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NFE2L2 encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. Additionally we are shipping NRF2 Kits (33) and NRF2 Proteins (8) and many more products for this protein.
Showing 10 out of 171 products:
Human Polyclonal NRF2 Primary Antibody for IHC (fro), IF (p) - ABIN676673
Lee, Hsu, Chang, Kuo, Hsu, Pan: Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. in Free radical biology & medicine 2012
Show all 15 references for ABIN676673
Human Polyclonal NRF2 Primary Antibody for IF (p), IHC (p) - ABIN737271
Wang, Fang, Huang, Chen, Fan, Wang: The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats. in Environmental toxicology and pharmacology 2013
Show all 12 references for ABIN737271
Human Polyclonal NRF2 Primary Antibody for EIA, WB - ABIN359515
Zhao, Sun, Zhang, Strong, Dash, Kan, Grotta, Aronowski: Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. in Stroke; a journal of cerebral circulation 2007
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Human Polyclonal NRF2 Primary Antibody for EIA, WB - ABIN359516
Li, Jang, Na, Cha, Surh: Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling. in The Journal of biological chemistry 2007
Show all 2 references for ABIN359516
Human Polyclonal NRF2 Primary Antibody for ChIP, ICC - ABIN442777
Sullivan, Martinez-Garcia, Nguyen, Mullen, Dufour, Sudarshan, Licht, Deberardinis, Chandel: The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. in Molecular cell 2013
Show all 2 references for ABIN442777
Human Polyclonal NRF2 Primary Antibody for IHC, ELISA - ABIN1584873
Bagul, Middela, Matapally, Padiya, Bastia, Madhusudana, Reddy, Chakravarty, Banerjee: Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. in Pharmacological research : the official journal of the Italian Pharmacological Society 2012
Show all 2 references for ABIN1584873
Chicken Polyclonal NRF2 Primary Antibody for WB - ABIN2780749
Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006
Human Monoclonal NRF2 Primary Antibody for IHC, ELISA - ABIN1724931
Sandford, Malhotra, Boezen, Siedlinski, Postma, Wong, Akhabir, He, Connett, Anthonisen, Paré, Biswal: NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease. in Physiological genomics 2012
Bach1 (show BACH1 Antibodies) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Antibodies) inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
The expression of nrf (show NRF1 Antibodies) genes varies temporally throughout development and nrf (show NRF1 Antibodies) genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b (show GABPb Antibodies).
oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.
results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles
compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds
Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.
mutation of either residual cysteine residue in Keap1a (show KEAP1 Antibodies) and Keap1b disrupted the ability of Keap1 (show KEAP1 Antibodies) to repress Nrf2, indicating that the presence of either Cys (show DNAJC5 Antibodies)-273 or Cys (show DNAJC5 Antibodies)-288 is sufficient for fish Keap1 (show KEAP1 Antibodies) molecules to fully function
study reports that the Keap1 (show KEAP1 Antibodies)-Nrf2 system comprises discrete sensor sites, including the Keap1 (show KEAP1 Antibodies) cysteines Cys (show DNAJC5 Antibodies)-151 and Cys (show DNAJC5 Antibodies)-273, for a variety of Nrf2-activating compounds
findings demonstrate that antioxidant responses are a component of polycyclic aromatic hydrocarbon (PAH)synergistic developmental toxicity and that NRF2 is protective against prooxidant and PAH challenges during development
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (show HMOX1 Antibodies) within these cells.
the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (show HMOX1 Antibodies) gene expression in aortic endothelial cells by advanced glycation end products
The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.
A marked (show GABPA Antibodies) increase in Nrf2 expression was detected in the leukocytes obtained from the Hemorrhagic shock patients, which indicates a correlation between Nrf (show MPO Antibodies)2 expression and the development of Hemorrhagic shock.
Glioma patients with high Nrf2 (show GABPA Antibodies) brain expression had shorter overall survival than those with low levels.
stress. Our combined data revealed a protective role of miR (show MLXIP Antibodies)-214 signaling in erythroid cells against oxidative stress, and also shed new light on Nrf2 (show GABPA Antibodies)-mediated cytoprotective machinery.
