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NFE2L2 encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. Additionally we are shipping NRF2 Kits (36) and NRF2 Proteins (10) and many more products for this protein.
Showing 10 out of 194 products:
Human Polyclonal NRF2 Primary Antibody for IHC (fro), IF (p) - ABIN676673
Lee, Hsu, Chang, Kuo, Hsu, Pan: Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. in Free radical biology & medicine 2012
Show all 15 references for ABIN676673
Human Polyclonal NRF2 Primary Antibody for IF (p), IHC (p) - ABIN737271
Wang, Fang, Huang, Chen, Fan, Wang: The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats. in Environmental toxicology and pharmacology 2013
Show all 12 references for ABIN737271
Human Polyclonal NRF2 Primary Antibody for ICC, IF - ABIN4340688
Suchocki, Misiewicz-Krzemińska, Skupińska, Niedźwiecka, Lubelska, Fijałek, Kasprzycka-Guttman: Selenitetriglicerydes affect CYP1A1 and QR activity by involvement of reactive oxygen species and Nrf2 transcription factor. in Pharmacological reports : PR 2010
Show all 3 references for ABIN4340688
Human Polyclonal NRF2 Primary Antibody for EIA, WB - ABIN359516
Li, Jang, Na, Cha, Surh: Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling. in The Journal of biological chemistry 2007
Show all 2 references for ABIN359516
Human Polyclonal NRF2 Primary Antibody for ChIP, ICC - ABIN442777
Sullivan, Martinez-Garcia, Nguyen, Mullen, Dufour, Sudarshan, Licht, Deberardinis, Chandel: The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. in Molecular cell 2013
Show all 2 references for ABIN442777
Human Polyclonal NRF2 Primary Antibody for EIA, WB - ABIN359515
Zhao, Sun, Zhang, Strong, Dash, Kan, Grotta, Aronowski: Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. in Stroke; a journal of cerebral circulation 2007
Show all 2 references for ABIN359515
Human Polyclonal NRF2 Primary Antibody for IHC, ELISA - ABIN1584873
Bagul, Middela, Matapally, Padiya, Bastia, Madhusudana, Reddy, Chakravarty, Banerjee: Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. in Pharmacological research : the official journal of the Italian Pharmacological Society 2012
Show all 2 references for ABIN1584873
Human Monoclonal NRF2 Primary Antibody for IHC, ELISA - ABIN1724931
Sandford, Malhotra, Boezen, Siedlinski, Postma, Wong, Akhabir, He, Connett, Anthonisen, Paré, Biswal: NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease. in Physiological genomics 2012
Chicken Polyclonal NRF2 Primary Antibody for WB - ABIN2780749
Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006
Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt (show AKT1 Antibodies) and JNK (show MAPK8 Antibodies)/Nrf2/NQO1 (show NQO1 Antibodies) pathway.
Bach1 (show BACH1 Antibodies) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Antibodies) inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
The expression of nrf (show NRF1 Antibodies) genes varies temporally throughout development and nrf (show NRF1 Antibodies) genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b (show GABPb Antibodies).
oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.
results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles
compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds
Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.
mutation of either residual cysteine residue in Keap1a (show KEAP1 Antibodies) and Keap1b disrupted the ability of Keap1 (show KEAP1 Antibodies) to repress Nrf2, indicating that the presence of either Cys (show DNAJC5 Antibodies)-273 or Cys (show DNAJC5 Antibodies)-288 is sufficient for fish Keap1 (show KEAP1 Antibodies) molecules to fully function
study reports that the Keap1 (show KEAP1 Antibodies)-Nrf2 system comprises discrete sensor sites, including the Keap1 (show KEAP1 Antibodies) cysteines Cys (show DNAJC5 Antibodies)-151 and Cys (show DNAJC5 Antibodies)-273, for a variety of Nrf2-activating compounds
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (show HMOX1 Antibodies) within these cells.
the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (show HMOX1 Antibodies) gene expression in aortic endothelial cells by advanced glycation end products
The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.
Elevated oxidative DNA lesion 8-OHdG was associated with shorter survival. Experimentally, ROS (show ROS1 Antibodies) enhanced Nrf2 (show GABPA Antibodies) expression, 8-OHdG formation and tumor progression in HCC (show FAM126A Antibodies) cells.
