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The protein encoded by RAD18 is highly similar to S. Additionally we are shipping RAD18 Proteins (6) and RAD18 Kits (1) and many more products for this protein.
Showing 10 out of 94 products:
Human Monoclonal RAD18 Primary Antibody for IF, IHC (p) - ABIN566046
Hicks, Chute, Paulsen, Ragland, Howlett, Guéranger, Glover, Canman: Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links. in Molecular and cellular biology 2010
Show all 7 references for ABIN566046
Human Monoclonal RAD18 Primary Antibody for WB - ABIN393575
Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: A Large-scale genetic association study of esophageal adenocarcinoma risk. in Carcinogenesis 2010
Show all 5 references for ABIN393575
Human Monoclonal RAD18 Primary Antibody for IF, WB - ABIN393742
Yang, Moldovan, DAndrea: RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger. in The Journal of biological chemistry 2010
Show all 5 references for ABIN393742
Mouse (Murine) Polyclonal RAD18 Primary Antibody for IF, IP - ABIN2452085
Sun, Yomogida, Sakao, Yamamoto, Yoshida, Watanabe, Morita, Araki, Yamamura, Tateishi: Rad18 is required for long-term maintenance of spermatogenesis in mouse testes. in Mechanisms of development 2009
Show all 4 references for ABIN2452085
Human Polyclonal RAD18 Primary Antibody for IF, IP - ABIN2452086
Tateishi, Sakuraba, Masuyama, Inoue, Yamaizumi: Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. in Proceedings of the National Academy of Sciences of the United States of America 2000
Show all 3 references for ABIN2452086
Human Polyclonal RAD18 Primary Antibody for ELISA, WB - ABIN1451241
Zody, Garber, Sharpe, Young, Rowen, ONeill, Whittaker, Kamal, Chang, Cuomo, Dewar, FitzGerald, Kodira, Madan, Qin, Yang, Abbasi, Abouelleil, Arachchi, Baradarani, Birditt, Bloom, Bloom, Borowsky et al.: Analysis of the DNA sequence and duplication history of human chromosome 15. ... in Nature 2006
Chicken Polyclonal RAD18 Primary Antibody for WB - ABIN2774765
Tsuji, Watanabe, Araki, Shinohara, Yamagata, Tsurimoto, Hanaoka, Yamamura, Yamaizumi, Tateishi: Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. in Genes to cells : devoted to molecular & cellular mechanisms 2008
USP7 (show USP7 Antibodies)-mediated de-ubiquitylation protects Rad18 from proteasomal degradation and is necessary for the integrity of the specialized translesion synthesis pathway
RAD18 can function as a mediator for DNA damage response signals to activate the G2/M checkpoint in order to maintain genome integrity and cell survival after IR exposure.
Significantly restored tolerance of RAD18-/- and RNF8 (show RNF8 Antibodies)-/- cells to camptothecin and olaparib without affecting Rad51 (show RAD51 Antibodies) focus formation.
these results suggest that miR (show MLXIP Antibodies)-145 can act as an RAD18 inhibitor and contribute as an important factor in reversing drug resistance after chemotherapy.
We obtained a molecular envelope for Rad18 UBZ-ELRM:linear Ub2 polyubiquitin (show UBB Antibodies) chains by small-angle X-ray scattering and derived a structural model for the complex.
Rad18 protein ubiquitin-binding zinc fingers domain has alpha-helix and strand beta1 conformation.
Monoubiquitination has a role in controlling Rad18 function.
The Rad6/18 ubiquitin complex interacts with the Epstein-Barr virus deubiquitinating enzyme, BPLF1, and contributes to virus infectivity.
HHR6 and hRad18 can monoubiquitinate FANCD2 (show FANCD2 Antibodies) at lysine 561 in vitro. This activity may represent a novel stress response pathway.
Findings indicate that RAD18 may serve as a key mediator of the ionizing radiation (IR)response and may function as a potential target for circumventing IR resistance in glioblastoma multiforme (GBM).
RAD18 contributes to maintenance of genomic stability through postreplication repair
Rad18Sc localizes to the XY body and to other chromosomal regions that are unpaired and transcriptionally silenced during male meiotic prophase
Rad18 suppresses viral infection in a non-specific fashion, probably by targeting incoming DNA.
RAD18 is intrinsically required for the long-term maintenance of spermatogenesis.
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.
E3 ubiquitin-protein ligase RAD18
, RAD18 homolog (S. cerevisiae)
, postreplication repair protein hRAD18p
, similar to postreplication repair protein hRAD18p
, E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair
, hypothetical protein
, DNA repair protein and ATPase
, SAP DNA-binding domain-containing protein
, RAD18 homolog
, E3 ubiquitin-protein ligase RAD18-like
, e3 ubiquitin-protein ligase RAD18-like
, RAD18, S. cerevisiae, homolog
, RING finger protein 73
, postreplication repair protein RAD18
, RAD18-like protein
, post-replication repair protein RAD18SC