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anti-Transcription Factor 12 (TCF12) Antibodies

The protein encoded by TCF12 is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. Additionally we are shipping TCF12 Proteins (7) and TCF12 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
TCF12 6938 Q99081
TCF12 21406 Q61286
TCF12 25720 P51514
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Top anti-TCF12 Antibodies at antibodies-online.com

Showing 10 out of 85 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-TCF12 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Jurkat cell lysate WB Suggested Anti-TCF12  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: Jurkat cell lysate  TCF12 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-TCF12 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-TCF12 Antibody Titration: 0.06ug/mlELISA Titer: 1:1562500Positive Control: Human Lung Host: Rabbit  Target Name: TCF12  Sample Tissue: Human Fetal Brain  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB TCF12 Antibody (N-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TCF12 antibody detected the TCF12 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of TCF12 in HeLa cell lysate with TCF12 antibody at (A) 0.5 and (B) 1 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to TCF12 on HeLa cell (antibody concentration 10 µg/mL). Western Blot analysis of TCF12 expression in transfected 293T cell line by TCF12 monoclonal antibody (M01), clone 2E9. Lane 1: TCF12 transfected lysate(75.8 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details

TCF12 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-TCF12 Antibodies

  1. Cow (Bovine) Polyclonal TCF12 Primary Antibody for WB - ABIN2780487 : Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006 (PubMed)
    Show all 2 references for ABIN2780487

  2. Chicken Polyclonal TCF12 Primary Antibody for WB - ABIN2774659 : Wissmüller, Kosian, Wolf, Finzsch, Wegner: The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. in Nucleic acids research 2006 (PubMed)
    Show all 2 references for ABIN2774659

  3. Human Polyclonal TCF12 Primary Antibody for EIA, WB - ABIN783743 : Murre, McCaw, Vaessin, Caudy, Jan, Jan, Cabrera, Buskin, Hauschka, Lassar: Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. in Cell 1989 (PubMed)
    Show all 2 references for ABIN783743

  4. Human Polyclonal TCF12 Primary Antibody for EIA, WB - ABIN955126 : Schotte, Dontje, Nagasawa, Yasuda, Bakker, Spits, Blom: Synergy between IL-15 and Id2 promotes the expansion of human NK progenitor cells, which can be counteracted by the E protein HEB required to drive T cell development. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)

More Antibodies against TCF12 Interaction Partners

Human Transcription Factor 12 (TCF12) interaction partners

  1. Two novel translocations leading to the inactivation of RUNX1 (show RUNX1 Antibodies) and its partners SIN3A (show SIN3A Antibodies) and TCF12 in myeloid leukemia (show BCL11A Antibodies).

  2. Studies suggest that transcription factor 12 (TCF12) should be included in level 2 genetic testing.

  3. show that these mutations compromise TCF12 transcriptional activity and are associated with a more aggressive tumour type

  4. several familial cases of coronal synostosis associated with mutations in TCF12

  5. In t(8;21) leukemia cells, the two E proteins, HEB and E2A (show TCF3 Antibodies), function as components of the stable AML1 (show RUNX1 Antibodies)-ETO (show RUNX1T1 Antibodies)-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.

  6. haploinsufficiency of TCF12 causes coronal synostosis in humans and that severe bilateral coronal synostosis occ (show TWIST1 Antibodies)urs in mice with 50% of the wild-type dosage of both the T (show TWIST1 Antibodies)cf12 and Twist1 genes highlights the key role of TCF12 acting with TWIST1.

  7. the CD91 (show LRP1 Antibodies)/IKK (show CHUK Antibodies)/NF-kappaB (show NFKB1 Antibodies) signaling cascade is involved in secreted HSP90alpha (show HSP90AA2 Antibodies)-induced TCF12 expression, leading to E-cadherin (show CDH1 Antibodies) down-regulation and enhanced CRC (show CALR Antibodies) cell migration/invasion

  8. TCF12 functioned as a transcriptional repressor of E-cadherin (show CDH1 Antibodies) and its overexpression was significantly correlated with the occurrence of CRC (show CALR Antibodies) metastasis.

