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anti-Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) Antibodies

The import of proteins into the nucleus is a process that involves at least 2 steps. Additionally we are shipping KPNA2 Proteins (12) and KPNA2 Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KPNA2 16647 P52293
KPNA2 85245  
KPNA2 3838 P52292
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Top anti-KPNA2 Antibodies at antibodies-online.com

Showing 10 out of 108 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KPNA2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Transfected 293T 100 μL Log in to see 2 to 3 Days
$289.00
Details
Mouse Rat Un-conjugated WB 50 μL Log in to see 5 to 6 Days
$455.84
Details
Dog Goat Un-conjugated IF, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB ABIN185157 staining (0.1µg/ml) of Hela lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. ABIN185157 staining (top panel and green) of 4% formaldahyde-fixed HeLa with endogenously expressed HistonH2B-GFP fusion as DNA marker (mid panel and red). Data kindly provided by Francisco Iborra, MRC Mol. Haematol. Unit, Oxford. 100 μg Log in to see 4 to 5 Days
$326.89
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of KPNA2 in rat heart tissue lysate with KPNA2 antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
REACT_Fly Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of Karyopherin alpha. Lysates from HeLa cells (5 µg/lane), S2 cells (7.5 µg/lane), and 0-12 hours Drosophila embryos (7.5 µg/lane) were probed with the mouse anti-karyopherin antibody at concentrations of 1 µg/ml (lane 1), 0.5 µg/ml (lane 2), and 0.25 µg/ml (lane 3). The mouse anti-karyopherin alpha antibody detects a band of 58 kDa in all lysates. Immunofluorescence staining of 0-12 hour embryos. Formalin-fixed embryos kept in ethanol at -20°C, were re-hydrated and incubated with the mouse anti-karyopherin antibody at 1 µg/ml in TBST. After extensive washes to remove unbound antibody, signal was visualized by confocal microscopy with an Alexa Fluor® 488 anti-mouse secondary antibody (1:300 dilution). Ventral view of a cellularizing embryo. Staining is perinuclear. 50 μg Log in to see 5 to 6 Days
$154.07
Details
Dog Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of Karyopherin alpha on a HeLa cell lysate (Human cervical epitheloid carcinoma, ATCC CCL-2.2). Lane 1: 1:2500, lane 2: 1:5000, lane 3: 1:10,000 dilution of the mouse anti-karyopherin antibody. Immunofluorescence staining of WI-38 cells (Human lung fibroblasts, ATCC CCL-75). 50 μg Log in to see 5 to 6 Days
$154.07
Details
Human Goat Un-conjugated ICC, IF, ELISA, WB ABIN250131 staining (top panel and green) of 4% formaldahyde-fixed HeLa with endogenously expressed HistonH2B-GFP fusion as DNA marker (mid panel and red). Data kindly provided by Francisco Iborra, MRC Mol. Haematol. Unit, Oxford. 0.1 mg Log in to see 5 to 7 Days
$408.19
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: Importin alpha 2/KPNA2 Antibody [NBP1-31098] - Analysis of HeLa, using KPNA2 antibody at 1:200 dilution. Immunohistochemistry-Paraffin: Importin alpha 2/KPNA2 Antibody [NBP1-31098] - Paraffin-embedded human lung adenocarcinoma. karyopherin alpha 2 antibody [C3], C-term diluted at 1:250. 0.1 mL Log in to see 6 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), IP, WB Immunohistochemistry-Paraffin: Importin alpha 2/KPNA2 Antibody [ABIN2566797] - FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-RCH1 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB. 100 μL Log in to see 5 to 7 Days
$486.94
Details

KPNA2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-KPNA2 Antibodies

  1. Human Polyclonal KPNA2 Primary Antibody for ICC, IF - ABIN256679 : Sato, Maquat: Remodeling of the pioneer translation initiation complex involves translation and the karyopherin importin beta. in Genes & development 2009 (PubMed)
    Show all 5 references for ABIN256679

  2. Dog (Canine) Monoclonal KPNA2 Primary Antibody for IF, IP - ABIN967998 : Cuomo, Kirch, Gyuris, Brent, Oettinger: Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Show all 4 references for ABIN967998

