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The product of GAPDH catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). Additionally we are shipping GAPDH Proteins (74) and GAPDH Kits (43) and many more products for this protein.
Showing 10 out of 803 products:
Broad Bean (Vicia faba) Polyclonal GAPDH Primary Antibody for EIA, IF - ABIN401403
Sirover: New nuclear functions of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in mammalian cells. in Journal of cellular biochemistry 2005
Show all 7 references for ABIN401403
Dog (Canine) Polyclonal GAPDH Primary Antibody for EIA, IF - ABIN782939
Henson, Roberts, Salimi, Vadlamudi, Hamer, Gilmore, Jarskog, Philpot: Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex. in Cerebral cortex (New York, N.Y. : 1991) 2008
Show all 7 references for ABIN782939
Dog (Canine) Polyclonal GAPDH Primary Antibody for EIA, IHC (fro) - ABIN374640
Chakir, Daya, Aiba, Tunin, Dimaano, Abraham, Jaques-Robinson, Jacques, Lai, Pacak, Zhu, Xiao, Tomaselli, Kass: Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy. in Circulation 2009
Show all 6 references for ABIN374640
Human Polyclonal GAPDH Primary Antibody for FACS, IF - ABIN392354
Azam, Jouvet, Jilani, Vongsamphanh, Yang, Yang, Ramotar: Human glyceraldehyde-3-phosphate dehydrogenase plays a direct role in reactivating oxidized forms of the DNA repair enzyme APE1. in The Journal of biological chemistry 2008
Show all 3 references for ABIN392354
Human Polyclonal GAPDH Primary Antibody for EIA, FACS - ABIN360237
Lu, Suzuki, Lu, Suzuki: Involvement of glyceraldehyde-3-phosphate dehydrogenase in the X-Ray resistance of HeLa cells. in Bioscience, biotechnology, and biochemistry 2008
Show all 3 references for ABIN360237
Human Polyclonal GAPDH Primary Antibody for EIA, IHC (p) - ABIN360236
Zhou, Yi, Stoffer, Bonafe, Gilmore-Hebert, McAlpine, Chambers: The multifunctional protein glyceraldehyde-3-phosphate dehydrogenase is both regulated and controls colony-stimulating factor-1 messenger RNA stability in ovarian cancer. in Molecular cancer research : MCR 2008
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Human Monoclonal GAPDH Primary Antibody for EIA, IF - ABIN492380
Chuang, Hough, Senatorov: Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases. in Annual review of pharmacology and toxicology 2005
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Dog (Canine) Polyclonal GAPDH Primary Antibody for WB - ABIN2778645
Rinne, Clements, Lamme, Duijf, Bolat, Meijer, Scheffer, Rosser, Tan, McGrath, Schalkwijk, Brunner, Zhou, van Bokhoven: A novel translation re-initiation mechanism for the p63 gene revealed by amino-terminal truncating mutations in Rapp-Hodgkin/Hay-Wells-like syndromes. in Human molecular genetics 2008
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GAPDH with CytOx could be the point of interest as it has already been shown that GAPDH protein damage results in a marked decrease in cellular ATP levels
present in, and accounts for, glycolysis and glutamate (show GRIN2A Antibodies) accumulation into synaptic vesicles
GAPDH phosphorylates the long intracellular loop of GABA(A) receptor alpha1 subunit at Ser (show SIGLEC1 Antibodies)-416 & Thr (show TRH Antibodies)-337. The neuronal membrane-attached GAPDH is a dual-purpose enzyme, a glycolytic dehydrogenase, & a receptor-associated kinase.
Results show that expression of GAPD increased during the late fattening stage of of hanwoo steers and it is involved in metabolic pathways such as glycolysis and the TCA cycle.
GAPC levels play important roles in the overall cellular production of reductants, energy, and carbohydrate metabolites and that GAPC levels are directly correlated with seed oil accumulation.
The addition of GSSG, and much more efficiently of S-nitrosoglutathione, was shown to inactivate the enzymes GapC1 and GapC2 from Arabidopsis thaliana, spinach, yeast and rabbit muscle. [GapC2]
transient silencing of GAPDH reduces intracellular ROS (show ROS1 Antibodies) and facilitates increased autophagy, thereby reducing acute hypoxia and reoxygenation injury as well as the resulting apoptosis and necrosis.
This review will summarize our current understanding of GAPDH-mediated regulation of RNA function
analysis of PSCA (show PSCA Antibodies) level in the peripheral blood of PC patients who underwent radical prostatectomy shows it is related to a GADPH reference level (PSCA (show PSCA Antibodies)/GAPDH ratio)
In 60 % of patients with type 2 diabetes, a reversible inhibition of GAPDH is observed.
The results of this study led us to conclude that in cancer cells constantly exposed to conditions of oxidative stress, the protective power of Hsp70 (show HSP70 Antibodies) should be abolished by specific inhibitors of Hsp70 (show HSP70 Antibodies) expression.
GAPDH and protoporphyrinogen oxidase (show PPOX Antibodies) were shown to have higher expression in faster growing cell lines and primary tumors. Pharmacologic inhibition of GAPDH or PPOX (show OX Antibodies) reduced the growth of colon cancer cells in vitro
The levels of GAPDH protein were significantly up-regulated in lung squamous cell carcinoma tissues and elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas.
