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IL24 encodes a member of the IL10 family of cytokines. Additionally we are shipping Interleukin 24 Antibodies (87) and Interleukin 24 Kits (49) and many more products for this protein.
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Human IL24 Protein expressed in Human Cells - ABIN2005154
Sauane, Coso, Giulianelli, Giráldez, Rudland, Jimenez de Asua: Leukaemia inhibitory factor or oncostatin M induction of Swiss 3T3 cells does not require mevalonic acid synthesis nor protein isoprenylation to initiate DNA replication. in Biochemical and biophysical research communications 2004
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Single nucleotide polymorphisms in IL-17F (show IL17F Proteins) A7488G but not IL-17A (show IL17A Proteins) are associated with the development of chronic immune thrombocytopenia in China.
Study represents a comprehensive meta-analysis of the role of IL-17A (show IL17A Proteins) rs2275913 and IL-17F (show IL17F Proteins) rs763780 polymorphisms in cancer risk and demonstrated that these two polymorphisms significantly increase the risk of development of cancer, particularly gastric cancer.
Expression of IL-24 enhanced the sensitivity of B lymphoma cells to chemotherapy agents by altering the expression of multidrug-resistance genes via downregulating GTP (show AK3 Proteins)-RhoA (show RHOA Proteins)-ERK (show EPHB2 Proteins) signaling pathway
Polymorphism of IL-17 (show IL17A Proteins) rs3748067 and rs763780 is closely associated with gastric cancer development. Polymorphism of L-17 rs2275913 and rs4711998 may be correlated with the risk for gastric cancer.
ELISA analysis verified high levels of Th17-associated proinflammatory cytokines such as interleukin-17A (show IL17A Proteins)/F, interleukin-6 (show IL6 Proteins) and interleukin-23 and low levels of inflammatory inhibitory factors including interleukin-10 (show IL10 Proteins) and transforming growth factor-beta in primary immune thrombocytopenia patients compared with normal controls.
IL20R1 (show IL20RA Proteins) correlated with prognosis of patients with pancreatic cancer, and mediates pancreatic cancer cell growth and migration. It may be a potential biomarker for IL24 molecular-targeted therapy.
The GGAGAA combined genotype and the GGA haplotype of IL-17A (show IL17A Proteins) rs2275913, IL-17F (show IL17F Proteins) rs763780 and rs2397084 can be considered risk factors for the development of systemic lupus erythematosus in Egyptian children.
GA genotype of the rs11465553 IL17F (show IL17F Proteins) gene polymorphism may be associated with a significantly higher risk of graft function loss and return to dialysis after kidney transplantation.
No associations were found between rs8193036, rs2275913 and rs3748067 in IL-17A (show IL17A Proteins) and rs763780 in IL-17F (show IL17F Proteins) SNPs and myasthenia gravis in Chinese patients
In vitro, CSE stimulation significantly increased IL-17F and IL-17R in 16HBE (2.5%) and A549 (5%) while IL-17A and IL-17F in PBMC (10%). IL-17A and CSE stimulation, rather than CSE or rhIL-17A alone, increased proliferation in 16HBE and apoptosis in A549
Loss of IL-24 expression is associated with breast cancer.
A psoriasis-like skin inflammation in mice with epidermis-specific inhibition of NF-kappaB (show NFKB1 Proteins) was triggered by TNFR1 (show TNFRSF1A Proteins)-dependent upregulation of interleukin-24 & activation of STAT3 (show STAT3 Proteins) signaling in keratinocytes.
IL-24 suppresses the growth of normal vascular smooth muscle cells by inhibiting hydrogen peroxide-induced reactive oxygen species (ROS (show ROS1 Proteins)) production through the regulation of mitochondrial ROS (show ROS1 Proteins) production and expression of antioxidant enzymes
Secretory mIL-24 did not induce the expression of the IL-6 (show IL6 Proteins), TNF-alpha (show TNF Proteins) or IFN-gamma (show IFNG Proteins) gene in spleen cells
T cell receptor stimulation induces IL-24 expression in T helper type (Th)2 cells by the coordinate action of Stat6 (show STAT6 Proteins) and c-Jun (show JUN Proteins) transcription factors at the transcriptional level.
induction of Il24 by oncogenes may support tumor growth at the early stages of cancer
Grp170 (show HYOU1 Proteins) enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24
the novel splicing variant of IL24, FISP-sp dimerizes with FISP and blocks its secretion and inhibits FISP-induced apoptosis in vivo
Data demonstrated that IL-24 predominately stimulated neutrophils to produce IFN-gamma (show IFNG Proteins) and IL-12 (show IL12A Proteins), subsequently activating CD8 (show CD8A Proteins)+ T cells both in vivo and in vitro.
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
, cytokine ML-1
, mutant IL-17F
, IL-4-induced secreted protein
, melanocyte-associated Mda-7
, melanoma differentiation-associated gene 7 protein
, suppression of tumorigenicity 16 (melanoma differentiation)
, cytokine-like protein Mob-5
, th2-specific cytokine FISP