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The protein encoded by RAB8A is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. Additionally we are shipping RAB8A Proteins (14) and RAB8A Kits (7) and many more products for this protein.
Showing 10 out of 84 products:
Dog (Canine) Monoclonal RAB8A Primary Antibody for IF, IP - ABIN968210
Bahadoran, Aberdam, Mantoux, Buscà, Bille, Yalman, de Saint-Basile, Casaroli-Marano, Ortonne, Ballotti: Rab27a: A key to melanosome transport in human melanocytes. in The Journal of cell biology 2001
Show all 5 references for ABIN968210
Human Polyclonal RAB8A Primary Antibody for FACS, IHC (p) - ABIN1881723
Kato, Sekine, Oh, Kim, Umezawa, Abe, Yokoyama-Kobayashi, Aoki: Construction of a human full-length cDNA bank. in Gene 1995
Show all 2 references for ABIN1881723
Cow (Bovine) Polyclonal RAB8A Primary Antibody for ELISA, WB - ABIN374945
Yoshimura, Egerer, Fuchs, Haas, Barr: Functional dissection of Rab GTPases involved in primary cilium formation. in The Journal of cell biology 2007
Chicken Polyclonal RAB8A Primary Antibody for WB - ABIN2792290
Roland, Kenworthy, Peranen, Caplan, Goldenring: Myosin Vb interacts with Rab8a on a tubular network containing EHD1 and EHD3. in Molecular biology of the cell 2007
Rab8 can induce Rac1- and Tiam1 (show TIAM1 Antibodies)-dependent cortical actin polymerization and focal adhesion disassembly through the proteases MT1-MMP (show MMP14 Antibodies) and calpain, and Rho-GTPase (show RACGAP1 Antibodies)-dependent mechanisms
Data demonstrate that EHBP1L1 links Rab8 and the Bin1 (show BIN1 Antibodies)-dynamin (show DNM1 Antibodies) complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport.
Further exploration of the NINL (show NINL Antibodies)-associated interactome identifies MICAL3, a protein known to interact with Rab8 and to play an important role in vesicle docking and fusion.
The small GTPase (show RACGAP1 Antibodies) Rab8 interacts with VAMP-3 (show VAMP3 Antibodies) to regulate the delivery of recycling T-cell receptors to the immune synapse.
the role of Rabin8 (show RAB3IP Antibodies) (a mammalian ortholog of Sec2p) with Rab8-nucleotide-exchange factor activity in autophagy in mammalian cells, was examined.
DLC3 (show STARD8 Antibodies) is recruited to Rab8-positive membrane tubules and is required for the integrity of the Rab8 and Golgi compartments.
Rab8A GTPase (show RACGAP1 Antibodies) Ser (show SIGLEC1 Antibodies)(111) phosphorylation is not directly regulated by PINK1 (show PINK1 Antibodies) in vitro and demonstrate in cells the time course of Ser (show SIGLEC1 Antibodies)(111) phosphorylation of Rab8A, 8B and 13 is markedly delayed compared to phosphorylation of Parkin (show PARK2 Antibodies) at Ser (show SIGLEC1 Antibodies)(65).
Intercellular transfer of transferrin receptor by a contact-, Rab8-dependent mechanism involving tunneling nanotubes.
High expression of RAB8A is associated with endometrial cancer.
Study established a direct interaction between alpha-synclein and Rab8a and provided unique insights into the molecular mechanisms of alpha-synclein toxicity
Cc2d2a (show CC2D2A Antibodies), localized at the photoreceptor connecting cilium/transition zone, facilitates protein transport through a role in Rab8-dependent vesicle trafficking and fusion.
Data show that elipsa (show TRAF3IP1 Antibodies) encodes a coiled-coil polypeptide that localizes to cilia, and that it interacts genetically with Rabaptin5, a well-studied regulator of endocytosis, which in turn interacts with Rab8, a small GTPase (show RACGAP1 Antibodies), known to localize to cilia.
Results highlight a novel role of Rab8, downstream of IFT20, in the pathway that regulates T cell receptor (TCR) recycling, through recruiting VAMP-3 and promoting the fusion with the synaptic membrane of endosomes carrying TCR cargoes.
Rab8a thus controls Wnt (show WNT2 Antibodies) delivery in producing cells and is crucial for Paneth cell maturation.
Rab8a acts as an activator of Fsp27 (show CIDEC Antibodies)-mediated LD fusion and growth.
Simultaneous loss of Rab8a and Rab8b (show RAB8B Antibodies) has little effect on ciliogenesis, whereas additional loss of Rab10 (show RAB10 Antibodies) greatly affects ciliogenesis.
acidosis-induced NBCe1 (show SLC4A4 Antibodies)-A, but not NBCe1 (show SLC4A4 Antibodies)-B/C, trafficking is mediated by Rab8a.
AS160 (show TBC1D4 Antibodies) and Rab8a regulate membrane recruitment of CD36 (show CD36 Antibodies).
Cdc42 (show CDC42 Antibodies) and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice
Rab8a colocalizes with IL-1b (show IL1B Antibodies) and LC3 (show MAP1LC3A Antibodies) and controls IL-1b (show IL1B Antibodies) secretion
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.
, hematopoietic SH2 domain containing
, ras-related protein Rab-8A
, RAB8A, member RAS oncogene family
, member RAS oncogene family
, Ras-related protein Rab-8A
, mel transforming oncogene (RAB8 homolog)
, mel transforming oncogene (derived from cell line NK14)
, mel transforming oncogene (derived from cell line NK14)- RAB8 homolog
, oncogene c-mel
, ras-associated protein RAB8
, RAB8, member RAS oncogene family
, cell line NK14 derived transforming oncogene