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DHCR24 encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. Additionally we are shipping Seladin 1 Proteins (7) and Seladin 1 Kits (3) and many more products for this protein.
Showing 10 out of 55 products:
Human Polyclonal Seladin 1 Primary Antibody for EIA, WB - ABIN358014
Cecchi, Rosati, Pensalfini, Formigli, Nosi, Liguri, Dichiara, Morello, Danza, Pieraccini, Peri, Serio, Stefani: Seladin-1/DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol content. in Journal of cellular and molecular medicine 2008
Show all 3 references for ABIN358014
Human Polyclonal Seladin 1 Primary Antibody for EIA, WB - ABIN358015
Wang, Rogers, Stayrook, Su, Varga, Shen, Nagpal, Burris: The selective Alzheimer's disease indicator-1 gene (Seladin-1/DHCR24) is a liver X receptor target gene. in Molecular pharmacology 2008
Show all 3 references for ABIN358015
Human Polyclonal Seladin 1 Primary Antibody for WB - ABIN389353
Greeve, Hermans-Borgmeyer, Brellinger, Kasper, Gomez-Isla, Behl, Levkau, Nitsch: The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2000
Show all 2 references for ABIN389353
Human Polyclonal Seladin 1 Primary Antibody for WB - ABIN389352
Bonaccorsi, Luciani, Nesi, Mannucci, Deledda, Dichiara, Paglierani, Rosati, Masieri, Serni, Carini, Proietti-Pannunzi, Monti, Forti, Danza, Serio, Peri: Androgen receptor regulation of the seladin-1/DHCR24 gene: altered expression in prostate cancer. in Laboratory investigation; a journal of technical methods and pathology 2008
Show all 2 references for ABIN389352
Human Polyclonal Seladin 1 Primary Antibody for WB - ABIN514969
Gilk, Cockrell, Luterbach, Hansen, Knodler, Ibarra, Steele-Mortimer, Heinzen: Bacterial colonization of host cells in the absence of cholesterol. in PLoS pathogens 2013
Human Polyclonal Seladin 1 Primary Antibody for WB - ABIN2782832
Tedde, Cellini, Bagnoli, Sorbi, Peri: Mutational screening analysis of DHCR24/seladin-1 gene in Italian familial Alzheimer's disease. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007
DHCR24 auto-antibody represents a potential noninvasive biomarker for hepatitis C virus-related liver disease and may facilitate the diagnosis of PIVKA-II and AFP (show AFP Antibodies)-negative hepatocellular carcinoma.
physical and functional interaction between DHCR24 and DHCR7 (show DHCR7 Antibodies)
In vitro experiments showed that DHCR24 overexpression induced tumor proliferation.
Data (including data from studies using RNA from post-mortem brain tissue) suggest that expression of DHCR24 is up-regulated in parietal cortex of patients with Huntington's disease as compared to control subjects.
Data indicate a mechanism whereby 3beta-hydroxysterol Delta24-reductase (DHCR24) activity is regulated by signaling.
DHCR24 expression protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum stress.
TR-beta (show TXNRD2 Antibodies) and LXR-alpha (show NR1H3 Antibodies) competitively up-regulate the human Seladin-1 promoter, sharing the same response element, site A.
DHCR24 gene expression is regulation by cholesterol availability.
a novel role for 24,25EC in cholesterol homeostasis, through its rapid inhibition of cholesterol synthesis at DHCR24.
a gender dependent effect of DHCR24 rs600491 polymorphism on the susceptibility to Alzheimer disease.
When DHCR24 is genetically deleted there is a decreased association of EAAT2 (show SLC1A2 Antibodies) with lipid rafts after ischemia.
Data (including data from transgenic mice) suggest that expression of Dhcr24 is down-regulated in brain tissues of mice exhibiting symptoms modeling advanced Huntington's disease.
RE1-silencing transcription factor (show REST Antibodies) acts because it is bound in close proximity to SREBP, thus amplifying its ability to upregulate 24-dehydrocholesterol reductase
concluded that TH up-regulates Seladin-1 gene expression at the transcriptional level and LXR-alpha (show NR1H3 Antibodies) maintains the gene expression
This is the first demonstration that DHCR24 plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.
Seladin-1 is shown to be an LPS (show TLR4 Antibodies)-responsive gene that negatively regulates the TNF- alpha (show TNF Antibodies) production and bone resorption in response to LPS (show TLR4 Antibodies).
Seladin-1-dependent cholesterol synthesis is involved in lowering Abeta (show APP Antibodies) levels.
cellular cholesterol biosynthesis is critical for the activation and maintenance of the Akt (show AKT1 Antibodies)-Bad cell survival cascade in response to growth factors such as insulin (show INS Antibodies).
Cholesterol homeostasis in Dhcr24 knockout mice is characterized by strong activation of liver X receptor-targeted genes and by mechanisms compensating for cholesterol depletion.
ablation of DHCR24/seladin-1 prevented apoptosis of primary neurons in a p53 (show TP53 Antibodies)-dependent manner
This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
, 3 beta-hydroxysterol delta 24-reductase
, 3-beta-hydroxysterol delta-24-reductase
, delta(24)-sterol reductase
, desmosterol-to-cholesterol enzyme
, diminuto/dwarf1 homolog
, seladin 1
, selective AD indicator 1
, 3-beta-hydroxysterol delta-24 reductase