TGF-beta (show TGFB1 Antibodies) and hypoxia/reoxygenation promoted tumor progression and radioresistance of A549 cells through reactive oxygen species-mediated activation of Nrf2 (show GABPA Antibodies) and EGFR (show EGFR Antibodies).
Inhibition of NRF2 (show GABPA Antibodies) by KEAP1 (show KEAP1 Antibodies) overexpression compromises metabolic reprogramming of fibroblasts and results in reduced efficiency of induced pluripotent stem cells colony formation.
Phycocyanin prevented mitochondrial-dependent apoptosis in methylglyoxal induced INS-1 (show FOXM1 Antibodies) cells and the effect was associated with Nrf2 (show GABPA Antibodies) activation.
Results suggest that NRF2 (show GABPA Antibodies) plays an important role in regulating p53 (show TP53 Antibodies) and SIRT1 (show SIRT1 Antibodies) to maintain MSC (show MSC Antibodies) stemness.
Nrf2 (show GABPA Antibodies) being elevated in early precursor lesions counteracts the growth inhibiting function of TGF-beta1 (show TGFB1 Antibodies) already in benign and premalignant pancreatic ductal epithelial cells.
antiangiogenic and anti-inflammatory activities of Hericium erinaceus may contribute to its anticancer property through inhibition of TNF-alpha (show TNF Antibodies) and modulation of MMP-9 (show MMP9 Antibodies)/NF-kappaB (show NFKB1 Antibodies) and Nrf2 (show GABPA Antibodies)-antioxidant signaling pathways
the inhibition of HO-1 or the knockdown of Nrf-2 significantly enhanced cisplatin's anticancer effects on Hep-2 cells.
Is closely associated with upregulation of the Ref1 (show THOC4 Antibodies)/Nrf2 signalling pathway.
SIRT1 (show SIRT1 Antibodies) promoted the stability of NRF2 by regulating the deacetylation and activation of the NRF2/ARE antioxidant pathway.
The Nrf2-KO mice exhibited more severe lung and liver injury following hemorrhagic shock as evidenced by increased tissue damage, increased myeloperoxidase (show MPO Antibodies) activity and the increased production of pro-inflammatory cytokines. Additionally, Nrf2 deficiency augmented cytokine production induced by the exposure of peritoneal mouse macrophages to lipopolysaccharide following hemorrhagic shock.
high NRF2 activity is advantageous for cochlear protection from noise-induced injury, and NRF2 is a promising target for NIHL prevention.
These results suggest for the first time that FF prevents the development of diabetic nephropathy via up-regulating FGF21 (show FGF21 Antibodies) and stimulating PI3K/Akt (show AKT1 Antibodies)/GSK-3beta (show GSK3b Antibodies)/Fyn (show FYN Antibodies)-mediated activation of the Nrf2 pathway.
Our results show that epicatechin protects the TBI brain by activating the Nrf2 pathway, inhibiting heme oxygenase-1 protein expression, and reducing iron deposition The latter two effects could represent an Nrf2-independent mechanism in this model of TBI
These results provide a new mechanism by which LXA4 inhibits LPS (show TLR4 Antibodies)-induced ALI through Nrf2-mediated E-cadherin (show CDH1 Antibodies) expression
Caffeic acid induces Nrf2 activation by decreasing the expression of its inhibitor protein Keap1 (show KEAP1 Antibodies) and blocking the binding of Nrf2 with Keap1 (show KEAP1 Antibodies).
Our observations that oral DMF treatment promoted immune modulation and provided equal clinical benefit in acute EAE in Nrf2(-/-) and WT mice, suggest that the antiinflammatory activity of DMF in treatment of MS patients may occur through alternative pathways, independent of Nrf2.
SIN (show POLR3E Antibodies) treatment of nephropathy mice effectively reduced the kidney damage and inflammatory responses, balanced renal oxidative stress, and improved the pathological protein expression in an Nrf2 dependent manner
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
, nuclear factor (erythroid-derived 2)-like 2
, nuclear factor erythroid 2-related factor 2
, NF-E2-related factor 2
, NFE2-related factor 2
, nuclear factor, erythroid derived 2, like 2
, nuclear factor erythroid-derived 2-like 2
, nuclear factor erythroid 2-like 2