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anti-24-Dehydrocholesterol Reductase (DHCR24) Antibodies

DHCR24 encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. Additionally we are shipping Seladin 1 Proteins (7) and Seladin 1 Kits (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DHCR24 1718 Q15392
DHCR24 74754 Q8VCH6
DHCR24 298298  
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Top anti-Seladin 1 Antibodies at antibodies-online.com

Showing 10 out of 51 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-DHCR24 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: 721_B cell lysate Host: Rabbit  Target Name: DHCR24  Sample Tissue: Human Fetal Heart  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-DHCR24 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-DHCR24 Antibody (N-term) (ABIN389352) in HepG2 cell line lysates (35 µg/lane). DHCR24 (arrow) was detected using the purified polyclonal antibody. Western blot analysis of anti-DHCR24 Antibody (N-term) (ABIN389352) in mouse liver tissue lysates (35 µg/lane). DHCR24 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-DHCR24 Antibody (Center)(ABIN389353) in HepG2 cell line lysates (35 µg/lane). DHCR24 (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded SW480 xenograft, using Seladin 1, antibody at 1:100 dilution. ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using Seladin 1, antibody at 1:200 dilution. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated WB Western Blot analysis of DHCR24 expression in transfected 293T cell line by DHCR24 MaxPab polyclonal antibody.Lane 1: DHCR24 transfected lysate(56.76 KDa).Lane 2: Non-transfected lysate. 50 μg Log in to see 9 Days
$430.00
Details

DHCR24 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Seladin 1 Antibodies

  1. Human Polyclonal Seladin 1 Primary Antibody for EIA, WB - ABIN358015 : Wang, Rogers, Stayrook, Su, Varga, Shen, Nagpal, Burris: The selective Alzheimer's disease indicator-1 gene (Seladin-1/DHCR24) is a liver X receptor target gene. in Molecular pharmacology 2008 (PubMed)
    Show all 3 references for ABIN358015

  2. Human Polyclonal Seladin 1 Primary Antibody for EIA, WB - ABIN358014 : Cecchi, Rosati, Pensalfini, Formigli, Nosi, Liguri, Dichiara, Morello, Danza, Pieraccini, Peri, Serio, Stefani: Seladin-1/DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content. in Journal of cellular and molecular medicine 2008 (PubMed)
    Show all 3 references for ABIN358014

  3. Human Polyclonal Seladin 1 Primary Antibody for WB - ABIN389352 : Bonaccorsi, Luciani, Nesi, Mannucci, Deledda, Dichiara, Paglierani, Rosati, Masieri, Serni, Carini, Proietti-Pannunzi, Monti, Forti, Danza, Serio, Peri: Androgen receptor regulation of the seladin-1/DHCR24 gene: altered expression in prostate cancer. in Laboratory investigation; a journal of technical methods and pathology 2008 (PubMed)
    Show all 2 references for ABIN389352

  4. Human Polyclonal Seladin 1 Primary Antibody for WB - ABIN389353 : Greeve, Hermans-Borgmeyer, Brellinger, Kasper, Gomez-Isla, Behl, Levkau, Nitsch: The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2000 (PubMed)
    Show all 2 references for ABIN389353

  5. Human Polyclonal Seladin 1 Primary Antibody for WB - ABIN514969 : Gilk, Cockrell, Luterbach, Hansen, Knodler, Ibarra, Steele-Mortimer, Heinzen: Bacterial colonization of host cells in the absence of cholesterol. in PLoS pathogens 2013 (PubMed)

  6. Cow (Bovine) Polyclonal Seladin 1 Primary Antibody for WB - ABIN2782831 : Tedde, Cellini, Bagnoli, Sorbi, Peri: Mutational screening analysis of DHCR24/seladin-1 gene in Italian familial Alzheimer's disease. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007 (PubMed)

More Antibodies against Seladin 1 Interaction Partners

Human 24-Dehydrocholesterol Reductase (DHCR24) interaction partners

  1. DHCR24 auto-antibody represents a potential noninvasive biomarker for hepatitis C virus-related liver disease and may facilitate the diagnosis of PIVKA-II and AFP (show AFP Antibodies)-negative hepatocellular carcinoma.