  9. HEB and E2A (show TCF3 Antibodies)-bind the SCA motif at regions overlapping SMAD2 (show SMAD2 Antibodies)/3 and FOXH1 (show FOXH1 Antibodies)

  10. As a first exploitation of this unique cohort, we identify three novel candidate dyslexia genes, ZNF280D (show ZNF280D Antibodies) and TCF12 at 15q21, and PDE7B (show PDE7B Antibodies) at 6q23.3, by molecular mapping of the familial translocation with the 15q21 breakpoint.

Mouse (Murine) Transcription Factor 12 (TCF12) interaction partners

  1. HEB (show FREM1 Antibodies) is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells

  2. severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 and Twist1 (show TWIST1 Antibodies) genes highlights the key role of TCF12 acting with TWIST1 (show TWIST1 Antibodies) in the normal development of the coronal sutures

  3. Deficiency in the E proteins, E2A (show TCF3 Antibodies) and HEB (show FREM1 Antibodies), led to increased frequency of terminally differentiated effector KLRG1 (show KLRG1 Antibodies)(hi) CD8 (show CD8A Antibodies)(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.

  4. Deletion of HEB (show FREM1 Antibodies) and E2A (show TCF3 Antibodies) in DP thymocytes specifically blocked the development of CD4 (show CD4 Antibodies)(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 (show ID3 Antibodies) allowed CD4 (show CD4 Antibodies)(+) T cell development but blocked CD8 (show CD8A Antibodies)(+) lineage development.

  5. the earliest event in B-cell specification involves the induction of FOXO1 (show FOXO1 Antibodies) expression and requires the combined activities of E2A (show TCF3 Antibodies) and HEB (show FREM1 Antibodies)

  6. These results showed a new set of interactions between HEB (show FREM1 Antibodies), Notch1 (show NOTCH1 Antibodies), and GATA3 (show GATA3 Antibodies) that regulate the T-cell fate choice in developing thymocytes.

  7. Developmental progression of fetal HEB (show FREM1 Antibodies)(-/-) precursors to the pre-T-cell stage is restored by HEBAlt.

  8. HEB (show FREM1 Antibodies) is a specific and essential factor in T-cell development and in the generation of the iNKT cell lineage.

  9. the dosage of HEB (show FREM1 Antibodies) determines pT alpha (show PTCRA Antibodies) gene expression in immature T cells

  10. the Tcf12 gene may be involved in the control of proliferating neural stem cells and progenitor cells

TCF12 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Gene names and symbols associated with TCF12

  • transcription factor 12 (TCF12) antibody
  • transcription factor 12 (LOC100339415) antibody
  • transcription factor 12 (tcf12) antibody
  • transcription factor 12 (Tcf12) antibody
  • transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) (tcf12) antibody
  • A130037E08Rik antibody
  • ALF1 antibody
  • bHLHb20 antibody
  • CRS3 antibody
  • HEB antibody
  • HEBAlt antibody
  • HsT17266 antibody
  • HTF-4 antibody
  • HTF4 antibody
  • ME1 antibody
  • REB antibody
  • SCBPA antibody
  • TCF12 antibody
  • wu:fb74g05 antibody
  • wu:fc43e06 antibody
  • zgc:85956 antibody
  • zgc:110341 antibody

Protein level used designations for TCF12

transcription factor 12 , transcription factor 12 (HTF4, helix-loop-helix transcription factors 4) , DNA-binding protein HTF4 , E-box-binding protein , TCF-12 , class B basic helix-loop-helix protein 20 , helix-loop-helix transcription factor 4 , transcription factor HTF-4 , class A helix-loop-helix transcription factor ME1 , SCBP alpha , SCBP-alpha , salivary-specific cAMP response element-binding protein alpha , TF12 , basic helix-loop-helix protein , class A helix-loop-helix transcription factor GE1 , XE1.1

GENE ID SPECIES
453466 Pan troglodytes
100339415 Oryctolagus cuniculus
100460448 Pongo abelii
100553875 Anolis carolinensis
100603993 Nomascus leucogenys
6938 Homo sapiens
509039 Bos taurus
21406 Mus musculus
25720 Rattus norvegicus
407985 Danio rerio
396334 Gallus gallus
100684199 Canis lupus familiaris
399451 Xenopus laevis
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