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anti-Regulator of Calcineurin 1 (RCAN1) Antibodies

The protein encoded by RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. Additionally we are shipping Regulator of Calcineurin 1 Proteins (17) and Regulator of Calcineurin 1 Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RCAN1 1823 Q08554
RCAN1 54720 Q9JHG6
RCAN1 266766 Q6IN33
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Top anti-Regulator of Calcineurin 1 Antibodies at antibodies-online.com

Showing 10 out of 135 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-RCAN1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB The anti-DSCR1 Pab (ABIN390298) is used in Western blot to detect DSCR... Endothelial cell lysate transferred to membrane was incubated with pri... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB TOP: The anti-DSCR1 Pab is used in Western blot to detect DSCR1 in end... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB TOP: The anti-DSCR1 Pab is used in Western blot to detect DSCR1 in end... 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of Calcipressin-1 Antibody  in 293 cell line lys... Western blot analysis of RCAN1 (arrow) using Calcipressin-1 Antibody .... 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-RCAN1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:... WB Suggested Anti-RCAN1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: ... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-Rcan1 AntibodyTitration: 1.0 µg/mL  Positive Control... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg Log in to see 2 to 3 Days
$275.00
Details
Human Rabbit Un-conjugated WB The anti-DSCR1 Pab (ABIN390297) is used in Western blot to detect DSCR... Endothelial cell lysate transferred to membrane was incubated with pri... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, WB WB Image Sample (30 ug of whole cell lysate) A: Hela 12% SDS PAGE anti... ICC/IF Image Calcipressin 1 antibody detects Calcipressin 1 protein at... 100 μL Log in to see 2 to 3 Days
$358.60
Details

RCAN1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Rat (Rattus) , , , ,
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Top referenced anti-Regulator of Calcineurin 1 Antibodies

  1. Human Polyclonal RCAN1 Primary Antibody for WB - ABIN390298 : Hirakawa, Nary, Medh: Glucocorticoid evoked upregulation of RCAN1-1 in human leukemic CEM cells susceptible to apoptosis. in Journal of molecular signaling 2009 (PubMed)
    Show all 6 references for ABIN390298

  2. Human Polyclonal RCAN1 Primary Antibody for EIA, WB - ABIN358860 : Minami, Horiuchi, Miura, Abid, Takabe, Noguchi, Kohro, Ge, Aburatani, Hamakubo, Kodama, Aird: Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. in The Journal of biological chemistry 2004 (PubMed)
    Show all 3 references for ABIN358860

  3. Chicken Polyclonal RCAN1 Primary Antibody for WB - ABIN2780590 : Riper, Jayakumar, Latchana, Bhoiwala, Mitchell, Valenti, Crawford: Regulation of vascular function by RCAN1 (ADAPT78). in Archives of biochemistry and biophysics 2008 (PubMed)
    Show all 2 references for ABIN2780590

  4. Human Polyclonal RCAN1 Primary Antibody for EIA, WB - ABIN951003 : Tam, van de Lagemaat, Redon, Strathdee, Croning, Malloy, Muir, Pickard, Deary, Blackwood, Carter, Grant: Confirmed rare copy number variants implicate novel genes in schizophrenia. in Biochemical Society transactions 2010 (PubMed)
    Show all 2 references for ABIN951003

  5. Human Polyclonal RCAN1 Primary Antibody for ELISA, WB - ABIN1451085 : Fuentes, Pritchard, Estivill: Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. in Genomics 1997 (PubMed)

  6. Human Polyclonal RCAN1 Primary Antibody for EIA, WB - ABIN358861 : Yang, Chen, Edgar, Li, Molkentin, Berman, Lin: Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function. in The Journal of experimental medicine 2009 (PubMed)

More Antibodies against Regulator of Calcineurin 1 Interaction Partners

Xenopus laevis Regulator of Calcineurin 1 (RCAN1) interaction partners

  1. RCAN1-regulated vascular branching which may play a role in the patterning of morphologically different vasculature.

Human Regulator of Calcineurin 1 (RCAN1) interaction partners

  1. Results support overexpression of RCAN1 and particularly the RCAN1.1S isoform during aging as a pathogenic mechanism in both Down syndrome-related and sporadic Alzheimer's disease

  2. RCAN1 can interact with IkappaBalpha (show NFKBIA Antibodies) and affect the phosphorylation of IkappaBalpha (show NFKBIA Antibodies) at tyrosine 42.

  3. The sequence variations in RCAN1 promoter are not major genetic factors involved in sporadic CHD (show CHDH Antibodies), at least in the current research population.

  4. E4BP4 (show NFIL3 Antibodies) and BIM (show BCL2L11 Antibodies) regulation correlated with that of RCAN1-1. A putative GRE and four EBPREs were identified within 1500bp upstream from the transcription start site of RCAN1-1

  5. Rcan1-1L may play a protective role in Ang II (show AGT Antibodies)-treated cardiomyocytes through the induction of mitochondrial autophagy, and may be an alternative method of cardiac protection.

  6. Results show that Rcan1 isoform 1L (Rcan1-1L) overexpression specifically activates mitophagy and increases cell survival under hypoxic conditions.

