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anti-Vacuolar Protein Sorting 35 Homolog (S. Cerevisiae) (vps35) Antibodies

vps35 belongs to a group of vacuolar protein sorting (VPS) genes. Additionally we are shipping vps35 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
vps35 65114 Q9EQH3
vps35 55737 Q96QK1
vps35 25479  
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Top anti-vps35 Antibodies at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Goat Un-conjugated EIA, IF, IHC (p), WB 20 μg Log in to see 6 to 8 Days
$203.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN185182 staining (1 ug/ml) of Human Brain lysate (RIPA buffer, 35 ug total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. ABIN185182 staining of paraffin embedded Human Testis showing A) Epithelial cells of the epididymis and B) Some leydig cells.  Microwaved antigen retrieval with A)Tris/EDTA buffer pH9 at 3 ug/ml or B)Citrate buffer pH6 at 10ug/ml., HRP-staining. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: Vps35  Sample Tissue: Mouse Lung lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated ELISA, WB VPS35 monoclonal antibody (M02), clone 2D3. Western Blot analysis of VPS35 expression in human colon. VPS35 monoclonal antibody (M02), clone 2D3. Western Blot analysis of VPS35 expression in HeLa. 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image VPS35 antibody [C3], C-term detects VPS35 protein at cytoplasm and membrane on human colon carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded colon carcinoma. VPS35 antibody [C3], C-term , dilution: 1:250. WB Image VPS35 antibody [C3], C-term detects VPS35 protein by western blot analysis. A. 30 μg A549 whole cell extract B. 30 μg H1299 whole cell extract C. 30 μg HCT116 whole cell extract 7.5 % SDS-PAGE VPS35 antibody [C3], C-term , dilution: 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Goat Un-conjugated IF, IHC, ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Breast, Epithelium: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB   500 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated ICC, IHC (p), WB   100 μL Log in to see 8 to 10 Days
$507.83
Details
Mouse Rabbit Un-conjugated IHC, WB   500 μg Log in to see 7 to 8 Days
$454.67
Details

vps35 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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Human
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Rat (Rattus)
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Top referenced anti-vps35 Antibodies

  1. Mouse (Murine) Polyclonal vps35 Primary Antibody for IHC, WB - ABIN350530 : Edgar, Polak: Human homologues of yeast vacuolar protein sorting 29 and 35. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 5 references for ABIN350530

  2. Cow (Bovine) Polyclonal vps35 Primary Antibody for EIA, IF - ABIN782935 : Nielsen, Gustafsen, Madsen, Nyengaard, Hermey, Bakke, Mari, Schu, Pohlmann, Dennes, Petersen: Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. in Molecular and cellular biology 2007 (PubMed)
    Show all 4 references for ABIN782935

  3. Human Monoclonal vps35 Primary Antibody for ELISA, WB - ABIN565910 : Prosser, Tran, Schooley, Wendland, Ngsee: A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. in Traffic (Copenhagen, Denmark) 2010 (PubMed)
    Show all 3 references for ABIN565910

  4. Human Polyclonal vps35 Primary Antibody for IHC, ELISA - ABIN185182 : Zhang, Yu, Gao, Fu, Dai, Zhao, Zheng, Zhao: Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21. in Genomics 2001 (PubMed)
    Show all 2 references for ABIN185182

More Antibodies against vps35 Interaction Partners

Fruit Fly (Drosophila melanogaster) Vacuolar Protein Sorting 35 Homolog (S. Cerevisiae) (vps35) interaction partners

  1. The in vivo effects of P316S, D620N and L774M of VPS35 using Drosophila as a model, were investigated.

  2. The findings of this study indicate that the VPS35 may play a crucial role in alpha-synucle in degradation by modulating the maturation of cathepsin D (show CTSD Antibodies) and might thereby contribute to the pathogenesis of the disease.

  3. overexpression of Vps35 ameliorates the pathogenic mutant LRRK2 (show LRRK2 Antibodies) eye phenotype in a Drosophila model of Parkinson's disease

  4. Vps35 negatively regulates actin (show ACTB Antibodies) polymerisation, and genetic interactions suggest that some of the endocytic and signalling defects of vps35 mutants are due to this function

Mouse (Murine) Vacuolar Protein Sorting 35 Homolog (S. Cerevisiae) (vps35) interaction partners

  1. These results provide evidence for VPS35's function in promoting spine maturation, which is likely through increasing AMPA (show GRIA3 Antibodies) receptor targeting to the postsynaptic membrane.

