anti-Polymerase (DNA Directed), theta (POLQ) Antibodies

Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
POLQ 10721 O75417
POLQ 77782  
POLQ 288079  
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Top anti-POLQ Antibodies at

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using DNA Polymerase thet Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Cow Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
Human Goat Un-conjugated ICC, IF, ELISA   0.1 mg Log in to see 7 to 9 Days
Human Goat Un-conjugated ELISA   0.1 mg Log in to see 2 to 3 Days
Human Goat Un-conjugated ELISA   100 μg Log in to see 7 to 9 Days
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged POLQ is approximately 1ng/ml as a capture antibody. Western Blot detection against Immunogen (37.73 KDa) . 100 μg Log in to see 11 to 12 Days
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
Human Rabbit Un-conjugated ELISA, IHC   100 μL Log in to see 7 to 9 Days
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 3 to 7 Days
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 3 to 7 Days

POLQ Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , , , ,
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Mouse (Murine) , ,

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Rat (Rattus) , ,

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Top referenced anti-POLQ Antibodies

  1. Human Polyclonal POLQ Primary Antibody for ICC, IF - ABIN450054 : Kawamura, Bahar, Seimiya, Chiyo, Wada, Okada, Hatano, Tokuhisa, Kimura, Watanabe, Honda, Sakiyama, Tagawa, O-Wang: DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers. in International journal of cancer 2004 (PubMed)

More Antibodies against POLQ Interaction Partners

Human Polymerase (DNA Directed), theta (POLQ) interaction partners

  1. Use fluorescence resonance energy transfer to monitor assembly of the human replicative polymerase holoenzyme.

  2. These results suggest that variants in the POLQ gene may be associated with the risk of Luminal breast cancer

  3. A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients.

  4. Polymerase theta; uses a specialized thumb subdomain to establish unique upstream contacts to the primer DNA strand.

  5. depletion of Poltheta; has a synergistic effect on cell survival in the absence of BRCA genes, suggesting that the inhibition of this mutagenic polymerase (show RAD51 Antibodies) represents a valid therapeutic avenue for tumours carrying mutations in homology-directed repair genes

  6. results reveal a synthetic lethal relationship between the homol (show FANCD2 Antibodies)ogous-recombination pathway and Poltheta;-mediated repair in epithelial ovarian cancers, and identify Poltheta; as a novel druggable target for cancer therapy

  7. A role for DNA polymerase theta; in promoting replication through oxidative DNA lesion, thymine glycol, in human cells.

  8. POLQ possesses a DNA polymerase (show POLB Antibodies) activity that appears to be template independent and allows efficient extension of single-stranded DNA as well as duplex DNA with either protruding or multiply mismatched 3'-OH termini.

  9. Data show that POLQ overexpression may be a promising genetic instability and prognostic marker for breast cancer.

  10. DNA polymerase theta purified from human cells is a high-fidelity enzyme.

Mouse (Murine) Polymerase (DNA Directed), theta (POLQ) interaction partners

  1. Here, the authors discover that mammalian Poltheta; transfers nucleotides to the 3' terminus of DNA during alt (show ALT Antibodies)-EJ in vitro and in vivo by oscillating between three different modes of terminal transferase (show DNTT Antibodies) activity: non-templated extension, templated extension in cis (show CISH Antibodies), and templated extension in trans.

  2. DNA polymerase theta mediates end joining repair of chromosome breaks and helps to sustain cell viability and genome stability by rescuing chromosome break repair when resection is misregulated or NHEJ is compromised.

  3. A role for POLQ in an alternative end joining pathway that suppresses the formation of chromosomal translocations.

  4. loss of Polq in mice results in increased rates of homology-directed repair, evident by recombination of dysfunctional telomeres and accumulation of RAD51 (show RAD51 Antibodies) at double-stranded breaks

  5. genetic inactivation of an homologous-recombination gene (Fancd2 (show FANCD2 Antibodies)) and Polq in mice results in embryonic lethality

  6. the polymerase and other functional domains of POLQ both play important roles in tolerance to etoposide and gamma-irradiation.

  7. DNA Pol theta has a specialized function in lymphocytes and in tumor progression

  8. Polq has a role in maintaining genomic integrity, which is probably distinctive from the major homologous recombination pathway regulated by ATM (show ATM Antibodies)

  9. Polq-inactive mice exhibited a reduced level of serum IgM and IgG1.

  10. dominant role in Ig somatic hypermutation possibly by introducing mismatches while bypassing abasic sites generated by UDG (show UNG Antibodies)-mediated deglycosylation of AID-effected dU, by extending DNA past such abasic sites & by synthesizing DNA during mismatch repair

POLQ Antigen Profile

Protein Summary

Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.

Gene names and symbols associated with POLQ

  • polymerase (DNA directed), theta (POLQ) antibody
  • polymerase (DNA directed), theta (polq) antibody
  • polymerase (DNA directed), theta (Polq) antibody
  • A430110D14Rik antibody
  • POLH antibody
  • PRO0327 antibody

Protein level used designations for POLQ

polymerase (DNA directed), theta , DNA polymerase theta , DNA polymerase eta

535323 Bos taurus
418326 Gallus gallus
460619 Pan troglodytes
488003 Canis lupus familiaris
713828 Macaca mulatta
733897 Xenopus (Silurana) tropicalis
100092568 Ornithorhynchus anatinus
100179525 Ciona intestinalis
100221673 Taeniopygia guttata
100341958 Oryctolagus cuniculus
100060882 Equus caballus
100566188 Anolis carolinensis
100600241 Nomascus leucogenys
10721 Homo sapiens
77782 Mus musculus
288079 Rattus norvegicus
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