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EPAS1 encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. Additionally we are shipping EPAS1 Kits (13) and EPAS1 Proteins (10) and many more products for this protein.
Showing 10 out of 176 products:
Human EPAS1 Primary Antibody for IHC (fro), IHC (p) - ABIN1742588
Wiesener, Turley, Allen, Willam, Eckardt, Talks, Wood, Gatter, Harris, Pugh, Ratcliffe, Maxwell: Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. in Blood 1998
Show all 4 references for ABIN1742588
Human Monoclonal EPAS1 Primary Antibody for ICC, IF - ABIN863099
Kim, Perera, Zhou, Carretero, Yeh, Heathcote, Jackson, Nikolinakos, Ospina, Naumov, Brandstetter, Weigman, Zaghlul, Hayes, Padera, Heymach, Kung, Sharpless, Kaelin, Wong: HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. in The Journal of clinical investigation 2009
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Human Polyclonal EPAS1 Primary Antibody for FACS, WB - ABIN654664
Bougatef, Menashi, Khayati, Naïmi, Porcher, Podgorniak, Millot, Janin, Calvo, Lebbé, Mourah: EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2. in PLoS ONE 2010
Show all 2 references for ABIN654664
Human Polyclonal EPAS1 Primary Antibody for WB - ABIN658111
Mowat, Luhmann, Smith, Lange, Duran, Harten, Shukla, Maxwell, Ali, Bainbridge: HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia. in PLoS ONE 2010
Show all 2 references for ABIN658111
Human Polyclonal EPAS1 Primary Antibody for EIA, FACS - ABIN952733
Yi, Liang, Huerta-Sanchez, Jin, Cuo, Pool, Xu, Jiang, Vinckenbosch, Korneliussen, Zheng, Liu, He, Li, Luo, Nie, Wu, Zhao, Cao, Zou, Shan, Li, Yang, Asan, Ni, Tian, Xu, Liu, Jiang, Wu, Zhou, Tang, Qin, Wang, Feng, Li, Huasang, Luosang, Wang, Chen, Wang, Zh: Sequencing of 50 human exomes reveals adaptation to high altitude. in Science (New York, N.Y.) 2010
Show all 2 references for ABIN952733
Chicken Polyclonal EPAS1 Primary Antibody for WB - ABIN2779523
Koizume, Yokota, Miyagi, Hirahara, Tsuchiya, Miyagi: Heterogeneity in binding and gene-expression regulation by HIF-2alpha. in Biochemical and biophysical research communications 2008
First trimester extravillous cytotrophoblasts in placentas from pregnancy terminations exhibit nuclear localisation of both HIF-1a and HIF-2a.
CCL5 (show CCL5 Antibodies) signals from infiltrating bone marrow mesenchymal stem cells to HIF2alpha signals within prostate cancer (PCa (show FLVCR1 Antibodies)) cells might play a key role to increase PCa (show FLVCR1 Antibodies) stem cell population and PCa (show FLVCR1 Antibodies) metastasis via altering the androgen receptor (show AR Antibodies) signals
Data indicate that both hypoxia inducible factor 1 alpha subunit (HIF-1alpha (show HIF1A Antibodies)) and hypoxia-inducible factor 2 alpha (HIF-2alpha) play a role in the metastatic cascade in these two cell lines.
results are consistent with distant shared ancestry for African and Asian EPAS1 haplotypes and Denisovan adaptive introgression
Demonstrate that mTORC1 inhibition leads to AKT (show AKT1 Antibodies) activation and an increase in HIF2A expression, leading to chondrogenic differentiation of amniotic fluid stem cells.
Most human soft tissue sarcomas have lower levels of EPAS1 expression relative to normal tissue.
these data reveal a novel mechanism for the regulation of the expression of HIF2a, demonstrating that the HIF2a promoter is regulated by E2F1 (show E2F1 Antibodies) directly and that Cezanne (show OTUD7B Antibodies) regulates HIF2a expression through control of E2F1 (show E2F1 Antibodies) levels
HIF2alpha-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma (show MOK Antibodies)
although Hif-1alpha (show HIF1A Antibodies) and Hif-2alpha synergize to suppress the development of acute myeloid leukemia (show BCL11A Antibodies), they are not required for leukemic stem cells maintenance.
the genetic polymorphism of the EPAS1 gene may lead to variation of its gene expression levels to drive progression of the cancer and serve as a prognostic marker for NSCLC.
This review emphasizes that sympathetic nervous system homeostasis is dependent on a balance between HIF-2alpha and HIF-1alpha (show HIF1A Antibodies).
genetic analysis suggests that tubulointerstitial cellular crosstalk modulates renal EPO (show EPO Antibodies) production under conditions of epithelial HIF activation in the kidney.
Chondrocytes co-cultured with HIF-2alpha-overexpressing fibroblast-like synoviocytes exhibited upregulation of Mmp3 (show MMP3 Antibodies) and Mmp13 (show MMP13 Antibodies), which is similar to the effects induced by interleukin (IL)-6 (show IL6 Antibodies) treatment of chondrocytes.
HIF-2alpha inhibits high-grade soft tissue sarcoma cell growth. Loss of HIF-2alpha promotes sarcoma proliferation and increases calcium and mTORC1 signalling in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.
HIF-2alpha-deficient mice displayed brown adipose tissue dysregulation, associated with reduced levels of uncoupling protein 1 (UCP1 (show UCP1 Antibodies)) and a dysfunctional thermogenic response to cold exposure.
Loss of Hif-2alpha Rescues the Hif-1alpha (show HIF1A Antibodies) Deletion Phenotype of Neonatal Respiratory Distress In Mice
Letter: HIF2alpha is expressed in a distinct spatial and temporal pattern throughout venous thrombus resolution.
Results show that HIF2-a is up regulated in an in vitro model of nicotine plus lipopolysccharide-stimulated periodontal ligament cell line and primary culture. Its inhibition exhibits anti-inflammatory activity.
High expression of HIF-2A is associated with leukemia and lymphoma.
immunostaining for HIF-1alpha (show HIF1A Antibodies) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification
There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
endothelial PAS domain protein 1
, endothelial PAS domain-containing protein 1-like
, HIF-1-alpha-like factor
, HIF-1alpha-like factor
, PAS domain-containing protein 2
, basic-helix-loop-helix-PAS protein MOP2
, class E basic helix-loop-helix protein 73
, endothelial PAS domain-containing protein 1
, hypoxia-inducible factor 2 alpha
, hypoxia-inducible factor 2-alpha
, member of PAS protein 2
, HIF-related factor
, HIF1 alpha-like factor
, HIF1alpha-like factor
, HLF (HIF1alpha-like factor)
, Hif like protein
, hypoxia inducible transcription factor 2alpha
, HIF-2 alpha
, HIF2 alpha
, hypoxia inducible factor 2, alpha subunit
, hypoxia inducible factor 2a