Genetic variants in GAPDH confer susceptibility to sporadic Parkinson's disease in a Chinese Han population.
Data revealed that GAPDH is a phosphorylation substrate for AMPK (show PRKAA1 Antibodies) and its interaction with Sirt1 (show SIRT1 Antibodies) in the nucleus. The phosphorylation and the nuclear translocation of GAPDH mediate rapid Sirt1 (show SIRT1 Antibodies) activation and autophagy initiation under glucose deprivation.
findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of diabetic retinopathy
The structure-bound sperm-specific enzymes, GAPDH-S and pyruvate kinase(PK-S), appeared only late in spermatogenesis simultaneously with the development of the structures to which they are bound.
The level of GAPDH-AP DNA adduct formation depends on oxidation of the protein SH-groups; disulfide bond reduction in GAPDH leads to the loss of its ability to form the adducts with AP DNA
The strength, selectivity, reversibility, and redox sensitivity of heme binding to GAPDH are consistent with it performing heme sensing or heme chaperone-like functions in cells.
Purified UCH-L1 (show UCHL1 Antibodies) and GAPDH were nitrated in vitro with peroxynitrite and the presence of nitrated proteins was confirmed by anti-3-nitrotyrosine Western blots.Subsequent validation with synthetic peptides was conducted for selected nitropeptides.
dissociation of alpha-crystallin and GAPDH
results strongly suggest that Tyr311 and Tyr317 nitration prohibits NAD(+) binding, leading to the loss of catalytic activity of GAPDH.
In the presence of alpha-crystallin or GroEL (show GroEL Antibodies) the kinetic of GAPDH aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation.
The interactions described herein between the beta subunit (show POLG Antibodies) of PhK (show PHKA2 Antibodies) and GAPDH provide a possible mechanism for the direct linkage of glycogenolysis and glycolysis in skeletal muscle.
FKBP36 (show FKBP6 Antibodies) diminishes GAPDH activity by direct interaction and down-regulation of GAPDH
astrocytic production of D-serine is modulated by glycolytic activity via interactions between GAPDH and SRR (show SRR Antibodies).
Selective inhibition of the glycolytic pathway through GAPDH in chronic lymphocytic leukemia cells with nanoliposomal C6-ceramide could be an effective therapy for leukemia by targeting the Warburg effect.
glyceraldehyde-3-phosphate dehydrogenase plays a critical role in determining the superior functions of female bone marrow-derived mesenchymal stem cells in cell therapy against pulmonary arterial hypertension.
Data indicate that the HNO-nonsteroidal anti-inflammatory drugs (NSAIDs) prodrug inhibited cylcooxgenase-2 and glyceraldehyde 3-phosphate dehydrogenase activity and triggered significant sarcomere shortening on murine ventricular myocytes.
Gapdh is a moonlighting protein that functions as a glycolytic enzyme and a transferrin receptor.
Gapdh is a moonlighting protein that functions as a glycolytic enzyme and additionally is involved in regulating mRNA stability.
Gapdh is a moonlighting protein that functions as a glycolytic enzyme and a nuclear protein nitrosylase.
Overexpression of GAPDH significantly augmented Mst1 (show MST1 Antibodies) mediated apoptosis, whereas knockdown of GAPDH markedly attenuated Mst1 (show MST1 Antibodies) activation and cardiomyocyte apoptosis.
analysis of a GAPDH/PKCdelta (show PKCd Antibodies) signaling switch, which is activated during oxidative stress to regulate the balance between cell survival by mitophagy and cell death due to accumulation of damaged mitochondria
For gene expression analysis in the developing murine neocortex, Gapdh is recommended as a reference gene based on the authors' ranking.
The effect of metal ions on the activity of glyceraldehyde-3-phosphate dehydrogenase.
amino acid sequences were used to establish the 3D structures of the active site of glyceraldehyde-3-phosphate dehydrogenase and the phylogenetic relationships of the sardine and octopus enzymes
The expression level of GAPDH was upregulated to a greater extent than those for myogenin (show MYOG Antibodies) and myostatin 1 under restricted feeding.
The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The enzyme exists as a tetramer of identical chains. Many pseudogenes similar to this locus are present in the human genome. Two transcript variants encoding different isoforms have been found for this gene.
, G3-P dehydrogenase
, glyceraldehyde 3 phosphate dehydrogenase 2
, glyceraldehyde 3-phosphate dehydrogenase
, glyceraldehyde-3-phosphate dehydrogenase
, glyceraldehyde phosphate dehydrogenase
, peptidyl-cysteine S-nitrosylase GAPDH
, glyceraldehyde-3-phosphate dehydrogenase, type I
, glyceraldehyde-3-phosphate dehydrogenase-like
, Glyceraldehyde-3-phosphate dehydrogenase1
, glyceraldehyde 3 phosphate dehydrogenase
, glyceraldehyde 3 phosphate dehydrogenase 1
, glyceraldehyde 3 phosphate dehydrogenase1
, aging-associated gene 9 protein
, 38 kDa BFA-dependent ADP-ribosylation substrate