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TACC3 encodes a member of the transforming acidic colied-coil protein family. Additionally we are shipping TACC3 Proteins (4) and many more products for this protein.
Showing 10 out of 57 products:
Human Monoclonal TACC3 Primary Antibody for WB - ABIN2838594
Lin, Hu, Shih: Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability. in The Journal of cell biology 2010
Show all 6 references for ABIN2838594
Human Polyclonal TACC3 Primary Antibody for IF, IHC - ABIN1535500
Still, Vince, Cowell et al.: The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell ... in Genomics 1999
Show all 2 references for ABIN1535500
Aurora-A kinase (show AURKA Antibodies) does not regulate TACC3-chTOG (show CKAP5 Antibodies) complex formation, indicating that Aurora-A (show AURKA Antibodies) solely functions as a recruitment factor for the TACC3-chTOG (show CKAP5 Antibodies) complex to centrosomes and proximal mitotic spindles.
The TACC3 and clathrin were interdependent for spindle recruitment, having to interact in order for either to be recruited to the spindle.
DOCK7 (show DOCK7 Antibodies) interaction with TACC3 controls interkinetic nuclear migration and the genesis of neurons from radial glial progenitor cells during cortical development
results show that Tacc3 is a vulnerable component of the spindle assembly in lymphoma cells and is a promising cancer chemotherapy target
Tacc3 is a negative regulator of the Notch (show NOTCH1 Antibodies) signaling pathway.
role in hematopoietic stem cell function and interface with p53 (show TP53 Antibodies)-regulated apoptosis
the alpha-helix of FOG (show APAF1 Antibodies)-ZF3 recognizes a C-terminal portion of the TACC3 coiled-coil.
in addition to spindle assembly, Tacc3 has critical roles in chromosome separation and cytokinesis, and is essential for the mitosis of sclerotome mesenchymal cells during axial formation in mammals.
Results showed that high level of TACC3 expression was correlated with advanced clinicopathological classifications, and poor prognosis in non-small cell lung cancer patients indicating that TACC3 is a potential prognostic marker.
TACC3 is enriched in hepatocellular carcinoma and down-regulation inhibits the proliferation, clonogenicity, and cancer stem cell-like phenotype of HCC (show FAM126A Antibodies) cells
The measurement of TACC3 protein expression may be beneficial for predicting clinical outcomes for gastric cancer patients
TACC3 depletion in human cell lines causes shorter mitotic spindles. co-immunoprecipitation experiments showed reduced binding between TACC3-F543A and Aurora-A (show AURKA Antibodies).
TACC3 is expressed in esophageal squamous cell carcinoma and correlates with poor prognosis
FGFR3 (show FGFR3 Antibodies)-TACC3 rearrangements occur in a subset of patients with lung adenocarcinoma. Such patients should be considered for clinical trials featuring FGFR (show FGFR2 Antibodies) inhibitors.
our data demonstrated the oncogenic role of FGFR3 (show FGFR3 Antibodies)-TACC3 in vitro, indicating that FGFR3 (show FGFR3 Antibodies)-TACC3 may be useful as a diagnostic marker and therapeutic target in cancers.
TACC3 depletion induces G1 arrest and cell death by activating p38 (show CRK Antibodies)-p53 (show TP53 Antibodies)-p21 (show CDKN1A Antibodies) signaling and triggering a centrosome-mediated cellular stress response.
findings suggest that TACC3 could be recruited as a bridge to cooperatively mediate between the HIF-2alpha (show EPAS1 Antibodies) PAS (show PASK Antibodies)-B.ARNT PAS (show PASK Antibodies)-B complex, thereby participating more directly in HIF-dependent gene transcription than previously anticipated
findings provide critical information regarding the mechanisms by which TACC3 contributes to genomic instability
TACC1 (show TACC1 Antibodies) and TACC3 are each required for maintaining normal microtubule growth speed in Xenopus
XTACC3 can induce the recruitment of larger amounts of XMAP215 (show CKAP5 Antibodies) by increasing its local concentration, thereby promoting efficient microtubule elongation during mitosis
TACC3 promotes axon outgrowth and regulates microtubule dynamics in multiple embryonic cell types.
Results suggest that phosphorylation of maskin by Aurora-A (show AURKA Antibodies) prevents meiosis II proteins from being produced during meiosis I.
Maskin functions in mitotic spindle assembly.
Maskin activity and localization is controlled by differential phosphorylation
Maskin phosphorylation-dephosphorylation also oscillates with the cell cycle and is controlled by the kinase CDK1 (show CDK1 Antibodies) and the phosphatase calcineurin (show PPP3CA Antibodies)
Maskin mRNA is translationally regulated by at least two repressor elements and an activation element.
This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells.
, Arnt interacting protein
, transforming acidic coiled-coil-containing protein 3
, transforming acidic coiled coil 3
, CPEB-associated factor Maskin
, cytoplasmic polyadenylation element-binding protein-associated factor Maskin