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PLAU encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. Additionally we are shipping PLAU Kits (99) and PLAU Proteins (56) and many more products for this protein.
Showing 10 out of 334 products:
Human Polyclonal PLAU Primary Antibody for EIA, IHC (p) - ABIN360681
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002
Show all 5 references for ABIN360681
Human Polyclonal PLAU Primary Antibody for IHC (p), ELISA - ABIN360680
Sperl, Jacob, Arroyo de Prada, Stürzebecher, Wilhelm, Bode, Magdolen, Huber, Moroder: (4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase. in Proceedings of the National Academy of Sciences of the United States of America 2000
Show all 5 references for ABIN360680
Human Monoclonal PLAU Primary Antibody for DB, EIA - ABIN1109451
Bashkov, Stepanova, Domogatsky: Collagen-targeted antibodies inhibit platelet-dependent thrombosis in vivo. in Thrombosis research 1994
Show all 2 references for ABIN1109451
Human Monoclonal PLAU Primary Antibody for ELISA (Capture), EIA - ABIN112281
Plas, Carroll, Jilch, Mihaly, Vesely, Ulrich, Pflüger, Binder: Analysis of fibrinolytic proteins in relation to DNA ploidy in prostate cancer. in International journal of cancer. Journal international du cancer 1998
Human Polyclonal PLAU Primary Antibody for ELISA, WB - ABIN185470
Morgan, Hill: Human breast cancer cell-mediated bone collagen degradation requires plasminogen activation and matrix metalloproteinase activity. in Cancer cell international 2005
Data suggest that enhanced levels of uPA (show PRAP1 Antibodies) in breast cancer modulate the mitogenic effects of EGF (show EGF Antibodies) which helps to better understand breast cancer pathogenesis.
Results found high levels of uPA (show PRAP1 Antibodies) and uPAR (show PLAUR Antibodies) exclusively in metastatic osteosarcoma (OS)cells and suggest that malignant conversion of OS cells to uPA (show PRAP1 Antibodies)/uPAR (show PLAUR Antibodies) axis in an autocrine and paracrine fashion.
The morphologically normal tissue adjacent to the tumor shows the substantial expression of MMP-2 (show MMP2 Antibodies) and MMP-9 (show MMP9 Antibodies) and in some cases the enhanced activity of uPA (show PRAP1 Antibodies) and ACE (show ACE Antibodies), which makes an additional contribution to the increased invasive potential of tumor
Crystal structure of uPA (show PRAP1 Antibodies) bound with cyclic peptidic inhibitors.
data on the stromal macrophages immunoreactivity of uPAR (show PLAUR Antibodies), MMP-2 (show MMP2 Antibodies), and MMP-9 (show MMP9 Antibodies) in a few small cell lung cancer (SCLC) and lung squamous cell carcinoma (SCC (show CYP11A1 Antibodies)) biopsies was included. uPAR (show PLAUR Antibodies), MMP-2 (show MMP2 Antibodies), and MMP-9 (show MMP9 Antibodies) were confirmed in stromal cells including macrophages
u-PA is a dysregulated gene involved in the tumorigenesis, bio-pathological features and outcomes of EEC.
High cytoplasmic expression of uPA (show PRAP1 Antibodies) is associated with cells of rectal cancer and metastases of perienteric lymph nodes.
DIM can influence the cell migratory and invasive properties of human colorectal cancer cells and may decrease the invasive capacity of colorectal cancer through downregulation of uPA (show PRAP1 Antibodies) and MMP9 (show MMP9 Antibodies) mediated by suppression of the transcription factor FOXM1 (show FOXM1 Antibodies)
Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage uPA (show PRAP1 Antibodies).
Taking uPA (show PRAP1 Antibodies)(1-43) amino acids specifically binding to uPAR (show PLAUR Antibodies) as targeted part of fusion protein, and making use of antitumor activity of melittin, the recombinant fusion protein it (show KRT20 Antibodies) was able to inhibit growth of ovarian tumors .
GM-CSF (show CSF2 Antibodies) and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.
Plau deficiency does not worsen controlled cortical impact-induced brain pathology or epileptogenesis caused by TBI.
we have firstly shown a fundamental mechanism of urokinase system(uPa and uPAR (show PLAUR Antibodies))-dependent regulation of the trajectory of growth and branching of blood vessels in early embryogenesis and in adults during the repair/regeneration of tissues.
Pharmacological inhibition of either uPA or selected MMPs decreased atherosclerosis in transgenic uPA mice.
Study shows that the competitive expression or activity of tPA (show PLAT Antibodies) and/or PAI-1 (show SERPINE1 Antibodies), rather than an altered uPA expression, determines the plasmin (show PLG Antibodies)-mediated Abeta (show APP Antibodies) proteolysis in brains affected by Alzheimer's disease
Porphyromonas gingivalis-derived RgpA-Kgp complex activates the macrophage uPA.
beta-elemene downregulates expression of uPA, uPAR (show PLAUR Antibodies), MMP-2 (show MMP2 Antibodies), and MMP-9 (show MMP9 Antibodies) in a murine intraocular melanoma model
Data indicate that closed head trauma sequentially releases tissue-type plasminogen activator (tPA (show PLAT Antibodies)) followed by delayed synthesis and release of urokinase plasminogen (show PLG Antibodies) activator (uPA) from injured brain.
Binding of urokinase to urokinase plasminogen activator receptor (show PLAUR Antibodies) promotes dendritic spine recovery and functional outcome after ischemic stroke.
Protein kinase C-delta (show PKCd Antibodies) mediates sepsis-induced activation of complement 5a and urokinase-type plasminogen activator signaling in macrophages
uPA-mediated arterial constriction is a vasomotor process that is mediated by uPA catalytic activity, not by the NH(2)-terminal domains.
uPA/uPAR (show PLAUR Antibodies) binding is involved in signaling pathways that activate transcription factors that regulate the synthesis of molecules concerned with the arrangement of a particular oviductal microenvironment.
These data indicated that E. coli LPS (show IRF6 Antibodies) led to an increase in u-PA activity and RNA expression of u-PA and u-PAR (show PLAUR Antibodies) in BME-UV1 cells, thus strengthening the role of the PA system during pathological processes.
The plasminogen/plasminogen (show PLG Antibodies) activator/plasmin (show PLG Antibodies) system is activated during gamete interaction and regulates the sperm entry into the oocyte.
stage-dependent regulation of granulosa cell PA and SerpinE2 (show SERPINE2 Antibodies) production, consistent with a role in extracellular matrix remodeling during follicle growth.
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
urokinase-type plasminogen activator
, U-plasminogen activator
, plasminogen activator, urokinase
, plasminogen activator, urinary
, Urinary plasminogen activator, urokinase
, urokinase plasminogen activator preproprotein