  2. Deletion of the VPS35 gene in dopamine (DA) neurons resulted in Parkinson disease-like deficits, including loss of DA neurons and accumulation of alpha-synuclein (show SNCA Antibodies).

  3. These results suggest that VPS35 deficiency or mutation promotes Parkinson Disease (PD) pathogenesis, and reveals a crucial pathway, VPS35-Lamp2a-alpha-synuclein (show SNCA Antibodies), to prevent PD pathogenesis.

  4. Our studies reveal unexpected genetic and functional interactions between VPS35 and EIF4G1 (show EIF4G1 Antibodies), two seemingly unrelated PD genes, and functionally connect them to alpha-synuclein (show SNCA Antibodies) pathobiology in yeast, worms, and mouse.

  5. Vps35 is necessary for mouse retinal ganglion cell survival and regeneration.

  6. VPS35 critically deregulates RANK signaling, thus restraining increased formation of hyperresorptive OCs and preventing osteoporotic deficits.

  7. VPS35 as an essential role in the suppression of AD neuropathology and in the inhibition of BACE1 (show BACE Antibodies) activation and Abeta (show APP Antibodies) production by promoting BACE1 (show BACE Antibodies) endosome-to-Golgi retrieval.

  8. These results suggest that mouse Vps26b (show VPS26B Antibodies)-Vps29 (show VPS29 Antibodies)-Vps35 retromer complex is implicated in the transport of sortilin (show SORT1 Antibodies) from endosomes to the trans-Golgi network.

Human Vacuolar Protein Sorting 35 Homolog (S. Cerevisiae) (vps35) interaction partners

  1. findings provide evidence that the VPS35 D620N mutation likely confers pathogenicity through a partial loss of function mechanism and that this may be linked to other known pathogenic mechanisms such as mitochondrial dysfunction

  2. VPS35 mutations cause mitochondrial fragmentation and cell death in cultured neurons in vitro, in mouse substantia nigra neurons in vivo and in human fibroblasts from an individual with PD who has the VPS35(D620N) mutation.

  3. neither the R120W nor the N370S variant of the GBA (show GBA Antibodies) gene nor D620N mutation of the VPS35 gene were detected among the Parkinson disease cases or the controls.

  4. Mutagenesis studies coupled with coimmunoprecipitations revealed that retromer-mediated trafficking requires the Env cytoplasmic tail that we show binds directly to retromer components Vps35 and Vps26.

  5. VPS35 D620N and EIF4G1 (show EIF4G1 Antibodies) R1205H mutations are not a common cause of Parkinson disease in the Greek population.

  6. provides molecular insights into the essential role of Vps26 (show VPS26A Antibodies) and Vps35 in Rab7 (show RAB7B Antibodies)-mediated recruitment of the core retromer complex

  7. This study demonstrated that Genetic variability of VPS35 in parkinsonism.

  8. VPS35 p.D620N is loss-of-function mutation with respect to VPS35 regulating synaptic transmission and AMPA (show GRIA3 Antibodies)-type glutamate (show GRIN1 Antibodies) receptors recycling in mouse cortical neurons and dopamine neuron-like cells produced from stem cells of human p.D620N carriers.

  9. D620N mutation in VPS35 restricts WASH complex recruitment to endosomes, inhibiting autophagy. The autophagy defects can be explained, at least in part, by abnormal trafficking of the autophagy protein ATG9A (show ATG9A Antibodies).

  10. the major defect of the D620N mutation in the retromer component VPS35 lies in the association to the actin-nucleating Wiskott-Aldrich syndrome (show WASL Antibodies) and SCAR homolog (WASH) complex.

vps35 Antigen Profile

Protein Summary

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex.

