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results establish that RSPO2 (show RSPO2 Proteins), without the LGR4 (show LGR4 Proteins)/5/6 receptors, serves as a direct antagonistic ligand to RNF43 (show RNF43 Proteins) and ZNRF3, which together constitute a master switch that governs limb specification; these findings have direct implications for regenerative medicine and WNT (show WNT2 Proteins)-associated cancers
The present study suggests rs7290117 in ZNRF3 may be involved in the regulation of axial length, though our results do not support a contribution of the SNPs we tested in ZNRF3, HGF (show HGF Proteins) and MFRP (show MFRP Proteins) to primary angle-closure glaucoma in northern Chinese people
Missense variants of ZNRF3 are associated with Disorders of Sex Development.
Data suggest that inactivation of RNF43 (show RNF43 Proteins) and ZNRF3 is important in serrated tumorigenesis and has identified a potential therapeutic strategy for this cancer subtype.
ZNRF3 inhibited the metastasis and tumorigenesis via suppressing the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway in NPC (show NPC1 Proteins) cells.
Data indicate that clinical specimens showed a significant inverse correlation between zinc and ring finger 3 (ZNRF3) and beta-catenin (show CTNNB1 Proteins) mRNA levels.
miR (show MLXIP Proteins)-93/ZNRF3/Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) regulatory network contributes to the growth of lung carcinoma.
ZnRF3 negatively influences both the Wnt (show WNT2 Proteins) and Hedgehog (show SHH Proteins) proliferative pathways, and probably this way it negatively regulates cancer progression.
ZnRF3 negatively influences both the Wnt (show WNT2 Proteins) and Hedgehog (show SHH Proteins) proliferative pathways and probably this way it negatively regulates cancer progression
Report shows that miR (show MLXIP Proteins)-146b participated in migration, invasion and chemoresistance in osteosarcoma via downregulation of ZNRF3.
XY mice lacking ZNRF3 exhibit complete or partial gonadal sex reversal, or related defects.
RSPO (show RSPO1 Proteins)-LGR4 (show LGR4 Proteins)/5-ZNRF3/RNF43 (show RNF43 Proteins) module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.
Crystal structure confirming that Rspo (show RSPO1 Proteins) proteins cross-link LGRs and ZNRF3 into a 2:2:2 complex.
ZNRF3 binds RSPO1 (show RSPO1 Proteins) and LGR5 (show LGR5 Proteins)-RSPO1 (show RSPO1 Proteins) with micromolar affinity via RSPO1 (show RSPO1 Proteins) furin (show FURIN Proteins)-like 1 (Fu1) domain.
data suggest that R-spondin enhances Wnt (show WNT2 Proteins) signalling by inhibiting ZNRF3
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non- canonical Wnt signaling pathway.
, E3 ubiquitin-protein ligase ZNRF3
, RING finger protein 203
, novel C3HC4 type Zinc finger (ring finger)
, zinc/RING finger protein 3