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NFE2L2 encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. Additionally we are shipping NRF2 Kits (33) and NRF2 Proteins (8) and many more products for this protein.
Showing 10 out of 173 products:
Human Polyclonal NRF2 Primary Antibody for IHC (fro), IF (p) - ABIN676673
Lee, Hsu, Chang, Kuo, Hsu, Pan: Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. in Free radical biology & medicine 2012
Show all 15 references for ABIN676673
Human Polyclonal NRF2 Primary Antibody for IF (p), IHC (p) - ABIN737271
Wang, Fang, Huang, Chen, Fan, Wang: The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats. in Environmental toxicology and pharmacology 2013
Show all 12 references for ABIN737271
Human Polyclonal NRF2 Primary Antibody for EIA, WB - ABIN359516
Li, Jang, Na, Cha, Surh: Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling. in The Journal of biological chemistry 2007
Show all 2 references for ABIN359516
Human Polyclonal NRF2 Primary Antibody for EIA, WB - ABIN359515
Zhao, Sun, Zhang, Strong, Dash, Kan, Grotta, Aronowski: Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. in Stroke; a journal of cerebral circulation 2007
Show all 2 references for ABIN359515
Human Polyclonal NRF2 Primary Antibody for IHC, ELISA - ABIN1584873
Bagul, Middela, Matapally, Padiya, Bastia, Madhusudana, Reddy, Chakravarty, Banerjee: Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. in Pharmacological research : the official journal of the Italian Pharmacological Society 2012
Show all 2 references for ABIN1584873
Human Polyclonal NRF2 Primary Antibody for ChIP, ICC - ABIN442777
Sullivan, Martinez-Garcia, Nguyen, Mullen, Dufour, Sudarshan, Licht, Deberardinis, Chandel: The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. in Molecular cell 2013
Show all 2 references for ABIN442777
Human Monoclonal NRF2 Primary Antibody for IHC, ELISA - ABIN1724931
Sandford, Malhotra, Boezen, Siedlinski, Postma, Wong, Akhabir, He, Connett, Anthonisen, Paré, Biswal: NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease. in Physiological genomics 2012
Chicken Polyclonal NRF2 Primary Antibody for WB - ABIN2780749
Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006
Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt (show AKT1 Antibodies) and JNK (show MAPK8 Antibodies)/Nrf2/NQO1 (show NQO1 Antibodies) pathway.
Bach1 (show BACH1 Antibodies) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Antibodies) inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
The expression of nrf (show NRF1 Antibodies) genes varies temporally throughout development and nrf (show NRF1 Antibodies) genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b (show GABPb Antibodies).
oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.
results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles
compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds
Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.
mutation of either residual cysteine residue in Keap1a (show KEAP1 Antibodies) and Keap1b disrupted the ability of Keap1 (show KEAP1 Antibodies) to repress Nrf2, indicating that the presence of either Cys (show DNAJC5 Antibodies)-273 or Cys (show DNAJC5 Antibodies)-288 is sufficient for fish Keap1 (show KEAP1 Antibodies) molecules to fully function
study reports that the Keap1 (show KEAP1 Antibodies)-Nrf2 system comprises discrete sensor sites, including the Keap1 (show KEAP1 Antibodies) cysteines Cys (show DNAJC5 Antibodies)-151 and Cys (show DNAJC5 Antibodies)-273, for a variety of Nrf2-activating compounds
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (show HMOX1 Antibodies) within these cells.
the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (show HMOX1 Antibodies) gene expression in aortic endothelial cells by advanced glycation end products
The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.
The functional interaction of them depends on MEG3 (show FAM129B Antibodies)-Nrf2 (show GABPA Antibodies) protein formation.
Knockdown of Nrf2 (show GABPA Antibodies) expression sensitizes cholangiocarcinoma cells to the cytotoxic and antiproliferative effects of cisplatin
Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt (show AKT1 Antibodies) and JNK (show MAPK8 Antibodies)/Nrf2 (show GABPA Antibodies)/NQO1 (show NQO1 Antibodies) pathway.
Data show that periostin (show POSTN Antibodies) mitigates high glucose-induced mitochondrial apoptosis in endothelial cells, via activation of nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1 (show HMOX1 Antibodies)) signaling.
