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The protein encoded by CNTN1 is a member of the immunoglobulin superfamily. Additionally we are shipping Contactin 1 Kits (53) and Contactin 1 Proteins (8) and many more products for this protein.
Showing 10 out of 57 products:
Human Polyclonal Contactin 1 Primary Antibody for EIA, WB - ABIN951660
Compton, Albrecht, Seto, Cooper, Ilkovski, Jones, Challis, Mowat, Ranscht, Bahlo, Froehner, North: Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy. in American journal of human genetics 2008
Show all 2 references for ABIN951660
CNTN1 is a new gene which can be regulated by RET (show RET Antibodies)/PTC3 (show NCOA4 Antibodies) (Ret proto-oncogene (show RET Antibodies) and Ret-activating protein ELE1 (show NCOA4 Antibodies)) rearrangement gene and the protein level of CNTN1 is increasing in thyroid cancer.
Structurally, CASPR2 (show CNTNAP2 Antibodies) is highly glycosylated and has an overall compact architecture. CASPR2 (show CNTNAP2 Antibodies) associates with micromolar affinity with CNTN1 but, under the same conditions, it does not interact with any of the other members of the contactin family.
CNTN1 promotes prostate cancer progression.
High CNTN-1 expression is associated with metastasis in gastric cancer.
CNTN-1 is closely related with multidrug resistance of lung adenocarcinoma.
anti-CNTN1 IgG4 antibodies are associated with subacute onset of chronic inflammatory demyelinating polyneuropathy symptoms, sensory ataxia (show USP14 Antibodies), and good response to corticosteroids.
under hypoxia conditions, elevated HIF-1alpha (show HIF1A Antibodies) seems to up-regulate contactin-1 expression and by this activate RhoA (show RHOA Antibodies) and facilitate migration of cancer cells.
activation of AKT (show AKT1 Antibodies) plays a role in contactin-1-mediated downregulation of E-cadherin (show CDH1 Antibodies).
A high expression of CNTN1 was markedly associated with the regional lymph node metastasis of patients with oral squamous cell carcinoma.
The expression of CNTN-1 is upregulated in esophageal squamous cell carcinoma tissue and is related to stage and lymphatic invasion. Thus, it may be involved in the pathogenesis & progression of esophageal squamous cell carcinoma.
Data indicate that Contactin-1 expression is dependent upon EBF (show EBF1 Antibodies) factors; Cntn1 gene belongs to the expanding regulatory cascade driven by these transcriptional regulators so that changes in its activation may contribute to the Ebf2 (show EBF2 Antibodies) null mutant phenotype
Contactin-1 has roles in regulating myelination and nodal/paranodal domain organization in the central nervous system
The phenotype of the Cntn1 mice arises from dysfunction in the brain, spinal cord or peripheral nervous system.
Data show that TAG1 (show CNTN2 Antibodies) and F3 act antagonistically to control SHH (show SHH Antibodies)-induced proliferation: F3 suppresses SHH (show SHH Antibodies)-induced GNP proliferation and induces differentiation, whereas TAG1 (show CNTN2 Antibodies) antagonises F3.
these findings indicate that precise spatio-temporal regulation of TAG-1 (show CNTN2 Antibodies) and F3/contactin expression is critical for normal cerebellar morphogenesis
F3/contactin and caspr/paranodin (show CNTNAP1 Antibodies) traffic to the cell surface via a non-conventional pathway
These data provide evidence of a role for contactin in selectively regulating the cell surface expression and current densities of TTX-R but not TTX-S Na+ channel isoforms in nociceptive DRG neurons.
Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E.
Thus, our results suggest a contribution by DRG Na(v)1.6, and possibly Contactin to neuropathic pain in the neuroma model in mice.
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, contactin 1
, Neural cell surface protein F3
, glycoprotein gP135
, neural cell surface protein F3
, neural cell recognition molecule F11
, neural cell recognition protein