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anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) Antibodies

ASAH1 encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. Additionally we are shipping N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 Proteins (11) and N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ASAH1 427 Q13510
ASAH1 84431 Q6P7S1
ASAH1 11886 Q9WV54
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Top anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 Antibodies at antibodies-online.com

Showing 10 out of 63 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-ASAH1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Lung 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-ASAH1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: THP-1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to ASAH1 on formalin-fixed paraffin-embedded human heart (antibody concentration 3 µg/mL). 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of ASAH1 in human heart tissue with ASAH1 antibody at 2.5 μg/ml. Western blot analysis of ASAH1 in mouse heart tissue lysate with ASAH1 antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Dog Mouse Un-conjugated IF, WB Western blot analysis of Acid Ceramidase on NHEK lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of Acid Ceramidase. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Fruit Fly Rabbit Un-conjugated WB WB Suggested Anti-ac Antibody Titration: 0.2-1 ug/mlPositive Control: Drosophila 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to ASAH1 on formalin-fixed paraffin-embedded human heart. [antibody concentration 3 ug/ml] Detection limit for recombinant GST tagged ASAH1 is 0.1 ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 14 Days
$527.15
Details
Human Rabbit Un-conjugated IHC (p), WB Human Heart (formalin-fixed, paraffin-embedded) stained with ASAH1 antibody ABIN396932 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Adrenal (formalin-fixed, paraffin-embedded) stained with ASAH1 antibody ABIN396932 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details

ASAH1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 Antibodies

  1. Human Monoclonal ASAH1 Primary Antibody for IHC (p), ELISA - ABIN394138 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Show all 5 references for ABIN394138

  2. Human Polyclonal ASAH1 Primary Antibody for EIA, IHC (p) - ABIN783822 : Koch, Gärtner, Li, Quintern, Bernardo, Levran, Schnabel, Desnick, Schuchman, Sandhoff: Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber disease. in The Journal of biological chemistry 1997 (PubMed)
    Show all 4 references for ABIN783822

  3. Dog (Canine) Monoclonal ASAH1 Primary Antibody for IF, WB - ABIN968809 : Bernardo, Hurwitz, Zenk, Desnick, Ferlinz, Schuchman, Sandhoff: Purification, characterization, and biosynthesis of human acid ceramidase. in The Journal of biological chemistry 1995 (PubMed)
    Show all 3 references for ABIN968809

  4. Cow (Bovine) Polyclonal ASAH1 Primary Antibody for WB - ABIN2787375 : Kim, Satta: Population genetic analysis of the N-acylsphingosine amidohydrolase gene associated with mental activity in humans. in Genetics 2008 (PubMed)

  5. Human Monoclonal ASAH1 Primary Antibody for IHC (p), ELISA - ABIN559962 : Singh, Dharmarajan, Aye, Keelan: Ceramide biosynthesis and metabolism in trophoblast syncytialization. in Molecular and cellular endocrinology 2012 (PubMed)

More Antibodies against N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 Interaction Partners

Human N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) interaction partners

  1. Data suggest up-regulation of ASAH1 activity by androgen in androgen-sensitive prostate cancer cells (not other cancer cells) is due to prolonged stability of ASAH1 by androgen-stimulated induction of USP2 (ubiquitin specific peptidase 2 (show USP2 Antibodies)) expression.

  2. Genetic or pharmacological acid ceramidase inhibition promotes cisplatin cytotoxicity in head and neck tumor cells.

  3. high ASAH1 expression is generally associated with an improved prognosis in invasive breast cancer independent of adjuvant treatment and could also be valuable as prognostic factor for pre-invasive DCIS.

  4. novel ASAH1 mutations affecting polypyrimidine tract deletion, and exon skipping and resulting in Farber lipogranulomatosis

  5. Acid ceramidase promotes nuclear export of PTEN (show PTEN Antibodies) through sphingosine 1-phosphate mediated Akt (show AKT1 Antibodies) signaling.

  6. Depletion of both Akt2 (show AKT2 Antibodies) and ASAH1 is much more potent than depleting each alone at inhibiting neoplastic cell viability/proliferation and invasion.

  7. This work unravels for the first time the mutations underlying the neonatal form of Farber disease and represents the first report of a large deletion identified in the ASAH1 gene.

  8. Immunohistochemical analysis of human prostate cancer tissues revealed higher levels of ASAH1 after radiotherapy failure.

  9. These observations confirm ASAH1 as a therapeutic target in advanced and chemoresistant forms of prostate cancer

  10. Acid ceramidase is a prognostic factor in epithelial ovarian cancer

Mouse (Murine) N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) interaction partners

  1. cells deficient in acid ceramidase (aCDase) also exhibited defects in CCL5 (show CCL5 Antibodies) induction, whereas cells deficient in sphingosine kinase-1 (show SPHK1 Antibodies) and -2 exhibited higher levels of CCL5 (show CCL5 Antibodies).

  2. biochemistry of acid ceramidase reaction with acid sphingomyelinase (show SMPD1 Antibodies)

  3. Acid and neutral sphingomyelinase (show SMPD2 Antibodies), ceramide synthase, and acid ceramidase have roles in cutaneous aging

  4. These results provide the first characterization of the Acid Ceremidase promoter from any species and demonstrate that Kruppel-like factor 6 (KLF6 (show KLF6 Antibodies)) is one transcription factor involved in the regulation of AC gene expression.

  5. acid ceramidase is an essential factor required for embryo survival that functions by removing ceramide from the newly formed embryos, thus inhibiting the default apoptosis pathway

N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) Antigen Profile

Protein Summary

This gene encodes a heterodimeric protein consisting of a nonglycosylated alpha subunit and a glycosylated beta subunit that is cleaved to the mature enzyme posttranslationally. The encoded protein catalyzes the synthesis and degradation of ceramide into sphingosine and fatty acid. Mutations in this gene have been associated with a lysosomal storage disorder known as Farber disease. Multiple transcript variants encoding several distinct isoforms have been identified for this gene.

Gene names and symbols associated with ASAH1

  • N-acylsphingosine amidohydrolase (acid ceramidase) 1 (asah1) antibody
  • N-acylsphingosine amidohydrolase (acid ceramidase) 1a (asah1a) antibody
  • N-acylsphingosine amidohydrolase (acid ceramidase) 1 (ASAH1) antibody
  • N-acylsphingosine amidohydrolase (acid ceramidase) 1 (Asah1) antibody
  • N-acylsphingosine amidohydrolase 1 (Asah1) antibody
  • Protein ASAH-1 (asah-1) antibody
  • 2310081N20Rik antibody
  • AC antibody
  • ACDase antibody
  • Asah antibody
  • ASAH1 antibody
  • MGC82286 antibody
  • PHP antibody
  • PHP32 antibody
  • SMAPME antibody
  • zgc:101637 antibody

Protein level used designations for ASAH1

N-acylsphingosine amidohydrolase (acid ceramidase) 1 , N-acylsphingosine amidohydrolase 1 , acid ceramidase , acid CDase , acylsphingosine deacylase , putative 32 kDa heart protein , AC , ACDase , Acylsphingosine deacylase

GENE ID SPECIES
447327 Xenopus laevis
450068 Danio rerio
703699 Macaca mulatta
100171626 Pongo abelii
427 Homo sapiens
482897 Canis lupus familiaris
510620 Bos taurus
84431 Rattus norvegicus
464022 Pan troglodytes
422727 Gallus gallus
11886 Mus musculus
173120 Caenorhabditis elegans
Selected quality suppliers for anti-N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1) Antibodies
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