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Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Additionally we are shipping PD-L1 Antibodies (315) and PD-L1 Proteins (64) and many more products for this protein.
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Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN417524
Curry, Lawrence, Burden: Ovarian sympathectomy in the golden hamster: effects on estrous cyclicity and follicular development. in Experimental and clinical endocrinology 1986
Show all 6 references for ABIN417524
Data show that Qiyusanlong decoction (QYSL) can moderately inhibit the growth of the transplanted tumor by decreasing programmed death 1 (show PDCD1 ELISA Kits) and programmed death ligand 1 (PD-1 (show PDCD1 ELISA Kits)/PD-L1) level.
Expression of PD-L1 is correlated with the severity of periodontitis in the mouse model of experimental periodontitis.
Blockade of TGFbeta (show TGFB1 ELISA Kits) downregulated PD-1 (show PDCD1 ELISA Kits) and PD-L1 expression and precipitated graft rejection.
Loss of Cdk5 (show CDK5 ELISA Kits) results in persistent expression of the PD-L1 transcriptional repressors, the interferon (show IFNA ELISA Kits) regulatory factors IRF2 (show IRF2 ELISA Kits) and IRF2BP2 (show IRF2BP2 ELISA Kits), which likely leads to reduced PD-L1 expression on tumors.
The endogenous PD-1 (show PDCD1 ELISA Kits)/PD-L pathway does not limit acute experimental foreign antigen-induced circulating immune complex glomerulonephritis.
addition to inhibiting T cells, hepatic stellate cells (HSCs) concurrently inhibit B cells via PD-L1; this direct B cell-inhibitory activity of HSCs should contribute to the mechanism by which HSCs maintain the liver's immune homeostasis
The results demonstrated that blockade of PD-1 (show PDCD1 ELISA Kits)/B7H1 pathway could promote mouse NK cells to kill the GL261GSCs, and the PD-1 (show PDCD1 ELISA Kits)-inhibited NK cells could be a feasible immune therapeutic approach against Glioblastoma multiforme.
These findings provide evidence for a novel immune escape mechanism during acute retroviral infection based on PD-L1 expression levels on virus infected target cells
These results suggest a novel and specific role for PspA (show SFTPA1 ELISA Kits) in modulating immune responses against S. pneumoniae by regulating PD-L1 expression.
Upregulation of PD-1 (show PDCD1 ELISA Kits) and PD-L1 was associated with marked increases in GADD153 (show DDIT3 ELISA Kits) during myocardial ischemic reperfusion injury.
Study demonstrates that PD-1 (show PDCD1 ELISA Kits)(+) TIMC and intratumoral PD-L1(+) expression did not significantly impact tumor aggressiveness or clinical outcome in non-ccRCC specimens.
Immune surveillance is an important mechanism in prevention of cancer development and inhibition of growth of tumors and metastasis. Checkpoint pathways prevent immune response through multiple methods including CTLA-4 (show CTLA4 ELISA Kits) and PD-1 (show PDCD1 ELISA Kits)/PD-L1 pathways.A variety of immune checkpoint inhibitors (PD-1 (show PDCD1 ELISA Kits)/PD-L1 and CTLA-4 (show CTLA4 ELISA Kits) inhibitors) have been studied in recurrent and metastatic head and neck cancers with encouraging efficacy
n combination with anti-PD-1 (show PDCD1 ELISA Kits)/PD-L1, the CTLA-4 (show CTLA4 ELISA Kits)-expanded T cells are prevented from being functionally inhibited when they enter into the tumor microenvironment.
The CTLA-4 (show CTLA4 ELISA Kits) receptor was one of the first checkpoint inhibitors to be targeted with limited exploration and efficacy in sarcoma.The PD-1 (show PDCD1 ELISA Kits)/PD-L1 immunologic checkpoint pathway has demonstrated efficacy in many malignancies; studies are ongoing in sarcoma.
High CD274 expression is associated with gliomas.
We provide first evidence that expression of the therapy target PD-L1 is not only highly prevalent in primary prostate cancer cells but is also an independent indicator of BCR (show BCR ELISA Kits), suggesting a biologic relevance in primary tumors.
High PD-L1 expression is Correlated with Non-Small Cell Lung Cancer.
Overexpression of PDL1 is associated with poor treatment response in esophageal squamous cell carcinoma.
PD-L1-PD-1 (show PDCD1 ELISA Kits) axis plays a critical role in dampening RFA (show RPA1 ELISA Kits)-induced antitumor immune responses, and this study provides a strong rationale for combining RFA (show RPA1 ELISA Kits) and the PD-L1/PD-1 (show PDCD1 ELISA Kits) blockade in the clinical setting.
smallest amplified 9p24.1 region was restricted to the JAK2-PDL1/2-RANBP6 interval. In the next step, we screened 200 cases of classical Hodgkin lymphoma by interphase FISH and identified PDL1/2 rearrangement (CIITA- and IGH-negative) in four cases (2%), what is a novel finding. Forty (25%) cases revealed high level amplification of 9p24.1
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (show PDCD1LG2 ELISA Kits) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
This study provides novel information for the understanding of signalling through PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
, CD274 antigen
, programmed cell death 1 ligand 1
, programmed cell death ligand 1
, B7 homolog 1
, PDCD1 ligand 1
, programmed death ligand 1