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anti-Discs, Large Homolog 4 (Drosophila) (DLG4) Antibodies

The product of DLG4 is one of the membrane-associated guanylate kinases localized at postsynaptic density in neuronal cells. Additionally we are shipping Discs, Large Homolog 4 (Drosophila) Kits (11) and Discs, Large Homolog 4 (Drosophila) Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DLG4 13385 Q62108
DLG4 29495 P31016
DLG4 1742 P78352
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Top anti-Discs, Large Homolog 4 (Drosophila) Antibodies at

Showing 10 out of 223 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Goat Un-conjugated WB Staining of Mouse Brain lysate usng DLG4 / PSD95 antibody at 0.3 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
Cow Mouse Un-conjugated ICC, IF, IHC, WB western rat membrane 1 in 1000 PSD 95 copy. 100 μg Log in to see 3 to 4 Days
Cow Rabbit Un-conjugated WB 0.1 mL Log in to see 6 to 8 Days
Mouse Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of PSD-95 on a rat cerebrum lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti- PSD-95 antibody. Immunofluorescence staining of PC12 cells (Rat neuroblastoma, ATCC CRL-1721). 50 μg Log in to see 5 to 6 Days
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded: rat brain tissue labeled with Anti-PSD-95 Polyclonal Antibody (ABIN725930), Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
Mouse Rabbit Un-conjugated WB Detection of PSD-95 in rat hippocampal lysate using ABIN152631. Western Blot: PSD-95 Antibody [ABIN152631] 0.1 mL Log in to see 5 to 7 Days
Human Rabbit Un-conjugated WB WB Suggested Anti-DLG4 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: HT1080 cell lysate WB Suggested Anti-DLG4  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500  Positive Control: HT1080 cell lysate 100 μL Log in to see 2 to 3 Days
Cow Mouse HRP ICC, IF, IHC, WB   100 μg Log in to see 3 to 4 Days
Cow Mouse FITC ICC, IF, IHC, WB   100 μg Log in to see 3 to 4 Days
Cow Mouse Alkaline Phosphatase (AP) ICC, IF, IHC, WB   100 μg Log in to see 3 to 4 Days

DLG4 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Discs, Large Homolog 4 (Drosophila) Antibodies

  1. Cow (Bovine) Monoclonal DLG4 Primary Antibody for ICC, IF - ABIN361694 : Cai, Li, Rivera, Keinänen: Interaction between SAP97 and PSD-95, two Maguk proteins involved in synaptic trafficking of AMPA receptors. in The Journal of biological chemistry 2006 (PubMed)
    Show all 7 references for ABIN361694

  2. Mouse (Murine) Monoclonal DLG4 Primary Antibody for IF, IP - ABIN968002 : Brenman, Chao, Gee, McGee, Craven, Santillano, Wu, Huang, Xia, Peters, Froehner, Bredt: Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. in Cell 1996 (PubMed)
    Show all 5 references for ABIN968002

  3. Human Polyclonal DLG4 Primary Antibody for IF (p), IHC (p) - ABIN725930 : Zhao, Li, Wei, Savage, Zhou, Ma: Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. in Neurobiology of disease 2014 (PubMed)
    Show all 4 references for ABIN725930

  4. Cow (Bovine) Polyclonal DLG4 Primary Antibody for WB - ABIN372707 : Baya, Maresca, Poli, Coppel, Maseras, Lledós, Belkova, Dub, Epstein, Shubina: Dihydrogen to dihydride isomerization mechanism in [(C5Me5)FeH2(Ph2PCH2CH2PPh2)]+ through the experimental and theoretical analysis of kinetic isotope effects. in Inorganic chemistry 2006 (PubMed)
    Show all 3 references for ABIN372707

  5. Cow (Bovine) Monoclonal DLG4 Primary Antibody for ICC, IF - ABIN2484833 : Yao, Gainetdinov, Arbuckle, Sotnikova, Cyr, Beaulieu, Torres, Grant, Caron: Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity. in Neuron 2004 (PubMed)
    Show all 2 references for ABIN2484833

  6. Cow (Bovine) Monoclonal DLG4 Primary Antibody for ICC, IF - ABIN2484813 : Cline: Synaptogenesis: a balancing act between excitation and inhibition. in Current biology : CB 2005 (PubMed)
    Show all 2 references for ABIN2484813

  7. Mouse (Murine) Polyclonal DLG4 Primary Antibody for WB - ABIN152631 : Reissner, Boyle, Ye, Carew: Aplysia synapse associated protein (APSAP): identification, characterization, and selective interactions with Shaker-type potassium channels. in Journal of neurochemistry 2008 (PubMed)

  8. Cow (Bovine) Polyclonal DLG4 Primary Antibody for WB - ABIN499166 : Marks, Fadool: Post-synaptic density perturbs insulin-induced Kv1.3 channel modulation via a clustering mechanism involving the SH3 domain. in Journal of neurochemistry 2007 (PubMed)

More Antibodies against Discs, Large Homolog 4 (Drosophila) Interaction Partners

Fruit Fly (Drosophila melanogaster) Discs, Large Homolog 4 (Drosophila) (DLG4) interaction partners

  1. Banderuola (Bnd) is a novel regulator of asymmetric cell division (ACD (show ACD Antibodies)). The data place Bnd at the top of the hierarchy of the factors involved in ACD (show ACD Antibodies), suggesting that its main function is mediating localization and function of Dlg tumor suppressor.

