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NFE2L2 encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. Additionally we are shipping NRF2 Kits (34) and NRF2 Proteins (8) and many more products for this protein.
Showing 10 out of 167 products:
Human Polyclonal NRF2 Primary Antibody for IF (p), IHC (p) - ABIN737271
Lee, Hsu, Chang, Kuo, Hsu, Pan: Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. in Free radical biology & medicine 2012
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Human Polyclonal NRF2 Primary Antibody for IHC (fro), IF (p) - ABIN676673
Lee, Hsu, Hsu, Pan: Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid. in Free radical biology & medicine 2013
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Human Polyclonal NRF2 Primary Antibody for EIA, WB - ABIN359515
Zhao, Sun, Zhang, Strong, Dash, Kan, Grotta, Aronowski: Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. in Stroke; a journal of cerebral circulation 2007
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Human Polyclonal NRF2 Primary Antibody for EIA, WB - ABIN359516
Li, Jang, Na, Cha, Surh: Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling. in The Journal of biological chemistry 2007
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Human Polyclonal NRF2 Primary Antibody for ChIP, ICC - ABIN442777
Sullivan, Martinez-Garcia, Nguyen, Mullen, Dufour, Sudarshan, Licht, Deberardinis, Chandel: The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. in Molecular cell 2013
Show all 2 references for ABIN442777
Human Polyclonal NRF2 Primary Antibody for IHC, ELISA - ABIN1584873
Bagul, Middela, Matapally, Padiya, Bastia, Madhusudana, Reddy, Chakravarty, Banerjee: Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. in Pharmacological research : the official journal of the Italian Pharmacological Society 2012
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Human Monoclonal NRF2 Primary Antibody for IHC, ELISA - ABIN1724931
Sandford, Malhotra, Boezen, Siedlinski, Postma, Wong, Akhabir, He, Connett, Anthonisen, Paré, Biswal: NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease. in Physiological genomics 2012
Chicken Polyclonal NRF2 Primary Antibody for WB - ABIN2780749
Padmanabhan, Tong, Ohta, Nakamura, Scharlock, Ohtsuji, Kang, Kobayashi, Yokoyama, Yamamoto: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. in Molecular cell 2006
Bach1 (show BACH1 Antibodies) regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 (show BACH1 Antibodies) inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
The expression of nrf (show NRF1 Antibodies) genes varies temporally throughout development and nrf (show NRF1 Antibodies) genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b (show GABPb Antibodies).
oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.
results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles
compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds
Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.
mutation of either residual cysteine residue in Keap1a (show KEAP1 Antibodies) and Keap1b disrupted the ability of Keap1 (show KEAP1 Antibodies) to repress Nrf2, indicating that the presence of either Cys (show DNAJC5 Antibodies)-273 or Cys (show DNAJC5 Antibodies)-288 is sufficient for fish Keap1 (show KEAP1 Antibodies) molecules to fully function
study reports that the Keap1 (show KEAP1 Antibodies)-Nrf2 system comprises discrete sensor sites, including the Keap1 (show KEAP1 Antibodies) cysteines Cys (show DNAJC5 Antibodies)-151 and Cys (show DNAJC5 Antibodies)-273, for a variety of Nrf2-activating compounds
findings demonstrate that antioxidant responses are a component of polycyclic aromatic hydrocarbon (PAH)synergistic developmental toxicity and that NRF2 is protective against prooxidant and PAH challenges during development
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 (show HMOX1 Antibodies) within these cells.
the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 (show HMOX1 Antibodies) gene expression in aortic endothelial cells by advanced glycation end products
The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.
Data suggest gene expression in vascular endothelium can be altered by dietary factors; here, aged garlic extract induces expression of HMOX1 (heme oxygenase-1 (show HMOX1 Antibodies)) and GCLM (glutamate-cysteine ligase modifier subunit (show GCLM Antibodies)) via activation of NRF2 (show GABPA Antibodies)-ARE signaling.
Studies indicate a negative impact of nuclear factor erythroid 2-like factor 2 (Nrf2 (show GABPA Antibodies)) signal on non-small cell lung cancer (NSCLC) patients' survival.
