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At different points of development, dWnt4 switches from using the non-canonical pathway components to using a beta-catenin-dependent canonical pathway in the escort cells to facilitate the proper differentiation of Germline stem cells.
disruption of Wnt4 and components of the canonical Wnt pathway results in a complex germ cell phenotype marked by an expansion of germline stem cell-like cells, pre-cystoblasts and cystoblasts in young females.
Wnt4 and the canonical Wnt signaling pathway are essential for ostia formation in Drosophila
dSETDB1 is required for the expression of a Wnt ligand, Drosophila Wingless type mouse mammary virus integration site number 4 (dWnt4) in the somatic niche.
this study identifies a transcriptional switch involving the kinase Btk29A/Btk and its phosphorylation target, beta-catenin, which functions downstream of Wnt4 in escort cells to terminate Drosophila germ cell proliferation through up-regulation of piwi expression.
Wg and Wnt4 act redundantly in planar cell polarity determination in Drosophila.
We re-evaluated the expression pattern of DWnt4 during embryogenesis and show that transcripts are not restricted to the dorsal ectoderm but are also present in the cardiogenic mesoderm.
In Drosophila, Otk interacts with Wnt4 and opposes canonical Wnt signalling in embryonic patterning.
It works as a negative signal in neural connectivity. (review)
DWnt4 regulates cell movement and focal adhesion kinase during Drosophila ovarian morphogenesis.
DWnt4 antagonizes the polarizing effect of four-jointed
in DWnt4 mutants, ventral retinal axons misprojected to the dorsal lamina
urinary Wnt4 could be a potential noninvasive biomarker for the early detection of tubular injury.
SHH-dependent activation of WNT signaling supports regeneration of the cortex following long-term glucocorticoid treatment.
Wnt4 and Wnt11 cooperatively contribute to mammalian neuromuscular junction formation.
GLP-1 promoted adipogenesis through the modulation of the Wnt4/beta-catenin signaling pathway
Results suggest that the Wnt4 gene encodes signals that are important for various aspects of female reproductive tract development.
Our functional study revealed that WNT4 molecules were involved in regulating zygotic cleavage and early embryogenesis
Data indicate that a balance between supporting cell self-renewal and differentiation is maintained in the developing ovary by relative Wnt4 protein/beta-catenin and p27Kip1 protein (p27)/Forkhead box L2 (FOXL2) activities.
decreased expression of Wnt4 in the aging thymus may be one of the molecular triggers underlying the process of age-related thymic senescence.
Mir-29c regulates WNT4 signaling.
Wnt4 is essential to normal mammalian lung development.
RSPO1, WNT4, and beta-catenin have roles in the signaling pathway during ovarian differentiation in mice.
The Runx-1 gene can be a Wnt-4 signalling target, and that Runx-1 and Wnt-4 are mutually interdependent in their expression.
Progesterone and Wnt4 control stem cell function through a luminal-myoepithelial crosstalk with Wnt4 acting independent of progesterone receptor perinatally.
significant role in supporting thymocyte development and maturation
study presents for the first time that estrogen regulates Egr1 expression through LIF-STAT3 signaling pathway in mouse uterus, and Egr1 functions as a critical mediator of stromal cell decidualization by regulating Wnt4
results suggest that Wnt4 signaling could be an attractive therapeutic target for treating osteoporosis and preventing skeletal aging
Data indicate that Wnt4 signaling is necessary during maturation of the ovarian follicle.
Data from several types of in vitro angiogenesis assays suggest that Wnt4 (but not Wnt1) is a potent inhibitor of capillary outgrowth; Wnt4 and Wnt1 appear to be secreted by vascular endothelial cells into extracellular matrix during angiogenesis.
Wnt4-null and Rspo1-null pregranulosa cells transition through a differentiated granulosa cell state prior to transdifferentiating towards a Sertoli cell fate.
Wnt4 signaling through beta-catenin stabilization is sufficient to drive spontaneous myofibroblast differentiation in interstitial pericytes and fibroblasts, emphasizing the importance of this pathway in renal fibrosis.
results show that the WNT4 gene is associated with epithelial ovarian cancer risk
Annotation of rs2072920 in WNT4 in tissues might be related to obesity.
We found a genetic association between rs11031006 (FSHB) SNP and endometriosis. WNT4 and VEZT genes constitute the most consistently associated genes with endometriosis. In the present study, an association of rs7521902 (WNT4) and rs10859871 (VEZT) was confirmed in women with endometriosis at the genotypic but not the allelic level.
were not able to replicate or further verify the genetic association of polymorphisms in WNT4 and WNT5B with bone mineral density
These findings demonstrate that autocrine human growth hormone regulates WNT4 expression and that WNT4 is a potential therapeutic target in human breast cancer.
