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PAK6 encodes a member of the p21-activated kinase (PAK) family. Additionally we are shipping P21-Activated Kinase 6 Proteins (6) and many more products for this protein.
Showing 10 out of 154 products:
Human Polyclonal PAK6 Primary Antibody for EIA, IF - ABIN953980
Lee, Mcclelland, Wang, Long, Choi, Lee: Distinct DNA methylation profiles between adenocarcinoma and squamous cell carcinoma of human uterine cervix. in Oncology research 2010
Show all 5 references for ABIN953980
Human Polyclonal PAK6 Primary Antibody for EIA, IP - ABIN360326
Ching, Leong, Wong, Kung: Identification of an autoinhibitory domain of p21-activated protein kinase 5. in The Journal of biological chemistry 2003
Show all 3 references for ABIN360326
Human Polyclonal PAK6 Primary Antibody for WB - ABIN392439
Pandey, Dan, Kristiansen, Watanabe, Voldby, Kajikawa, Khosravi-Far, Blagoev, Mann: Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain. in Oncogene 2002
Show all 3 references for ABIN392439
Human Polyclonal PAK6 Primary Antibody for IF, IHC (p) - ABIN656098
Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: A Large-scale genetic association study of esophageal adenocarcinoma risk. in Carcinogenesis 2010
Human Polyclonal PAK6 Primary Antibody for EIA, IHC (p) - ABIN500445
Jaffer, Chernoff: p21-activated kinases: three more join the Pak. in The international journal of biochemistry & cell biology 2002
p21-activated kinase 6 (PAK6) as a novel interactor of leucine-rich repeat kinase 2 (LRRK2 (show LRRK2 Antibodies)), a kinase involved in Parkinson's disease
PAK6 is directly targeted by miR (show MLXIP Antibodies)-328. miR (show MLXIP Antibodies)-328 inhibits cell growth and promotes cell apoptosis in prostate cancer cells.
negative correlation between PAK6 and EZH2 (show EZH2 Antibodies) expression was observed in hepatoma tissues from HCC (show FAM126A Antibodies) patients. These data identified the tumor suppressive role and potential underlying mechanism of PAK6 in hepatocarcinogenesis
the results of the present study suggested that miR (show MLXIP Antibodies)-429 inhibits the migration and invasion of colon cancer cells, partly at least, by mediating the expression of PAK6, as well as the activity of cofilin (show CFL1 Antibodies) signaling
we report that in colon cancer PAK6 promotes tumor progression and chemoresistance both in vitro and in vivo
PAK6 is specifically required for carcinoma cell-cell dissociation downstream of hepatocyte growth factor (HGF (show HGF Antibodies)) for both DU145 prostate cancer and HT29 colon cancer cells.
PAK5 plays an essential role in the initiation and progression of hepatocellular carcinoma.
These results demonstrate that androgen-stimulated PAK6 activation is mediated through a direct interaction between AR and PAK6 and PAK6 activation promotes prostate cancer cells motility and invasion.
PAK6 is overexpressed in hepatocellular carcinoma, compared with the adjacent noncancerous liver tissues, and is associated with poor prognosis.
PAK6 phosphorylates Mdm2 on Thr-158 and Ser-186, which is critical for AR ubiquitin-mediated degradation.
data suggest that PAK-6 p21 (show D4S234E Antibodies)-activated kinase plays a role in weight gain unrelated to exercise and caloric intake
functional deficits in PAK5 (show PAK7 Antibodies), PAK6 and PAK5/PAK6 knockout mice
Our results indicate that Pak5 (show PAK7 Antibodies) and Pak6 together are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory.
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants.
p21 protein (Cdc42/Rac)-activated kinase 6
, p21-activated kinase 6
, serine/threonine-protein kinase PAK 6
, p21(CDKN1A)-activated kinase 6
, p21 (CDKN1A)-activated kinase 6