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anti-Methionine Adenosyltransferase I, alpha (MAT1A) Antibodies

MAT1A catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. Additionally we are shipping Methionine Adenosyltransferase I, alpha Kits (20) and Methionine Adenosyltransferase I, alpha Proteins (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MAT1A 17420 P51949
MAT1A 4143 Q00266
MAT1A 25331 P13444
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Top anti-Methionine Adenosyltransferase I, alpha Antibodies at

Showing 10 out of 53 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB MAT1A Antibody (N-term) (ABIN656632) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
Caenorhabditis elegans Rabbit Un-conjugated IHC, WB 100 μL Log in to see 2 to 3 Days
Chicken Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue reacted with MAT1A Antibody (N-term) followed which was peroxidase conjugated to the secondary antibody and  followed by DAB staining. Western blot analysis of MAT1A Antibody (N-term) in MDA-MB435 cell line lysates (35ug/lane). This demonstrates the MAT1A antibody detected the MAT1A protein (arrow). 0.4 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: MAT1A Antibody [NBP1-55120] - Human kidney Tissue, antibody concentration 4-8ug/ml. Cells with positive label: renal corpuscle cells (indicated with arrows) 400X magnification. Western Blot: MAT1A Antibody [NBP1-55120] - WB analysis of MAT1A in mouse liver lysate. Image courtesy of product review submitted by Hua Jiang. 100 μL Log in to see 6 to 9 Days
Human Rabbit Un-conjugated ELISA, IHC, WB Western Blot (WB) analysis of specific cells using Mat1 Polyclonal Antibody. 100 μL Log in to see 14 Days
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HeLa/HepG2/293 cells, using MAT1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Human Mouse Un-conjugated EIA, IF, WB 0.1 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IHC (p), WB 100 μg Log in to see 8 to 10 Days
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days

MAT1A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)

Human ,
, , , , ,
Rat (Rattus)

Top referenced anti-Methionine Adenosyltransferase I, alpha Antibodies

  1. Human Polyclonal MAT1A Primary Antibody for EIA, IHC (p) - ABIN953327 : Wu, Huang, Lu, Chien, Yeh, Tsai, Liao, Chen, Liao, Cheng, Lin: Thyroid hormone receptor-mediated regulation of the methionine adenosyltransferase 1 gene is associated with cell invasion in hepatoma cell lines. in Cellular and molecular life sciences : CMLS 2010 (PubMed)
    Show all 4 references for ABIN953327

  2. Human Monoclonal MAT1A Primary Antibody for EIA, IF - ABIN1108162 : Chamberlin, Ubagai, Mudd, Levy, Chou: Dominant inheritance of isolated hypermethioninemia is associated with a mutation in the human methionine adenosyltransferase 1A gene. in American journal of human genetics 1997 (PubMed)
    Show all 3 references for ABIN1108162

  3. Human Polyclonal MAT1A Primary Antibody for ICC, IF - ABIN4332790 : Yang, Cho, Li, Peng, Ko, Mato, Lu: MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma. in The Journal of clinical investigation 2013 (PubMed)
    Show all 2 references for ABIN4332790

  4. Caenorhabditis elegans (C. elegans) Polyclonal MAT1A Primary Antibody for IHC, WB - ABIN2776785 : Oh, Yang, Hahn, Kim, Byun, Jeon, Kim, Song, Noh, Kim, Yoo, Kim, Kim: Transcriptome analysis of human gastric cancer. in Mammalian genome : official journal of the International Mammalian Genome Society 2005 (PubMed)

  5. Human Polyclonal MAT1A Primary Antibody for IHC (p), WB - ABIN656632 : Bing, Zhu, Yu, Li, Liu, Li, Wang, Qi, Guo, Yuan, He, Liu, Liu: Glucocorticoid-induced S-adenosylmethionine enhances the interferon signaling pathway by restoring STAT1 protein methylation in hepatitis B virus-infected cells. in The Journal of biological chemistry 2014 (PubMed)

More Antibodies against Methionine Adenosyltransferase I, alpha Interaction Partners

Mouse (Murine) Methionine Adenosyltransferase I, alpha (MAT1A) interaction partners

  1. MAT1A is required for normal VLDL assembly and plasma lipid homeostasis in mice. Impaired VLDL synthesis, mainly due to SAMe deficiency, contributes to NAFLD (show TSC2 Antibodies) development in MAT1A-KO mice.

  2. Deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced RNA polymerase II Ser5 phosphorylation.

  3. DUSP1 (show DUSP1 Antibodies) mRNA and protein levels are lower in Mat1a knockout livers and fall rapidly in cultured hepatocytes.

  4. investigated the function of the Cdk7 (show CDK7 Antibodies).cyclin (show PCNA Antibodies) H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells

  5. This study demonstrates a requirement for MAT1 in the operation of PGC-1 (show PPARGC1A Antibodies) coactivators that control cell metabolism.

