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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Additionally we are shipping IL27 Antibodies (152) and IL27 Kits (40) and many more products for this protein.
Showing 10 out of 27 products:
Human IL27 Protein expressed in CHO Cells - ABIN2002020
Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. in Immunity 2002
Show all 5 references for ABIN2002020
Mouse (Murine) IL27 Protein expressed in Human Cells - ABIN2008620
Fakruddin, Lempicki, Gorelick, Yang, Adelsberger, Garcia-Pineres, Pinto, Lane, Imamichi: Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27. in Blood 2007
Show all 5 references for ABIN2008620
Human IL27 Protein expressed in Wheat germ - ABIN1307800
Di Meo, Airoldi, Sorrentino, Zorzoli, Esposito, Di Carlo: Interleukin-30 expression in prostate cancer and its draining lymph nodes correlates with advanced grade and stage. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Show all 2 references for ABIN1307800
Data indicate that the CC genotype of interleukin 27 (IL-27) single nucleotide polymorphism rs153109 was significantly more prevalent in pre-eclampsia (PE) cases than controls.
IL-27 is a viable candidate biomarker to identify bacterial infection among ED patients and is comparable with PCT (show UROD Proteins).
The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis
Our results showed that the IL-27 2905T/G genotypes were associated with decreased the susceptibility and development of cervical cancer in Chinese Han population.
the genetic polymorphisms of IL-27 rs153109 and rs181206 may be involved in the progression of human cancers and diseases.
Findings demonstrated that IL-27 and IL-27R (show IL27RA Proteins) were elevated in multiple sclerosis lesions and that local IL-27 can modulate immune properties of astrocytes and infiltrating immune cells
IL-27 attenuates epithelial-mesenchymal transition in alveolar epithelial cells in the absence or presence of TGF-beta1 (show TGFB1 Proteins) through the JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) and TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signalling pathways.
results provided new insights into the effect of IL-27 on the TNF-alpha (show TNF Proteins) mediated activation of human coronary artery endothelial cells in atherosclerotic vascular inflammation
The 153109 of the IL27 (show EBI3 Proteins) gene may be associated with the susceptibility to CHD (show CHDH Proteins), including atrial septal defect and ventricular septal defect.
It is biologically plausible that SNPs in IL-27 may have effect on individual susceptibility to pre-eclampsia.
An IL-27/Lag3 (show LAG3 Proteins) axis enhances Foxp3 (show FOXP3 Proteins)+ regulatory T cell-suppressive function and therapeutic efficacy.
IL-27 is one of the limited unique cytokines directly acting on hematopoietic stem cells (HSCs) to promote differentiation into myeloid progenitors during emergency myelopoiesis.
These results provide the first evidences that Fli-1 (show FLI1 Proteins) positively regulates LPS (show TLR4 Proteins)-induced IL-27 production in macrophages
of autocrine/paracrine mechanisms involving IL-27 in adipocytes under conditions of inflammatory stress that may link obesity with inflammatory diseases.
Increased IL-27 expression in bleomycin-induced pulmonary fibrosis was noted.
IL-27 induces the endothelial differentiation in cardiac resident stem cells through STAT3 (show STAT3 Proteins)/Pim-1 (show PIM1 Proteins) signaling pathway.
demonstrate that suppression mediated by interferon (show IFNA Proteins) and IL-27 is a negative feedback mechanism for group 2 innate lymphoid cells function in vivo
Natural killer cells-dendritic cells interaction elicits a positive feedback loop for IFN-gamma (show IFNG Proteins) and IL-27 production.
demonstrate the essential role of IL-27 signaling in regulating immune responses to extracellular protozoan infections
IL-27 regulates enhanced susceptibility to S. aureus pneumonia following influenza infection, potentially through the induction of IL-10 (show IL10 Proteins) and suppression of IL-17 (show IL17A Proteins).
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
, IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interleukin 27 p28 subunit
, interluekin 27