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May have a role in the regulation of spermatogenesis.. Additionally we are shipping PD-1 Antibodies (662) and PD-1 Proteins (93) and many more products for this protein.
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Human PD-1 ELISA Kit for Sandwich ELISA - ABIN2703394
Yanaba, Hayashi, Yoshihara, Nakagawa: Serum levels of soluble programmed death-1 and programmed death ligand-1 in systemic sclerosis: Association with extent of skin sclerosis. in The Journal of dermatology 2016
Pre-menopausal FRT tissues showed increased PD-L1 (show CD274 ELISA Kits) expression on CD8 (show CD8A ELISA Kits)(+) T cells, but decreased expression on DCs when compared to post-menopausal women. In vitro estradiol treatment up-regulated PD-L1 (show CD274 ELISA Kits) expression specifically on CD8 (show CD8A ELISA Kits)(+) T cells from endocervix, but had no effect on PD-1/PD-L1 (show CD274 ELISA Kits) expression on the other cell types.
Data show that both CD4 (show CD4 ELISA Kits)+PD-1+ and CD8 (show CD8A ELISA Kits)+PD-1+ tumor-infiltrating lymphocytes (TIL (show TLR1 ELISA Kits)) are functionally anergic in the setting of PD-L1 (show CD274 ELISA Kits) expression.
The substantially high expression of PD-L1 (show CD274 ELISA Kits) and the increase in PD-L1 (show CD274 ELISA Kits) and PD-1 expression after chemotherapy supports anti-PD-1/L1 drugs therapy for TM and TC as well as the development of a strategy for its sequential use after chemotherapy.
PD-1 was up-regulated in T cells in AA patients compared with healthy volunteers. The NF-kappaB (show NFKB1 ELISA Kits) pathway participated in the process of apoptosis of CD4 (show CD4 ELISA Kits)+CD25 (show IL2RA ELISA Kits)+FOXP3 (show FOXP3 ELISA Kits)+ T cells and BMHSCs induced by PD-1 in AA patients.
CD38, BCL-2 (show BCL2 ELISA Kits), PD-1, and PD-1L expression in nodal peripheral T-cell lymphoma
Immune checkpoint blockade with agents targeting the PD-1/PD-L1 (show CD274 ELISA Kits) pathway has shown antitumor activity in two clinical trials for advanced Merkel cell carcinoma. There is also promise for immune checkpoint blockade in combination with radiotherapy and other treatments for advanced Merkel cell carcinoma
review PD-L1 (show CD274 ELISA Kits) expression, PD-L1 (show CD274 ELISA Kits)-mediated immunosuppressive mechanisms, and the clinical applications of PD-1/PD-L1 (show CD274 ELISA Kits) inhibitors in gliomas.
High PD1 expression is associated with Malignant Pleural Mesothelioma.
Programmed death 1 is highly expressed on CD8 (show CD8A ELISA Kits)(+) CD57 (show B3GAT1 ELISA Kits)(+) T cells in patients with stable multiple sclerosis and inhibits their cytotoxic response to Epstein-Barr virus
Blocking PD-1/PD-L1 (show CD274 ELISA Kits) signaling markedly enhances cytokines production and degranulation and suppresses apoptosis of NK cells in vitro. PD-1/PD-L1 (show CD274 ELISA Kits) exerts inhibitory effect through repressing the activation of PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling in NK cells.
PD-1 plays a vital role in brain inflammation via regulation of Fgl-2 (show FGL2 ELISA Kits) after ICH (show ACE ELISA Kits), and that manipulation of PD-1 might be a promising therapeutical target in ICH (show ACE ELISA Kits).
We identified PD-1 to be specifically expressed in PLZF(+) ILCp and revealed that the timing and order of expression of the transcription factors NFIL3 (show NFIL3 ELISA Kits), ID2, and TCF-1 (show HNF1A ELISA Kits) was critical. Importantly, induction of ILC (show CCL27 ELISA Kits) lineage commitment required only transient expression of NFIL3 (show NFIL3 ELISA Kits) prior to ID2 and TCF-1 (show HNF1A ELISA Kits) expression.
The identification of the role for PD-1 in regulating B cell-dependent antitumor immunity to Tn antigen highlights an opportunity to develop new therapeutic strategies targeting tumor-associated carbohydrate antigens
These findings suggest that PD-1 pathway blockade may reverse adaptive immune resistance following cyclic dinucleotide treatment, enhancing both local and systemic antitumor immunity.
data suggest that increased expression of checkpoint blockade molecules PD-1 and CTLA-4 (show CTLA4 ELISA Kits) on donor T cells is not sufficient to prevent GvHD, and that cooperation between checkpoint blockade signaling by host cells and donor Tregs is necessary to limit GvHD in allo-HSCT recipients
PD-1 Blockade Promotes Epitope Spreading in Anticancer CD8 (show CD8A ELISA Kits)(+) T Cell Responses by Preventing Fratricidal Death of Subdominant Clones To Relieve Immunodomination
Adoptive transfer of murine T cells expressing a chimeric-PD1-Dap10 (show HCST ELISA Kits) receptor may induce a preferential cytokine profile and T-cell differentiation phenotype for anti-lymphoma therapies.
soluble PD-1 is elevated in critical illness and may represent a potential biomarker for Acute respiratory distress syndrome.
Together, our results suggest an important role of PD-1 in glioma-induced immune escape, and provide translational evidence for the use of PD-1 blocking antibodies in human malignant gliomas.
study found that Bcl6 positively regulates PD-1 expression by inhibiting the ability of T-bet/Tbx21 to repress Pdcd1 transcription.
Data show that CTLA-4 (show CTLA4 ELISA Kits)(+)PD-1(-) memory CD4 (show CD4 ELISA Kits)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (show GUSB ELISA Kits), and contained replication-competent and infectious virus.
Compared to before immunosuppression, PD-1 expression increased at reactivation. Increased T cells before zoster is likely due to virus reactivation.
A PD-1(high) phenotype is associated with accelerated in vivo CD8 (show CD8A ELISA Kits) T cell turnover in SIV-infections, especially within the SIV-specific CD8 (show CD8A ELISA Kits) T cell pool.
High levels of PD-1 expression on CD4 (show CD4 ELISA Kits)(+) T cells in lymph nodes of rhesus macaques can serve as a valuable marker to identify T follicular helper cells.
Data indicate that PD-1 expression is increased as a result of T cell activation during a primary immune response as well as during persistent immune activation in macaques.
PD-1 can serve as a sensitive indicator of persistent, low-level virus replication
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
programmed cell death protein 1
, protein PD-1
, programmed cell death 1
, programmed death 1