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RNF216 encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Additionally we are shipping and many more products for this protein.
Showing 10 out of 73 products:
Mouse (Murine) Polyclonal RNF216 Primary Antibody for WB - ABIN265155
Takeda, Kaisho, Akira: Toll-like receptors. in Annual review of immunology 2003
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Mouse (Murine) Polyclonal RNF216 Primary Antibody for IHC, ELISA - ABIN1003372
Sweet, Leung, Kang, Sogaard, Schulz, Trajkovic, Campbell, Xu, Liew: A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression. in Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 4 references for ABIN1003372
Human Polyclonal RNF216 Primary Antibody for EIA, IHC (p) - ABIN501040
Vogel, Fitzgerald, Fenton: TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. in Molecular interventions 2004
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Human Polyclonal RNF216 Primary Antibody for EIA, IHC (p) - ABIN357474
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
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Mouse (Murine) Polyclonal RNF216 Primary Antibody for IHC (p), WB - ABIN121917
Brint, Xu, Liu, Dunne, McKenzie, ONeill, Liew: ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. in Nature immunology 2004
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identifies a novel negative regulator of autophagy and suggests that RNF216 may be a target for treatment of inflammatory diseases
Novel RNF216 mutations causing an Huntington (show HTT Antibodies)-like phenotype with pure monogenic recessive inheritance. .
Loss of Triad3A mimics and occludes Arc (show NOL3 Antibodies)-dependent forms of synaptic plasticity.
The syndrome of hypogonadotropic hypogonadism, ataxia (show USP14 Antibodies), and dementia can be caused by inactivating mutations in RNF216 or by the combination of mutations in RNF216 and OTUD4 (show OTUD4 Antibodies).
By promoting polyubiquitylation and degradation, E3 ubiquitin ligase (show MUL1 Antibodies) Triad3A is identified as an interaction partner for the killer cell Ig-like receptor (show KIR2DL5B Antibodies) KIR2DL4 (show KIR2DL4 Antibodies) cytoplasmic domain.
Triad3A represents a versatile E3 ubiquitin ligase (show MUL1 Antibodies) that negatively regulates RIG (show DIRAS1 Antibodies)-like receptor signaling by targeting TRAF3 (show TRAF3 Antibodies) for degradation following RNA virus infection.
interacts with RIP (show HRB Antibodies) and inhibits tnf (show TNF Antibodies) and il1 (show IL1A Antibodies)-induced NFKB activation
ZIN (show STRN4 Antibodies) binds to purified Vif (show BTG1 Antibodies) in vitro and Triad 3/ZIN interacts with HIV-1 Vif (show BTG1 Antibodies) in transfected human 293T cells, as demonstrated by coimmunoprecipitation
Triad3A regulates ubiquitination and proteasomal degradation of RIP1 (show UQCRFS1 Antibodies) following disruption of Hsp90 (show HSP90 Antibodies) binding and play a crucial role in innate immunity
Gene expression of RIPK3 (show RIPK3 Antibodies) and RNF216 in PBMC could identify those obese subjects, who will regain more weight after a successful initial weight loss. The mRNA levels of these genes could be nutrigenomic biomarkers for predicting obesity treatment outcome.
This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.
E3 ubiquitin-protein ligase RNF216
, ring finger protein 216
, TRIAD3 protein
, E3 ubiquitin ligase
, triad domain-containing protein 3
, ubcM4-interacting protein 83
, ubiquitin-conjugating enzyme 7-interacting protein 1
, zinc finger protein inhibiting NF-kappa-B