  7. Data show that after IL-1beta (show IL1B Antibodies) treatment, the levels of reactive oxygen species and interleukin 8 (IL-8 (show IL8 Antibodies)) mRNA of Down syndrome candidate region-1 (DSCR1)-transfected cells treated without BAPTA was significantly lower than those in pcDNA-transfected cells.

  8. Study showed that RCAN1 further contributes to Alzheimer's disease pathogenesis by increasing N-glycosylation and Abeta (show APP Antibodies) production

  9. These results suggest that USP22 (show USP22 Antibodies) positively regulates RCAN1 levels, which would consequently affect diverse RCAN1-linked cellular processes.

  10. results suggest the presence of a novel phosphorylation site in RCAN1 and that its phosphorylation influences calcineurin (show PPP3CA Antibodies)-dependent inflammatory target gene expression

Mouse (Murine) Regulator of Calcineurin 1 (RCAN1) interaction partners

  1. These results uncover a critical link between calcineurin (show PPP3CA Antibodies) signalling, impaired neurotrophin (show BDNF Antibodies) trafficking and neurodevelopmental deficits in the peripheral nervous system in Down syndrome.

  2. Data suggest that expression of Dscr1 in hippocampus can be regulated by dietary factors; supplementation of maternal diet and offspring diet with fish oil down-regulates Dscr1 in hippocampus of offspring; Dscr1 is a presumed target in Down syndrome.

  3. inhibition of the calcineurin (show PPP3CA Antibodies)-nuclear factor of activated T cells pathway enhances the proliferation of granulocyte-monocyte progenitors both in vitro and in vivo

  4. PACAP (show ADCYAP1 Antibodies) targets RCAN1 to control neuronal differentiation.

  5. We also confirmed that overexpression of RCAN1-1L could inhibit the transcriptional activation of an NFAT (show NFATC1 Antibodies)-dependent promoter in response to PMA and ionomycin by inhibiting Calcineurin (show PPP3CA Antibodies) activity in HEK293T cells

  6. found that RCAN1/3 interact with RAF (show RAF1 Antibodies) kinases and CN in a non-exclusive manner. Our data suggests that the balance of RCAN interactions with CN and/or RAF (show RAF1 Antibodies) kinases may influence T cell positive selection

  7. Calcineurin (show PPP3CA Antibodies) and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion.

  8. Data indicate that neuron from Down syndrome candidate region 1 (DSCR1)-transgenic mice were more resistant than wild-type neurons to apoptotic cell death following 24 h of glucose deprivation.

  9. A major role for haematopoietic Rcan1 in atherosclerosis and suggest that therapies aimed at inhibiting RCAN1 expression or function might significantly reduce atherosclerosis burden.

  10. SCF (show KITLG Antibodies)-mediated activation induced expression of Rcan1 in bone-marrow-derived mast cells. Rcan1 suppresses SCF (show KITLG Antibodies)-induced activation of calcineurin (show PPP3CA Antibodies) & NF-kappaB (show NFKB1 Antibodies), & negatively regulates its own expression via Egr1 (show EGR1 Antibodies).

Regulator of Calcineurin 1 (RCAN1) Antigen Profile

Protein Summary

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.

Gene names and symbols associated with RCAN1

  • regulator of calcineurin 1 (RCAN1) antibody
  • regulator of calcineurin 1b (rcan1b) antibody
  • Down syndrome critical region gene 1 (dscr1) antibody
  • regulator of calcineurin 1 (rcan1) antibody
  • desmocollin 1 (DSC1) antibody
  • DSCR1-like protein (LOC443255) antibody
  • regulator of calcineurin 1 (Rcan1) antibody
  • 2410048A02Rik antibody
  • AA408855 antibody
  • Adapt78 antibody
  • AI429645 antibody
  • AL024459 antibody
  • AV028423 antibody
  • CALP1L antibody
  • CDHF1 antibody
  • CSP1 antibody
  • DG2/DG3 antibody
  • DSC1 antibody
  • Dscr1 antibody
  • Mcip1 antibody
  • MGC53636 antibody
  • MGC69428 antibody
  • rcan1 antibody
  • RCN1 antibody
  • wu:fr92c05 antibody

Protein level used designations for RCAN1

regulator of calcineurin 1 , Down syndrome critical region gene 1 , cadherin family member 1 , desmocollin-1 , desmosomal glycoprotein 2/3 , calcipressin-1 , down syndrome critical region protein 1 , Down syndrome candidate region 1 , calcium and oxidant-inducible mRNA , modulatory calcineurin-interacting protein 1 , myocyte-enriched calcineurin-interacting protein 1 , near DSCR proline-rich protein , Down syndrome critical region homolog 1 , calcineurin inhibitor , calcipressin 1 , down syndrome critical region protein 1 homolog , myocyte-enriched calcineurin interactin protein 1 , Down syndrome critical region protein 1 homolog , Oxidative-induced protein Adapt78

GENE ID SPECIES
697108 Macaca mulatta
336348 Danio rerio
380353 Xenopus laevis
448016 Xenopus (Silurana) tropicalis
1823 Homo sapiens
443255 Ovis aries
1827 Homo sapiens
54720 Mus musculus
379550 Xenopus laevis
418510 Gallus gallus
607887 Canis lupus familiaris
539640 Bos taurus
266766 Rattus norvegicus
100171642 Pongo abelii
100689474 Cricetulus griseus
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