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The protein encoded by DBN1 is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. Additionally we are shipping DBN1 Kits (9) and DBN1 Proteins (3) and many more products for this protein.
Showing 10 out of 86 products:
Cow (Bovine) Monoclonal DBN1 Primary Antibody for ICC, IF - ABIN151450
Kojima, Kato, Shirao, Obata: Nucleotide sequences of two embryonic drebrins, developmentally regulated brain proteins, and developmental change in their mRNAs. in Brain research 1989
Show all 6 references for ABIN151450
Human Monoclonal DBN1 Primary Antibody for FACS - ABIN1449752
Sasaki, Hayashi, Shirao, Ishikawa, Kohama: Inhibition by drebrin of the actin-bundling activity of brain fascin, a protein localized in filopodia of growth cones. in Journal of neurochemistry 1997
Show all 6 references for ABIN1449752
Human Monoclonal DBN1 Primary Antibody for FACS, WB - ABIN1558085
Hayashi, Ishikawa, Kawai-Hirai, Takagi, Taketomi, Shirao: Domain analysis of the actin-binding and actin-remodeling activities of drebrin. in Experimental cell research 2000
Show all 5 references for ABIN1558085
Cow (Bovine) Polyclonal DBN1 Primary Antibody for IHC (fro), IF - ABIN126107
Peitsch, Grund, Kuhn, Schnölzer, Spring, Schmelz, Franke: Drebrin is a widespread actin-associating protein enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells. in European journal of cell biology 2000
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Human Monoclonal DBN1 Primary Antibody for FACS, WB - ABIN1558079
Hayashi, Ishikawa, Ye, He, Takata, Kohama, Shirao: Modulatory role of drebrin on the cytoskeleton within dendritic spines in the rat cerebral cortex. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1996
Show all 4 references for ABIN1558079
Cow (Bovine) Polyclonal DBN1 Primary Antibody for IHC (fro), IF - ABIN126106
Peitsch, Hofmann, Endlich, Prätzel, Kuhn, Spring, Gröne, Kriz, Franke: Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli. in Journal of the American Society of Nephrology : JASN 2003
Show all 3 references for ABIN126106
Cow (Bovine) Monoclonal DBN1 Primary Antibody for IHC (fro), IF - ABIN126022
Peitsch, Hofmann, Bulkescher, Hergt, Spring, Bleyl, Goerdt, Franke: Drebrin, an actin-binding, cell-type characteristic protein: induction and localization in epithelial skin tumors and cultured keratinocytes. in The Journal of investigative dermatology 2005
Show all 2 references for ABIN126022
Exploring the relationship between drebrin and cognitive function may provide insight into the early prevention of cognitive impairment and in the diagnosis and treatment of Alzheimer's disease.
Drebrin is critical for progranulin (show GRN Antibodies)-dependent activation of the Akt (show AKT1 Antibodies) and MAPK (show MAPK1 Antibodies) pathways and modulates motility, invasion and anchorage-independent growth in bladder neoplasms.
The study compared the proteome profiles of the human colon adenocarcinoma cell line HCT-116 with its metastatic derivative E1. DBN1 was found to be overexpressed in E1 as compared to HCT-116 cells.
In basal cell carcinoma tissues, intense and homogeneous drebrin expression was observed mainly at tumor cell-cell boundaries. In contrast, drebrin was stained only weakly and non-homogeneously in trichoblastoma and trichoepthelioma tissue samples.
Rab8a (show RAB8A Antibodies) and Drebrin E act as key proteins in the regulation of apical trafficking in intestinal epithelial cells.
drebrin has a role in HIV infection by modulating viral entry, mainly through the control of actin cytoskeleton polymerization in response to HIV-1
These findings show that drebrin contains a cryptic F-actin-bundling activity regulated by phosphorylation and provide a mechanistic model for microtubule-F-actin coupling.
decreasing the drebrin E levels disrupted the normal subapical F-actin-myosin-IIB (show MYH10 Antibodies)-betaII-spectrin network and the apical accumulation of EB3 (show MAPRE3 Antibodies), a microtubule-plus-end-binding protein
Drebrin contributes to the maintenance of cell shape, and may play an important role in glioma cell motility.
The results of this study showed that Hippocampal drebrin loss in mild cognitive impairment.
Study demonstrated that isoform conversion of drebrin is critical, and that drebrin A is indispensable for adult hippocampal synaptic plasticity and hippocampus-dependent fear learning; the phenotype of drebrin A knockout mice suggests functional differences between drebrin A and drebrin E
These findings provide unprecedented experimental support for a role of drebrin in the regulation of memory-related synaptic plasticity and neurotransmitter receptor (show GRIN1 Antibodies) signaling
Dbn1 regulates systemic anaphylaxis and IgE/Fcgr1-induced degranulation in mast cells by regulating actin reorganization and actin dynamics.
SAHA likely inhibits ADDL (show ADD3 Antibodies)-induced drebrin loss from dendritic spines by stabilizing drebrin in these structures, rather than by increasing drebrin clusters or dendritic protrusions
These results suggest that Cdk5 (show CDK5 Antibodies)-p35 (show CDK5R1 Antibodies) regulates neuronal migration through phosphorylation of drebrin in growth cone processes.
Double knockout Psen1Psen2 leads to a decrease in immunoreactivity for drebrin A at both synaptic and nonsynaptic areas of CA1 (show CA1 Antibodies) hippocampus.
The density of drebrin-positive glutamatergic synapses formed on GABAergic neurons is lower than those on glutamatergic neurons.
These results suggest that the actin-binding domain of drebrin is centered on actin subdomain 2 and may adopt a folded conformation upon binding to F-actin.
Drebrin A plays an indispensable role in some processes of generating fear learning and memory.
Drebrin is involved in regulation of actin dynamics also outside the nervous system. Drebrin is one of the actin-binding proteins regulating the actomyosin system and the dynamics of mesangial cells and foot processes in podocytes.
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene.
, developmentally-regulated brain protein
, drebrin E
, drebrin E2
, drebrin A
, developmentally regulated brain protein