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NFE2L2 encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. Additionally we are shipping NRF2 Kits (34) and NRF2 Proteins (8) and many more products for this protein.
Showing 10 out of 165 products:
Human Polyclonal NRF2 Primary Antibody for IF (p), IHC (p) - ABIN737271
Lee, Hsu, Chang, Kuo, Hsu, Pan: Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. in Free radical biology & medicine 2012
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Human Polyclonal NRF2 Primary Antibody for IHC (fro), IF (p) - ABIN676673
Lee, Hsu, Hsu, Pan: Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid. in Free radical biology & medicine 2013
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Human Polyclonal NRF2 Primary Antibody for EIA, WB - ABIN359516
Li, Jang, Na, Cha, Surh: Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling. in The Journal of biological chemistry 2007
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Human Polyclonal NRF2 Primary Antibody for IHC, ELISA - ABIN1584873
Bagul, Middela, Matapally, Padiya, Bastia, Madhusudana, Reddy, Chakravarty, Banerjee: Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. in Pharmacological research : the official journal of the Italian Pharmacological Society 2012
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Human Polyclonal NRF2 Primary Antibody for EIA, WB - ABIN359515
Zhao, Sun, Zhang, Strong, Dash, Kan, Grotta, Aronowski: Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. in Stroke; a journal of cerebral circulation 2007
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Human Monoclonal NRF2 Primary Antibody for IHC, ELISA - ABIN1724931
Sandford, Malhotra, Boezen, Siedlinski, Postma, Wong, Akhabir, He, Connett, Anthonisen, Paré, Biswal: NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease. in Physiological genomics 2012
Chicken Polyclonal NRF2 Primary Antibody for WB - ABIN2780749
Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006
Bach1 (show BACH1 Antibodies) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Antibodies) inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
The expression of nrf (show NRF1 Antibodies) genes varies temporally throughout development and nrf (show NRF1 Antibodies) genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b (show GABPb Antibodies).
oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.
results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles
compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds
Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.
mutation of either residual cysteine residue in Keap1a (show KEAP1 Antibodies) and Keap1b disrupted the ability of Keap1 (show KEAP1 Antibodies) to repress Nrf2, indicating that the presence of either Cys (show DNAJC5 Antibodies)-273 or Cys (show DNAJC5 Antibodies)-288 is sufficient for fish Keap1 (show KEAP1 Antibodies) molecules to fully function
study reports that the Keap1 (show KEAP1 Antibodies)-Nrf2 system comprises discrete sensor sites, including the Keap1 (show KEAP1 Antibodies) cysteines Cys (show DNAJC5 Antibodies)-151 and Cys (show DNAJC5 Antibodies)-273, for a variety of Nrf2-activating compounds
findings demonstrate that antioxidant responses are a component of polycyclic aromatic hydrocarbon (PAH)synergistic developmental toxicity and that NRF2 is protective against prooxidant and PAH challenges during development
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (show HMOX1 Antibodies) within these cells.
the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (show HMOX1 Antibodies) gene expression in aortic endothelial cells by advanced glycation end products
The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.
Nrf2 (show GABPA Antibodies) could be activated by ionizing radiation.
Interspecies differences were identified between humans and rats in the expression of Nrf2 (show GABPA Antibodies) in testis and epididymis.
Data suggest that HBV upregulates G6PD (show G6PD Antibodies) expression by HBx-mediated activation of Nrf2 (show GABPA Antibodies).
Mutant p53 (show TP53 Antibodies) may confer cisplatin resistance via upregulation of Nrf2 (show GABPA Antibodies) expression in non-small cell lung carcinoma.
expression of Nrf2 (show GABPA Antibodies)-Keap1 (show KEAP1 Antibodies) is abnormal in osteosarcoma tissue and shows significant clinical relevance for determining the prognosis of osteosarcoma
that targeted repression of Keap1 and activation of Nrf2 pathway, in part, underlies the protective effects of miR-7 against 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity in SH-SY5Y
This review focuses on the Nrf2 (show GABPA Antibodies)/HO-1 (show HMOX1 Antibodies) stress response mechanism as a promising target for anticancer treatment which is able to overcome resistance to therapies.
NFE2L2-mediated gene expression reflects lung cancer severity and progression. [meta-analysis]
review the recent findings on the roles of NRF2 (show GABPA Antibodies) in maintenance of the redox state and multidrug resistance in CSCs, focusing on how NRF2 (show GABPA Antibodies)-mediated ROS (show ROS1 Antibodies) modulation influences the growth and resistance of CSCs.
findings suggest that Nrf2 (show GABPA Antibodies) pathway and autophagy have a negative interaction with each other upon ROS (show ROS1 Antibodies) stimulation.
These results indicated that the Nrf2-ARE system exhibited a protective role in Pb-induced neurotoxicity, providing potential therapeutic strategies for the prevention and treatment of Pb-related diseases.
These results indicate that sargaquinoic acid(SQA) inhibits the lipopolysaccharide-induced expression of inflammatory mediators as well as up-regulation of the Nrf2/HO-1 (show HMOX1 Antibodies) pathway.
Nrf2-/- mice have accelerated ovarian aging and increased sensitivity to the ovarian toxicity of benzo[a]pyrene.
Nrf2 expression increases in the lung and BALF of ALI mice, suggesting that Nrf2 is involved in the inflammation during acute lung injury
The Interplay Between Peroxiredoxin-2 (show PRDX2 Antibodies) and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in beta-Thalassemic Erythropoiesis
load of mice to +9 Gz hypergravity causes AMPKalpha (show GRK4 Antibodies) repression with liver injury, which may be overcome by multiple loads to hypergravity as mediated by Nrf2
Irradiation inhibits osteoblast differentiation and mineralization of MC3T3-E1 cells through the oxidative stress-mediated activation of Nrf2/HO-1 (show HMOX1 Antibodies) pathway.
low 4-Hydroxy-2-nonenal (HNE (show ELANE Antibodies)) doses activate Nrf2 in cardiomyocytes and provide the first evidence of Nrf2 binding to the Ucp3 (show UCP3 Antibodies) promoter in response to HNE (show ELANE Antibodies), leading to increased protein expression
Mechanistic interpretation for this GSTP (show GSTP1 Antibodies)-dependent effect may include a direct and redox-sensitive interaction of GSTP (show GSTP1 Antibodies) with Nrf2 protein
Results demonstrate Nrf2 regulates the generation, survival, and suppressive potency of myeloid-derived suppressor cells (MDSC), and that a feedback homeostatic mechanism maintains a steady-state level of circulating MDSC in tumor-bearing individuals.
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
, nuclear factor (erythroid-derived 2)-like 2
, nuclear factor erythroid 2-related factor 2
, NF-E2-related factor 2
, NFE2-related factor 2
, nuclear factor, erythroid derived 2, like 2
, nuclear factor erythroid-derived 2-like 2
, nuclear factor erythroid 2-like 2