  3. Fly (Calliphora) Monoclonal KPNA2 Primary Antibody for IF, IP - ABIN968901 : Moroianu, Blobel, Radu: Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes. in Proceedings of the National Academy of Sciences of the United States of America 1995 (PubMed)
    Show all 4 references for ABIN968901

  4. Human Polyclonal KPNA2 Primary Antibody for ICC, IF - ABIN4325749 : Sun, van Koningsbruggen, Long, Straasheijm, Klooster, Jones, Bellini, Levesque, Brieher, van der Maarel, Jones: Facioscapulohumeral muscular dystrophy region gene 1 is a dynamic RNA-associated and actin-bundling protein. in Journal of molecular biology 2011 (PubMed)

  5. Human Polyclonal KPNA2 Primary Antibody for EIA, WB - ABIN783733 : Moroianu: Molecular mechanisms of nuclear protein transport. in Critical reviews in eukaryotic gene expression 1997 (PubMed)

  6. Mouse (Murine) Monoclonal KPNA2 Primary Antibody for WB - ABIN108571 : Fischer, Kremmer, Lautscham, Mueller-Lantzsch, Grässer: Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin alpha2. in The Journal of biological chemistry 1997 (PubMed)

  7. Cow (Bovine) Polyclonal KPNA2 Primary Antibody for WB - ABIN2785824 : Kodiha, Tran, Qian, Morogan, Presley, Brown, Stochaj: Oxidative stress mislocalizes and retains transport factor importin-alpha and nucleoporins Nup153 and Nup88 in nuclei where they generate high molecular mass complexes. in Biochimica et biophysica acta 2008 (PubMed)

More Antibodies against KPNA2 Interaction Partners

Xenopus laevis Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. Nuclear import rates correlated with nuclear size, and varying the concentrations of two transport factors, importin alpha (show KPNA4 Antibodies) and Ntf2 (show NUTF2 Antibodies), was sufficient to account for nuclear scaling between the two species.

Mouse (Murine) Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. Results demonstrated that radiation-induced dying colorectal cancer cells released considerable amounts of KPNA2 that induce the maturation and activation of DCs for synergistic antitumor effect of radiation.

  2. mTORC1 positively regulated the importer protein KPNA2, which participated in glycolysis regulation downstream of mTORC1 in a HIF1alpha (show HIF1A Antibodies)-independent manner, indicating that mTORC1 regulates glycolysis through multiple ways.

  3. provided support for a link between autophagy and epithelial-to-mesenchymal (-like) transition status in WT TP53 (show TP53 Antibodies) glioblastoma cells and provided evidence for the signaling pathway (MIR517C-KPNA2-cytoplasmic TP53 (show TP53 Antibodies)) involved in attenuating autophagy

  4. Structure of importin-alpha (show KPNA4 Antibodies) bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein has been reported.

  5. Specific interaction with the nuclear transporter (show RPAIN Antibodies) importin (show KPNA4 Antibodies) alpha2 can modulate paraspeckle protein 1 (show PSPC1 Antibodies) delivery to nuclear paraspeckles.

  6. constitutive expression of Kpna2 during the differentiation culture of ESCs (show NR2E3 Antibodies) significantly impairs clock development, and KPNA2 facilitates cytoplasmic localization of PER1 (show PER1 Antibodies)/

  7. a significant correlation of KPNA2 expression and tumour aggressiveness in a large variety of other solid tumour entities

  8. study reports a cell-fate determination mechanism in which importin (show KPNA4 Antibodies) alpha2 negatively regulates the nuclear import of certain transcription factors to maintain embryonic stem cell properties

  9. importin alpha (show KPNA4 Antibodies) binds to Nup153 (show NUP153 Antibodies)

  10. results collectively reveal that nuclear-localized importin (show KPNA4 Antibodies) alpha2 influences gene expression and contributes directly to cell fate outcomes including non-apoptotic cell death.

Human Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. p53 (show TP53 Antibodies)/p21Cip1/Waf1 (show CDKN1A Antibodies)/p16INK4a (show CDKN2A Antibodies) may be an important pathway involved in the function of KPNA2 in tongue squamous cell carcinoma (TSCC) CAL (show FBLIM1 Antibodies)-27 cells.

