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DLG3 encodes a member of the membrane-associated guanylate kinase protein family. Additionally we are shipping DLG3 Proteins (6) and DLG3 Kits (3) and many more products for this protein.
Showing 10 out of 85 products:
Human Monoclonal DLG3 Primary Antibody for IP, IHC - ABIN361791
Cuthbert, Stanford, Coba, Ainge, Fink, Opazo, Delgado, Komiyama, ODell, Grant: Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Show all 3 references for ABIN361791
Human Monoclonal DLG3 Primary Antibody for IP, IHC - ABIN2482575
Müller, Kistner, Kindler, Chung, Kuhlendahl, Fenster, Lau, Veh, Huganir, Gundelfinger, Garner: SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. in Neuron 1996
Cow (Bovine) Polyclonal DLG3 Primary Antibody for WB - ABIN2781529
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Insertion of a guanine into the DLG3 5' UTR (show UTS2R Antibodies), 7 bp upstream of the start codon, down regulated DLG3 protein levels. This non-coding variant segregates with X-linked intellectual disability in a large family.
Trans-homophilic interaction of CADM1 (show CADM1 Antibodies) activates PI3K (show PIK3CA Antibodies) by forming a complex with MAGuK-family proteins MPP3 (show MPP3 Antibodies) and Dlg (show DLG4 Antibodies).
miR (show MLXIP Antibodies)-1246 might play a role in neurological pathogenesis of human enterovirus 71 by regulating DLG3 gene in infected cells.
These data shed new light on the role of SAP102 in the regulation of NMDAR (show GRIN1 Antibodies) trafficking.
This study identified DLG3 significantly associated loci with a biologically plausible role in schizophrenia.
The data of this study suggested that DLG3 is down-regulated in this cancer type.
The PDZ (show INADL Antibodies)-independent interaction between SAP102 and GluN2B (show GRIN2B Antibodies) mediates the synaptic clearance of GluN2B (show GRIN2B Antibodies)-containing NMDARs.(SAP102 protein)
Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin (show NBEA Antibodies).
DLG3 was identified by genome-wide gene expression analyses as correlated with cellular sensitivity to cisplatin and carboplatin. DLG3 was also found to correlate with cellular sensitivity to platinating agents in NCI-60 cancer cell lines.
DLG3 did not associate with non-syndromic mental retardation in Chinese Han population; however, further studies are needed.
our current study identified a functional interplay between PSD-95 (show DLG4 Antibodies) and synapse-associated protein 102 (SAP102) to regulate synaptic AMPA (show GRIA3 Antibodies) receptors
SAP102 has a fundamental role in trafficking the NMDA receptor complex to the synaptic sites.
The Dlg3 have functions in complex cognitive processes.
Dlg3 exerts a distinct function by recruiting the ubiquitin ligases Nedd4 and Nedd4-2 (show NEDD4L Antibodies) through its PPxY motifs. These interactions are required for Dlg3 monoubiquitination, apical membrane recruitment, and tight junction consolidation.
Membrane-associated guanylate kinase (show GUK1 Antibodies) homolog SAP102 is a central organizers of the postsynaptic density at excitatory synapses on pyramidal neurons.
SAP102 interacts with the PDZ (show INADL Antibodies)-binding domain of Sec8 (show EXOC4 Antibodies), a member of the exocyst complex. nteractions between the two proteins are involved in the delivery of N-methyl-D-aspartate receptors to the cell surface in heterologous cells and neurons.
SAP102 was required for normal spatial learning. Loss of SAP102 results in changes in spatial strategy usage. Altered long term potentiation and spike-timing-dependent plasticity in SAP102 mutants. Couples NMDA receptors to MAPK/ERK (show MAPK1 Antibodies) pathway.
Results describe E-dlg (show DLG4 Antibodies), a mouse homologue of the Drosophila discs large (show DLG4 Antibodies) tumor suppressor (show LATS1 Antibodies) (Dlg (show DLG4 Antibodies), also known as SAP97 (show DLG1 Antibodies)), that binds preferentially to SAP102.
SAP102 and PSD-95 (show DLG4 Antibodies) regulate the synaptic trafficking of distinct glutamate (show GRIN1 Antibodies) receptor subtypes at different developmental stages, thereby playing necessary roles in excitatory synapse development.
This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described.
PSD-95/SAP90-related protein 1
, discs large homolog 3
, disks large homolog 3
, synapse-associated protein 102
, discs, large homolog 3 (neuroendocrine-dlg, Drosophila)
, membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)