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anti-SMAD, Mothers Against DPP Homolog 5 (SMAD5) Antibodies

The protein encoded by SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. Additionally we are shipping SMAD5 Proteins (14) and SMAD5 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SMAD5 4090 Q99717
SMAD5 17129 P97454
SMAD5 59328 Q9R1V3
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Top anti-SMAD5 Antibodies at antibodies-online.com

Showing 10 out of 95 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-SMAD5 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: HepG2 cell lysate WB Suggested Anti-SMAD5  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500  Positive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated WB SMAD5 Antibody (Center) (ABIN1881816) pre-incubated without(lane 1) and with(lane 2) blocking peptide in Hela cell line lysate. SMAD5 Antibody (Center) (arrow) was detected using the purified Pab. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB Figure 1: Flow cytometric analysis of Jurkat cells using SMAD5 mouse mAb (green) and negative control (purple) . Figure 2: Immunofluorescence analysis of NTERA-2 cells using SMAD5 mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Mouse Un-conjugated ICC, FACS, WB SMAD5 antibody at 1/1000 dilution, Lane 1: 293 whole cell lysate 40ug/Lane, Lane 2: MCF7 whole cell lysate 40ug/Lane, Lane 3: K562 whole cell lysate 40ug/Lane, Lane 4: Hela whole cell lysate 40ug/Lane, Predicted band size:55kDa, Observed band size:55kDa, Additional band size:75kDa 100 μL Log in to see 8 to 9 Days
$392.86
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-SMAD5 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue Anti-SMAD5 antibody, IHC(P) IHC(P): Rat Intestine Tissue 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated ICC, IF, WB ICC/IF Image Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using SMAD5, antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with  (Red) at 1:2000. 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Mouse Un-conjugated ICC, FACS, IF, IHC, ELISA, WB 100 μL Log in to see 8 to 10 Days
$522.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of SMAD5 expression in HeLa (A), mouse testis (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details

SMAD5 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-SMAD5 Antibodies

  1. Human Polyclonal SMAD5 Primary Antibody for WB - ABIN1881816 : Park, Lee, Ahn, Kim: Predicting the multi-modal binding propensity of small molecules: towards an understanding of drug promiscuity. in Molecular bioSystems 2009 (PubMed)
    Show all 5 references for ABIN1881816

  2. Human Monoclonal SMAD5 Primary Antibody for ICC, FACS - ABIN969404 : Chang, Chang, Lee, Lee, Yeh, Yeh, Cheng, Chien, Chiu: Tumor cell cycle arrest induced by shear stress: Roles of integrins and Smad. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)
    Show all 2 references for ABIN969404

  3. Dog (Canine) Polyclonal SMAD5 Primary Antibody for WB - ABIN2779415 : Langenfeld, Kong, Langenfeld: Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5. in Oncogene 2006 (PubMed)

  4. Chicken Polyclonal SMAD5 Primary Antibody for WB - ABIN2779414 : Zimonjic, Durkin, Keck-Waggoner, Park, Thorgeirsson, Popescu: SMAD5 gene expression, rearrangements, copy number, and amplification at fragile site FRA5C in human hepatocellular carcinoma. in Neoplasia (New York, N.Y.) 2003 (PubMed)

More Antibodies against SMAD5 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway.

  2. Alk3 and Alk3b, as well as SMAD5, are essential cellular mediators of BMP signaling in zebrfish.

  3. Data show that interplay of Smad1 (show SMAD1 Antibodies)/5 and MAP kinase (show MAPK1 Antibodies) signaling system (ERK (show MAPK1 Antibodies) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.

  4. this study uncovers that smad1 (show SMAD1 Antibodies) and smad9 (show SMAD9 Antibodies) act redundantly to each other downstream of smad5 to mediate ventral specification and to regulate embryonic myelopoiesis.

  5. Functional investigation of a subset of these genes, fgf10a (show FGF10 Antibodies), tgfb2 (show TGFB2 Antibodies), pax9 (show PAX9 Antibodies), and smad5 revealed their necessity in zebrafish palatogenesis.

  6. maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2 (show BMP4 Antibodies)/7 signaling to establish the initial dorsoventral asymmetry

  7. Data show that patterning of the eye primordia in Smad5-deficient embryos starts during blastula and early gastrula stages.

  8. that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 (show SMAD1 Antibodies) and Smad5.

  9. Data show that Smad5 expression is ubiquitous during testis development but becomes cell-specific in the adult.

Human SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. miR (show MLXIP Antibodies)-23a and miR (show MLXIP Antibodies)-27a target SMAD5 and regulate apoptosis in human granulosa cells via the FasL (show FASL Antibodies)-Fas (show FAS Antibodies) pathway

  2. Our findings suggest that suppression of miR (show MLXIP Antibodies)-222-3p activity promoted osteogenic differentiation hBMSCs through regulating Smad5-RUNX2 (show RUNX2 Antibodies) signaling axis.

  3. Overexpression of the BMP4 (show BMP4 Antibodies)/SMAD4 (show SMAD4 Antibodies)/SMAD5 signaling pathway could predict poor clinical outcome in skull base chordomas, suggesting activation of this pathway is involved in chordoma pathogenesis.

  4. The polycomb group protein L3MBTL1 (show L3MBTL1 Antibodies) represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells.

  5. adult human Sertoli cells assumed similar morphological features, stable global gene expression profiles and numerous proteins, and activation of AKT (show AKT1 Antibodies) and SMAD1 (show GARS Antibodies)/5 during long-period culture.

