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The import of proteins into the nucleus is a process that involves at least 2 steps. Additionally we are shipping KPNA2 Proteins (12) and KPNA2 Kits (7) and many more products for this protein.
Showing 10 out of 104 products:
Fly (Calliphora) Monoclonal KPNA2 Primary Antibody for IF, IP - ABIN968901
Cuomo, Kirch, Gyuris, Brent, Oettinger: Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. in Proceedings of the National Academy of Sciences of the United States of America 1994
Show all 4 references for ABIN968901
Dog (Canine) Monoclonal KPNA2 Primary Antibody for IF, IP - ABIN967998
Grozinger, Schreiber: Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. in Proceedings of the National Academy of Sciences of the United States of America 2000
Show all 4 references for ABIN967998
Cow (Bovine) Polyclonal KPNA2 Primary Antibody for WB - ABIN2785824
Kodiha, Tran, Qian, Morogan, Presley, Brown, Stochaj: Oxidative stress mislocalizes and retains transport factor importin-alpha and nucleoporins Nup153 and Nup88 in nuclei where they generate high molecular mass complexes. in Biochimica et biophysica acta 2008
Human Polyclonal KPNA2 Primary Antibody for EIA, WB - ABIN783733
Moroianu: Molecular mechanisms of nuclear protein transport. in Critical reviews in eukaryotic gene expression 1997
Mouse (Murine) Monoclonal KPNA2 Primary Antibody for WB - ABIN108571
Fischer, Kremmer, Lautscham, Mueller-Lantzsch, Grässer: Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin alpha2. in The Journal of biological chemistry 1997
Nuclear import rates correlated with nuclear size, and varying the concentrations of two transport factors, importin alpha (show KPNA4 Antibodies) and Ntf2 (show NUTF2 Antibodies), was sufficient to account for nuclear scaling between the two species.
mTORC1 positively regulated the importer protein KPNA2, which participated in glycolysis regulation downstream of mTORC1 in a HIF1alpha (show HIF1A Antibodies)-independent manner, indicating that mTORC1 regulates glycolysis through multiple ways.
provided support for a link between autophagy and epithelial-to-mesenchymal (-like) transition status in WT TP53 (show TP53 Antibodies) glioblastoma cells and provided evidence for the signaling pathway (MIR517C-KPNA2-cytoplasmic TP53 (show TP53 Antibodies)) involved in attenuating autophagy
Structure of importin-alpha (show KPNA4 Antibodies) bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein has been reported.
Specific interaction with the nuclear transporter (show RPAIN Antibodies) importin (show KPNA4 Antibodies) alpha2 can modulate paraspeckle protein 1 (show PSPC1 Antibodies) delivery to nuclear paraspeckles.
constitutive expression of Kpna2 during the differentiation culture of ESCs (show NR2E3 Antibodies) significantly impairs clock development, and KPNA2 facilitates cytoplasmic localization of PER1 (show PER1 Antibodies)/
a significant correlation of KPNA2 expression and tumour aggressiveness in a large variety of other solid tumour entities
study reports a cell-fate determination mechanism in which importin (show KPNA4 Antibodies) alpha2 negatively regulates the nuclear import of certain transcription factors to maintain embryonic stem cell properties
importin alpha (show KPNA4 Antibodies) binds to Nup153 (show NUP153 Antibodies)
results collectively reveal that nuclear-localized importin (show KPNA4 Antibodies) alpha2 influences gene expression and contributes directly to cell fate outcomes including non-apoptotic cell death.
Chrp, Arip3 (show PIAS2 Antibodies), and Hop2 (show PSMC3IP Antibodies) are binding partners of IMPalpha2 in the developmental context of germ line development.
anti-importin (show KPNA4 Antibodies) alpha1 antibody treatment suppressed the importin (show KPNA4 Antibodies) alpha1-FGF1 (show FGF1 Antibodies) complex formation and ERK1/2 (show MAPK1/3 Antibodies) activation, resulting in decreased cell growth. This study provides novel evidence that functional importin (show KPNA4 Antibodies) alpha1 is located at the cell surface, where it accelerates the proliferation of cancer cells.
The combination of low nuclear and cytoplasmic KPNA2 expression is associated with adverse outcome in head and neck squamous cell carcinoma treated with radio(chemo)therapy.
Suggest that KPNA2 may play a key role in the inflammation process of rheumatoid arthritis via NF-kappaB (show NFKB1 Antibodies) P65 (show GORASP1 Antibodies) signal transduction pathway.
KPNA2 might play an important role in colorectal carcinogenesis and functions as a novel prognostic indicator and a potential therapeutic target for colorectal cancer.
High KPNA2 expression was found to be associated with poor prognosis and resistance to hyperthermochemoradiation therapy (HCRT (show OX Antibodies)).
RBBP4 (show RBBP4 Antibodies) functions as a novel regulatory factor to increase the efficiency of importin alpha (show KPNA4 Antibodies)/beta-mediated nuclear import
A novel role of karyopherin alpha 2 in cell migration through the regulation of vimentin-pErk protein complex levels in lung cancer.
High KPNA2 immunoreactivity is a predictor of bladder recurrence and poor survival in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy.
High KPNA2 expression is associated with osteoarthritis.
Authors demonstrated that swine importin (show KPNA4 Antibodies) alpha1 interacts with the M1 protein and transports it to the nucleus.
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination
importin subunit alpha-2
, Importin subunit alpha-2
, karyopherin subunit alpha-2
, RAG cohort protein 1
, importin alpha P1
, importin subunit alpha-1
, pore targeting complex 58 kDa subunit
, karyopherin (importin) alpha 2
, nuclear import protein
, RAG cohort 1
, importin alpha 1
, importin alpha 2
, importin subunit alpha-8
, karyopherin subunit alpha-7
, nuclear transport receptor