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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. Additionally we are shipping DDX41 Kits (19) and DDX41 Proteins (5) and many more products for this protein.
Showing 10 out of 67 products:
Human Monoclonal DDX41 Primary Antibody for IF, WB - ABIN394166
Sowa, Bennett, Gygi, Harper: Defining the human deubiquitinating enzyme interaction landscape. in Cell 2009
Show all 5 references for ABIN394166
Human Polyclonal DDX41 Primary Antibody for WB - ABIN1881255
Wu, Ma, Brown, Geisler, Li, Tzeng, Jia, Jurisica, Li: Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. in Proteomics 2007
Show all 3 references for ABIN1881255
Cow (Bovine) Polyclonal DDX41 Primary Antibody for WB - ABIN2775231
Irion, Leptin: Developmental and cell biological functions of the Drosophila DEAD-box protein abstrakt. in Current biology : CB 2000
Cow (Bovine) Polyclonal DDX41 Primary Antibody for WB - ABIN2775230
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in 2007
This study expands both the mutation and phenotypic spectra observed in families with germ line DDX41 mutations.
corresponding deletions on 5q35.3 present in 6% of cases led to haploinsufficient DDX41 expression. DDX41 lesions caused altered pre-mRNA splicing and RNA processing
results suggest a mechanism whereby c-di-GMP (show NT5C2 Antibodies) and c-di-AMP (show APRT Antibodies) are detected by DDX41, which forms a complex with STING to signal to TBK1 (show TBK1 Antibodies)-IRF3 (show IRF3 Antibodies) and activate the interferon (show IFNA Antibodies) response
DDX41 is an additional DNA sensor that depends on STING to sense pathogenic DNA.
The N-terminal domain of Abs interacts with the phox homology (PX) domain of SNX2 (show SNX2 Antibodies) suggesting that PX domains may also participate in protein-protein interaction.
Tyr364 and Tyr414 of DDX41 are critical for its recognition of AT-rich DNA and binding to STING, and tandem mass spectrometry identifies Tyr414 as the BTK (show BTK Antibodies) phosphorylation site.
TRIM21 (show TRIM21 Antibodies) is an interferon (show IFNA Antibodies)-inducible E3 ligase that induces the Lys48-linked ubiquitination and degradation of DDX41 and negatively regulates the innate immune response to intracellular double-stranded DNA.
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression.
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
, DEAD-box protein abstrakt
, probable ATP-dependent RNA helicase DDX41-like
, DEAD box protein 41
, DEAD box protein abstrakt homolog
, probable ATP-dependent RNA helicase DDX41
, putative RNA helicase