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Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Additionally we are shipping PD-L1 Antibodies (263) and PD-L1 Proteins (61) and many more products for this protein.
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Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN417524
Curry, Lawrence, Burden: Ovarian sympathectomy in the golden hamster: effects on estrous cyclicity and follicular development. in Experimental and clinical endocrinology 1986
Show all 6 references for ABIN417524
Blockade of TGFbeta (show TGFB1 ELISA Kits) downregulated PD-1 (show PDCD1 ELISA Kits) and PD-L1 expression and precipitated graft rejection.
Loss of Cdk5 (show CDK5 ELISA Kits) results in persistent expression of the PD-L1 transcriptional repressors, the interferon (show IFNA ELISA Kits) regulatory factors IRF2 (show IRF2 ELISA Kits) and IRF2BP2 (show IRF2BP2 ELISA Kits), which likely leads to reduced PD-L1 expression on tumors.
The endogenous PD-1 (show PDCD1 ELISA Kits)/PD-L pathway does not limit acute experimental foreign antigen-induced circulating immune complex glomerulonephritis.
addition to inhibiting T cells, hepatic stellate cells (HSCs) concurrently inhibit B cells via PD-L1; this direct B cell-inhibitory activity of HSCs should contribute to the mechanism by which HSCs maintain the liver's immune homeostasis
The results demonstrated that blockade of PD-1 (show PDCD1 ELISA Kits)/B7H1 pathway could promote mouse NK cells to kill the GL261GSCs, and the PD-1 (show PDCD1 ELISA Kits)-inhibited NK cells could be a feasible immune therapeutic approach against Glioblastoma multiforme.
These findings provide evidence for a novel immune escape mechanism during acute retroviral infection based on PD-L1 expression levels on virus infected target cells
These results suggest a novel and specific role for PspA (show SFTPA1 ELISA Kits) in modulating immune responses against S. pneumoniae by regulating PD-L1 expression.
Upregulation of PD-1 (show PDCD1 ELISA Kits) and PD-L1 was associated with marked increases in GADD153 (show DDIT3 ELISA Kits) during myocardial ischemic reperfusion injury.
Breg cells can suppress through the PD-1 (show PDCD1 ELISA Kits)/PD-L1 pathway in limiting the differentiation and function of TFH cells
Programmed death 1 (show PDCD1 ELISA Kits)/programmed death ligand 1 pathway likely plays a crucial role in the mechanisms underlying spontaneous tolerization of B cells responding to ABO (show ABO ELISA Kits)-blood group (show DARC ELISA Kits) antigens in liver transplantation.
PD-L1 expression and HLA class I antigen (show MICA ELISA Kits) expression by ICC cells was observed in 8 and 11, respectively, of the 27 tumors analyzed.
Higher CD8 (show CD8A ELISA Kits)+ lymphocyte infiltration was related to lower PD-L1 expression and higher FOXP3 (show FOXP3 ELISA Kits)+ tumor-infiltrating lymphocyte infiltration in breast cancer
Genetic amplification of the PD-L1 gene was correlated with Non-Small Cell Lung Cancer.
High CD274 expression is correlated with glioblastoma.
IL-27 (show IL27 ELISA Kits) induced IDO (show IDO1 ELISA Kits) or PD-L1 expression in monocytes and in human PC3 (show PCSK1 ELISA Kits) prostate and A549 lung cancer cells
PD-L1 expression in neutrophils is elevated in patients with systemic lupus erythematosus.
Immune checkpoint inhibitors, particularly those targeting PD-1 (show PDCD1 ELISA Kits) and PD-L1 are clinically active for the treatment of lung cancer and represent an exciting step forward in lung cancer therapy.
Data show that the serum soluble programmed death-ligand 1 (sPD (show HOXD13 ELISA Kits)-L1) level is a valuable biomarker for predicting treatment response and an independent prognostic factor for progression free survival (PFS).
PD-L1 copy number gain is present in approximately five percent of non-small cell lung cancer with a slight preference to squamous cell carcinoma.
PD-L1 expression is frequently discordant between surgical resected and matched biopsy specimens and thus may be potentially misleading in defining the sensitivity to treatment with PD-L1 targeted therapy.
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (show PDCD1LG2 ELISA Kits) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
This study provides novel information for the understanding of signalling through PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
, CD274 antigen
, programmed cell death 1 ligand 1
, programmed cell death ligand 1
, B7 homolog 1
, PDCD1 ligand 1
, programmed death ligand 1