  2. The inactivation of cellular cortex polarization is the most likely target of dlg inactivation in mitosis.

  3. Loss of scrib (show SCRIB Antibodies), dlg and lgl had no effect on gonad formation, but Dlg and Scrib (show SCRIB Antibodies) in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads.

  4. Gliotactin and Discs large are co-regulated to maintain epithelial integrity.

  5. Hts (show APCDD1 Antibodies) regulates Dlg targeting to the neuromuscular junction in muscle and the lateral membrane of epithelial cells.

  6. Electron microscopy reveals that during metamorphosis the subsynaptic reticulum vacuolizes in the early stages of synapse dismantling, concomitant with diffuse localization of Dlg.

  7. DlgS97-Metro-DLin-7-type complexes control the proper organization of a synaptic junction; findings accentuate the importance of perisynaptic scaffold complexes for synaptic stabilization and organization

  8. Study provide evidence that scrib (show SCRIB Antibodies) and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib (show SCRIB Antibodies) and dlg act in a common pathway to regulate PFC (show CFP Antibodies) fate induction.

  9. integrins act through CaMKII (show CAMK2 Antibodies) activation to control the localization of dlg in the development of NMJ synaptic morphology

  10. conclude that Dlg/Scrib (show SCRIB Antibodies)/Lgl are important in regulating cortical polarity, cell size asymmetry and mitotic spindle asymmetry in Drosophila neuroblasts

Mouse (Murine) Discs, Large Homolog 4 (Drosophila) (DLG4) interaction partners

  1. critical roles of PSD-95 in regulating synaptic kainate receptors.

  2. Phenylketonuric mice given a specific nutrient combination showed a significant reduction in PSD-95 expression in the hippocampus, specifically in the granular cell layer of the dentate gyrus, with a similar trend seen in the cornus ammonis 1 (CA1 (show CA1 Antibodies)) and cornus ammonis 3 (CA3 (show CA3 Antibodies)) pyramidal cell layer.

  3. Lambda-cyhalothrin (LCT (show LCT Antibodies)) could increase the PSD95 protein level via the ERalpha (show ESR1 Antibodies)-dependent Akt (show AKT1 Antibodies) pathway, and LCT (show LCT Antibodies) might disrupt the up-regulation effect of estradiol on PSD95 protein expression via this signaling pathway.

  4. Data indicate a contribution of D2 dopamine receptors to the effects of repetitive transcranial magnetic stimulation (rTMS) on postsynaptic density protein-95 (PSD-95) and cyclin-dependent kinase 5 (CDK5 (show CDK5 Antibodies)) levels.

  5. Data show that in adult PSD-95 knockout mice, ocular dominance plasticity in visual cortex (V1) was preserved after a stroke lesion in somatosensory cortex (S1).

  6. adult mice lacking interleukin-1 receptor 1 (show IL1RL1 Antibodies) (IL-1R1) exhibit increased expression of both the excitatory scaffolding protein postsynaptic density-95 (PSD-95 (show DLGAP2 Antibodies)) and inhibitory scaffolding proteingephyrin, respectively, in the hippocampus.

  7. Data demonstrate a role for SNAP-25 (show SNAP25 Antibodies) in controlling PSD-95 clustering and open the possibility that genetic reductions of the protein levels may contribute to the pathology through an effect on postsynaptic function and plasticity.

  8. Rph3A (show RPH3A Antibodies) interacts with GluN2A (show GRIN2A Antibodies) and PSD-95 forming a complex that regulates NMDARs stabilization at postsynaptic membranes.

  9. Egr-1 (show EGR1 Antibodies) is involved in NMDAR (show GRIN1 Antibodies)-mediated PSD-95 down-regulation and AMPAR endocytosis, a process important in the expression of long term depression

  10. Homer1a (show HOMER1 Antibodies) may be a key neuroprotective endogenous molecule that protects against NMDA-induced neuronal injury by disassembling NR2B (show GRIN2B Antibodies)-PSD95-nNOS (show NOS1 Antibodies) complexes and reducing the membrane distribution of NR2B (show GRIN2B Antibodies).

Human Discs, Large Homolog 4 (Drosophila) (DLG4) interaction partners

  1. The differences in cortical NMDAR (show GRIN1 Antibodies) expression and post-synaptic density protein 95 are present in psychiatric disorders and suicide completion and may contribute to different responses to ketamine.

  2. Mutation C>T at the rs13331 in the PSD95 gene is strikingly associated with an increased risk of autism spectrum disorders.

  3. Data demonstrate a role for SNAP-25 (show SNAP25 Antibodies) in controlling PSD-95 clustering and open the possibility that genetic reductions of the protein levels may contribute to the pathology through an effect on postsynaptic function and plasticity.