  6. study found that Mat1 and Cdk7 (show CDK7 Antibodies) levels are undetectable in adipose tissues in vivo and downregulated during adipogenesis

  7. Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A

  8. MAT1A knockout hepatocytes have more baseline DNA synthesis but no mitogenic response to hepatocyte growth factor (show HGF Antibodies). MAT1A-produced SAMe has a major role in ERK (show EPHB2 Antibodies) signaling & cyclin D1 (show CCND1 Antibodies) regulation during liver regeneration & mitogenic signal response.

  9. Mat1a(-/-) mice have expansion of liver stem cells as they age. These cells have increased expression of several oncogenes and are tumorigenic in vivo.

  10. C/EBPbeta (show CEBPB Antibodies) plays an important role in epigenetic regulation of the mature hepatic gene MAT1A

Human Methionine Adenosyltransferase I, alpha (MAT1A) interaction partners

  1. S-adenosyl-L-methionine (show AS3MT Antibodies) diminishes hepatitis C virus expression by altering MAT1A/2A signaling in hepatocytes.

  2. Data suggest the role of the phospholipase C epsilon (show PLCL1 Antibodies)-Protein kinase D (show PRKD1 Antibodies)-PEA15 (show PEA15 Antibodies) protein-ribosomal S6 kinase (show RPS6KB1 Antibodies)-IkappaB-NF-kappa B (show NFKB1 Antibodies) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.

  3. Integrin alpha5beta1 and p53 (show TP53 Antibodies) convergent pathways in the control of anti-apoptotic proteins PEA-15 (show PEA15 Antibodies) and survivin (show BIRC5 Antibodies) in high-grade glioma.

  4. High PED expression is associated with esophageal carcinoma.

  5. The nuclear translocation of SApErk1/ 2 apart from PEA-15 (show PEA15 Antibodies) as an important mechanism to reverse senescence phenotype.

  6. Latent HCMV infection of CD34 (show CD34 Antibodies) + cells protects cells from FAS (show FAS Antibodies)-mediated apoptosis through the cellular IL-10 (show IL10 Antibodies)/PEA-15 (show PEA15 Antibodies) pathway.

  7. New therapeutic targets based around PEA-15 (show PEA15 Antibodies) and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.

  8. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism

  9. Omi/HtrA2 (show HTRA2 Antibodies) overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 (show HTRA2 Antibodies) pro-apoptotic marker in the various hepatocellular carcinoma cell lines

  10. Results suggest that neurochemical adaptations of brain FADD (show FADD Antibodies), as well as its interaction with PEA-15 (show PEA15 Antibodies), could play a major role to counteract the known activation of the mitochondrial apoptotic pathway in major depression

Methionine Adenosyltransferase I, alpha (MAT1A) Antigen Profile

Protein Summary

This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.

Gene names and symbols associated with MAT1A

  • menage a trois 1 (Mnat1) antibody
  • methionine adenosyltransferase I, alpha (mat1a) antibody
  • methionine adenosyltransferase I, alpha (MAT1A) antibody
  • methionine adenosyltransferase I, alpha (Mat1a) antibody
  • phosphoprotein enriched in astrocytes 15 (PEA15) antibody
  • AdoMet antibody
  • AI046368 antibody
  • Ams antibody
  • E130115E11Rik antibody
  • HMAT1 antibody
  • HUMMAT1H antibody
  • MAT antibody
  • MAT1 antibody
  • MAT1H antibody
  • MATA1 antibody
  • P36 antibody
  • PEA-15 antibody
  • PED antibody
  • SADE antibody
  • SAMS antibody
  • SAMS1 antibody
  • SAS antibody
  • wu:fi35e01 antibody
  • zgc:55442 antibody

Protein level used designations for MAT1A

CDK-activating kinase assembly factor MAT1 , CDK7/cyclin H assembly factor , CDK7/cyclin-H assembly factor , RING finger protein MAT1 , p35 , S-adenosylmethionine synthase isoform type-1 , MAT 1 , MAT-I/III , S-adenosylmethionine synthetase isoform type-1 , adoMet synthase 1 , adoMet synthetase 1 , methionine adenosyltransferase 1 , methionine adenosyltransferase I/III , S - adenosylmethionine synthetase , 15 kDa phosphoprotein enriched in astrocytes , Phosphoprotein enriched in astrocytes, 15kD , astrocytic phosphoprotein PEA-15 , homolog of mouse MAT-1 oncogene , phosphoprotein enriched in diabetes

17420 Mus musculus
334195 Danio rerio
423628 Gallus gallus
4143 Homo sapiens
608788 Canis lupus familiaris
100156922 Sus scrofa
541078 Bos taurus
11720 Mus musculus
25331 Rattus norvegicus
8682 Homo sapiens
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