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anti-Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) Antibodies

NFE2L2 encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. Additionally we are shipping NRF2 Kits (33) and NRF2 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NFE2L2 4780 Q16236
NFE2L2 18024 Q60795
NFE2L2 83619 O54968
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Top anti-NRF2 Antibodies at antibodies-online.com

Showing 10 out of 171 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of NFE2L2 (arrow) using NFE2L2 Antibody . 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the NFE2L2 gene (Lane 2) (Origene Technologies). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-NFE2L2 Antibody Titration: 1.25ug/mlELISA Titer: 1:1562500Positive Control: A172 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-NFE2L2 (N-term) in Ramos cell line lysates (35 µg/lane). Nrf2 (arrow) was detected using the purified Pab (1:60 dilution). Western blot analysis of Nrf2(Nfe2l2)(arrow) using rabbit polyclonal Nrf2(Nfe2l2) Antibody (N-term) . 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the Nrf2(Nfe2l2) gene (Lane 2) (Origene Technologies). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human endometrial cancer labeled with Rabbit Anti-Nrf2 Polyclonal Antibody, Unconjugated (ABIN737271) 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse myocardium labeled with (ABIN737271) Rabbit Anti-Nrf2 Polyclonal Antibody, Unconjugated 1:300 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated IHC (fro), IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat tongue tissue labeled with Anti-phospho-Nrf2 (Ser40) Polyclonal Antibody (ABIN676673), Unconjugated 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat kidney tissue labeled with Anti-phospho-Nrf2 (Ser40) Polyclonal Antibody (ABIN676673), Unconjugated 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$291.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 2 to 6 Days
$327.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-NFE2L2 Antibody (N-term) (ABIN391424) in Ramos cell line lysates (35 µg/lane). Nrf2(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Western blot analysis of Nrf2(Nfe2l2)(arrow) using rabbit polyclonal Nrf2(Nfe2l2) Antibody (N-term) (ABIN391424). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the Nrf2(Nfe2l2) gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ChIP, ICC, IF, IHC, IHC (p), IP, WB Immunoprecipitation: Nrf2 Antibody [NBP1-32822] - Immunoprecipitation of NRF2 protein from HepG2 whole cell extracts using 5 ug of NRF2 antibody [N2C2], Internal Western blot analysis was performed using NRF2 antibody [N2C2], Internal.. EasyBlot anti-Rabbit IgG was used as a secondary reagent. Western Blot: Nrf2 Antibody [NBP1-32822] - Untreated (-) and treated (+) MDA-MB-231 nuclear extracts (30 ug) were separated by 7.5% SDS-PAGE, and the membrane was blotted with NRF2 antibody diluted at 1:500.The observed M.W. is based on the publication: PMID: 22703241 0.1 mL Log in to see 5 to 7 Days
$500.06
Details
Human Rabbit Un-conjugated IHC (p) 7 mL Log in to see 2 to 3 Days
$231.00
Details

NFE2L2 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-NRF2 Antibodies

  1. Human Polyclonal NRF2 Primary Antibody for IHC (fro), IF (p) - ABIN676673 : Lee, Hsu, Chang, Kuo, Hsu, Pan: Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. in Free radical biology & medicine 2012 (PubMed)
    Show all 15 references for ABIN676673

  2. Human Polyclonal NRF2 Primary Antibody for IF (p), IHC (p) - ABIN737271 : Wang, Fang, Huang, Chen, Fan, Wang: The chronic effects of low lead level on the expressions of Nrf2 and Mrp1 of the testes in the rats. in Environmental toxicology and pharmacology 2013 (PubMed)
    Show all 12 references for ABIN737271

  3. Human Polyclonal NRF2 Primary Antibody for EIA, WB - ABIN359515 : Zhao, Sun, Zhang, Strong, Dash, Kan, Grotta, Aronowski: Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. in Stroke; a journal of cerebral circulation 2007 (PubMed)
    Show all 2 references for ABIN359515

  4. Human Polyclonal NRF2 Primary Antibody for EIA, WB - ABIN359516 : Li, Jang, Na, Cha, Surh: Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 references for ABIN359516

  5. Human Polyclonal NRF2 Primary Antibody for ChIP, ICC - ABIN442777 : Sullivan, Martinez-Garcia, Nguyen, Mullen, Dufour, Sudarshan, Licht, Deberardinis, Chandel: The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. in Molecular cell 2013 (PubMed)
    Show all 2 references for ABIN442777

