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anti-Stromal Interaction Molecule 1 (STIM1) Antibodies

STIM1 encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). Additionally we are shipping STIM1 Proteins (18) and STIM1 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
STIM1 6786 Q13586
STIM1 20866 P70302
STIM1 361618 P84903
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Top anti-STIM1 Antibodies at antibodies-online.com

Showing 10 out of 145 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB STIM1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the STIM1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. STIM1 Antibody (C-term) western blot analysis in CEM cell line lysates (35µg/lane).This demonstrates the STIM1 antibody detected the STIM1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of STIM1 in human spleen tissue with this product at 2.5 μg/ml. Western blot analysis of STIM1 in mouse thymus tissue lysate with this product at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to STIM1 on HeLa cell (antibody concentration 10 µg/mL). STIM1 monoclonal antibody (M01), clone 5A2 Western Blot analysis of STIM1 expression in HeLa. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IF, WB Western blot analysis of GOK on rat liver lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of anti-GOK antibody. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Mouse Un-conjugated IF, IHC (p), IP, WB 0.1 mg Log in to see 6 to 8 Days
$308.00
Details
Human Mouse Un-conjugated ICC, IHC (p), IP, WB Immunofluorescence staining of HeLa human cervix carcinoma cell line using anti-STIM1 (CDN3H4 ; methanol-aceton fixation; detection by Goat anti-mouse IgG1 Alexa Fluor® 598; red). Nuclei were stained with DAPI (blue). Western Blotting analysis (non-reducing conditions) of whole cell lysate of RBL rat basophilic leukemia cell line. Lane 1: immunostaining with anti-STIM1 () Lane 2: immunostaining with Isotype mouse IgG1 control (PPV-06 0.1 mg Log in to see 4 to 5 Days
$288.75
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-STIM1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: PANC1 cell lysate WB Suggested Anti-STIM1  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:12500  Positive Control: PANC1 cell lysate  STIM1 is supported by BioGPS gene expression data to be expressed in PANC1 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB STIM1 Antibody (C-term) (ABIN654073) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- STIM1 Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue Anti- STIM1 Picoband antibody, IHC(P) IHC(P): Rat Intestine Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Dog Goat Un-conjugated EIA, WB   0.1 mg Log in to see 6 to 8 Days
$379.50
Details

STIM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-STIM1 Antibodies

  1. Human Monoclonal STIM1 Primary Antibody for ICC, IHC (p) - ABIN192394 : Ng, Ramduny, Airey, Singer, Keller, Shen, Tian, Valencik, Hume: Orai1 interacts with STIM1 and mediates capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells. in American journal of physiology. Cell physiology 2010 (PubMed)
    Show all 9 references for ABIN192394

  2. Human Monoclonal STIM1 Primary Antibody for IF, WB - ABIN968271 : Hu, Lee, Connors, Johnson, Burn, Su, Landes, Feinberg: A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. in Genomics 1998 (PubMed)
    Show all 5 references for ABIN968271

  3. Human Polyclonal STIM1 Primary Antibody for EIA, IHC (p) - ABIN500827 : Spassova, Soboloff, He, Xu, Dziadek, Gill: STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 4 references for ABIN500827

  4. Human Polyclonal STIM1 Primary Antibody for EIA, IHC (p) - ABIN954978 : Byun, Abhyankar, Lelarge, Plancoulaine, Palanduz, Telhan, Boisson, Picard, Dewell, Zhao, Jouanguy, Feske, Abel, Casanova: Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma. in The Journal of experimental medicine 2010 (PubMed)
    Show all 4 references for ABIN954978

  5. Human Monoclonal STIM1 Primary Antibody for IF, WB - ABIN396503 : Verma, Hoffmann, Kumar, Huang, Roe, Nguyen-Wu, Hashimoto, Hoffmann: Selenoprotein K knockout mice exhibit deficient calcium flux in immune cells and impaired immune responses. in Journal of immunology (Baltimore, Md. : 1950) 2011 (PubMed)

