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EPAS1 encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. Additionally we are shipping EPAS1 Kits (13) and EPAS1 Proteins (10) and many more products for this protein.
Showing 10 out of 213 products:
Fish Polyclonal EPAS1 Primary Antibody for ChIP, ELISA - ABIN151051
Conrad, Freeman, Beitner-Johnson, Millhorn: EPAS1 trans-activation during hypoxia requires p42/p44 MAPK. in The Journal of biological chemistry 1999
Show all 433 references for ABIN151051
Hamster Monoclonal EPAS1 Primary Antibody for ChIP, ELISA - ABIN151063
Bernhardt, Wiesener, Weidemann, Schmitt, Weichert, Lechler, Campean, Ong, Willam, Gretz, Eckardt: Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. in The American journal of pathology 2007
Show all 134 references for ABIN151063
Hamster Monoclonal EPAS1 Primary Antibody for IHC (p), IHC - ABIN250056
Harvey, Kind, Pantaleon, Armstrong, Thompson: Oxygen-regulated gene expression in bovine blastocysts. in Biology of reproduction 2004
Show all 17 references for ABIN250056
Fish Polyclonal EPAS1 Primary Antibody for IHC (p), IHC - ABIN249868
Alvarez-Tejado, Naranjo-Suarez, Jiménez, Carrera, Landázuri, del Peso: Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. in The Journal of biological chemistry 2001
Show all 17 references for ABIN249868
Hamster Monoclonal EPAS1 Primary Antibody for IHC (p), IHC - ABIN250055
Mekhail, Gunaratnam, Bonicalzi, Lee: HIF activation by pH-dependent nucleolar sequestration of VHL. in Nature cell biology 2004
Show all 15 references for ABIN250055
Human Monoclonal EPAS1 Primary Antibody for ICC, IF - ABIN863099
Kim, Perera, Zhou, Carretero, Yeh, Heathcote, Jackson, Nikolinakos, Ospina, Naumov, Brandstetter, Weigman, Zaghlul, Hayes, Padera, Heymach, Kung, Sharpless, Kaelin, Wong: HIF2alpha cooperates with RAS to promote lung tumorigenesis in mice. in The Journal of clinical investigation 2009
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Human Polyclonal EPAS1 Primary Antibody for EIA, FACS - ABIN952733
Yi, Liang, Huerta-Sanchez, Jin, Cuo, Pool, Xu, Jiang, Vinckenbosch, Korneliussen, Zheng, Liu, He, Li, Luo, Nie, Wu, Zhao, Cao, Zou, Shan, Li, Yang, Asan, Ni, Tian, Xu, Liu, Jiang, Wu, Zhou, Tang, Qin, Wang, Feng, Li, Huasang, Luosang, Wang, Chen, Wang, Zh: Sequencing of 50 human exomes reveals adaptation to high altitude. in Science (New York, N.Y.) 2010
Show all 2 references for ABIN952733
Human Polyclonal EPAS1 Primary Antibody for FACS, WB - ABIN654664
Bougatef, Menashi, Khayati, Naïmi, Porcher, Podgorniak, Millot, Janin, Calvo, Lebbé, Mourah: EMMPRIN promotes melanoma cells malignant properties through a HIF-2alpha mediated up-regulation of VEGF-receptor-2. in PLoS ONE 2010
Show all 2 references for ABIN654664
Human Polyclonal EPAS1 Primary Antibody for WB - ABIN658111
Mowat, Luhmann, Smith, Lange, Duran, Harten, Shukla, Maxwell, Ali, Bainbridge: HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia. in PLoS ONE 2010
Show all 2 references for ABIN658111
Chicken Polyclonal EPAS1 Primary Antibody for WB - ABIN2779523
Koizume, Yokota, Miyagi, Hirahara, Tsuchiya, Miyagi: Heterogeneity in binding and gene-expression regulation by HIF-2alpha. in Biochemical and biophysical research communications 2008
HBV induces the HIF2alpha expression through its encoded protein HBx. This upregulates the HIF-2alpha expression by binding to the pVHL (show VHL Antibodies) activating the NF-kappaB (show NFKB1 Antibodies) signaling pathway
Findings indicated that HIF-2alpha promotes epithelial-mesenchymal transition in pancreatic cancer by regulating Twist2 (show TWIST2 Antibodies) binding to the promoter of E-cadherin (show CDH1 Antibodies).
