3. Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt (show WNT2 Proteins) signaling inhibitor, Dkk (show DKK1 Proteins), and induced expression of the Wnt (show WNT2 Proteins) ligand, Wnt4a.

4. Findings provide the first convincing line of evidence that EAF and Wnt4 form an auto-regulatory negative feedback loop in vivo.

5. three Wnt (show WNT2 Proteins) noncanonical ligands wnt4a, silberblick/wnt11 (show WNT11 Proteins), and wnt11 (show WNT11 Proteins)-related regulate the process of convergence of endoderm and organ precursors toward the embryonic midline by acting in a largely redundant way