Clopidogrel diminishes TNFalpha (show TNF Antibodies)-stimulated VCAM-1 (show VCAM1 Antibodies) expression at least in part via HO-1 (show HMOX1 Antibodies) induction and CaMKKbeta/AMPK (show PRKAA1 Antibodies)/Nrf2 (show GABPA Antibodies) pathway in endothelial cells.
SIRT6 (show SIRT6 Antibodies) in a protein complex with both nuclear factor erythroid 2-related factor 2 (NRF2) and RNA polymerase II.
nuclear factor kappa B (NF-kappaB (show NFKB1 Antibodies)), nuclear E2-related factor 2 (Nrf2 (show GABPA Antibodies)), glycolytic, and p53 (show TP53 Antibodies) pathways during neuronal differentiation, were evaluated.
NRF2 (show GABPA Antibodies) regulates both HER2 (show ERBB2 Antibodies) and HER3 (show ERBB3 Antibodies) receptors to influence cellular responses to HER2 (show ERBB2 Antibodies) targeting.
Oxidative stress-responsive transcription factor NRF2 (show GABPA Antibodies) is not indispensable for the human hepatic Flavin-containing monooxygenase-3 (FMO3 (show FMO3 Antibodies)) gene expression in HepG2 cells
Studies show NRF2 (show GABPA Antibodies) as an important player in the cellular antioxidant response and other functions in a cell-type specific manner. Its expression is under the control of microRNA. [review]
Studies demonstrate that Keap1 (show KEAP1 Antibodies)-Nrf2 (show GABPA Antibodies) pathway is important to orchestrate an elaborate genetic program that enhances the intrinsic cytoprotective functions, including drug metabolizing, antioxidant and antiinflammatory networks. [review]
Studies suggest a functional cross-talk between Nrf2 (show GABPA Antibodies) and NF-kappaB (show NFKB1 Antibodies) pathways. The absence of Nrf2 (show GABPA Antibodies) can exacerbate NF-kappaB (show NFKB1 Antibodies) activity, whereas NF-kappaB (show NFKB1 Antibodies) can modulate Nrf2 (show GABPA Antibodies) transcription and activity, both having effects on the target gene expression. [review]
Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2-mediated control of SLPI (show SLPI Antibodies) and syndecan 4 (show SDC4 Antibodies).
loss of Nrf2 or NF-kappaB (show NFKB1 Antibodies)/RelA (show NFkBP65 Antibodies) altered the expression of different genes, and the combination of these alterations likely affects liver homeostasis in the double mutant mice
Left ventricular diastolic dysfunction in Nrf2 knock out mice is associated with cardiac hypertrophy, decreased expression of SERCA2a (show ATP2A2 Antibodies), and preserved endothelial function.
Protection against acetaminophen-induced acute liver failure by omentum adipose tissue derived stem cells through the mediation of Nrf2 and cytochrome P450 (show CYP Antibodies) expression.
These results indicated that the Nrf2-ARE system exhibited a protective role in Pb-induced neurotoxicity, providing potential therapeutic strategies for the prevention and treatment of Pb-related diseases.
These results indicate that sargaquinoic acid(SQA) inhibits the lipopolysaccharide-induced expression of inflammatory mediators as well as up-regulation of the Nrf2/HO-1 (show HMOX1 Antibodies) pathway.
Nrf2-/- mice have accelerated ovarian aging and increased sensitivity to the ovarian toxicity of benzo[a]pyrene.
Nrf2 expression increases in the lung and BALF of ALI mice, suggesting that Nrf2 is involved in the inflammation during acute lung injury
The Interplay Between Peroxiredoxin-2 (show PRDX2 Antibodies) and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in beta-Thalassemic Erythropoiesis
load of mice to +9 Gz hypergravity causes AMPKalpha (show GRK4 Antibodies) repression with liver injury, which may be overcome by multiple loads to hypergravity as mediated by Nrf2
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
, nuclear factor (erythroid-derived 2)-like 2
, nuclear factor erythroid 2-related factor 2
, NF-E2-related factor 2
, NFE2-related factor 2
, nuclear factor, erythroid derived 2, like 2
, nuclear factor erythroid-derived 2-like 2
, nuclear factor erythroid 2-like 2