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anti-Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) Antibodies

The import of proteins into the nucleus is a process that involves at least 2 steps. Additionally we are shipping KPNA2 Kits (13) and KPNA2 Proteins (11) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KPNA2 16647 P52293
KPNA2 85245  
KPNA2 3838 P52292
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Top anti-KPNA2 Antibodies at antibodies-online.com

Showing 10 out of 80 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-KPNA2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Transfected 293T 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Goat Un-conjugated IF, WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB ABIN185157 staining (0.1µg/ml) of Hela lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. ABIN185157 staining (top panel and green) of 4% formaldahyde-fixed HeLa with endogenously expressed HistonH2B-GFP fusion as DNA marker (mid panel and red). Data kindly provided by Francisco Iborra, MRC Mol. Haematol. Unit, Oxford. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of KPNA2 in rat heart tissue lysate with KPNA2 antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Mouse Rat Un-conjugated WB 50 μL Log in to see 5 to 6 Days
$455.84
Details
REACT_Fly Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of Karyopherin alpha. Lysates from HeLa cells (5 µg/lane), S2 cells (7.5 µg/lane), and 0-12 hours Drosophila embryos (7.5 µg/lane) were probed with the mouse anti-karyopherin antibody at concentrations of 1 µg/ml (lane 1), 0.5 µg/ml (lane 2), and 0.25 µg/ml (lane 3). The mouse anti-karyopherin alpha antibody detects a band of 58 kDa in all lysates. Immunofluorescence staining of 0-12 hour embryos. Formalin-fixed embryos kept in ethanol at -20°C, were re-hydrated and incubated with the mouse anti-karyopherin antibody at 1 µg/ml in TBST. After extensive washes to remove unbound antibody, signal was visualized by confocal microscopy with an Alexa Fluor® 488 anti-mouse secondary antibody (1:300 dilution). Ventral view of a cellularizing embryo. Staining is perinuclear. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Dog Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of Karyopherin alpha on a HeLa cell lysate (Human cervical epitheloid carcinoma, ATCC CCL-2.2). Lane 1: 1:2500, lane 2: 1:5000, lane 3: 1:10,000 dilution of the mouse anti-karyopherin antibody. Immunofluorescence staining of WI-38 cells (Human lung fibroblasts, ATCC CCL-75). 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image karyopherin alpha 2 antibody [C3], C-term detects karyopherin alpha 2 protein at nucleus on human lung adenocarcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human lung adenocarcinoma. karyopherin alpha 2 antibody [C3], C-term , diluted at 1:250. WB Image Sample(30 μg of whole cell lysate) A:HeLa S3, B:Hep G2, C:MOLT4, 10% SDS PAGE antibody diluted at 1:500 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rat Un-conjugated WB 50 μL Log in to see 8 to 10 Days
$676.50
Details

KPNA2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-KPNA2 Antibodies

  1. Fly (Calliphora) Monoclonal KPNA2 Primary Antibody for IF, IP - ABIN968901 : Cuomo, Kirch, Gyuris, Brent, Oettinger: Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. in Proceedings of the National Academy of Sciences of the United States of America 1994 (PubMed)
    Show all 4 references for ABIN968901

  2. Dog (Canine) Monoclonal KPNA2 Primary Antibody for IF, IP - ABIN967998 : Grozinger, Schreiber: Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. in Proceedings of the National Academy of Sciences of the United States of America 2000 (PubMed)
    Show all 4 references for ABIN967998

  3. Cow (Bovine) Polyclonal KPNA2 Primary Antibody for WB - ABIN2785824 : Kodiha, Tran, Qian, Morogan, Presley, Brown, Stochaj: Oxidative stress mislocalizes and retains transport factor importin-alpha and nucleoporins Nup153 and Nup88 in nuclei where they generate high molecular mass complexes. in Biochimica et biophysica acta 2008 (PubMed)

  4. Mouse (Murine) Monoclonal KPNA2 Primary Antibody for WB - ABIN108571 : Fischer, Kremmer, Lautscham, Mueller-Lantzsch, Grässer: Epstein-Barr virus nuclear antigen 1 forms a complex with the nuclear transporter karyopherin alpha2. in The Journal of biological chemistry 1997 (PubMed)

  5. Human Polyclonal KPNA2 Primary Antibody for EIA, WB - ABIN783733 : Moroianu: Molecular mechanisms of nuclear protein transport. in Critical reviews in eukaryotic gene expression 1997 (PubMed)

More Antibodies against KPNA2 Interaction Partners

Xenopus laevis Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. Nuclear import rates correlated with nuclear size, and varying the concentrations of two transport factors, importin alpha (show KPNA4 Antibodies) and Ntf2 (show NUTF2 Antibodies), was sufficient to account for nuclear scaling between the two species.

Mouse (Murine) Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. Structure of importin-alpha (show KPNA4 Antibodies) bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein has been reported.

  2. Specific interaction with the nuclear transporter (show RPAIN Antibodies) importin (show KPNA4 Antibodies) alpha2 can modulate paraspeckle protein 1 (show PSPC1 Antibodies) delivery to nuclear paraspeckles.

