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anti-Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) Antibodies

MAPK8IP1 encodes a regulator of the pancreatic beta-cell function. Additionally we are shipping MAPK8IP1 Proteins (4) and MAPK8IP1 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MAPK8IP1 19099 Q9WVI9
MAPK8IP1 116457 Q9R237
MAPK8IP1 9479 Q9UQF2
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Top anti-MAPK8IP1 Antibodies at antibodies-online.com

Showing 10 out of 65 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from COLO205 cells treated with Serum 20% 15', using JIP1 (Phospho-Thr103) Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of NIH-3T3 cells, using JIP1 (Phospho-Thr103) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of JIP1 Antibody (C-term) (ABIN652961) in MCF-7 cell line lysates (35 µg/lane). JIP1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with JIP1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from COLO205 cells, treated with Serum 20% 15', using JIP1 (Ab-103) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using JIP1 (Ab-103) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Mouse Mouse Un-conjugated FM, WB Western blot analysis of JIP-1 on a mouse cerebellum lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the mouse anti- JIP-1 antibody. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated WB Western blot analysis of JIP-1 in Jurkat cell lysate (Lane 1) mouse intestine (Lane 2) and rat kidney (Lane 3) tissue lysates. 100 μg Log in to see 2 to 3 Days
$283.50
Details
Mouse Rabbit Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB WB Image Sample(30 ug whole cell lysate) A:Hep G2 , 7.5% SDS PAGE antibody diluted at 1:1000 IHC-P Image JIP1 antibody detects JIP1 protein at cytoplasm on mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. JIP1 antibody , diluted at 1:500. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-MAPK8IP1 Polyclonal Antibody, Unconjugated (ABIN716441) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB 100 μg Log in to see 11 to 16 Days
$412.86
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$302.50
Details

MAPK8IP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MAPK8IP1 Antibodies

  1. Mouse (Murine) Monoclonal MAPK8IP1 Primary Antibody for FM, WB - ABIN968696 : Bonny, Nicod, Waeber: IB1, a JIP-1-related nuclear protein present in insulin-secreting cells. in The Journal of biological chemistry 1998 (PubMed)
    Show all 3 references for ABIN968696

  2. Human Polyclonal MAPK8IP1 Primary Antibody for IF, ELISA - ABIN1531616 : Mooser, Maillard, Bonny, Steinmann, Shaw, Yarnall, Burns, Schorderet, Nicod, Waeber: Genomic organization, fine-mapping, and expression of the human islet-brain 1 (IB1)/c-Jun-amino-terminal kinase interacting protein-1 (JIP-1) gene. in Genomics 1999 (PubMed)

More Antibodies against MAPK8IP1 Interaction Partners

Mouse (Murine) Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) interaction partners

  1. It mediates Alzheimer-disease like pathologies in AICD-Tg mice and that JNK (show MAPK8 Antibodies) signaling may contribute to amyloid-independent mechanisms of AD pathogenesis.

  2. Enhanced fast-velocity and efficient high-frequency APP (show APP Antibodies) anterograde transport observed in neurons are mediated by novel roles of JIP1b.

  3. a simple yet modular mechanism for JIP1 scaffold assembly in mammals

  4. There is a collaborative relationship between JIP1 and AKT (show AKT1 Antibodies) that is required for axon growth and can be regulated by changes in neuronal activity.

  5. identify plenty of SH3 (POSH (show SH3RF1 Antibodies)) and JNK-interacting protein 1 (JIP-1) as a multiprotein scaffold network for TCR-mediated JNK1 (show MAPK8 Antibodies) activation in CD8 (show CD8A Antibodies)(+) T cells.

  6. The phosphorylation of S421 of JIP1 serves as a molecular switch to regulate the direction of APP (show APP Antibodies) transport in neurons.

  7. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 (show MAP3K11 Antibodies) interaction with JIP1 scaffold protein (show HOMER1 Antibodies) in cytokine-induced pancreatic beta cell death

  8. JIP1 forms a trimetric complex with RBP-Jk (show RBPJ Antibodies) and Notch1 (show NOTCH1 Antibodies)-IC, prevents physical association between Notch1 (show NOTCH1 Antibodies)-IC and RBP-Jk (show RBPJ Antibodies), sequesters RBP-JK (show RBPJ Antibodies) in the cytoplasm, and suppresses the Notch1 (show NOTCH1 Antibodies) signaling pathway.