Gene names and symbols associated with vps35

  • vacuolar protein sorting 35 homolog (S. cerevisiae) (VPS35) antibody
  • vacuolar protein sorting-associated protein 35 (Tc00.1047053511367.170) antibody
  • vacuolar protein sorting-associated protein 35 (Tb10.70.5460) antibody
  • vacuolar protein sorting-associated protein 35 (BBOV_IV009740) antibody
  • vacuolar protein sorting-associated protein 35 (CC1G_12185) antibody
  • vacuolar protein sorting-associated protein 35 (PTRG_08682) antibody
  • vacuolar protein sorting-associated protein 35 (CMU_017400) antibody
  • vacuolar protein sorting-associated protein 35 (PHATR_43830) antibody
  • vacuolar protein sorting-associated protein 35 (MCYG_00751) antibody
  • vacuolar protein sorting-associated protein 35 (MGYG_01212) antibody
  • vacuolar protein sorting-associated protein 35 (PGTG_10018) antibody
  • vacuolar protein sorting-associated protein 35 (Tsp_09825) antibody
  • vacuolar protein sorting 35 homolog (S. cerevisiae) (vps35) antibody
  • Vacuolar protein sorting 35 (Vps35) antibody
  • vacuolar protein sorting 35 (yeast) (vps35) antibody
  • vacuolar protein sorting 35 (EHI_086580) antibody
  • vacuolar protein sorting 35 (EHI_002990) antibody
  • vacuolar protein sorting 35 (EHI_041950) antibody
  • vacuolar protein sorting 35 (EHI_096520) antibody
  • Vacuolar protein sorting 35 (Bm1_44045) antibody
  • vacuolar protein sorting 35 (LOC100285267) antibody
  • vacuolar protein sorting 35 (Vps35) antibody
  • vacuolar protein sorting 35 homolog (S. cerevisiae) (Vps35) antibody
  • 23.m05999 antibody
  • AI647796 antibody
  • bZ34G2.3 antibody
  • CG5625 antibody
  • DKFZp459E1510 antibody
  • Dmel\\CG5625 antibody
  • dvps35 antibody
  • MEM3 antibody
  • MGC81959 antibody
  • PARK17 antibody
  • si:rp71-34g2.3 antibody
  • vps35 antibody
  • wu:fa66e03 antibody
  • wu:fb95c08 antibody
  • zgc:136268 antibody

Protein level used designations for vps35

vacuolar protein sorting-associated protein 35 , vacuolar protein sorting 35 homolog (S. cerevisiae) , vacuolar protein sorting 35 homolog , vacuolar protein sorting 35-like , CG5625-PA , CG5625-PB , Vps35-PA , Vps35-PB , vacuolar protein sorting 35 , Vacuolar protein sorting 35 , maternal embryonic message 3 , maternal-embryonic 3 , vesicle protein sorting 35 , hVPS35

GENE ID SPECIES
415750 Gallus gallus
465139 Pan troglodytes
475346 Canis lupus familiaris
717394 Macaca mulatta
3551850 Trypanosoma cruzi strain CL Brener
3663050 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5479130 Babesia bovis T2Bo
6004947 Coprinopsis cinerea okayama7130
6346969 Pyrenophora tritici-repentis Pt-1C-BFP
6995620 Cryptosporidium muris RN66
7203962 Phaeodactylum tricornutum CCAP 1055/1
9223543 Arthroderma otae CBS 113480
10032453 Arthroderma gypseum CBS 118893
10544762 Puccinia graminis f. sp. tritici CRL 75-36-700-3
10907761 Trichinella spiralis
100015669 Monodelphis domestica
100056512 Equus caballus
100174173 Pongo abelii
100351202 Oryctolagus cuniculus
100367783 Saccoglossus kowalevskii
100551222 Meleagris gallopavo
100559729 Anolis carolinensis
100599794 Nomascus leucogenys
100623578 Sus scrofa
37536 Drosophila melanogaster
446307 Xenopus laevis
549980 Xenopus (Silurana) tropicalis
561697 Danio rerio
3405460 Entamoeba histolytica HM-1:IMSS
3407291 Entamoeba histolytica HM-1:IMSS
3410852 Entamoeba histolytica HM-1:IMSS
3411245 Entamoeba histolytica HM-1:IMSS
6103693 Brugia malayi
100285267 Zea mays
65114 Mus musculus
55737 Homo sapiens
25479 Rattus norvegicus
521864 Bos taurus
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