The NRF2 (show GABPA Antibodies) role in hepatocellular carcinoma [review]
Report modulation of Nrf2 (show GABPA Antibodies) signaling in Hct116 colon carcinoma cells by baicalein and its methylated derivative negletein.
Data suggest that a dietary component/supplement, L-carnitine, protects hepatocytes against oxidative stress/cell damage (induced here by hydrogen peroxide) through AKT (show AKT1 Antibodies)- (proto-oncogene (show RAB1A Antibodies) protein c (show PROC Antibodies)-akt (show AKT1 Antibodies))-mediated activation of NRF2 (show GABPA Antibodies) (nuclear factor [erythroid-derived 2]-like 2 protein) signaling pathway.
chitosan-caffeic acid protects liver cells against hydrogen peroxide-induced injury and this ability is attributed to the induction of antioxidants and phase II detoxifying enzymes that are mediated by Nrf2 (show GABPA Antibodies) translocation via JNK (show MAPK8 Antibodies)/ERK (show EPHB2 Antibodies) signaling.
Nrf2 (show GABPA Antibodies)-Gadd45b (show GADD45B Antibodies) signaling axis exhibited a protective role in antimony trioxide-induced cell apoptosis.
Both Nrf2 (show GABPA Antibodies) and NF-kappaB (show NFKB1 Antibodies) signaling may be pivotal in the regulation of drug-induced liver injury. NF-kappaB (show NFKB1 Antibodies)-inhibiting effects that coincide with a strong Nrf2 (show GABPA Antibodies) stress response likely sensitize liver cells to pro-apoptotic signaling cascades induced by intrinsic cytotoxic pro-inflammatory cytokines.
Protection against phalloidin hepatotoxicity by oleanolic acid involves activation of Nrf2 and suppression of Oatp1b2.
Nrf2 may be useful molecular markers in radiation-induced cellular responses and is important for detecting abnormal spermatogenesis following exposure to space radiation
Induction of Nrf2 expression could serve as an adaptive self-defense mechanism, although it is insufficient to completely protect primary astrocytes from Fe2+-induced neurotoxicity.
Interestingly, SKPs showed higher protein levels of Bcl-2 (show BCL2 Antibodies), Nrf2, and HO-1 (show HMOX1 Antibodies) than FBs (show FBS Antibodies). SKPs exert a beneficial effect on resisting UVB-induced apoptosis, which may be associated with Bcl-2 (show BCL2 Antibodies) and Nrf2 upregulation.
results demonstrate that a mild oxidative stress activates Nrf2/HO-1 (show HMOX1 Antibodies) signaling and an ERK (show EPHB2 Antibodies)-mediated pathway, and facilitates the mineralization of ES cells with a corresponding increase in Runx2 (show RUNX2 Antibodies).
Activation of CB2 (show CNR2 Antibodies) ameliorates myocardial fibrosis via Nrf2-mediated inhibition of TGF-beta1 (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies) pathway in mice with myocardial infarction.
Nrf2 deficiency increased susceptibility to oxidative stress-induced (show SQSTM1 Antibodies) small intestinal carcinogenesis in mice
Is closely associated with upregulation of the Ref1 (show THOC4 Antibodies)/Nrf2 signalling pathway.
SIRT1 (show SIRT1 Antibodies) promoted the stability of NRF2 by regulating the deacetylation and activation of the NRF2/ARE antioxidant pathway.
The Nrf2-KO mice exhibited more severe lung and liver injury following hemorrhagic shock as evidenced by increased tissue damage, increased myeloperoxidase (show MPO Antibodies) activity and the increased production of pro-inflammatory cytokines. Additionally, Nrf2 deficiency augmented cytokine production induced by the exposure of peritoneal mouse macrophages to lipopolysaccharide following hemorrhagic shock.
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
, nuclear factor (erythroid-derived 2)-like 2
, nuclear factor erythroid 2-related factor 2
, NF-E2-related factor 2
, NFE2-related factor 2
, nuclear factor, erythroid derived 2, like 2
, nuclear factor erythroid-derived 2-like 2
, nuclear factor erythroid 2-like 2