  6. Human Polyclonal NRF2 Primary Antibody for IHC, ELISA - ABIN1584873 : Bagul, Middela, Matapally, Padiya, Bastia, Madhusudana, Reddy, Chakravarty, Banerjee: Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. in Pharmacological research : the official journal of the Italian Pharmacological Society 2012 (PubMed)
    Show all 2 references for ABIN1584873

  7. Chicken Polyclonal NRF2 Primary Antibody for WB - ABIN2780749 : Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006 (PubMed)

  8. Human Monoclonal NRF2 Primary Antibody for IHC, ELISA - ABIN1724931 : Sandford, Malhotra, Boezen, Siedlinski, Postma, Wong, Akhabir, He, Connett, Anthonisen, Paré, Biswal: NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease. in Physiological genomics 2012 (PubMed)

More Antibodies against NRF2 Interaction Partners

Zebrafish Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. Bach1 (show BACH1 Antibodies) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Antibodies) inhibition based on its level in each tissue.

  2. The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.

  3. The expression of nrf (show NRF1 Antibodies) genes varies temporally throughout development and nrf (show NRF1 Antibodies) genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b (show GABPb Antibodies).

  4. oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.

  5. results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles

  6. compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds

  7. Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.

  8. mutation of either residual cysteine residue in Keap1a (show KEAP1 Antibodies) and Keap1b disrupted the ability of Keap1 (show KEAP1 Antibodies) to repress Nrf2, indicating that the presence of either Cys (show DNAJC5 Antibodies)-273 or Cys (show DNAJC5 Antibodies)-288 is sufficient for fish Keap1 (show KEAP1 Antibodies) molecules to fully function

  9. study reports that the Keap1 (show KEAP1 Antibodies)-Nrf2 system comprises discrete sensor sites, including the Keap1 (show KEAP1 Antibodies) cysteines Cys (show DNAJC5 Antibodies)-151 and Cys (show DNAJC5 Antibodies)-273, for a variety of Nrf2-activating compounds

  10. findings demonstrate that antioxidant responses are a component of polycyclic aromatic hydrocarbon (PAH)synergistic developmental toxicity and that NRF2 is protective against prooxidant and PAH challenges during development

Cow (Bovine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (show HMOX1 Antibodies) within these cells.

  2. the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.

  3. investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (show HMOX1 Antibodies) gene expression in aortic endothelial cells by advanced glycation end products

Pig (Porcine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.

Human Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. A marked (show GABPA Antibodies) increase in Nrf2 expression was detected in the leukocytes obtained from the Hemorrhagic shock patients, which indicates a correlation between Nrf (show MPO Antibodies)2 expression and the development of Hemorrhagic shock.

  2. Glioma patients with high Nrf2 (show GABPA Antibodies) brain expression had shorter overall survival than those with low levels.

  3. stress. Our combined data revealed a protective role of miR (show MLXIP Antibodies)-214 signaling in erythroid cells against oxidative stress, and also shed new light on Nrf2 (show GABPA Antibodies)-mediated cytoprotective machinery.

  4. TGF-beta (show TGFB1 Antibodies) and hypoxia/reoxygenation promoted tumor progression and radioresistance of A549 cells through reactive oxygen species-mediated activation of Nrf2 (show GABPA Antibodies) and EGFR (show EGFR Antibodies).

  5. Inhibition of NRF2 (show GABPA Antibodies) by KEAP1 (show KEAP1 Antibodies) overexpression compromises metabolic reprogramming of fibroblasts and results in reduced efficiency of induced pluripotent stem cells colony formation.

  6. Phycocyanin prevented mitochondrial-dependent apoptosis in methylglyoxal induced INS-1 (show FOXM1 Antibodies) cells and the effect was associated with Nrf2 (show GABPA Antibodies) activation.

  7. Results suggest that NRF2 (show GABPA Antibodies) plays an important role in regulating p53 (show TP53 Antibodies) and SIRT1 (show SIRT1 Antibodies) to maintain MSC (show MSC Antibodies) stemness.

  8. Nrf2 (show GABPA Antibodies) being elevated in early precursor lesions counteracts the growth inhibiting function of TGF-beta1 (show TGFB1 Antibodies) already in benign and premalignant pancreatic ductal epithelial cells.

