STIM1 antibody (AA 509-538)

Catalog No. ABIN3032757

The Rabbit Polyclonal anti-STIM1 antibody (ABIN3032757) specifically detects STIM1 in WB, IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for STIM1 antibody (AA 509-538) (ABIN3032757)

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STIM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-STIM1 Antibody

Binding Specificity: AA 509-538

Purpose: STIM1 Antibody

Cross-Reactivity (Details): Expected species reactivity: Mouse

Purification: Antigen affinity

Immunogen: A portion of amino acids 509-538 from the human protein was used as the immunogen for this STIM1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the STIM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the STIM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for STIM1

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Alternative Name: STIM1

Background: This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.

UniProt: Q13586

Pathways: TCR Signaling, BCR Signaling