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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Additionally we are shipping Histone Deacetylase 8 Proteins (21) and Histone Deacetylase 8 Kits (13) and many more products for this protein.
Showing 10 out of 160 products:
Human Polyclonal HDAC8 Primary Antibody for EIA, IHC (p) - ABIN356653
McDonell, Ramser, Francis, Vinet, Rider, Sudbrak, Riesselman, Yaspo, Reinhardt, Monaco, Ross, Kahn, Kearney, Buckle, Chelly: Characterization of a highly complex region in Xq13 and mapping of three isodicentric breakpoints associated with preleukemia. in Genomics 2000
Show all 4 references for ABIN356653
Human Polyclonal HDAC8 Primary Antibody for IHC (p), WB - ABIN387958
Hu, Chen, Fredrickson, Zhu, Kirkpatrick, Zhang, Johanson, Sung, Liu, Winkler: Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor. in The Journal of biological chemistry 2000
Show all 2 references for ABIN387958
Human Polyclonal HDAC8 Primary Antibody for IF, IHC - ABIN871411
Lee, Rezai-Zadeh, Seto: Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A. in Molecular and cellular biology 2003
Cow (Bovine) Polyclonal HDAC8 Primary Antibody for WB - ABIN2775889
Balasubramanian, Ramos, Luo, Sirisawad, Verner, Buggy: A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas. in Leukemia 2008
Human Polyclonal HDAC8 Primary Antibody for IP, IHC - ABIN223303
Mao, Hou, Cao, Wang, Li, Chen, Fei, Hurren, Gronda, Wu, Trudel, Schimmer: The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence. in Molecular pharmacology 2011
study elucidates an HDAC8-mediated p53 (show TP53 Antibodies)-inactivating mechanism promoting leukemia stem cells activity
Studies indicate that histone deacetylase 8 protein (HDAC8) aberrantly deacetylates p53 (show TP53 Antibodies) protein and promotes leukemia stem cells (LSCs) transformation and maintenance.
Our data exhibited an important role of HDAC8 in promoting gastric cancer tumorigenesis and identify this HDAC8 as a potential therapeutic target for the treatment of gastric cancer.
The H143A and H142A/H143A mutants exhibit activity that is >80000-fold lower than that of wild-type HDAC8; the buried D176N and D176A mutants have significant catalytic effects, with more subtle effects caused by D183N and D183A
cAMP signaling increases HDAC8 protein levels by reducing JNK (show MAPK8 Antibodies)-mediated autophagy and ubiquitin-proteasome-dependent degradation of the HDAC8 protein in H1299 lung cancer cells.
Report the preparation and biophysical evaluation of five HDAC8 mutants: P91L, G117E, H180R, D233G, and G304R. Additionally, the double mutants D233G-Y306F and P91L-Y306F were prepared to enable cocrystallization of intact enzyme-substrate complexes.
HDAC8 was increased in BRAF (show BRAF Antibodies)-mutated melanoma. Increased cytoplasmic HDAC8 immunoreactivity was independently associated with an improved survival from both diagnosis of primary melanoma and from first detection of stage IV disease to melanoma death
findings show how HDAC8 drives nonalcoholic fatty liver disease-associated hepatocarcinogenesis
Data reveal a role for miR (show MLXIP Antibodies)-21-3p in regulating HDAC8 expression and Akt (show AKT1 Antibodies)/Gsk3beta (show GSK3b Antibodies) pathway in cardiac hypertrophy.
Studied the kinetics, thermodynamics, and selectivity of Zn(II) and Fe(II) binding to HDAC8.
this study demonstrates a novel role of HDAC8 in LeTx immunotoxicity and regulation of pro-IL-1beta (show IL1B Antibodies) production likely through eRNAs.
histone deacetylase 8 inhibition reduces gene expression and production of proinflammatory cytokines in vitro and in vivo
HDAC8 and Sirt1 (show SIRT1 Antibodies) were also demonstrated to interact directly with ERRalpha (show ESRRA Antibodies) in vivo and to deacetylate and increase the DNA binding affinity of ERRalpha (show ESRRA Antibodies) in vitro.
Global deletion of Hdac8 in mice leads to perinatal lethality due to skull instability, and deletion of Hdac8 in cranial neural crest cells and Hdac8 specifically represses the aberrant expression of homeobox (show PRRX1 Antibodies) transcription factors such as Otx2 (show OTX2 Antibodies) and Lhx1 (show LHX1 Antibodies)
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene.
histone deacetylase 8
, histone deacetylase-like 1