  9. antiangiogenic and anti-inflammatory activities of Hericium erinaceus may contribute to its anticancer property through inhibition of TNF-alpha (show TNF Antibodies) and modulation of MMP-9 (show MMP9 Antibodies)/NF-kappaB (show NFKB1 Antibodies) and Nrf2 (show GABPA Antibodies)-antioxidant signaling pathways

  10. the inhibition of HO-1 or the knockdown of Nrf-2 significantly enhanced cisplatin's anticancer effects on Hep-2 cells.

Mouse (Murine) Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2) interaction partners

  1. Is closely associated with upregulation of the Ref1 (show THOC4 Antibodies)/Nrf2 signalling pathway.

  2. SIRT1 (show SIRT1 Antibodies) promoted the stability of NRF2 by regulating the deacetylation and activation of the NRF2/ARE antioxidant pathway.

  3. The Nrf2-KO mice exhibited more severe lung and liver injury following hemorrhagic shock as evidenced by increased tissue damage, increased myeloperoxidase (show MPO Antibodies) activity and the increased production of pro-inflammatory cytokines. Additionally, Nrf2 deficiency augmented cytokine production induced by the exposure of peritoneal mouse macrophages to lipopolysaccharide following hemorrhagic shock.

  4. high NRF2 activity is advantageous for cochlear protection from noise-induced injury, and NRF2 is a promising target for NIHL prevention.

  5. These results suggest for the first time that FF prevents the development of diabetic nephropathy via up-regulating FGF21 (show FGF21 Antibodies) and stimulating PI3K/Akt (show AKT1 Antibodies)/GSK-3beta (show GSK3b Antibodies)/Fyn (show FYN Antibodies)-mediated activation of the Nrf2 pathway.

  6. Our results show that epicatechin protects the TBI brain by activating the Nrf2 pathway, inhibiting heme oxygenase-1 protein expression, and reducing iron deposition The latter two effects could represent an Nrf2-independent mechanism in this model of TBI

  7. These results provide a new mechanism by which LXA4 inhibits LPS (show TLR4 Antibodies)-induced ALI through Nrf2-mediated E-cadherin (show CDH1 Antibodies) expression

  8. Caffeic acid induces Nrf2 activation by decreasing the expression of its inhibitor protein Keap1 (show KEAP1 Antibodies) and blocking the binding of Nrf2 with Keap1 (show KEAP1 Antibodies).

  9. Our observations that oral DMF treatment promoted immune modulation and provided equal clinical benefit in acute EAE in Nrf2(-/-) and WT mice, suggest that the antiinflammatory activity of DMF in treatment of MS patients may occur through alternative pathways, independent of Nrf2.

  10. SIN (show POLR3E Antibodies) treatment of nephropathy mice effectively reduced the kidney damage and inflammatory responses, balanced renal oxidative stress, and improved the pathological protein expression in an Nrf2 dependent manner

NRF2 (NFE2L2) Antigen Profile

Protein Summary

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NFE2L2

  • nuclear factor (erythroid-derived 2)-like 2a (nfe2l2a) antibody
  • nuclear factor (erythroid-derived 2)-like 2 (nfe2l2) antibody
  • nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) antibody
  • nuclear factor, erythroid 2-like 2 (NFE2L2) antibody
  • nuclear factor, erythroid derived 2, like 2 (Nfe2l2) antibody
  • AI194320 antibody
  • NF-E2R2 antibody
  • nfe2l2 antibody
  • NRF2 antibody
  • wu:fc15g09 antibody
  • wu:fj67e03 antibody

Protein level used designations for NFE2L2

Nrf2a , nuclear factor (erythroid-derived 2)-like 2 , nuclear factor erythroid 2-related factor 2 , ECH , NF-E2-related factor 2 , NFE2-related factor 2 , nuclear factor, erythroid derived 2, like 2 , HEBP1 , nuclear factor erythroid-derived 2-like 2 , nrf2 , nuclear factor erythroid 2-like 2

GENE ID SPECIES
360149 Danio rerio
444736 Xenopus laevis
396014 Gallus gallus
478813 Canis lupus familiaris
497024 Bos taurus
100516343 Sus scrofa
4780 Homo sapiens
18024 Mus musculus
83619 Rattus norvegicus
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