  4. Data indicate the very high affinities of the trimeric ligands to postsynaptic density protein 95 (PSD-95) PDZ (show INADL Antibodies) domains.

  5. In this review, we focus on palmitoylation of PSD-95, which is a major postsynaptic scaffolding protein and makes discrete postsynaptic nanodomains in a palmitoylation-dependent manner and discuss a determinant role of local palmitoylation cycles

  6. An association was found between reduced PSD95 in the prefrontal cortex and cognitive impairment in patients with either dementia with Lewy bodies or Parkinson's disease dementia.

  7. Docosahexaenoic acid-containing phosphatidylcholines and PSD-95 decrease after loss of synaptophysin (show SYP Antibodies) and before neuronal loss in patients with Alzheimer's disease.

  8. The postsynaptic membrane protein PSD95 was increased in schizophrenia in CA3 (show CA3 Antibodies) tissue, but not in CA1 (show CA1 Antibodies) tissue.

  9. The crystal structures of the Dlg4 GK domain in complex with two phosphor-Lgl2 (show LLGL2 Antibodies) peptides reveal the molecular mechanism underlying the specific and phosphorylation-dependent Dlg/Lgl complex formation.

  10. PSD-95 mRNA G-rich region folds into alternate G quadruplex conformations that coexist in equilibrium and miR (show MLXIP Antibodies)-125a forms a stable complex with PSD-95 mRNA.

Discs, Large Homolog 4 (Drosophila) (DLG4) Antigen Profile

Protein Summary

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DLG4

  • discs large 1 (dlg1) antibody
  • discs, large homolog 4 (dlg4) antibody
  • lethal giant larvae homolog 1 (Drosophila) (DLG4) antibody
  • discs, large homolog 4 (Drosophila) (DLG4) antibody
  • discs, large (Drosophila) homolog 4 (dlg4) antibody
  • discs, large homolog 4 (Drosophila) (Dlg4) antibody
  • lethal giant larvae homolog 1 (Drosophila) (LLGL1) antibody
  • 11 antibody
  • anon-EST:Posey93 antibody
  • anon-WO03040301.258 antibody
  • anon-WO03040301.260 antibody
  • anon-WO03040301.268 antibody
  • CG1725 antibody
  • CG1730 antibody
  • CPD antibody
  • d. lg.-1 antibody
  • Discs-large antibody
  • dlg antibody
  • dlg-1 antibody
  • dlg-A antibody
  • Dlg1 antibody
  • DLG4 antibody
  • dlgA antibody
  • Dlgh4 antibody
  • dlgS97 antibody
  • Dmel\\CG1725 antibody
  • Drodlg antibody
  • l(1)10Bf antibody
  • l(1)bwn antibody
  • l(1)d.lg-1 antibody
  • l(1)d.lg.-1 antibody
  • l(1)discs large antibody
  • l(1)dlg antibody
  • l(1)dlg-1 antibody
  • l(1)dlg1 antibody
  • l(1)G0276 antibody
  • l(1)G0342 antibody
  • l(1)G0456 antibody
  • l(1)G19 antibody
  • l(1) antibody
  • l(1)L11 antibody
  • l(1)lpr-2 antibody
  • LLGL1 antibody
  • misb antibody
  • PSD-95 antibody
  • psd95 antibody
  • SAP-90 antibody
  • Sap90 antibody
  • SAP90A antibody
  • SAP97 antibody

Protein level used designations for DLG4

CG1725-PA , CG1725-PB , CG1725-PC , CG1725-PD , CG1725-PE , CG1725-PF , CG1725-PG , CG1725-PH , CG1725-PI , CG1725-PJ , CG1725-PK , CG1725-PL , CG1725-PM , CG1725-PN , CG1725-PO , CG1725-PP , CG1725-PQ , CG1725-PR , CG1725-PS , CG1725-PT , CG1725-PU , Disc-large , Discs-large , disc large , discs large , discslarge , disk large , dlg1-PA , dlg1-PB , dlg1-PC , dlg1-PD , dlg1-PE , dlg1-PF , dlg1-PG , dlg1-PH , dlg1-PI , dlg1-PJ , dlg1-PK , dlg1-PL , dlg1-PM , dlg1-PN , dlg1-PO , dlg1-PP , dlg1-PQ , dlg1-PR , dlg1-PS , dlg1-PT , dlg1-PU , lethal(1)benign wing imaginal disc neoplasm , lethal(1)discs large , lethal(1)discs-large , lethal(2)discs large , discs, large homolog 4 , postsynaptic density protein 95 , disks large homolog 4 , PSD-95 , PSD95/SAP90 , PSD-95 alpha 2b , PSD-95 beta , SAP-90 , discs large homolog 4 , synapse-associated protein 90 , synapse-associated protein SAP90 , Tax interaction protein 15 , post-synaptic density protein 95

32083 Drosophila melanogaster
779559 Xenopus (Silurana) tropicalis
468444 Pan troglodytes
489462 Canis lupus familiaris
100137840 Bos taurus
405796 Danio rerio
13385 Mus musculus
29495 Rattus norvegicus
1742 Homo sapiens
100339587 Oryctolagus cuniculus
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