WNT4 encodes wingless-type MMTV integration site family member 4. WNT4 mutations have been found in women with mullerian duct abnormalities, primary amenorrhea, and hyperandrogenism and common variants in WNT4, which are in high linkage disequilibrium with our index SNPs, are associated with endometriosis, ovarian cancer,and bone mineral density of WNT4, and the T allele generates a strong ESR1-binding site.
Our MRKH families included 43 quads, 26 trios, and 30 duos. Of our MRKH probands, 87/147 (59%) had MRKH type 1 and 60/147 (41%) had type 2 with additional anomalies. CONCLUSION(S): Although the prevalence of WNT4, HNF1B, and LHX1 point mutations is low in people with MRKH, the prevalence of CNVs was approximately 19%.
WNT4 drives a novel signaling pathway in ILC cells, with a critical role in estrogen-induced growth that may also mediate endocrine resistance. WNT4 signaling may represent a novel target to modulate endocrine response specifically for patients with ILC.
The etiology of MRKH syndrome is still largely unknown, probably because of its intrinsic heterogeneity. Several candidate causative genes have been investigated, but to date only WNT4 has been associated with MRKH with hyperandrogenism. This review summarizes and discusses the clinical features and details progress to date in understanding the genetics of MRKH syndrome.
We highlight the cooperation of WNT4, RSPO1 and FOXL2 within a regulatory network and the need for further research to better understand their role in defining and maintaining ovarian identity.
The WNT4 expression level in eutopic endometrium was significantly reduced compared with that in normal endometrium of the control group.
Studied the roles of WNT4 and WNT5A in human decidulization and their relationship with preeclampsia.
Polymorphisms on WNT4 gene might be involved in the pathogenesis of endometriosis in the infertile women.
the expression of WNT4, a Wnt ligand, and three targets of Wnt-ss-catenin transcription activation, namely, MMP7, cyclinD1 (CD1) and c-MYC in 141 penile tissue cores from 101 unique samples, were investigated.
The results demonstrated that WNT4 rs2235529 is associated with endometriosis in Chinese Han women, which may result in aberrant expression of WNT4, leading to the pathogenesis of endometriosis.
Wnt4 might be a key gene during parathyroid hormone-induced epithelial mesenchymal transformation of proximal kidney tubule cells.
The 5'-flanking region of the Wnt4 gene is responsive to Pax8. Pax8 modulates the expression of Wnt4 in thyroid cells.
Our results suggest that the rs10965235 SNP in the CDKN2B-AS gene and the rs16826658 SNP near the WNT4 gene were significantly associated with endometriosis in this Korean population.
identified Wnt4 as the ligand that is expressed in the mesoderm of the ventral blood island and is essential for the expression of hematopoietic and erythroid marker genes
XWntless and the Retromer complex are required for the efficient secretion of XWnt4, facilitating its role in Xenopus eye development
Study shows that Wnt-4 acts through the Notch effector gene hrt1 by upregulating expression of wnt4; Wnt-4 then patterns the proximal pronephric anlagen to establish the specific compartments that span the medio-lateral axis.
single inhibition of melatonin receptor 1 or Wnt-4 expression decreased expression of neurogenesis-related genes, and bovine amniotic epithelial cell-derived neural cells were successfully colonized into injured spinal cord, which suggested participation in tissue repair.
Fox1 activation of Wnt4a in the ectoderm signals the epithelial stabilization of pouch-forming cells during late-stage of pouch morphogenesis.
Data show that in vivo, wnt11r and wnt4a initiate MuSK translocation from muscle membranes to recycling endosomes and that this transition is crucial for AChR accumulation at future synaptic sites.
Data show that injury-dependent induction of Ascl1a suppressed expression of the Wnt signaling inhibitor, Dkk, and induced expression of the Wnt ligand, Wnt4a.
Findings provide the first convincing line of evidence that EAF and Wnt4 form an auto-regulatory negative feedback loop in vivo.
three Wnt noncanonical ligands wnt4a, silberblick/wnt11, and wnt11-related regulate the process of convergence of endoderm and organ precursors toward the embryonic midline by acting in a largely redundant way
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.
, wingless-type MMTV integration site family, member 4
, protein Wnt-4
, signal molecule
, wingless-related MMTV integration site 4
, Wnt-4 protein
, protein Wnt-4a