  6. Dog (Canine) Polyclonal STIM1 Primary Antibody for EIA, WB - ABIN1109158 : López, Jardín, Bobe, Pariente, Enouf, Salido, Rosado: STIM1 regulates acidic Ca2+ store refilling by interaction with SERCA3 in human platelets. in Biochemical pharmacology 2008 (PubMed)

More Antibodies against STIM1 Interaction Partners

Pig (Porcine) Stromal Interaction Molecule 1 (STIM1) interaction partners

  1. Downregulation of STIM1 levels in oocytes by siRNA completely inhibited the repetitive Ca(2 (show CA2 Antibodies)+) signal triggered by the fertilizing sperm.

  2. findings suggest that in oocytes, STIM1 serves as a sensor of Ca(2 (show CA2 Antibodies)+) store content that after store depletion moves to the plasma membrane to stimulate store-operated Ca(2 (show CA2 Antibodies)+) entry

  3. STIM1 plays role in PAR1 (show F2R Antibodies)-mediated Ca2 (show CA2 Antibodies)+ influx and Ca2 (show CA2 Antibodies)+-dependent NO production in endothelial cells; DNA sequence alignment of porcine and human STIM1

Xenopus laevis Stromal Interaction Molecule 1 (STIM1) interaction partners

  1. STIM1/TRPC1 (show TRPC1 Antibodies)-dependent store-operated Ca2 (show CA2 Antibodies)+ entry plays an essential role in generating spatiotemporal Ca2 (show CA2 Antibodies)+ signals that mediate guidance responses of nerve growth cones.

Silk Worm Stromal Interaction Molecule 1 (STIM1) interaction partners

  1. STIM1 and Orai1 (show ORAI1 Antibodies) are essential components of the signal transduction cascade that regulates sex pheromone production.

Human Stromal Interaction Molecule 1 (STIM1) interaction partners

  1. STIM11-469 and Orai1 (show ORAI1 Antibodies) W76A mutants do not reduce channel open probability.

  2. T Cell Receptor-induced Nuclear Factor kappaB (NF-kappaB (show NFKB1 Antibodies)) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1 (show ORAI1 Antibodies)-mediated Calcium Entry.

  3. study reports recessive STIM1 mutations in patients presenting with amelogenesis imperfecta and hypohidrosis without overt clinical immunodeficiency or myopathy

  4. Data suggest that stromal interaction molecule 1 (STIM1) may be developed as a potential therapeutic target of cancer treatment.

  5. We demonstrate that the Orai1 (show ORAI1 Antibodies)/STIM1 channel is regulated by changes of both intracellular and extracellular pH.

  6. Sigma1 receptors attenuates STIM1 coupling to Orai1 (show ORAI1 Antibodies) and thereby inhibits SOCE.

  7. Studies suggest that STIM1 protein and calcium channel Orai1 (show ORAI1 Antibodies)-mediated Ca2 (show CA2 Antibodies)+ signaling are the potential target for cancer therapy.

  8. Studies indicate that Ca(2 (show CA2 Antibodies)+) sensor STIM1 and calcium channel Orai1 (show ORAI1 Antibodies) upregulation in cancer cells results in Ca2 (show CA2 Antibodies) + homeostasis remodeling and cell proliferation.

  9. STIM1 also promoted cell migration and the epithelial-to-mesenchymal transition by activating TGF-beta (show TGFB1 Antibodies), Snail (show SNAI1 Antibodies) and Wnt (show WNT2 Antibodies)/beta-Catenin (show CTNNB1 Antibodies) pathways.

  10. The abundance of mutated STIM1 and the MMP-2 (show MMP2 Antibodies) expression were higher in native human umbilical vein endothelial cells of patients with gestational hypertension than controls and were significantly correlated with blood pressure.

