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Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. Additionally we are shipping and many more products for this protein.
Showing 10 out of 37 products:
Human Polyclonal POLQ Primary Antibody for ICC, IF - ABIN450054
Kawamura, Bahar, Seimiya, Chiyo, Wada, Okada, Hatano, Tokuhisa, Kimura, Watanabe, Honda, Sakiyama, Tagawa, O-Wang: DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers. in International journal of cancer 2004
Use fluorescence resonance energy transfer to monitor assembly of the human replicative polymerase holoenzyme.
These results suggest that variants in the POLQ gene may be associated with the risk of Luminal breast cancer
A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients.
Polymerase theta; uses a specialized thumb subdomain to establish unique upstream contacts to the primer DNA strand.
depletion of Poltheta; has a synergistic effect on cell survival in the absence of BRCA genes, suggesting that the inhibition of this mutagenic polymerase (show RAD51 Antibodies) represents a valid therapeutic avenue for tumours carrying mutations in homology-directed repair genes
results reveal a synthetic lethal relationship between the homol (show FANCD2 Antibodies)ogous-recombination pathway and Poltheta;-mediated repair in epithelial ovarian cancers, and identify Poltheta; as a novel druggable target for cancer therapy
A role for DNA polymerase theta; in promoting replication through oxidative DNA lesion, thymine glycol, in human cells.
POLQ possesses a DNA polymerase (show POLB Antibodies) activity that appears to be template independent and allows efficient extension of single-stranded DNA as well as duplex DNA with either protruding or multiply mismatched 3'-OH termini.
Data show that POLQ overexpression may be a promising genetic instability and prognostic marker for breast cancer.
DNA polymerase theta purified from human cells is a high-fidelity enzyme.
Here, the authors discover that mammalian Poltheta; transfers nucleotides to the 3' terminus of DNA during alt (show ALT Antibodies)-EJ in vitro and in vivo by oscillating between three different modes of terminal transferase (show DNTT Antibodies) activity: non-templated extension, templated extension in cis (show CISH Antibodies), and templated extension in trans.
DNA polymerase theta mediates end joining repair of chromosome breaks and helps to sustain cell viability and genome stability by rescuing chromosome break repair when resection is misregulated or NHEJ is compromised.
A role for POLQ in an alternative end joining pathway that suppresses the formation of chromosomal translocations.
loss of Polq in mice results in increased rates of homology-directed repair, evident by recombination of dysfunctional telomeres and accumulation of RAD51 (show RAD51 Antibodies) at double-stranded breaks
genetic inactivation of an homologous-recombination gene (Fancd2 (show FANCD2 Antibodies)) and Polq in mice results in embryonic lethality
the polymerase and other functional domains of POLQ both play important roles in tolerance to etoposide and gamma-irradiation.
DNA Pol theta has a specialized function in lymphocytes and in tumor progression
Polq has a role in maintaining genomic integrity, which is probably distinctive from the major homologous recombination pathway regulated by ATM (show ATM Antibodies)
Polq-inactive mice exhibited a reduced level of serum IgM and IgG1.
dominant role in Ig somatic hypermutation possibly by introducing mismatches while bypassing abasic sites generated by UDG (show UNG Antibodies)-mediated deglycosylation of AID-effected dU, by extending DNA past such abasic sites & by synthesizing DNA during mismatch repair
Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.
polymerase (DNA directed), theta
, DNA polymerase theta
, DNA polymerase eta