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The protein encoded by MGP is secreted and likely acts as an inhibitor of bone formation. Additionally we are shipping Matrix Gla Protein Antibodies (56) and Matrix Gla Protein Proteins (24) and many more products for this protein.
Showing 10 out of 45 products:
Human MGP ELISA Kit for Sandwich ELISA - ABIN414669
Louvet, Büchel, Steppan, Passlick-Deetjen, Massy: Magnesium prevents phosphate-induced calcification in human aortic vascular smooth muscle cells. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2013
Show all 4 references for ABIN414669
Mouse (Murine) MGP ELISA Kit for Sandwich ELISA - ABIN857742
Wang, Chen, Zhang, Yu, Zhang, Gong, Shao, Lu, Gao, Chen, Chen, Hui: Common genetic variants of MGP are associated with calcification on the arterial wall but not with calcification present in the atherosclerotic plaques. in Circulation. Cardiovascular genetics 2013
Show all 2 references for ABIN857742
Usefulnees of nonmammalian model systems to elucidate the complex regulation of MGP gene transcription.
These data also indicate that MGP is under dual regulation by runx2 (show RUNX2 ELISA Kits) through the use of various isoforms and context-dependent formation of transcriptional complexes.
MGP is a multi-functional inhibitor of normal and abnormal angiogenesis that may function by coordinating with both Notch and BMP signaling pathways
In contrast with results obtained for previously studied marine fishes, in zebrafish and Senegal sole Mgp accumulates in both calcified tissues and non-mieralized vessel walls of the vascular system.
It is assumed that Lp-PLA2 (show Lp-PLA2 ELISA Kits) is involved in vascular calcification and that dp-ucMGP is a more appropriate biomarker of residual risk than Lp-PLA2 (show Lp-PLA2 ELISA Kits) itself.
Data shoed increased GAS6 (show GAS6 ELISA Kits) and decreased MGP levels in hemodialysis patients, as mediators of induction or prevention of vascular calcification.
Altering NOTCH1 (show NOTCH1 ELISA Kits) levels affected MGP mRNA and protein.
Uncarboxylated MGP in synovial fluid might serve as a novel biomarker for assessing knee osteoarthritis progression.
MGP expression is significantly lower in diseased relative to normal aortic valve interstitial cells. Lack of this important "anti-calcification" protein may contribute to calcification of the aortic valve.
Higher plasma dephosphorylated uncarboxylated MGP (reflective of lower vitamin K status) was associated with higher odds of meniscus damage, osteophytes, bone marrow lesions, and subarticular cysts.
High levels of desphospho-uncarboxylated MGP are independently and positively associated with arterial stiffness after adjustment for common cardiovascular risk factors, renal function, and age.
The association has been found between the ischemic atherothrombotic stroke and polymorphic variants of genes MGP and VKORC1 (show VKORC1 ELISA Kits).
MGP expression is impaired in patients with ankylosing spondylitis
The concentration of dephosphorylated-uncarboxylated Matrix Gla protein was higher in hemodialysis patients treated with vitamin K.
Matrix Gla protein limits pulmonary arteriovenous malformations in ALK1 (show ACVRL1 ELISA Kits) deficiency.
expression of MGP and OCN increased gradually in the murine developing tibial epiphysis, and the two mineral-associated proteins may occur at the same location during a particular period, but at different levels.
Elastin (show ELN ELISA Kits) haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice.
The arterial calcification, not MGP deficiency itself, causes the low bone mass phenotype in Mgp-/- mice.
Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 (show TGM2 ELISA Kits) and elastin (show ELN ELISA Kits) fragmentation associated with induction of adipsin (show CFD ELISA Kits).
Mgp gene deletion may have a role in arteriovenous malformations
MGP is a known inhibitor of mineralization, and mice deficient in Mgp show severe vascular calcification and premature bone mineralization.
Inorganic phosphate(Pi) regulates MGP expression in growth plate chondrocytes, thereby suggesting a key role for Pi and ERK1/2 (show MAPK1/3 ELISA Kits) in the regulation of bone formation.
PTH (show PTH ELISA Kits) regulates MGP via both PKA- and ERK (show EPHB2 ELISA Kits)-dependent pathways.
High DNA methylation (show HELLS ELISA Kits) resulting in the down regulation of matrix Gla protein is associated with osteochondrosis.
Selective CaSR (show CASR ELISA Kits) activation, either by extracellular calcium or AMG (show AMELX ELISA Kits) 641, increased MGP expression in vivo in the arterial wall and in vitro in bovine vascular smooth muscle cells.
the effect of MGP on calcification and osteogenic differentiation is determined by availability of BMP-2 (show BMP2 ELISA Kits)
MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF expression
MGP has a novel binding activity for vitronectin (show VTN ELISA Kits)
Heat shock protein 70 (show HSP70 ELISA Kits) enhances vascular bone morphogenetic protein-4 (show BMP4 ELISA Kits) signaling by binding matrix Gla protein.
The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene.
matrix Gla protein
, Matrix Gla protein
, cell growth-inhibiting gene 36 protein
, matrix gamma-carboxyglutamate (gla) protein