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The membrane protein encoded by HCN1 is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. Additionally we are shipping HCN1 Proteins (6) and many more products for this protein.
Showing 10 out of 99 products:
Human Monoclonal HCN1 Primary Antibody for IP, IHC - ABIN2483964
Zong, Eckert, Yuan, Wahl-Schott, Abicht, Fang, Li, Mistrik, Gerstner, Much, Baumann, Michalakis, Zeng, Chen, Biel: A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase. in The Journal of biological chemistry 2005
Human Polyclonal HCN1 Primary Antibody for IHC (p), WB - ABIN658149
Odefrey, Stone, Gurrin, Byrnes, Apicella, Dite, Cawson, Giles, Treloar, English, Hopper, Southey,: Common genetic variants associated with breast cancer and mammographic density measures that predict disease. in Cancer research 2010
A new mode of regulating HCN1 trafficking: through the use of a di-arginine ER retention signal that monitors processing of the channel in the early secretory pathway.
de novo HCN1 point mutations cause a recognizable early-onset epileptic encephalopathy in humans
acute abrogation of HCN1-FLNa (show FLNA Antibodies) interaction in neurons, with the use of decoy peptides that mimic the FLNa (show FLNA Antibodies)-binding domain of HCN1, abolishes the punctate distribution of HCN1 channels in neuronal cell bodies
Studies suggest that HCN1 channels may be therapeutic targets for treatment of depressive disorders.
Wild-type presynaptic HCN1 channel function is persistently decreased following seizures.
HCN1 channels make an important contribution to the maintenance of spontaneous burst activity in embryonic cortical neuron cultures.
Hyperpolarization-activated currents are smaller and slower, input resistances are higher, and membrane time constants are longer in HCN1-deficient than in HCN1-expressing neurons of the ventral cochlear nucleus.
Genetic analysis in 48 Sudden unexpected death in epilepsy cases identified six novel and three previously reported nonsynonymous (amino acid changing) variants in HCN1 , HCN2 (show HCN2 Antibodies), HCN3 (show HCN3 Antibodies) and HCN4 (show HCN4 Antibodies).
increasing cAMP levels in cells antagonized the up-regulation of HCN1 channels mediated by a TRIP8b (show PEX5L Antibodies) construct binding the CNBD exclusively.
Human HCN1 hyperpolarization activated current (Ih) amplitude is rapidly enhanced after establishment of the whole-cell configuration in HEK293 cells.
in the absence of HCN1-mediated feedback, the amplitude of rod signals remains at high levels for a prolonged period of time, leading to saturation of the retinal pathways.
These results demonstrate that the CB1R (show CNR1 Antibodies)-Ih pathway in the hippocampus is obligatory for the action of cannabinoids on long-term potentiation and spatial memory formation.
Resilience to tinnitus is developed in mice that show a re-emergence of KCNQ2/3 channel activity and a reduction in HCN channel activity.
HCN1, HCN2 (show HCN2 Antibodies), and HCN4 (show HCN3 Antibodies) subunits may have distinct physiological roles in the developing hippocampus.
Forebrain HCN1 channels contribute to hypnotic and amnestic effects of volatile anesthetics, but do not contribute to immobilizing actions.
This study demonstrated that Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.
Results suggest that spike-and-wave discharges in an established model of absence epilepsy reduce hippocampal HCN1 expression and function, and that the reduction associates with a spatial learning deficit
Grid fields in HCN1 KO mice display more experience-dependent asymmetry consistent with reports of enhanced long-term potentiation in the absence of HCN1. The loss of HCN1 improves temporal coding via the rate-phase transformation.
We conclude that TRIP8b (show PEX5L Antibodies) in the retina is needed to achieve maximal expression of HCN1.
HCN1 channels in cerebellar Purkinje cells reduce the duration of inhibitory synaptic responses.
The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes.
hyperpolarization activated cyclic nucleotide-gated potassium channel 1
, brain cyclic nucleotide gated channel 1
, brain cyclic nucleotide-gated channel 1
, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
, hyperpolarization-activated cyclic nucleotide-gated channel 1
, hyperpolarization-activated cation channel 2