  3. constitutive expression of Kpna2 during the differentiation culture of ESCs (show NR2E3 Antibodies) significantly impairs clock development, and KPNA2 facilitates cytoplasmic localization of PER1 (show PER1 Antibodies)/

  4. a significant correlation of KPNA2 expression and tumour aggressiveness in a large variety of other solid tumour entities

  5. study reports a cell-fate determination mechanism in which importin (show KPNA4 Antibodies) alpha2 negatively regulates the nuclear import of certain transcription factors to maintain embryonic stem cell properties

  6. importin alpha (show KPNA4 Antibodies) binds to Nup153 (show NUP153 Antibodies)

  7. results collectively reveal that nuclear-localized importin (show KPNA4 Antibodies) alpha2 influences gene expression and contributes directly to cell fate outcomes including non-apoptotic cell death.

  8. Chrp, Arip3 (show PIAS2 Antibodies), and Hop2 (show PSMC3IP Antibodies) are binding partners of IMPalpha2 in the developmental context of germ line development.

  9. Overexpression of a dominant-negative IMPalpha2 isoform, when assessed against adjacent untransfected or IMPalpha2 transfected cells, led to both a significant reduction in endogenous Oct3/4 (show POU5F1 Antibodies) protein levels and inhibition of Oct3/4 (show POU5F1 Antibodies) nuclear localization.

  10. knockdown of KPNA2 decreased myotube growth.

Human Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. Suggest that KPNA2 may play a key role in the inflammation process of rheumatoid arthritis via NF-kappaB (show NFKB1 Antibodies) P65 (show GORASP1 Antibodies) signal transduction pathway.

  2. KPNA2 might play an important role in colorectal carcinogenesis and functions as a novel prognostic indicator and a potential therapeutic target for colorectal cancer.

  3. High KPNA2 expression was found to be associated with poor prognosis and resistance to hyperthermochemoradiation therapy (HCRT (show OX Antibodies)).

  4. RBBP4 (show RBBP4 Antibodies) functions as a novel regulatory factor to increase the efficiency of importin alpha (show KPNA4 Antibodies)/beta-mediated nuclear import

  5. A novel role of karyopherin alpha 2 in cell migration through the regulation of vimentin-pErk protein complex levels in lung cancer.

  6. High KPNA2 immunoreactivity is a predictor of bladder recurrence and poor survival in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy.

  7. High KPNA2 expression is associated with osteoarthritis.

  8. Crystal structure of human importin (show KPNA4 Antibodies)-alpha1 (Rch1), revealing a potential autoinhibition mode involving homodimerization.

  9. OPN (show SPP1 Antibodies), SPINK1 (show SPINK1 Antibodies), GPC3 (show GPC3 Antibodies) and KNPA2 were significantly over-expressed in HCC (show FAM126A Antibodies) tissues. These genes may be useful in developing future biomarkers and therapeutic strategies for HCC (show FAM126A Antibodies)

  10. This study provides further evidence for the complexity of DDR (show DDR1 Antibodies) mechanism in BC, and that KNPA2 has a role in the aberrant subcellular localisation of DDR (show DDR1 Antibodies) proteins with subsequent impaired function.

Pig (Porcine) Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. Authors demonstrated that swine importin (show KPNA4 Antibodies) alpha1 interacts with the M1 protein and transports it to the nucleus.

KPNA2 Antigen Profile

Protein Summary

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination

Gene names and symbols associated with KPNA2

  • importin subunit alpha-2 (EDI_246290) antibody
  • importin subunit alpha-2 (EDI_335040) antibody
  • Importin subunit alpha-2 (ima2) antibody
  • importin alpha 1b (kpna2) antibody
  • karyopherin (importin) alpha 2 (Kpna2) antibody
  • karyopherin alpha 2 (Kpna2) antibody
  • karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2) antibody
  • karyopherin alpha 7 (importin alpha 8) (Kpna7) antibody
  • 2410044B12Rik antibody
  • AW146299 antibody
  • Gm1055 antibody
  • ima2 antibody
  • importin antibody
  • IPOA1 antibody
  • PTAC58 antibody
  • QIP2 antibody
  • RCH1 antibody
  • SRP1alpha antibody

Protein level used designations for KPNA2

importin subunit alpha-2 , Importin subunit alpha-2 , karyopherin subunit alpha-2 , RAG cohort protein 1 , SRP1-alpha , importin alpha P1 , importin subunit alpha-1 , m-importin-alpha-P1 , pendulin , pore targeting complex 58 kDa subunit , karyopherin (importin) alpha 2 , nuclear import protein , RAG cohort 1 , importin alpha 1 , importin alpha 2 , importin-alpha-P1 , importin subunit alpha-8 , karyopherin subunit alpha-7 , nuclear transport receptor

GENE ID SPECIES
5881743 Entamoeba dispar SAW760
5886378 Entamoeba dispar SAW760
100195132 Salmo salar
398027 Xenopus laevis
16647 Mus musculus
85245 Rattus norvegicus
3838 Homo sapiens
480469 Canis lupus familiaris
397218 Sus scrofa
513592 Bos taurus
381686 Mus musculus
Selected quality suppliers for anti-KPNA2 (KPNA2) Antibodies
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