RCAN1 antibody (AA 222-252)

Catalog No. ABIN3032453

Product Details anti-RCAN1 Antibody

Target: RCAN1 (Regulator of Calcineurin 1 (RCAN1))

Binding Specificity: AA 222-252

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RCAN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity (Details): Expected species reactivity: Mouse, Rat, Bovine, Hamster

Purification: Purified

Immunogen: A portion of amino acids 222-252 from the human protein was used as the immunogen for this DSCR1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the DSCR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the DSCR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Target Details for RCAN1

Target: RCAN1 (Regulator of Calcineurin 1 (RCAN1))

Alternative Name: DSCR1 (RCAN1 Products)

Synonyms: ADAPT78 antibody, CSP1 antibody, DSC1 antibody, DSCR1 antibody, MCIP1 antibody, RCN1 antibody, RCAN1 antibody, 2410048A02Rik antibody, AA408855 antibody, AI429645 antibody, AL024459 antibody, AV028423 antibody, Adapt78 antibody, CALP1L antibody, Dscr1 antibody, Mcip1 antibody, dscr1 antibody, rcan1 antibody, wu:fr92c05 antibody, adapt78 antibody, csp1 antibody, dsc1 antibody, mcip1 antibody, MGC53636 antibody, rcn1 antibody, MGC69428 antibody, regulator of calcineurin 1 antibody, regulator of calcineurin 1b antibody, regulator of calcineurin 1 L homeolog antibody, Down syndrome critical region gene 1 antibody, RCAN1 antibody, Rcan1 antibody, rcan1b antibody, rcan1.L antibody, dscr1 antibody, rcan1 antibody

Background: DSCR1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. The gene for this protein is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of DSCR1 may lead to neurofibrillary tangles such as those associated with Alzheimer disease.

UniProt: P53805

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development