  2. Results demonstrated that radiation-induced dying colorectal cancer cells released considerable amounts of KPNA2 that induce the maturation and activation of DCs for synergistic antitumor effect of radiation.

  3. These results suggest that the selected aptamers (76 and 72) warrant further study to explore not only their application in cancer diagnosis but also their use as a specific reagent to potentially block KPNA2-dependent nuclear transport of macromolecules across the nuclear membrane.

  4. anti-importin (show KPNA4 Antibodies) alpha1 antibody treatment suppressed the importin (show KPNA4 Antibodies) alpha1-FGF1 (show FGF1 Antibodies) complex formation and ERK1/2 (show MAPK1/3 Antibodies) activation, resulting in decreased cell growth. This study provides novel evidence that functional importin (show KPNA4 Antibodies) alpha1 is located at the cell surface, where it accelerates the proliferation of cancer cells.

  5. The combination of low nuclear and cytoplasmic KPNA2 expression is associated with adverse outcome in head and neck squamous cell carcinoma treated with radio(chemo)therapy.

  6. provided support for a link between autophagy and epithelial-to-mesenchymal (-like) transition status in WT TP53 (show TP53 Antibodies) glioblastoma cells and provided evidence for the signaling pathway (MIR517C-KPNA2-cytoplasmic TP53 (show TP53 Antibodies)) involved in attenuating autophagy

  7. Suggest that KPNA2 may play a key role in the inflammation process of rheumatoid arthritis via NF-kappaB (show NFKB1 Antibodies) P65 (show GORASP1 Antibodies) signal transduction pathway.

  8. KPNA2 might play an important role in colorectal carcinogenesis and functions as a novel prognostic indicator and a potential therapeutic target for colorectal cancer.

  9. High KPNA2 expression was found to be associated with poor prognosis and resistance to hyperthermochemoradiation therapy (HCRT (show OX Antibodies)).

  10. RBBP4 (show RBBP4 Antibodies) functions as a novel regulatory factor to increase the efficiency of importin alpha (show KPNA4 Antibodies)/beta-mediated nuclear import

Pig (Porcine) Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. Authors demonstrated that swine importin (show KPNA4 Antibodies) alpha1 interacts with the M1 protein and transports it to the nucleus.

KPNA2 Antigen Profile

Protein Summary

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination

Gene names and symbols associated with KPNA2

  • importin subunit alpha-2 (EDI_246290) antibody
  • importin subunit alpha-2 (EDI_335040) antibody
  • Importin subunit alpha-2 (ima2) antibody
  • importin alpha 1b (kpna2) antibody
  • karyopherin (importin) alpha 2 (Kpna2) antibody
  • karyopherin alpha 2 (Kpna2) antibody
  • karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2) antibody
  • karyopherin alpha 7 (importin alpha 8) (Kpna7) antibody
  • 2410044B12Rik antibody
  • AW146299 antibody
  • Gm1055 antibody
  • ima2 antibody
  • importin antibody
  • IPOA1 antibody
  • PTAC58 antibody
  • QIP2 antibody
  • RCH1 antibody
  • SRP1alpha antibody

Protein level used designations for KPNA2

importin subunit alpha-2 , Importin subunit alpha-2 , karyopherin subunit alpha-2 , RAG cohort protein 1 , SRP1-alpha , importin alpha P1 , importin subunit alpha-1 , m-importin-alpha-P1 , pendulin , pore targeting complex 58 kDa subunit , karyopherin (importin) alpha 2 , nuclear import protein , RAG cohort 1 , importin alpha 1 , importin alpha 2 , importin-alpha-P1 , importin subunit alpha-8 , karyopherin subunit alpha-7 , nuclear transport receptor

GENE ID SPECIES
5881743 Entamoeba dispar SAW760
5886378 Entamoeba dispar SAW760
100195132 Salmo salar
398027 Xenopus laevis
16647 Mus musculus
85245 Rattus norvegicus
3838 Homo sapiens
480469 Canis lupus familiaris
397218 Sus scrofa
513592 Bos taurus
381686 Mus musculus
Selected quality suppliers for anti-KPNA2 (KPNA2) Antibodies
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