Oxidative stress induced (show SQSTM1 Antibodies) by particulate matter, could up-regulates the expression of phase I and phase II metabolize enzymes. This up-regulation occurs by the activation of transcription factors (such as nuclear factor (erythroid-derived 2) -like 2-related factor (Nrf2 (show GABPA Antibodies)) and aryl hydrocarbon receptor (AhR (show AHR Antibodies))). [Review]
Antioxidant, S-propyl-cysteine protects against NAFLD (show TSC2 Antibodies) via PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/Nrf2 (show GABPA Antibodies)/HO-1 (show HMOX1 Antibodies) signaling pathway.
TXNIP (show TXNIP Antibodies) rs7211 polymorphism is a protective factor against obesity in nondiabetic subjects and in women. TT carriers had lower high-density lipoprotein cholesterol levels and lower body mass index.
Nrf2 (show GABPA Antibodies) pathway plays an important role in protecting retinal pigment epithelial cells against blue light-induced oxidative stress.
2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 (show HMOX1 Antibodies) and ARS2 (show SRRT Antibodies) expression by inhibiting Nrf2 (show GABPA Antibodies), NF-kappaB (show NFKB1 Antibodies), AP-1 (show FOSB Antibodies) and MAPK (show MAPK1 Antibodies) pathways in human proximal tubular cells.
miR (show MLXIP Antibodies)-200a was found to interact with the 3'-untranslated region of Keap1 (show KEAP1 Antibodies), the native regulator of Nrf2 (show GABPA Antibodies).
Ferulic acid triggered the activation of NHEJ repair pathway, prevented DNA damage and activated Nrf2 (show GABPA Antibodies) mediated up-regulation of antioxidant defense system.
We present the case that chemoprevention through the Keap1 (show KEAP1 Antibodies)/Nrf2 (show GABPA Antibodies) system may be context dependent and that the Nrf2 (show GABPA Antibodies) "dose-response curve" for electrophilic and redox balance may not be monotonic.
The results demonstrate the therapeutic potential of Ru complexes against Hepatocellular Carcinoma via Nrf2 (show GABPA Antibodies) pathway regulation.
SCE conferred a protective role in the DSS (show PMP22 Antibodies)-induced inflammation and the mechanism might be associated with the activated signals of the nuclear factor kappa B p65 and Nrf2.
Akt2 (show AKT2 Antibodies) ablation may protect against paraquat toxicity-induced cardiac contractile defect and apoptosis possibly via regulation of Nrf2 activation and mitochondrial homeostasis.
Antioxidant, S-propyl-cysteine protects against NAFLD (show TSC2 Antibodies) via PI3K/Akt (show AKT1 Antibodies)/Nrf2/HO-1 (show HMOX1 Antibodies) signaling pathway.
Avenanthramides regulate, in part, the function of osteoblasts and osteocytes and prevent osteoblast/osteocyte apoptosis and increase osteoclast apoptosis; further, these regulatory actions are independent of Nrf2.
Nrf2 pathway plays an important role in protecting retinal pigment epithelial cells against blue light-induced oxidative stress.
Protection against phalloidin hepatotoxicity by oleanolic acid involves activation of Nrf2 and suppression of Oatp1b2.
Nrf2 may be useful molecular markers in radiation-induced cellular responses and is important for detecting abnormal spermatogenesis following exposure to space radiation
Induction of Nrf2 expression could serve as an adaptive self-defense mechanism, although it is insufficient to completely protect primary astrocytes from Fe2+-induced neurotoxicity.
Interestingly, SKPs showed higher protein levels of Bcl-2 (show BCL2 Antibodies), Nrf2, and HO-1 (show HMOX1 Antibodies) than FBs (show FBS Antibodies). SKPs exert a beneficial effect on resisting UVB-induced apoptosis, which may be associated with Bcl-2 (show BCL2 Antibodies) and Nrf2 upregulation.
results demonstrate that a mild oxidative stress activates Nrf2/HO-1 (show HMOX1 Antibodies) signaling and an ERK (show EPHB2 Antibodies)-mediated pathway, and facilitates the mineralization of ES cells with a corresponding increase in Runx2 (show RUNX2 Antibodies).
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
, nuclear factor (erythroid-derived 2)-like 2
, nuclear factor erythroid 2-related factor 2
, NF-E2-related factor 2
, NFE2-related factor 2
, nuclear factor, erythroid derived 2, like 2
, nuclear factor erythroid-derived 2-like 2
, nuclear factor erythroid 2-like 2