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anti-Crystallin, alpha A (CRYAA) Antibodies

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. Additionally we are shipping Crystallin, alpha A Proteins (68) and Crystallin, alpha A Kits (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CRYAA 1409 P02489
CRYAA 24273 P24623
CRYAA 12954 P24622
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Top anti-Crystallin, alpha A Antibodies at

Showing 10 out of 97 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Mouse Un-conjugated ELISA, ICC, IF, WB Alpha A Crystallin (1H3 B8), alphaA (L) and AlphaB (R) crystallin. 50 μg Log in to see 3 to 4 Days
Human Mouse Un-conjugated EIA, WB Immunoblot analysis: Rat eye extracts were resolved by electrophoresis, transferred to PVDF membrane and probed with anti-crystallin alphaalpha(1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a DAP detection system. Arrow indicates crystalline alphaalpha(~20 kDa). 0.1 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated WB CRYAA Antibody (Center) (ABIN1881229) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the CRYAA antibody detected the CRYAA protein (arrow). 400 μL Log in to see 10 to 11 Days
Human Mouse Un-conjugated ELISA, WB 100 μL Log in to see 7 to 8 Days
Cow Mouse Un-conjugated EIA, WB Western blot analysis of Alpha A Crystallin in bovine tissues at a 1/1000 dilution of AM12021PU. This blot shows absolute specificity as Left: Alpha A Crystallin, Right: Alpha B Crystallin. 50 μg Log in to see 6 to 8 Days
Human Mouse Un-conjugated WB 100 μL Log in to see 8 to 10 Days
Human Rabbit Un-conjugated IHC (p), WB   100 μg Log in to see 4 to 6 Days
Cow Rabbit Un-conjugated IHC (p), IHC, WB Western Blot: AlphaA Crystallin/CRYAA Antibody [ABIN267342] - Analysis of alpha-A crystallin from bovine lens extract. 0.1 mg Log in to see 5 to 7 Days
Human Mouse Un-conjugated ELISA, WB 0.1 mg Log in to see 3 to 4 Days
Human Rabbit Un-conjugated WB 400 μL Log in to see 6 Days

CRYAA Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , ,
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Rat (Rattus)
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Mouse (Murine)
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Top referenced anti-Crystallin, alpha A Antibodies

  1. Cow (Bovine) Monoclonal CRYAA Primary Antibody for ELISA, WB - ABIN361798 : Bullard, Ferguson, Minajeva, Leake, Gautel, Labeit, Ding, Labeit, Horwitz, Leonard, Linke: Association of the chaperone alphaB-crystallin with titin in heart muscle. in The Journal of biological chemistry 2004 (PubMed)
    Show all 8 references for ABIN361798

  2. Human Polyclonal CRYAA Primary Antibody for WB - ABIN1881229 : Deng, Chen, Xie, Zhao, Gong, Liu, Zhang, Sun, Liu, Ma, Batra, Li: The small heat shock protein alphaA-crystallin is expressed in pancreas and acts as a negative regulator of carcinogenesis. in Biochimica et biophysica acta 2010 (PubMed)
    Show all 4 references for ABIN1881229

  3. Human Monoclonal CRYAA Primary Antibody for ELISA, WB - ABIN2477375 : Andley, Mathur, Griest, Petrash: Cloning, expression, and chaperone-like activity of human alphaA-crystallin. in The Journal of biological chemistry 1997 (PubMed)

  4. Human Monoclonal CRYAA Primary Antibody for ELISA, WB - ABIN165392 : Laksanalamai, Robb: Small heat shock proteins from extremophiles: a review. in Extremophiles : life under extreme conditions 2004 (PubMed)

More Antibodies against Crystallin, alpha A Interaction Partners

Xenopus laevis Crystallin, alpha A (CRYAA) interaction partners

  1. The ontogeny and localization of the alphaA-crystallin and betaB1-crystallin (show CRYBB1 Antibodies) during embryonic lens development and regeneration indicated a different development program, although they have identical origins, the ectoderm.

Zebrafish Crystallin, alpha A (CRYAA) interaction partners

  1. The normal development observed in alphaA-crystallin deficient zebrafish embryos may reflect similarly non-essential roles for this protein in the early stages of both zebrafish and mammalian lens development.

  2. Fndings establish that the C-terminal extension of alphaA crystallin can be either 3D domain swapped or non-3D domain swapped.

  3. alphaA-crystallin (HSPB4) is expressed during development.

Human Crystallin, alpha A (CRYAA) interaction partners

  1. The T allele of rs7278468 in the crystallin alpha A promoter is associated with age-related cataract through increasing binding of KLF-10 (show KLF10 Antibodies) and thus decreasing crystallin alpha A transcription.

  2. The evidence presented suggests that the methylation of the CpG sites of the CRYAA promotor directly affect Sp1 (show PSG1 Antibodies) binding, leading to down expression of CRYAA in human lens epithelial cells.

  3. The p.R21Q mutation of CRYAA is the most likely cause of paediatric cataract in this family.

  4. these results suggest that individuals carrying the alphaA-Crystallin R12C mutation are at an increased risk to develop early-onset cataract under condition of oxidative stress

  5. alphaA-crystallin membrane insertion is oligomer-size dependent

  6. isomerization of Asp (show ASIP Antibodies) might disrupt the higher order polymeric state of alpha-crystallin, resulting in decreased solubility and function, ultimately contributing to lens protein impairment and cataract formation with aging

  7. Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf (show MAF Antibodies).

