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Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Additionally we are shipping beta Arrestin 1 Kits (27) and beta Arrestin 1 Proteins (14) and many more products for this protein.
Showing 10 out of 128 products:
Human Polyclonal beta Arrestin 1 Primary Antibody for EIA, FACS - ABIN950521
Shukla, Kim, Ahn, Xiao, Shenoy, Liedtke, Lefkowitz: Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. in The Journal of biological chemistry 2010
Show all 5 references for ABIN950521
Human Monoclonal beta Arrestin 1 Primary Antibody for IF, IP - ABIN968032
Attramadal, Arriza, Aoki, Dawson, Codina, Kwatra, Snyder, Caron, Lefkowitz: Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. in The Journal of biological chemistry 1992
Show all 5 references for ABIN968032
Human Polyclonal beta Arrestin 1 Primary Antibody for FACS, IF - ABIN655944
Kim, Lakshmikanthan, Frilot, Daaka: Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome. in Molecular cancer research : MCR 2010
Show all 3 references for ABIN655944
Beta-arrestin-1 with beta-arrestin-2 shared common mechanisms to suppress podocyte autophagy by negative regulation of ATG12-ATG5 conjugation.
data suggest that beta-arr1 mediated nuclear signaling regulates the production of excretive factors derived from niche astrocytes and expansion of neural precursors in DG, thus maintaining homeostasis of adult hippocampal neurogenesis
beta-arr1 (show SAG Antibodies) has a critical role in modulating ERK (show EPHB2 Antibodies), JNK (show MAPK8 Antibodies) and p38 MAPK (show MAPK14 Antibodies) pathways mediated by TNF-alpha (show TNF Antibodies) in intestinal epithelial cells.
COX-2-derived PGE2 inhibits IL-10 expression in brain microglia through a novel EP2- and beta-arrestin-dependent signaling pathway.
A specific hyaluronan-blocking peptide (Pep-1 (show CNDP2 Antibodies)) has confirmed the inflammatory role of degraded hyaluronan as a mediator of the IL-1beta (show IL1B Antibodies)-induced activation of beta-arrestin-1.
Data suggest that ARRB1 enhances hepatocellular carcinogenesis by inflammation-mediated Akt (show AKT1 Antibodies) signaling.
Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways.
Data show that knockout or knockdown of beta-arrestin-2 (show ARRB2 Antibodies) (betaarr-2), but not of beta-arrestin-1 (betaarr-1), augments beta adrenoceptor (betaAR)-stimulated cyclic AMP (show TMPRSS5 Antibodies) (cAMP) production.
a neuroprotective role for ARRB1, in the context of cerebral ischemia, centered on the regulation of BECN1 (show BECN1 Antibodies)-dependent autophagosome formation
results indicate that beta-arrestin1 plays a critical role in the assembly and activation of two major canonical inflammasomes
In non-small cell lung cancer patients, the loss expression of beta-arrestin1 was frequently observed, and beta-arrestin1 expression was significantly correlated with the smoking index and E-cadherin (show CDH1 Antibodies) expression, which all indicated beta-arrestin1's significant clinicopathologic role
beta-arrestins regulate oxidative stress in a Nox4 (show NOX4 Antibodies)-dependent manner and increase fibrosis in heart failure.
These results indicated that b-arr1 regulated ER stress/PUMA-induced mucosal epithelial apoptosis through suppression of the TNF-a/p65/iNOS signaling pathway activation and that b-arr1 is a potential therapeutic target for Portal hypertensive gastropathy.
The nuclear accumulation of beta-arrestin 1 following TLR2 (show TLR2 Antibodies) activation promote H4 acetylation at specific target gene promoters and may thus affect transcription of target genes in BM CD34 (show CD34 Antibodies)+ cells.
The identified receptor-phospho-selective mechanism for arrestin (show SAG Antibodies) conformation and the spacing of the multiple phosphate-binding sites in the arrestin (show SAG Antibodies) enable arrestin (show SAG Antibodies) to recognize plethora phosphorylation states of numerous GPCRs.
We conclude that beta-arrestin1 had a high expression in lung adenocarcinoma and beta-arrestin1 may be a promising biomarker to identify individuals with poor prognosis for patients with lung adenocarcinoma.
Bradykinin stimulates pro-contractile signalling mechanisms in human myometrial cells and arrestin (show SAG Antibodies) proteins play key roles in their regulation.
After eight and 12 weeks of treatment with mirtazapine, scores on the 21-item Hamilton Depression Rating Scale (HAMD21) were significantly lower in patients with MDD with ARRB1 haplotype 1 than in those without haplotype 1
analysis of how NK1 receptor Gs versus Gq proteins and beta-arrestin signaling is determined by interactions in the water hydrogen bond network
Using in vivo time-lapse imaging and three-dimensional morphology analysis of microglia in intact zebrafish larvae, study found that beta-arrestin1, a multifunctional protein involved in various signal transductions, cell-autonomously regulated the microglial morphology.
Study demonstrated that beta-arrestin1 is critically involved in zebrafish primitive hematopoiesis, where beta-arrestin1 binds to and sequesters the PcG recruiter YY1 (show YY1 Antibodies), thus relieving PcG-mediated repression of cdx4-hox (show MSH2 Antibodies) pathway.
The presented functional map quantitatively connects critical interactions in the polar core and along the C tail of arrestin (show SAG Antibodies).
Reduced binding of arrestin-1 (show SAG Antibodies) to the phospho-opsin (show RHO Antibodies) form of G90D mutant likely contributes to night blindness caused by this mutation.
3.0 A crystal structure of the bovine arrestin-1 splice variant p44, in which the activation step is mimicked by C-tail truncation
Conformational dynamics of helix 8 in the GPCR (show GPRC6A Antibodies) rhodopsin (show RHO Antibodies) controls arrestin (show SAG Antibodies) activation in the desensitization process
similar to transducin (show GNAT1 Antibodies) activation, rhodopsin (show RHO Antibodies) phosphorylation by GRK1 (show GRK1 Antibodies) and high affinity arrestin-1 (show SAG Antibodies) binding only requires a rhodopsin (show RHO Antibodies) monomer
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.
arrestin, beta 1
, arrestin 1
, beta-arrestin 1
, arrestin beta 1
, arrestin beta-1
, arrestin 2