High HIF-2alpha expression is associated with papillary thyroid carcinoma.
HIF-2alpha is highly expressed in lung cancer stem cells, which may lead to radioresistance. In conclusion, HIF-2alpha is a potential prognostic marker for lung cancer
We observed higher HIF1a (show HIF1A Antibodies) and HIF2a expression in BA than in IHC.
Only the HIF2A haplotype was shared by individuals who exhibit the high altitude pulmonary edema phenotype
HIF-dependent regulation of ITGA6 (show ITGA6 Antibodies) is one mechanism by which sorting for CD49f (show ITGA6 Antibodies) (+) cells enhances cancer stem cells.
First trimester extravillous cytotrophoblasts in placentas from pregnancy terminations exhibit nuclear localisation of both HIF-1a and HIF-2a.
CCL5 (show CCL5 Antibodies) signals from infiltrating bone marrow mesenchymal stem cells to HIF2alpha signals within prostate cancer (PCa (show FLVCR1 Antibodies)) cells might play a key role to increase PCa (show FLVCR1 Antibodies) stem cell population and PCa (show FLVCR1 Antibodies) metastasis via altering the androgen receptor (show AR Antibodies) signals
Data indicate that both hypoxia inducible factor 1 alpha subunit (HIF-1alpha (show HIF1A Antibodies)) and hypoxia-inducible factor 2 alpha (HIF-2alpha) play a role in the metastatic cascade in these two cell lines.
demonstrate that HIF-2alpha is clearly implicated in the TSP1 (show GZMA Antibodies) pulmonary regulation and provide new insights on its contribution to pulmonary arterial hypertension-driven vascular remodelling and vasoconstriction
Findings identify a reciprocal activation mechanism involving HIF-2alpha and the zinc-ZIP8 (show SLC39A8 Antibodies)-MTF1 (show MTF1 Antibodies) axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction.
This review emphasizes that sympathetic nervous system homeostasis is dependent on a balance between HIF-2alpha and HIF-1alpha (show HIF1A Antibodies).
genetic analysis suggests that tubulointerstitial cellular crosstalk modulates renal EPO (show EPO Antibodies) production under conditions of epithelial HIF activation in the kidney.
Chondrocytes co-cultured with HIF-2alpha-overexpressing fibroblast-like synoviocytes exhibited upregulation of Mmp3 (show MMP3 Antibodies) and Mmp13 (show MMP13 Antibodies), which is similar to the effects induced by interleukin (IL)-6 (show IL6 Antibodies) treatment of chondrocytes.
HIF-2alpha inhibits high-grade soft tissue sarcoma cell growth. Loss of HIF-2alpha promotes sarcoma proliferation and increases calcium and mTORC1 signalling in undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.
HIF-2alpha-deficient mice displayed brown adipose tissue dysregulation, associated with reduced levels of uncoupling protein 1 (UCP1 (show UCP1 Antibodies)) and a dysfunctional thermogenic response to cold exposure.
Loss of Hif-2alpha Rescues the Hif-1alpha (show HIF1A Antibodies) Deletion Phenotype of Neonatal Respiratory Distress In Mice
although Hif-1alpha (show HIF1A Antibodies) and Hif-2alpha synergize to suppress the development of acute myeloid leukemia (show BCL11A Antibodies), they are not required for leukemic stem cells maintenance.
Letter: HIF2alpha is expressed in a distinct spatial and temporal pattern throughout venous thrombus resolution.
immunostaining for HIF-1alpha (show HIF1A Antibodies) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification
There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.
This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
endothelial PAS domain protein 1
, endothelial PAS domain-containing protein 1-like
, HIF-1-alpha-like factor
, HIF-1alpha-like factor
, PAS domain-containing protein 2
, basic-helix-loop-helix-PAS protein MOP2
, class E basic helix-loop-helix protein 73
, endothelial PAS domain-containing protein 1
, hypoxia-inducible factor 2 alpha
, hypoxia-inducible factor 2-alpha
, member of PAS protein 2
, HIF-related factor
, HIF1 alpha-like factor
, HIF1alpha-like factor
, HLF (HIF1alpha-like factor)
, Hif like protein
, hypoxia inducible transcription factor 2alpha
, HIF-2 alpha
, HIF2 alpha
, hypoxia inducible factor 2, alpha subunit
, hypoxia inducible factor 2a