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The protein encoded by RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. Additionally we are shipping Regulator of Calcineurin 1 Proteins (17) and Regulator of Calcineurin 1 Kits (7) and many more products for this protein.
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Human Polyclonal RCAN1 Primary Antibody for WB - ABIN390298
Hirakawa, Nary, Medh: Glucocorticoid evoked upregulation of RCAN1-1 in human leukemic CEM cells susceptible to apoptosis. in Journal of molecular signaling 2009
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Human Polyclonal RCAN1 Primary Antibody for EIA, WB - ABIN358860
Minami, Horiuchi, Miura, Abid, Takabe, Noguchi, Kohro, Ge, Aburatani, Hamakubo, Kodama, Aird: Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. in The Journal of biological chemistry 2004
Show all 3 references for ABIN358860
Chicken Polyclonal RCAN1 Primary Antibody for WB - ABIN2780590
Riper, Jayakumar, Latchana, Bhoiwala, Mitchell, Valenti, Crawford: Regulation of vascular function by RCAN1 (ADAPT78). in Archives of biochemistry and biophysics 2008
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Human Polyclonal RCAN1 Primary Antibody for EIA, WB - ABIN951003
Tam, van de Lagemaat, Redon, Strathdee, Croning, Malloy, Muir, Pickard, Deary, Blackwood, Carter, Grant: Confirmed rare copy number variants implicate novel genes in schizophrenia. in Biochemical Society transactions 2010
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Human Polyclonal RCAN1 Primary Antibody for ELISA, WB - ABIN1451085
Fuentes, Pritchard, Estivill: Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. in Genomics 1997
Human Polyclonal RCAN1 Primary Antibody for EIA, WB - ABIN358861
Yang, Chen, Edgar, Li, Molkentin, Berman, Lin: Rcan1 negatively regulates Fc epsilonRI-mediated signaling and mast cell function. in The Journal of experimental medicine 2009
RCAN1-regulated vascular branching which may play a role in the patterning of morphologically different vasculature.
The objective of this study was aimed to detect the association of Down syndrome critical region 1 (DSCR1) gene polymorphisms (rs149048873 and rs143081213) and congenital heart disease (CHD (show CHDH Antibodies)) susceptibility.
Results support overexpression of RCAN1 and particularly the RCAN1.1S isoform during aging as a pathogenic mechanism in both Down syndrome-related and sporadic Alzheimer's disease
RCAN1 can interact with IkappaBalpha (show NFKBIA Antibodies) and affect the phosphorylation of IkappaBalpha (show NFKBIA Antibodies) at tyrosine 42.
The sequence variations in RCAN1 promoter are not major genetic factors involved in sporadic CHD (show CHDH Antibodies), at least in the current research population.
E4BP4 (show NFIL3 Antibodies) and BIM (show BCL2L11 Antibodies) regulation correlated with that of RCAN1-1. A putative GRE and four EBPREs were identified within 1500bp upstream from the transcription start site of RCAN1-1
Rcan1-1L may play a protective role in Ang II (show AGT Antibodies)-treated cardiomyocytes through the induction of mitochondrial autophagy, and may be an alternative method of cardiac protection.
Results show that Rcan1 isoform 1L (Rcan1-1L) overexpression specifically activates mitophagy and increases cell survival under hypoxic conditions.
Data show that after IL-1beta (show IL1B Antibodies) treatment, the levels of reactive oxygen species and interleukin 8 (IL-8 (show IL8 Antibodies)) mRNA of Down syndrome candidate region-1 (DSCR1)-transfected cells treated without BAPTA was significantly lower than those in pcDNA-transfected cells.
Study showed that RCAN1 further contributes to Alzheimer's disease pathogenesis by increasing N-glycosylation and Abeta (show APP Antibodies) production
These results suggest that USP22 (show USP22 Antibodies) positively regulates RCAN1 levels, which would consequently affect diverse RCAN1-linked cellular processes.
These results uncover a critical link between calcineurin (show PPP3CA Antibodies) signalling, impaired neurotrophin (show BDNF Antibodies) trafficking and neurodevelopmental deficits in the peripheral nervous system in Down syndrome.
Data suggest that expression of Dscr1 in hippocampus can be regulated by dietary factors; supplementation of maternal diet and offspring diet with fish oil down-regulates Dscr1 in hippocampus of offspring; Dscr1 is a presumed target in Down syndrome.
inhibition of the calcineurin (show PPP3CA Antibodies)-nuclear factor of activated T cells pathway enhances the proliferation of granulocyte-monocyte progenitors both in vitro and in vivo
PACAP (show ADCYAP1 Antibodies) targets RCAN1 to control neuronal differentiation.
We also confirmed that overexpression of RCAN1-1L could inhibit the transcriptional activation of an NFAT (show NFATC1 Antibodies)-dependent promoter in response to PMA and ionomycin by inhibiting Calcineurin (show PPP3CA Antibodies) activity in HEK293T cells
found that RCAN1/3 interact with RAF (show RAF1 Antibodies) kinases and CN in a non-exclusive manner. Our data suggests that the balance of RCAN interactions with CN and/or RAF (show RAF1 Antibodies) kinases may influence T cell positive selection
Calcineurin (show PPP3CA Antibodies) and its regulator, RCAN1, confer time-of-day changes in susceptibility of the heart to ischemia/reperfusion.
Data indicate that neuron from Down syndrome candidate region 1 (DSCR1)-transgenic mice were more resistant than wild-type neurons to apoptotic cell death following 24 h of glucose deprivation.
A major role for haematopoietic Rcan1 in atherosclerosis and suggest that therapies aimed at inhibiting RCAN1 expression or function might significantly reduce atherosclerosis burden.
SCF (show KITLG Antibodies)-mediated activation induced expression of Rcan1 in bone-marrow-derived mast cells. Rcan1 suppresses SCF (show KITLG Antibodies)-induced activation of calcineurin (show PPP3CA Antibodies) & NF-kappaB (show NFKB1 Antibodies), & negatively regulates its own expression via Egr1 (show EGR1 Antibodies).
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.
regulator of calcineurin 1
, Down syndrome critical region gene 1
, cadherin family member 1
, desmosomal glycoprotein 2/3
, down syndrome critical region protein 1
, Down syndrome candidate region 1
, calcium and oxidant-inducible mRNA
, modulatory calcineurin-interacting protein 1
, myocyte-enriched calcineurin-interacting protein 1
, near DSCR proline-rich protein
, Down syndrome critical region homolog 1
, calcineurin inhibitor
, calcipressin 1
, down syndrome critical region protein 1 homolog
, myocyte-enriched calcineurin interactin protein 1
, Down syndrome critical region protein 1 homolog
, Oxidative-induced protein Adapt78