  8. Similar to wild type alphaA- and alphaB-crystallins, the deamidated mutants showed strong interaction with betaA3-crystallin (show CRYBA1 Antibodies).

  9. Identification of a novel mutation in CRYAA associated with congenital cataracts.

  10. A novel disease-causing mutation, c.246_248delCGC (p.117delR), of the CRYAA gene has been identified in a Chinese family with autosomal-type perinuclear congenital cataracts.

Cow (Bovine) Crystallin, alpha A (CRYAA) interaction partners

  1. For moderate O-GlcNAcylation on bovine crystalline alpha, the preferred amino acids were Pro > Ala > Gly at position -2, Ala > Thr (show TRH Antibodies) >Val > Lys (show LYZ Antibodies) > Pro at position -1, and Ala > Gly > Arg > Glu (show DCTN1 Antibodies) at position +2.

  2. Alpha-crystallin, in the presence of the sorbitol dehydrogenase (SDH (show SORD Antibodies)) pyridine cofactor NAD(H), can exert a remarkable chaperone action by favoring the recovery of the enzyme activity from chemically denaturated SDH (show SDS Antibodies) up to 77%.

  3. Conserved triad in alphaA-crystallin contributes to stability of higher order oligomers but is not essential for formation of tetramers.

  4. Mass spectrometry analysis and a database search identified carbamylated proteins originating from alphaA-crystallin, betaB2- and gammaS-(betaS)-crystallins.

Mouse (Murine) Crystallin, alpha A (CRYAA) interaction partners

  1. Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf (show MAF Antibodies).

  2. Knockout of alphaA-crystallin inhibited pathologic neovascularization through the VEGF (show VEGFA Antibodies) and VEGFR2 (show KDR Antibodies) signaling pathways both in vitro and in vivo.

  3. p53 (show TP53 Antibodies) can regulate lens differentiation by controlling expression of the differentiation genes coding for the lens crystallins.

  4. Alpha A crystallin is a moonlighting protein that functions as a heat shock protein as well as a lens crystalline.

  5. alphaA-crystallin may protect against geographic atrophy.

  6. alphaA and alphaB regulate caspase-3 (show CASP3 Antibodies) and Bax (show BAX Antibodies) in vitro and in vivo to regulate lens differentiation.

  7. these findings show that mutation of alphaA-crystallin induces activation of the UPR during cataract formation.

  8. Hydroimidazolone modification of human alphaA-crystallin: Effect on the chaperone function and protein refolding ability.

  9. Methionine oxidation of alpha-crystallin in combination with loss of MsrA (show MSR1 Antibodies) repair causes loss of alpha-crystallin chaperone function.

  10. mouse lens epithelial cell progression through the cell cycle is significantly affected by expression of alphaA and alphaB-crystallin (show CRYAB Antibodies)

Rabbit Crystallin, alpha A (CRYAA) interaction partners

Crystallin, alpha A (CRYAA) Antigen Profile

Protein Summary

Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families\; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone\; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits\; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed\; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).

Gene names and symbols associated with CRYAA

  • crystallin, alpha A (cryaa) antibody
  • crystallin, alpha A (CRYAA) antibody
  • alphaA-crystallin (CpipJ_CPIJ005646) antibody
  • alpha-A-crystallin protein (alpha-a-crystallin) antibody
  • alpha-crystallin A chain-like (LOC100384978) antibody
  • alpha-crystallin A chain-like (LOC100460863) antibody
  • crystallin, alpha A (Cryaa) antibody
  • Acry-1 antibody
  • AI323437 antibody
  • alpha-a-crystallin antibody
  • Crya-1 antibody
  • Crya1 antibody
  • CRYAA antibody
  • cryaa-A antibody
  • CTRCT9 antibody
  • DAcry-1 antibody
  • HSPB4 antibody
  • lop18 antibody
  • wu:fc06h04 antibody
  • zgc:92036 antibody

Protein level used designations for CRYAA

crystallin, alpha A , alphaA-crystallin , [a]A-crystallin , alpha-crystallin A chain , hspb4 , alpha-A-crystallin protein , alpha-crystallin A chain-like , crystallin, alpha-1 , heat shock protein beta-4 , human alphaA-crystallin (CRYA1) , Crystallin, alpha polypeptide A , crystallin, alpha 1 , lens opacity 18 , alpha-A-crystallin , alpha A crystallin , Alpha-crystallin A chain

378668 Xenopus laevis
458589 Pan troglodytes
791110 Ornithorhynchus anatinus
6037267 Culex quinquefasciatus
100000769 Danio rerio
100049490 Oryzias latipes
100384978 Callithrix jacchus
100460863 Pongo abelii
1409 Homo sapiens
24273 Rattus norvegicus
281718 Bos taurus
12954 Mus musculus
101083874 Felis catus
418546 Gallus gallus
487786 Canis lupus familiaris
100135506 Cavia porcellus
100051134 Equus caballus
100009294 Oryctolagus cuniculus
497275 Ovis aries
722370 Macaca mulatta
101520527 Ochotona princeps
101828899 Mesocricetus auratus
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