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The protein encoded by EDA is a type II membrane protein that can be cleaved by furin to produce a secreted form. Additionally we are shipping Ectodysplasin A Proteins (14) and Ectodysplasin A Kits (7) and many more products for this protein.
Showing 10 out of 103 products:
Chicken Polyclonal Ectodysplasin A Primary Antibody for WB - ABIN2773846
Zhao, Watt, Battle, Li, Bondow, Duncan: Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. in Developmental biology 2008
Show all 2 references for ABIN2773846
Human Polyclonal Ectodysplasin A Primary Antibody for EIA, IHC (p) - ABIN358789
Tariq, Wasif, Ayub, Ahmad: A novel 4-bp insertion mutation in EDA1 gene in a Pakistani family with X-linked hypohidrotic ectodermal dysplasia. in European journal of dermatology : EJD 2007
Show all 2 references for ABIN358789
Human Polyclonal Ectodysplasin A Primary Antibody for IHC, ELISA - ABIN1584385
Li, Yao, Sheng, Yang, Ma: Dual-modal tracking of transplanted mesenchymal stem cells after myocardial infarction. in International journal of nanomedicine 2011
Show all 2 references for ABIN1584385
Chicken Polyclonal Ectodysplasin A Primary Antibody for WB - ABIN2781905
Zhao, Hua, Zhao, Meng, Ao, Liu, Shang, Sun, Lo, Zhang: Three novel mutations of the EDA gene in Chinese patients with X-linked hypohidrotic ectodermal dysplasia. in The British journal of dermatology 2008
Show all 2 references for ABIN2781905
Human Polyclonal Ectodysplasin A Primary Antibody for IF (p), IHC (p) - ABIN738381
Oya, Yokoyama, Kokuryo, Uno, Yamauchi, Nagino: Inhibition of Toll-like receptor 4 suppresses liver injury induced by biliary obstruction and subsequent intraportal lipopolysaccharide injection. in American journal of physiology. Gastrointestinal and liver physiology 2014
Using an ex vivo culture system, we show that suppression of canonical Wnt (show WNT2 Antibodies) signalling leads to a dose-dependent inhibition of supernumerary placodes in K14 (show KRT14 Antibodies)-Eda tissue explants.
Eda and activin A (show INHBA Antibodies) are upstream regulators of Foxi3 (show FOXI3 Antibodies) in skin appendage placodes
Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 (show FGF20 Antibodies) signaling.
NF-kappaB (show NFKB1 Antibodies) downstream of the TNF (show TNF Antibodies)-like ligand ectodysplasin (Eda) is identified as a unique regulator of embryonic and prepubertal ductal morphogenesis.
Data found that Eda regulates growth and branching of the SMG (show SNRPG Antibodies) via transcription factor NF-kappaB (show NFKB1 Antibodies) in the epithelium, and that the hedgehog (show SHH Antibodies) pathway is an important mediator of Eda/NF-kappaB (show NFKB1 Antibodies).
Dkk4 (show DKK4 Antibodies) affects an auxiliary pathway for Eda-independent development of secondary hair
Treatment of Eda-/- minor salivary gland explants with EDA A1 rescues minor salivary gland induction.
The ectodysplasin-A gene plays a role in normal bone development in mice.
Eda and Edar (show EDAR Antibodies) expression is confined to the ectoderm and occurs in a pattern that suggests a role of ectodysplasin/Edar (show EDAR Antibodies) signaling in the interactions between the ectodermal compartments and the formation and function of hair placodes.
Gene expression profiling data are consistent with the regulation of the NF-kappa B (show NFKB1 Antibodies) and JNK (show MAPK8 Antibodies) pathways by EDA
EDA-A2 and its receptor XEDAR (show EDA2R Antibodies) are overexpressed in epithelial cells of salivary glands in Sjogren's syndrome patients, in comparison with healthy individuals. The EDA-A2/XEDAR (show EDA2R Antibodies) system in these cells is involved in the induction of apoptosis via CASP3 (show CASP3 Antibodies) activation.
Based on a computerized protein structure analysis, we suggest that the change p.Arg289His in EDA impairs protein stabilization and thus might possibly be involved in the development of oligodontia concomitant with a mild ED phenotype.
we identified a novel and three reported EDA missense mutations in four of six patients with X-linked hypohidrotic ectodermal dysplasia. Missense mutations and the mutations affecting the tumor necrosis factor (show TNF Antibodies) homology domain were correlated with fewer missing teeth.
Our findings indicate that a novel mutation (c.878T>G) of EDA is associated with XLHED and adds to the repertoire of EDA mutations.
We found a novel missense mutation in exon 1 of the EDA1 gene in a putative Mayan family from Mexico with XL-HED.
A novel missense mutation in the EDA gene in a Chinese family with X-linked hypohidrotic ectodermal dysplasia.
dentified a novel deletion mutation located in exon 1 which if expressed would produce a highly truncated protein in a Chinese Han family with X-linked hypohidrotic ectodermal dysplasia
novel non-synonymous mutation in ectodysplasin A (EDA) associated with non-syndromic X-linked dominant congenital tooth agenesis
novel one-nucleotide deletion mutation (c.855delG) of EDA in exon 8 which caused premature termination of the polypeptide at amino acid 307 was confirmed
WNT10A (show WNT10A Antibodies) and EDA digenic mutations could result in oligodontia and syndromic tooth agenesis in the Chinese population. Moreover, our results will greatly expand the genotypic spectrum of tooth agenesis.
Authors identifya mutation, never described before, that changes the regulation of alternative splicing in the EDA gene and causes ectodermal dysplasia in cattle.
The 161-bp-long LINE1-derived-pseudoexon introduces a shift in reading frame and a premature stop codon early in EDA exon 2 and is probably the cause of XHED in this Danish Red Holstein family.
describe a novel mutation of the EDA gene in which a 19 bp deletion in exon 1 in male Holstein calves demonstrated the phenotypic features of EDA
Eda and edar (show EDAR Antibodies) are not required for early development but are specific for the development of adult skeletal and dental structures.
The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.
, embryonic development factor 1
, protein CWC15 homolog
, spliceosome-associated protein CWC15 homolog
, X-linked anhidroitic ectodermal dysplasia protein
, oligodontia 1
, ectodysplasin A1
, ectodermal dysplasia 1, anhidrotic
, ectodermal dysplasia protein
, EDA protein homolog