  9. Data suggest that JIP1-mediated JNK (show MAPK8 Antibodies) activation plays a critical role in metabolic stress regulation of the JNK (show MAPK8 Antibodies) signaling pathway.

  10. JIP1b can directly modulate APP (show APP Antibodies) metabolism by interacting with the APP (show APP Antibodies) cytoplasmic domain, independent of its regulation of the JNK (show MAPK8 Antibodies) signaling cascade.

Human Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1) interaction partners

  1. analysis of the role of JIP1 in APP (show APP Antibodies) transport; knockdown of JIP1 did not affect either amyloid precursor protein (show APP Antibodies) transport or amyloid-beta peptide production

  2. Data show that small GTPase (show RACGAP1 Antibodies) RALA (show rala Antibodies) regulates formation of a JIP1 (C-Jun (show JUN Antibodies)-amino-terminal-interacting protein 1) scaffold complex to propagate JNK (show MAPK8 Antibodies) signaling toward FOXO4 (show FOXO4 Antibodies) (forkhead box O (show FOXO Antibodies) transcription factor) in response to reactive oxygen species (ROS (show ROS1 Antibodies)).

  3. In resected pancreatic cancer, carriers of a minor allele for rs3824872 (MAPK8IP1) were associated with a survival advantage compared with noncarriers with an additional 2-year survival if both minor alleles were present.

  4. Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 (show MAP3K11 Antibodies) interaction with JIP1 scaffold protein (show HOMER1 Antibodies) in cytokine-induced pancreatic beta cell death

  5. Data suggest that caspase 3 (show CASP3 Antibodies)-mediated cleavage of JIP1 scaffold proteins may represent an important mechanism for modulation of JNK (show MAPK8 Antibodies) signalling during apoptotic cell death.

  6. Data show that mechanical stress of urothelial cells activates in vivo JNK (show MAPK8 Antibodies), as a consequence of a regulated expression of IB1/JIP-1, and that urothelial connexin 26 (show GJB2 Antibodies) may be directly regulated by the AP-1 (show FOSB Antibodies) complex.

  7. results suggest that JIP (show SMAD4 Antibodies)-1b may function as a protein linking the kinesin-I motor protein to the cargo receptor, APP (show APP Antibodies), and that the JNK (show MAPK8 Antibodies) signaling pathway may regulate the phosphorylation of this cargo protein through the JIP (show SMAD4 Antibodies)-1b scaffold

  8. JIP1 may act as an Akt1 (show AKT1 Antibodies) scaffold, which regulates the enzymatic activity of Akt1 (show AKT1 Antibodies) and can exert signaling effects independent of JNK (show MAPK8 Antibodies) activity

  9. JIP-1 protein may regulate kinesin-I-dependent neuronal AbetaPP transport, which controls AbetaPP processing

  10. JIP-1 only facilitated (but is not required for) phosphorylation of Amyloid beta protein precursor but not of the two other family members APLP1 (amyloid precursor-like protein 1 (show APLP1 Antibodies)) and APLP2 (show APLP2 Antibodies)

MAPK8IP1 Antigen Profile

Protein Summary

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

Gene names and symbols associated with MAPK8IP1

  • mitogen-activated protein kinase 8 interacting protein 1 (MAPK8IP1) antibody
  • mitogen-activated protein kinase 8 interacting protein 1 (LOC100344706) antibody
  • mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1) antibody
  • IB1 antibody
  • Jip-1 antibody
  • JIP1 antibody
  • Mapk8ip antibody
  • mjip-2a antibody
  • PRKM8IP antibody
  • Skip antibody

Protein level used designations for MAPK8IP1

mitogen-activated protein kinase 8 interacting protein 1 , c-Jun-amino-terminal kinase-interacting protein 1-like , C-Jun-amino-terminal kinase-interacting protein 1 , IB-1 , JNK MAP kinase scaffold protein 1 , JNK-interacting protein 1 , islet-brain-1 , mitogen activated protein kinase 8 interacting protein 1 , mitogen-activated protein kinase 8-interacting protein 1 , protein kinase, mitogen-activated 8 interacting protein , JIP-1-related protein , JRP , mitogen activated protein kinase 8 interacting protein , PRKM8 interacting protein , islet-brain 1 , islet brain 1

GENE ID SPECIES
423202 Gallus gallus
100344706 Oryctolagus cuniculus
100473891 Ailuropoda melanoleuca
19099 Mus musculus
116457 Rattus norvegicus
9479 Homo sapiens
483640 Canis lupus familiaris
524806 Bos taurus
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