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The protein encoded by CD207 is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. Additionally we are shipping CD207 Proteins (8) and CD207 Kits (3) and many more products for this protein.
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Human Monoclonal CD207 Primary Antibody for Neut - ABIN2662535
Clausen, Kel: Langerhans cells: critical regulators of skin immunity? in Immunology and cell biology 2010
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Human Monoclonal CD207 Primary Antibody for FACS - ABIN2657032
Merad, Ginhoux, Collin: Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells. in Nature reviews. Immunology 2008
Show all 4 references for ABIN2657032
Human Monoclonal CD207 Primary Antibody for ICFC - ABIN2664388
Valladeau, Ravel, Dezutter-Dambuyant, Moore, Kleijmeer, Liu, Duvert-Frances, Vincent, Schmitt, Davoust, Caux, Lebecque, Saeland: Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. in Immunity 2000
Show all 3 references for ABIN2664388
Human Monoclonal CD207 Primary Antibody for WB - ABIN2657030
Mizumoto, Takashima: CD1a and langerin: acting as more than Langerhans cell markers. in The Journal of clinical investigation 2004
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Human Monoclonal CD207 Primary Antibody for FACS, IHC - ABIN2662533
de Witte, Nabatov, Pion, Fluitsma, de Jong, de Gruijl, Piguet, van Kooyk, Geijtenbeek: Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. in Nature medicine 2007
Show all 3 references for ABIN2662533
Data show that Candida albicans and Candida tropicalis preferentially localized in (and persisted within) a sub- population of Peyer's patch Langerin-positive dendritic cells.
Langerin is expressed by the XCR1(+) "DC1" populat (show CD1C Antibodies)ion of mice.
Langerin+ dermal dendritic cells appear to be site- and strain-specific
TLR7 (show TLR7 Antibodies)-activated langerin(neg) dendritic cells trigger psoriatic plaque formation via IL-23 (show IL23A Antibodies)-mediated activation of innate IL-17 (show IL17A Antibodies)/IL-22 (show IL22 Antibodies)-producing lymphocytes, independently of IFN-I.
model of epicutaneous ovalbumin (show OVA Antibodies) sensitization inducing an inflammatory skin resembling atopic dermatitis (AD) to explore the role of CD207 in the pathogenesis of AD
Langerin-positive dendritic cells appear to be the predominant, though not exclusive, population responsible for in vivo transport of anti-DEC-205 (show LY75 Antibodies) antibodies from the skin to the draining lymph nodes in steady state and inflammation.
Data demonstrated that CD207(+) CD8alpha(+) thymic DCs do not share a common origin with T cells but originate from intrathymic precursors.
The normal corneal epithelium is endowed with CD11c (show ITGAX Antibodies)(+) Langerin+ cells that are LCs, whereas the stroma is endowed with a separate population of (non-LC) Langerin+ DCs.
Comparable T helper 1 (Th1 (show HAND1 Antibodies)) and CD8 (show CD8A Antibodies) T-cell immunity by targeting HIV gag p24 to CD8 (show CD8A Antibodies) dendritic cells within antibodies to Langerin, DEC205 (show LY75 Antibodies), and Clec9A (show CLEC9A Antibodies).
Langerhan cells and (Langerin(+)) dermal dendritic cells thus seem to have a redundant function in regulating contact hypersensitivity
This study shows that mutations in the Langerin gene are present in the analysed populations at different genotypic and allelic frequencies and further studies should be conducted to verify the role of these mutations in HIV-1 susceptibility.
This study is the first to demonstrate that langerin represents an authentic receptor that binds and internalizes influenza A virus to facilitate infection.
Data suggest that Langerin (CD207)-mediated binding of Yersinia pestis to antigen-presenting cells (APCs (show APCS Antibodies)) may promote its dissemination and infection.
Langerin binds heparin (HEP)-like oligosaccharides in two different binding sites depending on the ligand size.
The authors not only show that langerin and caveolin-1 (show CAV1 Antibodies) co-localize at the cell membrane and in vesicles but that caveolin-1 (show CAV1 Antibodies) mediated HIV-1 uptake is an intrinsic restriction mechanism present in human Langerhans cells that prevents HIV-1 infection.
The impact of two carbohydrate recognition domains mutations, W264R and F241L, on langerin structure, function, and Birbeck granules assembly.
Langerin is not expressed by freshly isolated CD1c (show CD1C Antibodies)(+) blood DCs but is rapidly induced on CD1c (show CD1C Antibodies)(+) DCs by serum or TGF-beta (show TGFB1 Antibodies) via an ALK-3 (show BMPR1A Antibodies)-dependent pathway.
Cell-sorting experiments demonstrated that IDO1 (show IDO1 Antibodies) expression is found in a subset of CD1a (show CD1A Antibodies)(+)CD14 (show NDUFA2 Antibodies)(-)langerin(+) cells, expressing CD103 (show ITGAE Antibodies)
However, the superoxide dismutase (show SOD1 Antibodies) C (SodC (show SOD1 Antibodies)) protein of the Mycobacterium leprae cell wall was identified as a langerin-reactive ligand.
Both phases of HIV transfer from eLCs to T cells were inhibited when eLCs were pretreated with a mAb to langerin CRD (show CRX Antibodies) or when HIV was pretreated with a soluble langerin trimeric extracellular domain or by a CRD (show CRX Antibodies) homolog.
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.
CD207 molecule, langerin
, CD207 antigen, langerin
, C-type lectin domain family 4 member K
, Langerhans cell specific c-type lectin
, C-type lectin domain family 4, member K
, CD 207 antigen