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Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Additionally we are shipping PD-L1 Antibodies (360) and PD-L1 Proteins (83) and many more products for this protein.
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Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN417524
Curry, Lawrence, Burden: Ovarian sympathectomy in the golden hamster: effects on estrous cyclicity and follicular development. in Experimental and clinical endocrinology 1986
Show all 14 Pubmed References
Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN577883
Atesoglu, Tarkun, Demirsoy, Geduk, Mehtap, Batman, Kaya, Cekmen, Gulbas, Hacıhanefioglu: Soluble Programmed Death 1 (PD-1) Is Decreased in Patients With Immune Thrombocytopenia (ITP): Potential Involvement of PD-1 Pathway in ITP Immunopathogenesis. in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2014
Human PD-L1 ELISA Kit for Sandwich ELISA - ABIN579638
Baral, Ye, Jiang, Yao, Mao: B7-H3 and B7-H1 expression in cerebral spinal fluid and tumor tissue correlates with the malignancy grade of glioma patients. in Oncology letters 2014
It was concluded that down-regulated expression of miR (show MLXIP ELISA Kits)-143 and up-regulation of its direct target B7H1 may indicate a novel therapeutic method for radiation-induced thymic lymphoma by increased expression of miR (show MLXIP ELISA Kits)-143 or inhibition of B7H1.
HDAC6 inhibition reduces tu (show HDAC6 ELISA Kits)mor growth and PD-L1 production in vivo.
findings indicate that the PerC (show PPARGC1B ELISA Kits) B cells, including PD-L1/PD-L2 (show PDCD1LG2 ELISA Kits) B-1a cells, may suppress T cells responding to allostimulation, and thus may be optimal for donor lymphocyte injection
PD-L1 selectively enhances T cell-mediated immune responses, driving graft-versus-host disease lethality and suggesting a context-dependent function of the PD-1 (show PDCD1 ELISA Kits)/PD-L1 axis
Mesenteric lymph node CD11b (show ITGAM ELISA Kits)(-) CD103 (show ITGAE ELISA Kits)(+) PD-L1(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta (show TGFB1 ELISA Kits) activation.
These results indicate that the outcome of PD-L1-mediated signaling in CD8 (show CD8A ELISA Kits)+ T cells depends on the presence or absence of CD4 (show CD4 ELISA Kits)+ T cells, the nature of the interacting receptor expressed by CD8 (show CD8A ELISA Kits)+ T cells, and the tissue environment in which the signaling occurs.
CD169 (show SIGLEC1 ELISA Kits)(+) macrophages are important contributors to the IFN-I response and thereby influence antiviral activity, CD8 (show CD8A ELISA Kits)(+) T-cell exhaustion and immunopathology.
findings identify a previously unrecognized role of PD-L1 as an endogenous pain inhibitor and a neuromodulator.
reduced cytotoxicity as a key mechanism by which tumor PD-L1 suppresses antitumor immunity and demonstrate that tumor PD-L1 is not just a marker of suppressed antitumor immunity.
Apigenin inhibits IFN-gamma-induced (show SAMHD1 ELISA Kits) PD-L1 expression by breast cancer cells, potentially rendering BC cells that lack constitutive PD-L1 expression more susceptible to T cellmediated anti-tumor immune responses.
Increased BAG-1 (show BAG1 ELISA Kits) by PD-L1 confers resistance to tyrosine kinase (show TXK ELISA Kits) inhibitor in non-small cell lung cancer via persistent activation of ERK (show EPHB2 ELISA Kits) signaling.
PD-L1 expression is an important prognostic factor in patients with pancreatic ductal adenocarcinoma who underwent surgical resection.
PD-L1 detection in cancer cells and immune cells varied by antibody clone.
A meta-analysis indicates that circulating sPD (show HOXD13 ELISA Kits)-L1 changes may serve as a useful biomarker for cancer prognosis, and higher level of sPD (show HOXD13 ELISA Kits)-L1 may also be associated with poor outcomes in patients with cancer. Review.
Expression of PD-L1 in Hodgkin Lymphoma patients is positively correlated with microvessel density.
Activation of GPR81 (show GPR81 ELISA Kits) decreases intracellular cAMP levels and inhibits PKA activity, leading to activation of TAZ (show TAZ ELISA Kits) and upregulation of PD-L1. This study reveals a critical role for lactate in the immune checkpoint pathway and an unexpected function of TAZ (show TAZ ELISA Kits) in tumor evasion of the T-cell-mediated immune response.
PD-L1 expression is not a prognostic factor in surgically resected lung adenocarcinoma patients.
In gastric cancer (GC), tumour-derived GM-CSF (show CSF2 ELISA Kits) activated neutrophils and induced neutrophil PD-L1 expression via Janus kinase (JAK (show JAK3 ELISA Kits))-signal transducer and activator of transcription 3 (STAT3 (show STAT3 ELISA Kits)) signalling pathway. The activated PD-L1(+) neutrophils effectively suppressed normal T-cell immunity in vitro and contributed to the growth and progression of human GC in vivo.
PD-L1 was expressed on both tumor and/or tumor-infiltrating immune cells in primary central nervous system lymphomas.
Suggest of the positive conversion of PD-L1 expression after treatment including nivolumab and that PD-L1 expression must be assessed in not only the resected specimens, but also in the re-biopsied ones.
These results suggest that the soluble recombinant proteins may be used to prepare monoclonal antibodies to block the PD-1 (show PDCD1 ELISA Kits)/PD-L1 pathway.
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (show PDCD1LG2 ELISA Kits) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
This study provides novel information for the understanding of signalling through PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
, CD274 antigen
, programmed cell death 1 ligand 1
, programmed cell death ligand 1
, B7 homolog 1
, PDCD1 ligand 1
, programmed death ligand 1