Cow (Bovine) Stromal Interaction Molecule 1 (STIM1) interaction partners

  1. STIM1 and STIM2 (show Stim2 Antibodies) are expressed in bovine aortic endothelial cells and they both interact with IP3R-1 (show ITPR1 Antibodies).

Mouse (Murine) Stromal Interaction Molecule 1 (STIM1) interaction partners

  1. We conclude that STIM1 has an unexpected function in the heart where it alters communication between the sarcolemma and sarcoplasmic reticulum resulting in greater Ca(2 (show CA2 Antibodies)+) flux and a leaky SR compartment.

  2. Stim1 silencing prevented mTOR (show FRAP1 Antibodies) complex 2 phosphorylation of Akt (show AKT1 Antibodies)(S473) via a direct interaction between STIM1 and Rictor (show RICTOR Antibodies). This represses GSK-3beta (show GSK3b Antibodies) activity and prevents/reverses cardiac hypertrophy.

  3. role of STIM1, Orai1 (show TMEM132A Antibodies) and TRPCs, and thus SOCE, in thrombus formation, suggests that therapies directed against SOCE and targeting these molecules during cardiovascular and cerebrovascular events could improve traditional anti-thrombotic treatments

  4. Quantitative Proteomics Reveals the Essential Roles of Stromal Interaction Molecule 1 (STIM1) in the Testicular Cord Formation in Mouse Testis

  5. Results show the cytoplasmic domain of STIM1 as a target for calpains which cleave STIM1 to control its cellular abundance. Furthermore, STIM1's susceptibility to calpain cleavage leads to enhanced STIM1 degradation during the progression of apoptosis.

  6. Orai1 (show TMEM132A Antibodies) and STIM1 have roles in inhibiting matrix protein expression

  7. STIM1 plays opposing roles in vascular smooth muscle vs. endothelial cells in the regulation of vascular reactivity.

  8. STIM1 is a multifunctional regulator of Ca(2 (show CA2 Antibodies)+) dynamics in SANCs that links SR Ca(2 (show CA2 Antibodies)+) store content with electrical events occurring in the plasma membrane, thereby contributing to automaticity of the SAN

  9. STIM1L does not mediate rapid store-operated Ca(2 (show CA2 Antibodies)+) entry but can trap and gate Orai1 (show TMEM132A Antibodies) channels efficiently without remodeling cortical ER cisternae.

  10. STIM1 is a key regulator of mGluR1 (show GRM1 Antibodies)-dependent Ca(2 (show CA2 Antibodies)+) signaling.

STIM1 Antigen Profile

Protein Summary

This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.

Gene names and symbols associated with STIM1

  • stromal interaction molecule 1 (STIM1) antibody
  • stromal interaction molecule 1 (stim1) antibody
  • stromal interaction molecule 1a (stim1a) antibody
  • stromal interaction molecule 1b (stim1b) antibody
  • stromal interaction molecule 1 (Stim1) antibody
  • stromal interaction molecule 1 (LOC100345564) antibody
  • D11S4896E antibody
  • GOK antibody
  • MGC76045 antibody
  • MGC154748 antibody
  • si:ch211-112l17.2 antibody
  • si:dkey-24p1.5 antibody
  • SIM antibody
  • Stim1 antibody
  • TAM antibody

Protein level used designations for STIM1

stromal interaction molecule 1 , stromal interaction molecule 1b

GENE ID SPECIES
419082 Gallus gallus
100171399 Sus scrofa
100053079 Equus caballus
403095 Xenopus (Silurana) tropicalis
450973 Pan troglodytes
556360 Danio rerio
779419 Xenopus laevis
100005700 Danio rerio
100188967 Bombyx mori
100345564 Oryctolagus cuniculus
100380565 Salmo salar
6786 Homo sapiens
608643 Canis lupus familiaris
534816 Bos taurus
20866 Mus musculus
361618 Rattus norvegicus
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