  2. physical and functional interaction between DHCR24 and DHCR7 (show DHCR7 Antibodies)

  3. In vitro experiments showed that DHCR24 overexpression induced tumor proliferation.

  4. Data (including data from studies using RNA from post-mortem brain tissue) suggest that expression of DHCR24 is up-regulated in parietal cortex of patients with Huntington's disease as compared to control subjects.

  5. Data indicate a mechanism whereby 3beta-hydroxysterol Delta24-reductase (DHCR24) activity is regulated by signaling.

  6. DHCR24 expression protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum stress.

  7. TR-beta (show TXNRD2 Antibodies) and LXR-alpha (show NR1H3 Antibodies) competitively up-regulate the human Seladin-1 promoter, sharing the same response element, site A.

  8. DHCR24 gene expression is regulation by cholesterol availability.

  9. a novel role for 24,25EC in cholesterol homeostasis, through its rapid inhibition of cholesterol synthesis at DHCR24.

  10. a gender dependent effect of DHCR24 rs600491 polymorphism on the susceptibility to Alzheimer disease.

Mouse (Murine) 24-Dehydrocholesterol Reductase (DHCR24) interaction partners

  1. When DHCR24 is genetically deleted there is a decreased association of EAAT2 (show SLC1A2 Antibodies) with lipid rafts after ischemia.

  2. Data (including data from transgenic mice) suggest that expression of Dhcr24 is down-regulated in brain tissues of mice exhibiting symptoms modeling advanced Huntington's disease.

  3. RE1-silencing transcription factor acts because it is bound in close proximity to SREBP, thus amplifying its ability to upregulate 24-dehydrocholesterol reductase

  4. concluded that TH up-regulates Seladin-1 gene expression at the transcriptional level and LXR-alpha (show NR1H3 Antibodies) maintains the gene expression

  5. This is the first demonstration that DHCR24 plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.

  6. Seladin-1 is shown to be an LPS (show TLR4 Antibodies)-responsive gene that negatively regulates the TNF- alpha (show TNF Antibodies) production and bone resorption in response to LPS (show TLR4 Antibodies).

  7. Seladin-1-dependent cholesterol synthesis is involved in lowering Abeta (show APP Antibodies) levels.

  8. cellular cholesterol biosynthesis is critical for the activation and maintenance of the Akt (show AKT1 Antibodies)-Bad cell survival cascade in response to growth factors such as insulin (show INS Antibodies).

  9. Cholesterol homeostasis in Dhcr24 knockout mice is characterized by strong activation of liver X receptor-targeted genes and by mechanisms compensating for cholesterol depletion.

  10. ablation of DHCR24/seladin-1 prevented apoptosis of primary neurons in a p53 (show TP53 Antibodies)-dependent manner

Seladin 1 (DHCR24) Antigen Profile

Protein Summary

This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

Gene names and symbols associated with DHCR24

  • 24-dehydrocholesterol reductase (DHCR24) antibody
  • 24-dehydrocholesterol reductase (dhcr24) antibody
  • 24-dehydrocholesterol reductase (AaeL_AAEL012138) antibody
  • 24-dehydrocholesterol reductase (CpipJ_CPIJ000670) antibody
  • 24-dehydrocholesterol reductase (Dhcr24) antibody
  • 2310076D10Rik antibody
  • 5830417J06Rik antibody
  • DCE antibody
  • MGC82737 antibody
  • mKIAA0018 antibody
  • Nbla03646 antibody
  • seladin-1 antibody
  • SELADIN1 antibody
  • zgc:101638 antibody

Protein level used designations for DHCR24

24-dehydrocholesterol reductase , 3 beta-hydroxysterol delta 24-reductase , 3-beta-hydroxysterol delta-24-reductase , delta(24)-sterol reductase , desmosterol-to-cholesterol enzyme , diminuto/dwarf1 homolog , seladin 1 , selective AD indicator 1 , 3-beta-hydroxysterol delta-24 reductase , seladin-1

GENE ID SPECIES
424661 Gallus gallus
447786 Xenopus laevis
456879 Pan troglodytes
489573 Canis lupus familiaris
494102 Danio rerio
549554 Xenopus (Silurana) tropicalis
5575872 Aedes aegypti
6031429 Culex quinquefasciatus
100546716 Meleagris gallopavo
100584832 Nomascus leucogenys
1718 Homo sapiens
74754 Mus musculus
298298 Rattus norvegicus
533726 Bos taurus
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