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TPO encodes a membrane-bound glycoprotein. Additionally we are shipping Thyroperoxidase Kits (70) and Thyroperoxidase Proteins (52) and many more products for this protein.
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Lower pretreatment serum CXCL10 (show CXCL10 Antibodies) levels are associated with thyroid dysfunction. Thyroid dysfunction prevalence increases in female patients and patients who are positive for TPOAb at baseline.
Two novel inactivating mutations (c.1970T> C and c.2665G> T) in the TPO (show THPO Antibodies) gene cause congenital hypothyroidism.
function and autoantigenicity of TPO (show THPO Antibodies)
This study confirms the pathogenicity of Y55X mutation in two patients with congenital hypothyroidism and demonstrates that a nonsense mutation in the amino-terminal coding region of the TPO (show THPO Antibodies) gene could totally abolish the function of the TPO (show THPO Antibodies) enzyme leading to total iodide organification defect.
analysis of thyroid peroxidase autoantibody levels in type 1 diabetes in discordant twin pairs
Data show that thyroperoxidase (TPO) single nucleotide polymorphisms (SNPs) rs4927611 TT and rs732609 CC are genotypes associated with potential risk for the congenital hypothyroidism (CH).
A single base deletion in the carboxyl-terminal coding region of the TPO (show THPO Antibodies) gene could cause congenital hypothyroidism and helps to establish a genotype/phenotype correlation associated with the mutation.
Molecular cloning and functional studies of wild type and mutant forms harboring missense mutations in TPO (show THPO Antibodies) gene showed decreased activity in the three mutants, higher Km values and lower reaction efficiencies (Vmax/Km).
The effects of inhibition of the TPO (show THPO Antibodies)/c-MPL (show MPL Antibodies) pathway on enhancing the chemotherapy sensitivity of AML (show RUNX1 Antibodies) cells.
perioperative TPO (show THPO Antibodies) dynamics are associated with postoperative LD. Postoperative TPO (show THPO Antibodies) levels were found to be lowest in high-risk patients (HCC (show FAM126A Antibodies) patients undergoing major resection) but showed an independent predictive value.
Hearing impairment in hypothyroid dwarf (show POU1F1 Antibodies) mice caused by mutations of the thyroid peroxidase gene.
Findings demonstrate a novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO (show THPO Antibodies).
A novel hypothyroid dwarfism is due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse.
TPO gene was mapped
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.
, thyroid peroxidase-like
, thyroid microsomal antigen
, thyroid peroxidase (332 AA)