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anti-Titin-Cap (Telethonin) (TCAP) Antibodies

Sarcomere assembly is regulated by the muscle protein titin. Additionally we are shipping TCAP Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TCAP 8557 O15273
TCAP 21393 O70548
TCAP 688173  
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Top anti-TCAP Antibodies at antibodies-online.com

Showing 10 out of 32 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TCAP Antibody Titration: 5.0ug/mlPositive Control: HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Mouse Un-conjugated WB Western blot analysis of Telethonin of mouse heart lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of Telethonin. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged TCAP is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (36.74 KDa) . 200 μL Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB TCAP antibody used at 5 ug/ml to detect target protein. 100 μg Log in to see 3 to 4 Days
$388.93
Details
Human Mouse Un-conjugated IHC (p)   100 μL Log in to see 8 to 10 Days
$493.17
Details

TCAP Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , ,
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Mouse (Murine)
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Rat (Rattus)
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Top referenced anti-TCAP Antibodies

  1. Human Monoclonal TCAP Primary Antibody for WB - ABIN968822 : Mason, Bayol, Loughna: The novel sarcomeric protein telethonin exhibits developmental and functional regulation. in Biochemical and biophysical research communications 1999 (PubMed)
    Show all 4 references for ABIN968822

  2. Cow (Bovine) Polyclonal TCAP Primary Antibody for WB - ABIN2783290 : Bos, Theis, Tajik, Gersh, Ommen, Ackerman: Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy. in American heart journal 2008 (PubMed)

More Antibodies against TCAP Interaction Partners

Zebrafish Titin-Cap (Telethonin) (TCAP) interaction partners

  1. Data show show that tcap is functionally conserved and reduction of Tcap resulted in muscular dystrophy-like phenotypes including deformed muscle structure and impaired swimming ability.

Xenopus laevis Titin-Cap (Telethonin) (TCAP) interaction partners

  1. Distinct roles for telethonin N-versus C-terminus in sarcomere assembly and maintenance.

Human Titin-Cap (Telethonin) (TCAP) interaction partners

  1. Data indicate LGMD2G protein TCAP association with limb girdle muscular dystrophy 2G (LGMD2G).

  2. Report TCAP mutations in dilated cardiomyopathy.

  3. cardiac telethonin is constitutively bis (show BAG3 Antibodies)-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2 (show CA2 Antibodies)+) transients.

  4. This study identified no pathogenic mutations in BAG3 (show BAG3 Antibodies), MATR3 (show MATR3 Antibodies), PTRF (show PTRF Antibodies) or TCAP in Australian muscular dystrophy.

  5. reduced expression of dystrophin (show DMD Antibodies) and titin (show TTN Antibodies) is associated with the pathophysiology of dilated cardiomyopathy, and TNF-alpha (show TNF Antibodies) may modulate the expression of these proteins via NF-kappaB (show NFKB1 Antibodies) pathway.

  6. Genetic studies of tcap in zebrafish suggested that pathogenesis in LGMD2G is due to a disruption of sarcomere-T-tubular interaction, but not of sarcomere assembly per se.

  7. review of telethonin and other new proteins of the Z-disc of skeletal muscle

  8. telethonin protein levels seems to be at least in part regulated by neuronal activity and is thus linked to the dynamic control of myofibrillogenesis and muscle turnover in human skeletal muscle.

  9. telethonin may play a role in linking titin (show TTN Antibodies) filaments at the Z-disk periphery

  10. TCAP mutations identified which are associated with hypertrophic cardiomyopathy.

Mouse (Murine) Titin-Cap (Telethonin) (TCAP) interaction partners

  1. cardiac telethonin is constitutively bis (show BAG3 Antibodies)-phosphorylated and suggest that such phosphorylation is critical for normal telethonin function, which may include maintenance of transverse tubule organization and intracellular Ca(2 (show CA2 Antibodies)+) transients.

  2. Tcap is a critical, load-sensitive regulator of t-tubule structure and function.

  3. Telethonin knockout mice develop heart failure following biomechanical stress, owing at least in part to apoptosis of cardiomyocytes, an effect that may also play a role in human heart failure.

  4. Whereas both promotor E boxes in Tcap are required for full activation by MyoD (show MYOD1 Antibodies) or myogenin (show MYOG Antibodies) in NIH3T3 cells, the promoter proximal E box has a greater contribution to activation in C2C12 cells and to activation by MyoD (show MYOD1 Antibodies) in NIH3T3 cells.

  5. Findings suggest that TCAP knockdown with RNA interference alters normal muscle cell differentiation.

Pig (Porcine) Titin-Cap (Telethonin) (TCAP) interaction partners

  1. TCAP promoter can be activated by MyoD (show MYOD1 Antibodies), MyoG (show MYOG Antibodies) and MEF2 (show MYEF2 Antibodies) in myotubes, which indicated that TCAP may play a role in the regulation of skeletal muscle development.

TCAP Antigen Profile

Protein Summary

Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G.

Gene names and symbols associated with TCAP

  • titin-cap (telethonin) (TCAP) antibody
  • titin-cap (telethonin) (tcap) antibody
  • titin-cap (TCAP) antibody
  • titin-cap (Tcap) antibody
  • AI503981 antibody
  • AJ223855 antibody
  • CMD1N antibody
  • LGMD2G antibody
  • T-cap antibody
  • TCAP antibody
  • TELE antibody
  • telethonin antibody

Protein level used designations for TCAP

titin-cap (telethonin) , 19 kDa sarcomeric protein , limb girdle muscular dystrophy 2G (autosomal recessive) , telethonin , titin cap protein , titin-cap protein

GENE ID SPECIES
454633 Pan troglodytes
556258 Danio rerio
697327 Macaca mulatta
100380097 Xenopus (Silurana) tropicalis
100381005 Xenopus laevis
8557 Homo sapiens
608508 Canis lupus familiaris
21393 Mus musculus
688173 Rattus norvegicus
100271745 Sus scrofa
513257 Bos taurus
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