  6. balance between Smad1 (show GARS Antibodies)/5- and Smad2 (show SMAD2 Antibodies)/3-dependent signaling defines the outcome of the effect of TGF-beta (show TGFB1 Antibodies) on atherosclerosis where Smad1 (show GARS Antibodies)/5 is responsible for proatherogenic effects

  7. among the 15 SNPs, rs3206634 was significantly associated with KD in a recessive model (odds ratio = 2.31, p = 0.019), whereas there was no association between any of the 15 SNPs and CALs (show CA8 Antibodies).

  8. Our results indicated that KGN promoted the type-I collagen synthesis of dermal fibroblasts in vitro and in the dermis of mice through activation of the smad4 (show SMAD4 Antibodies)/smad5 pathway.

  9. Inhibiting Smurf1 (show SMURF1 Antibodies) mediated ubiquitination of Smad1 (show GARS Antibodies)/5.

  10. Specific gene siRNAs knock-down further confirmed the osteogenic effects of Genistein on BMP2 (show BMP2 Antibodies), SMAD5 and RUNX2 (show RUNX2 Antibodies) protein expression

Mouse (Murine) SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. The crystal structure of Smad5-MH1 (show SCN5A Antibodies) domain in complex with a composite DNA sequence demonstrates that the MH1 (show SCN5A Antibodies) domain is targeted to a binding site with modular binding modes, and the length of the DNA spacer affects the MH1 (show SCN5A Antibodies) assembly.

  2. The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2 (show BMP2 Antibodies)/Smad1 (show SMAD1 Antibodies)/5/8 and Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathways.

  3. FLI1 (show FLI1 Antibodies) and GATA2 (show GATA2 Antibodies) are upstream regulators of SMAD1 (show SMAD1 Antibodies) and SMAD5 expression in endothelial cells.

  4. Data indicate that PDGF (show PDGFA Antibodies)-AA promotes mesenchymal stem cel migration via bone morphogenetic protein 2 (BMP2 (show BMP2 Antibodies))-smad (show SMAD1 Antibodies) proteins smad1 (show SMAD1 Antibodies)/5/8 activation requires lysosome-mediated degradation of PDGF (show PDGFA Antibodies) alpha Receptor (PDGFRalpha).

  5. some pSMAD1/5 targets, like Gata3 (show GATA3 Antibodies), function specifically in transit amplifying cell lineage-progression.

  6. The effects of a soy-free diet on the risk of granulosa cell tumors in mice with conditional double knockout of Smad1 (show SMAD1 Antibodies) and Smad5 are reported.

  7. our data suggest a pivotal role for canonical BMP signaling demonstrating distinguished nonoverlapping function of pSmad8 with pSmad1 and pSmad5 in hfSCs regulation and hair morphogenesis but a redundant role in adult hair progenitors differentiation.

  8. Icariine has a direct stimulatory function on the differentiation of MC3T3-E1 osteoblastic cells in vitro, which may be mediated by increasing the production of Smad1 (show SMAD1 Antibodies) and Smad5 in osteoblasts

  9. we found a cross-talk between p38 (show CRK Antibodies) and Smad5, and that activation of p38 (show CRK Antibodies) is necessary for BMP-2 (show BMP2 Antibodies)-induced Smad5 phosphorylation and nuclear translocation.

  10. Data show that HtrA1 (show HTRA1 Antibodies) is produced during osteoclastogenesis, and negatively regulates osteoblast differentiation, osteoblast differentiation and BMP2 (show BMP2 Antibodies)-induced Smad1 (show SMAD1 Antibodies)/5/8, ERK1/2 (show MAPK1/3 Antibodies) and p38 (show CRK Antibodies) phosphorylation in pre-osteoblasts.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 5 (SMAD5) interaction partners

  1. a detailed computational model for TGF-beta (show TGFB1 Antibodies) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Antibodies)/5/8 and Smad2 (show SMAD2 Antibodies)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Antibodies).

SMAD5 Antigen Profile

Protein Summary

The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with SMAD5

  • SMAD family member 5 (SMAD5) antibody
  • MAD homolog 5 (Drosophila) (smad5) antibody
  • SMAD family member 4, gene 2 (smad4.2-b) antibody
  • SMAD family member 5 (Smad5) antibody
  • 1110051M15Rik antibody
  • AI451355 antibody
  • DKFZp468M0619 antibody
  • dpc4 antibody
  • Dwf-C antibody
  • DWFC antibody
  • fb67b04 antibody
  • jip antibody
  • JV5-1 antibody
  • mad antibody
  • madh4 antibody
  • Madh5 antibody
  • MusMLP antibody
  • sb:cb400 antibody
  • SBN antibody
  • SMAD5 antibody
  • smad10 antibody
  • smd5 antibody
  • wu:fb67b04 antibody
  • xsmad4 antibody
  • XSmad4alpha antibody

Protein level used designations for SMAD5

mothers against decapentaplegic homolog 5 , SMA- and MAD-related protein 5 , SMAD 5 , SMAD family member 5 , mothers against DPP homolog 5 , pgy , piggytail , somitabun , MAD, mothers against decapentaplegic homolog 5 , SMAD, mothers against DPP homolog 5 , mothers against decapentaplegic, drosophila, homolog of, 5 , MAD homolog 5 , Smad 5 , dwarfin-C , mSmad5 , Mothers against decapentaplegic homolog 5

GENE ID SPECIES
100033851 Equus caballus
30641 Danio rerio
403398 Xenopus laevis
4090 Homo sapiens
17129 Mus musculus
59328 Rattus norvegicus
395679 Gallus gallus
481520 Canis lupus familiaris
768050 Bos taurus
100173534 Pongo abelii
100303615 Sus scrofa
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